Download or read book Self Organized 3D Tissue Patterns written by Xiaolu Zhu and published by CRC Press. This book was released on 2022-05-26 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapies for regenerating damaged tissue and organs have been attracting much attention. In order to efficiently regenerate the functions of living tissue and organs, diverse attempts have been made to utilize scaffolds to “mold” artificial tissue structures. However, the structural complexity of reconstituted tissue is limited by the mechanical precision of scaffolds, which still cause problems arising from their degradation, immunogenic reactions, and so forth. It is also being realized that ultimately the best approach might be to rely on the innate self-organizing properties of cells and the regenerative capability of the organism itself. This book investigates the 3D-pattern formation and evolution mechanism in multipotent cells embedded in 3D semi-synthetic hydrogels and the control methodology for self-organized patterns. The authors theoretically and experimentally demonstrate several types of topological 3D-pattern formation by cells in a 3D matrix in vitro, which can be modeled and predicted by mathematical models based on the reaction-diffusion dynamics of various chemical, physical, and mechanical cues. The study, focused on the 3D pattern formation of cells, provides (i) a unique perspective for understanding the self-organized 3D tissue structures based on Turing instability, (ii) the scheme for rationally controlling the cellular self-organization via exogenous factors or tailored inner interfaces inside hydrogels, and (iii) the elaborate and sophisticated regulating method for tuning collective cellular behaviors in 3D matrices.

Download or read book Self Organized 3D Tissue Patterns written by Xiaolu Zhu and published by CRC Press. This book was released on 2022-05-25 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book involves the topics on the frontier of the tissue engineering and regenerative medicine. It transits new ideas, new scientific results, and discusses on the design of the self-organized tissues. This book will have a broader readership, because it provides scientific information for diverse disciplinary fields (biology, material science, engineering, medicine, and life science). More scientists, professors, graduates, undergraduates and researchers would be inspired.This book will provide some 3D structure images that would impress the readers with intuitional and abundant information which includes experimental and simulative results.

Download or read book Cell and Organ Printing written by Bradley R. Ringeisen and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell and organ printing has become a hot topic of scientific pursuit. Since several early publications between 2000-2003 that demonstrated proof-of-concept, cell and organ printing has blossomed into a rich area for scientific exploration that is being performed by researchers across the globe. Research has thoroughly demonstrated that living cells can be printed via a number of actuations including electrospray, extrusion via micropens and ejection through photothermal, thermal or optical mechanisms. This topic has come of age and it is ripe for exploring the underpinnings of the research to date. We have included research that uses printing technology to deposit or guide cells for tissue engineering applications and for completeness, we have also included chapters describing bacteria printing, biomolecular printing that could be used to build growth factors or recruitment macromolecules into scaffolds, tissue microdissection, as well as live cell printing. The breadth of approaches includes 3D freeform fabrication, ink jet, laser guidance and modified laser direct write techniques. We hope that this book is not the final word but the first word, defining how these tools have been used to take the first steps towards the ultimate goal of creating heterogeneous tissue constructs. Only time will tell whether cell printers will truly become organ printers, but the technologies described in this book hold promise to achieve what the field of regenerative medicine requires - functional 3D scaffolds with multiple cell types differentiated into functional tissue!

Download or read book Introduction to Tissue Engineering written by Ravi Birla and published by John Wiley & Sons. This book was released on 2014-06-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference and teaching aid on tissue engineering—covering everything from the basics of regenerative medicine to more advanced and forward thinking topics such as the artificial liver, bladder, and trachea Regenerative medicine/tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation. Introduction to Tissue Engineering: Applications and Challenges makes tissue engineering more accessible to undergraduate and graduate students alike. It provides a systematic and logical eight-step process for tissue fabrication. Specific chapters have been dedicated to provide in-depth principles for many of the supporting and enabling technologies during the tissue fabrication process and include biomaterial development and synthesis, bioreactor design, and tissue vascularization. The tissue fabrication process is further illustrated with specific examples for liver, bladder, and trachea. Section-coverage includes an overall introduction of tissue engineering; enabling and supporting technologies; clinical applications; and case studies and future challenges. Introduction to Tissue Engineering: Presents medical applications of stem cells in tissue engineering Deals with the effects of chemical stimulation (growth factors and hormones) Covers current disease pathologies and treatment options (pacemakers, prosthesis) Explains bioengineering, design and fabrication, and critical challenges during tissue fabrication Offers PowerPoint slides for instructors Features case studies and a section on future directions and challenges As pioneering individuals look ahead to the possibility of generating entire organ systems, students may turn to this text for a comprehensive understanding and preparation for the future of regenerative medicine.

Download or read book Stem Cells Basics and Clinical Translation written by Robert Chunhua Zhao and published by Springer. This book was released on 2015-09-14 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development.

Download or read book 3D Bioprinting in Regenerative Engineering written by Ali Khademhosseini and published by CRC Press. This book was released on 2018-04-17 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative engineering is the convergence of developmental biology, stem cell science and engineering, materials science, and clinical translation to provide tissue patches or constructs for diseased or damaged organs. Various methods have been introduced to create tissue constructs with clinically relevant dimensions. Among such methods, 3D bioprinting provides the versatility, speed and control over location and dimensions of the deposited structures. Three-dimensional bioprinting has leveraged the momentum in printing and tissue engineering technologies and has emerged as a versatile method of fabricating tissue blocks and patches. The flexibility of the system lies in the fact that numerous biomaterials encapsulated with living cells can be printed. This book contains an extensive collection of papers by world-renowned experts in 3D bioprinting. In addition to providing entry-level knowledge about bioprinting, the authors delve into the latest advances in this technology. Furthermore, details are included about the different technologies used in bioprinting. In addition to the equipment for bioprinting, the book also describes the different biomaterials and cells used in these approaches. This text: Presents the principles and applications of bioprinting Discusses bioinks for 3D printing Explores applications of extrusion bioprinting, including past, present, and future challenges Includes discussion on 4D Bioprinting in terms of mechanisms and applications

Download or read book Translational Medicine written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2018-03-13 with total page 1329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Download or read book Engineering Strategies for Regenerative Medicine written by Tiago G. Fernandes and published by Academic Press. This book was released on 2019-11-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry

Download or read book Biomaterial Control of Therapeutic Stem Cells written by Akon Higuchi and published by Royal Society of Chemistry. This book was released on 2019-02-18 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human pluripotent stem cells (hPSCs), which cover both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), show promise for drug discovery and regenerative medicine applications. These stem cells cannot be cultured on conventional tissue culture dishes but on biomaterials that have specific interactions with the hPSCs. Differentiation is regulated by the biological and physical cues conferred by the biomaterial. This book provides a systematic treatment of these topics bridging the gap between fundamental biomaterials research of stem cells and their use in clinical trials. The author looks at hPSC culture on a range of biomaterial substrates. Differentiation and control of hESCs and iPSCs into cardiomyocytes, osteoblasts, neural lineages and hepatocytes are covered. The author then considers their translation into stem cell therapies and looks at clinical trials across spinal cord injury, macular degeneration, bone disease and myocardial infarction. Finally, a chapter on future directions closes the book. By using this book, the reader will gain a robust overview of current research and a clearer understanding of the status of clinical trials for stem cell therapies.

Download or read book Nanotechnologies in Preventive and Regenerative Medicine written by Vuk Uskokovic and published by Elsevier. This book was released on 2017-10-30 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Download or read book Design Principle and Application of Self Assembled Nanobiomaterials in Biology and Medicine written by Alok Pandya and published by Academic Press. This book was released on 2022-08-04 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine discusses recent advances in science and technology using nanoscale units that show the novel concept of combining nanotechnology with various research disciplines within both the biomedical and medicine fields. Self-assembly of molecules, macromolecules, and polymers is a fascinating strategy for the construction of various desired nanofabrication in chemistry, biology, and medicine for advanced applications. It has a number of advantages: (1) It is involving atomic-level modification of molecular structure using bond formation advanced techniques of synthetic chemistry. (2) It draws from the enormous wealth of examples in biology for the development of complex, functional structures. (3) It can incorporate biological structures directly as components in the final systems. (4) It requires that the target self-assembled structures be thermodynamically most stable with relatively defect-free and self-healing. In this book, we cover the various emerging self-assembled nanostructured objects including molecular machines, nano-cars molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nano-flakes, nano-cubes, nano-disks, nanorings, DNA origami, transmembrane channels, and vesicles. These self-assembled materials are used for sensing, drug delivery, molecular recognition, tissue engineering energy generation, and molecular tuning. Provides a basic understanding of how to design, and implement various self-assembled nanobiomaterials Covers principles implemented in the constructions of novel nanostructured materials Offers many applications of self-assemblies in fluorescent biological labels, drug and gene delivery, bio-detection of pathogens, detection of proteins, probing of DNA structure, tissue engineering, and many more

Download or read book Stem Cells Handbook written by Stewart Sell and published by Springer Science & Business Media. This book was released on 2003-10-22 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The power of stem cells for tissue development, regeneration, and renewal has been well known by embryologists and developmental biologists for many years. Those presently active in research in the stem cell field owe much to previous work by embryologists and cancer researchers for their insights into what stem cells can do. In the last 4- 5 years, the rapid expansion of the concept of adult tissue stem cells as pluripotent progenitors for various tissues has led to an even greater appreciation of the power of stem cells. The demonstration that both embryonic and adult tissue stem cells have the ability to produce progenitor cells for tissue renewal has opened vast possibilities for treatment of congenital deficiency diseases as well as for regeneration of damaged tissues. Older concepts of determination leading to loss of potential during differentiation of adult tissues are being replaced by newer ideas that cells with multiple potential exist in different forms in various adult organs and that cells thought to be restricted to differentiation to one cell type may be able to "transdifferentiate" into other tissue cell types. Thus, the concept of "embryonic rests" in adult tissues, hypothesized to be the cellular origin of cancer by Durante and Conheim in the 1870s, now can be expanded to include survival of pluripotential embryonic-like stem cells in adult tissues.

Download or read book Fundamentals of Nanoparticles written by Abdel Salam Hamdy Makhlouf and published by William Andrew. This book was released on 2018-08-09 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Nanoparticles: Classifications, Synthesis Methods, Properties and Characterization explores the nanoparticles and architecture of nanostructured materials being used today in a comprehensive, detailed manner. This book focuses primarily on the characterization, properties and synthesis of nanoscale materials, and is divided into three major parts. This is a valuable reference for materials scientists, and chemical and mechanical engineers working in R&D and academia, who want to learn more about how nanoparticles and nanomaterials are characterized and engineered. Part one covers nanoparticles formation, self-assembly in the architecture nanostructures, types and classifications of nanoparticles, and signature physical and chemical properties, toxicity and regulations. Part two presents different ways to form nanometer particles, including bottom-up and top-down approaches, the classical and non-classical theories of nanoparticles formation and self-assembly, surface functionalization and other surface treatments to allow practical use. Part three covers characterization of nanoparticles and nanostructured materials, including the determination of size and shape, in addition to atomic and electronic structures and other important properties. Includes new physical and chemical techniques for the synthesis of nanoparticles and architecture nanostructures Features an in-depth treatment of nanoparticles and nanostructures, including their characterization and chemical and physical properties Explores the unusual properties of materials that are developed by modifying their shape and composition and by manipulating the arrangement of atoms and molecules Explains important techniques for the synthesis, fabrication and the characterization of complex nano-architectures

Download or read book The Biology and Therapeutic Application of Mesenchymal Cells 2 Volume Set written by Kerry Atkinson and published by John Wiley & Sons. This book was released on 2017-01-17 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Download or read book Novel Biomaterials for Tissue Engineering 2018 written by Emmanuel Stratakis and published by MDPI. This book was released on 2019-02-05 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Novel Biomaterials for Tissue Engineering 2018" that was published in IJMS

Download or read book 3D Bioprinting Revolution written by Dr. Sabrie Soloman and published by KHANNA PUBLISHING HOUSE. This book was released on with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provide a detailed guide and optimum implementations to each of the stated 3D printing technology, the basic understanding of its operation, and the similarity as well as the dissimilarity functions of each printer. School Students, University undergraduates =, and ost graduate students will find the book if immense value to equip them not only with the fundamental in design and implementation but also will encourage them to acquire a system and practice creating their own innovative samples. Furthermore, professionals and educators will be well prepared to use the knowledge and the expertise to practice and advance the technology for the ultimate good of their respective organizations.