Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Download or read book EPA s High Production Volume HPV Chemical Testing Program written by United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment and published by . This book was released on 1999 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book written by Jean-Christophe Rufin and published by W. W. Norton & Company. This book was released on 2002-08-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequel to The Abyssinian finds Jean-Baptiste Poncet in Persia practicing medicine for the Shah and trying to rescue his wife and daughter from inside the walls of a city under attack. Reprint. 11,500 first printing.
Download or read book Department of the Interior and Related Agencies Appropriations for written by United States. Congress. Senate. Committee on Appropriations and published by . This book was released on 2007 with total page 1484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Department of the Interior and Related Agencies Appropriations for Fiscal Year 2007 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on the Dept. of the Interior and Related Agencies and published by . This book was released on 2006 with total page 1494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nominations of the 107th Congress First Session written by United States. Congress. Senate. Committee on Environment and Public Works and published by . This book was released on 2002 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vitro Toxicology Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2000-11-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Download or read book Toxic Substances Control written by United States. Congress. House. Committee on Government Operations. Environment, Energy, and Natural Resources Subcommittee and published by . This book was released on 1993 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Federal Register written by and published by . This book was released on 2012-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book TSCA written by Lynn L. Bergeson and published by American Bar Association. This book was released on 2000 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemicals in progress Bulletin written by and published by . This book was released on 1991 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Silico Toxicology written by Mark Cronin and published by Royal Society of Chemistry. This book was released on 2010-10-28 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Silico methods to predict toxicity have become increasingly important recently, particularly in light of European legislation such as REACH and the Cosmetics Regulation. They are also being used extensively worldwide e.g. in the USA, Canada, Japan and Australia. In assessing the risk that a chemical may pose to human health or to the environment, focus is now being directed towards exploitation of in silico methods to replace in vivo or in vitro techniques. A prediction of potential toxicity requires several stages: 1) Collation and organisation of data available for the compound, or if this is not available, information for related compounds. 2) An assessment of the quality of the data. 3) Generation of additional information about the compound using computational techniques at various levels of complexity - calculation of physico-chemical properties, 2-D, 3-D / MO descriptors and specific receptor modelling / interaction. 4) Use of an appropriate strategy to predict toxicity - ie a statistically valid method which makes best use of all available information (mechanism of action, activity for related compounds, extrapolation across species and endpoints, likely exposure scenario amounts over time etc). 5) Consideration then needs to be given to how this information is used in the real world ie use of expert systems / tools as relevant to assessors (if sufficiently different to previous) - weight of evidence approaches. 6) Finally evidence should be presented from case studies within this area. No other publication brings together information on all of these areas in one book and this publication is unique in that it provides a logical progression through every one of these key stages and defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals. The volume is aimed at the developers and users of in silico toxicology and provides an analysis of all aspects required for in silico prediction of toxicology, including data collation, quality assessment and computational approaches. The contributions from recognised leaders in each of these areas include evidence of the use and applicability of approaches using real world case studies concerning both environmental and human health effects. The book provides a very useful single source reference for people working in this area including academics, professionals, under- and post-graduate students as well as Governmental Regulatory Scientists involved in chemical risk assessment and REACH.
Download or read book Toxicological Risk Assessment of Chemicals written by Elsa Nielsen and published by CRC Press. This book was released on 2008-02-21 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Download or read book Reauthorization of the Toxic Substances Control Act written by United States. Congress. Senate. Committee on Environment and Public Works. Subcommittee on Toxic Substances, Research, and Development and published by . This book was released on 1994 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distributed to some depository libraries in microfiche.
Download or read book Handbook of Plasticizers written by George Wypych and published by Elsevier. This book was released on 2023-02-08 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Plasticizers, Fourth Edition provides a comprehensive review of the current literature as well as cutting-edge details on plasticizers obtained from renewable resources. The book specifies the typical properties of plasticizers belonging to one of thirty-one groups, including expected properties in a given group. The mechanisms of plasticizers, plasticization production steps, and their material behavior in plasticized systems are outlined, along with theoretical background to help readers understand practical observations and methods of material improvement. Other chapters cover the effects on the physical and mechanical properties of plasticized materials, their use in polymers, processing defects formation, and more. This is an essential professional reference, providing R&D scientists, production chemists, and engineers the information they need to avoid certain plasticizers in applications where they may cause health or material durability problems. In addition, the book shows readers how and where to use plasticizers more effectively. - Provides detailed coverage of thirty-one groups of plasticizers, covering their properties, production, processing, applications, health and environmental aspects - Contains new material on odors in plastic materials and their removal - Includes expanded coverage of plasticizers from renewable resources
Download or read book Departments of Veterans Affairs and Housing and Urban Development and Independent Agencies Appropriations for 2005 written by United States. Congress. House. Committee on Appropriations. Subcommittee on VA, HUD, and Independent Agencies and published by . This book was released on 2004 with total page 1260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Departments of Veterans Affairs and Housing and Urban Development and Independent Agencies Appropriations for 2005 Environmental Protection Agency pt 5 American Battlefield Monuments Commission Selective Service System written by United States. Congress. House. Committee on Appropriations. Subcommittee on VA, HUD, and Independent Agencies and published by . This book was released on 2004 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
