Download or read book Selected Papers of Frederick Sanger written by Frederick Sanger and published by World Scientific. This book was released on 1996 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important volume is mainly concerned with the development of methods for ?sequencing? ? that is, determination of the order of the amino acids in proteins and of nucleotides in RNA and DNA. In 1943 the position of only one amino acid in a protein (insulin) was known, and Sanger's first paper resulted in finding a second amino acid. In his final paper in 1982 he describes the determination of a DNA sequence of 48,502 nucleotides. The papers describe the steady improvements in techniques, and exciting biological results revealed by the sequences.
Download or read book Chemical Biology Selected Papers Of H G Khorana With Introductions written by H Gobind Khorana and published by World Scientific. This book was released on 2000-05-24 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics.The selected papers illustrate the developments of the chemical synthesis of nucleotides and nucleotide coenzymes of ribo- and deoxy-ribo-polynucleotides (RNA, DNA), of the total synthesis of genes in the laboratory, and principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and the author's work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and the membrane protein bacteriorhodopsin, a biological proton pump. These studies elucidated the mechanism of proton translocation, which is central to bioenergetics.
Download or read book Fred Sanger Double Nobel Laureate written by George G. Brownlee and published by Cambridge University Press. This book was released on 2020-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
Download or read book The Discovery of Insulin written by Michael Bliss and published by University of Toronto Press. This book was released on 2017-06-22 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
Download or read book Basic Science Methods for Clinical Researchers written by Morteza Jalali and published by Academic Press. This book was released on 2017-03-31 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow's clinician scientists and future leaders in discovery science. - Serves as a helpful guide for clinical researchers who lack a conventional science background - Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms - Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data - Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)
Download or read book Frederick Sanger written by Joe S. Jeffers and published by Springer. This book was released on 2017-03-14 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.
Download or read book Sex and the Single Girl written by Helen Gurley Brown and published by Open Road Media. This book was released on 2012-07-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1962 blockbuster that took on “one of the most absurd (if universal) myths of our time: that every girl must be married” (The New York Times). Helen Gurley Brown, the iconic editor in chief of Cosmopolitan for thirty-two years, is considered one of the most influential figures of Second Wave feminism. Her first book sold millions of copies, became a cultural phenomenon, and ushered in a whole new way of thinking about work, men, and life. Feisty, fun, and totally frank, Sex and the Single Girl offers advice to unmarried women that is as relevant today as it was when it burst onto the scene in the 1960s. This spirited manifesto puts women—and what they want—first. It captures the exuberance, optimism, and independence that have influenced the lives of so many contemporary American women.
Download or read book A Nobel Fellow on Every Floor written by John Finch and published by Icon Books. This book was released on 2024-06-07 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Cambridge in the 1950s, several research groups funded by the Medical Research Council were producing exciting results. In the Biochemistry Department, Sanger determined the amino acid sequence of insulin, and was awarded a Nobel Prize for this in 1958. At the Cavendish Laboratory, in the MRC Unit for the Study of the Molecular Structure of Biological Systems, Watson and Crick solved the structure of DNA, and Perutz and Kendrew produced the first three-dimensional maps of protein structures – haemoglobin and myoglobin – for which all four were later awarded Nobel Prizes. This made it timely to create, in 1962, a new Laboratory of Molecular Biology in Cambridge by amalgamating these groups with other MRC-funded groups from London. The Laboratory has become one of the most successful in its field, and the number of Nobel Prizes awarded over the years to scientists at LMB has risen to thirteen. This book follows the development of LMB, through the people who moved into the new Laboratory and their research. It describes events and personalities that have given the Laboratory a friendly, family atmosphere, while continuing to be scientifically productive.
Download or read book International Books in Print written by and published by . This book was released on 1998 with total page 1332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecules and Life written by Joseph Stewart Fruton and published by John Wiley & Sons. This book was released on 1972 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Linus Pauling in His Own Words written by Barbara Marinacci and published by Simon and Schuster. This book was released on 1995-10-30 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two-time Nobel Prize winner, Linus Pauling was known for his scientific discoveries and of his breadth of knowledge, which spanned disciplines. The author, who knew Pauling well, has chosen from among more than 60 years of essays, letters, articles, books, speeches and interviews. As Pauling himself says in the Introduction, "This book will take me as close to writing my memoirs or autobiography as I shall ever get".
Download or read book Funding Feminism written by Joan Marie Johnson and published by UNC Press Books. This book was released on 2017-08-04 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joan Marie Johnson examines an understudied dimension of women's history in the United States: how a group of affluent white women from the late nineteenth through the mid-twentieth centuries advanced the status of all women through acts of philanthropy. This cadre of activists included Phoebe Hearst, the mother of William Randolph Hearst; Grace Dodge, granddaughter of Wall Street "Merchant Prince" William Earle Dodge; and Ava Belmont, who married into the Vanderbilt family fortune. Motivated by their own experiences with sexism, and focusing on women's need for economic independence, these benefactors sought to expand women's access to higher education, promote suffrage, and champion reproductive rights, as well as to provide assistance to working-class women. In a time when women still wielded limited political power, philanthropy was perhaps the most potent tool they had. But even as these wealthy women exercised considerable influence, their activism had significant limits. As Johnson argues, restrictions tied to their giving engendered resentment and jeopardized efforts to establish coalitions across racial and class lines. As the struggle for full economic and political power and self-determination for women continues today, this history reveals how generous women helped shape the movement. And Johnson shows us that tensions over wealth and power that persist in the modern movement have deep historical roots.
Download or read book Forthcoming Books written by Rose Arny and published by . This book was released on 2002 with total page 1752 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bulletin of the Atomic Scientists written by and published by . This book was released on 2008 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Non Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Download or read book Sources of Medical Technology written by Committee on Technological Innovation in Medicine and published by National Academies Press. This book was released on 1995-01-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence suggests that medical innovation is becoming increasingly dependent on interdisciplinary research and on the crossing of institutional boundaries. This volume focuses on the conditions governing the supply of new medical technologies and suggest that the boundaries between disciplines, institutions, and the private and public sectors have been redrawn and reshaped. Individual essays explore the nature, organization, and management of interdisciplinary R&D in medicine; the introduction into clinical practice of the laser, endoscopic innovations, cochlear implantation, cardiovascular imaging technologies, and synthetic insulin; the division of innovating labor in biotechnology; the government- industry-university interface; perspectives on industrial R&D management; and the growing intertwining of the public and proprietary in medical technology.
Download or read book YOUMARES 8 Oceans Across Boundaries Learning from each other written by Simon Jungblut and published by Springer. This book was released on 2018-08-29 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents the proceedings volume of the YOUMARES 8 conference, which took place in Kiel, Germany, in September 2017, supported by the German Association for Marine Sciences (DGM). The YOUMARES conference series is entirely bottom-up organized by and for YOUng MARine RESearchers. Qualified early career scientists moderated the scientific sessions during the conference and provided literature reviews on aspects of their research field. These reviews and the presenters’ conference abstracts are compiled here. Thus, this book discusses highly topical fields of marine research and aims to act as a source of knowledge and inspiration for further reading and research.
