Download or read book Salisphere Development for Salivary Gland Regeneration written by Rimah Abdullah A. Saleem and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Salisphere Development for Salivary Gland Regeneration written by Rimah Abdullah Saleem and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary gland stem/progenitor cells are considered a promising solution for ameliorating salivary gland damage. mTOR signalling is known to play a role during salivary gland atrophy as ligation of the salivary main excretory duct results in the activation of mammalian target of rapamycin (mTOR). Cultured mouse and human salivary gland stem/progenitor cells in vitro are able to form spherical non-adherent clusters named salispheres. As mTOR plays a role during glandular atrophy, salispheres were cultured from un-operated, ligated and de-ligated glands. This project aimed to understand several factors on the culture of salispheres. Indeed, mTOR is inactivated in healthy glands but activated during atrophy. Measuring changes in mTOR activity in growing salispheres highlighted the importance of this network for salisphere survival, and a potential correlation between glandular atrophy and salisphere culture. Rapamycin treatment illustrated the necessity of mTOR for growing salispheres, whereas LiCl treatment suggested that GSK-3 inhibition stimulated the expansion of salispheres. Interestingly, injury appeared to alter the growth behaviour of salispheres compared to controls. Mainly, salispheres adhere to a surface of the plastic dish and acquire fibroblastic-like structures suggesting that signalling alterations might be responsible for these changes. The detection of 4e-bp1 and S6 rp expression in salispheres suggested that mTOR was responsible for salisphere growth because it is involved in protein translation, but it was not responsible for the morphological modification post-injury. Changes in the ability of salispheres to adhere to a surface raised two questions. First, were morphological alterations mediated by the cytoskeletal rearrangement? For this reason, RhoA/ROCK and mTORC2 were investigated, as they are both involved in the cytoskeletal organisation.
Download or read book Salivary Gland Development and Regeneration written by Seunghee Cha and published by Springer. This book was released on 2017-02-20 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.
Download or read book Regeneration of Salivary Glands written by Guy Carpenter and published by . This book was released on 2017-03-31 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regeneration of Salivary Glands examines the current state of salivary regeneration by understanding the normal processes of development, function and tissue repair. It also explores the experimental and clinical approaches to stem cell therapy, mostly for irradiation induced salivary gland damage.Irradiation of head and neck cancers often involves the inclusion of salivary glands as it is difficult to focus the beams accurately enough. As a result, irritation of oral tissues and loss of saliva often lead to mucositis, which is the leading cause for patients not completing their treatments. Based on basic research that has shown stem cells develop into salivary glands, the regeneration process recapitulates aspects of this stem cell differentiation. This process involves several signaling pathways, but the Wnt pathway is of special interest as already shown in gut epithelial turnover and salivary gland stem cell differentiation.These challenges and new therapies developed in helping salivary gland regeneration are discussed in depth, and will be of interest to postgraduates and researchers in the fields of regenerative medicine and stem cell research.
Download or read book Salivary Glands written by Abigail S. Tucker and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary glands are of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. This publication highlights specific aspects of salivary gland development, investigating the mechanisms involved in embryonic development, the current research in stem cells, the ability of adult glands to regenerate and the signalling pathways involved in this process. Key stages of salivary gland development, moving from initiation to differentiation of the glands, are discussed, as well as unusual adaptations, ranging from making silk to making venom. The book finally provides new data on surgical techniques and diagnostic tools for clinicians involved in salivary gland disorders. Researchers and students with an interest in craniofacial sciences as well as clinicians dealing with salivary gland disorders will find this publication an excellent source of up-to-date information.
Download or read book Regulation of the Structure and the Origin of Salispheres for Their Potential in Promoting Salivary Gland Regeneration written by 李浩緯 and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stem Cells in Craniofacial Development and Regeneration written by George T.J. Huang and published by John Wiley & Sons. This book was released on 2013-04-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.
Download or read book Stem Cells Heterogeneity Novel Concepts written by Alexander Birbrair and published by Springer. This book was released on 2019-04-23 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.
Download or read book Progenitor Cell Contributions to Maintenance and Regeneration in Salivary Gland and Olfactory written by Pei-Lun Weng and published by . This book was released on 2018 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embryonic development of the salivary gland is well characterized, but the origin of adult secretory acinar cells during normal turnover or regeneration has been unclear. There is a significant body of literature suggesting that the adult salivary gland has bipotent stem cells responsible for tissue homeostasis and regeneration after injury. Various putative stem cells have been identified, including cells marked by expression of the basic helix-loop-helix transcription factor Ascl3. Ascl genes, members of the achaete scute-like family, are expressed in progenitor cells of many tissues. Early work in this thesis more closely investigated the nature of the Ascl3+ cells. The results showed that in the olfactory epithelium, Ascl3 expression marks progenitor cells that are lineage committed to generate microvillar cells and Bowman's glands, but that Ascl3 expression does not mark the multipotent stem cells. To further examine the origin of differentiated acinar cells in the salivary gland, two independent genetic models were used to investigate putative stem cells. Excretory and intercalated ducts are proposed to be the location of adult salivary gland stem cells. Keratin 5 (K5) is expressed in basal excretory duct and intercalated duct cells, and Axin 2, a specific target of the Wnt-signaling pathway, labels intercalated duct cells. This work showed that under normal homeostasis, K5- and Axin 2-labeled duct cells do not participate in acinar cell replacement. In addition, these cells are not involved in regeneration of acinar cells after ductal ligation injury. Surprisingly, after severe irradiation-induced salivary gland damage, K5- and Axin 2-labeled intercalated duct cells do generate acinar cells. Furthermore, the duct-derived acinar cells express several functional markers for secretion. This is the first in vivo lineage tracing analysis indicating that duct cells can regenerate acinar cells. These results suggest that the cellular plasticity of the duct cells provides an alternative route to rescue salivary gland function after irradiation-induced injury. This study opens an exciting possibility for future directions in engineering the regeneration of acinar cells for those head and neck cancer patients with radiation-induced dry mouth (xerostomia).
Download or read book Saliva Secretion and Functions written by A.J.M. Ligtenberg and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-31 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health professionals are more and more aware of the importance of saliva for oral health and well-being. As saliva secretion is steadily compromised with advancing age, it becomes a factor of concern in societies with an aging population, especially with a growing number of people who keep their own teeth. The numerous functions of saliva, like antimicrobial activity, lubrication, wound healing and its role in taste experience are only truly recognized when saliva secretion is hampered. In medical diagnostics, saliva shows its value as a safe and economical alternative to blood. This publication provides a comprehensive overview of the latest developments in salivary research by some of the world’s leading experts in the field. Chapters deal with various aspects: anatomy and physiology, e.g. regeneration of salivary glands, saliva functions, e.g. its protective and rheological properties, and diagnostics and disorders, e.g. xerostomia and hypersalivation. This book is not only recommended to basic scientists working in the field of oral biology, but also to dental students, dentists and health professionals who want to know more about one of the most underestimated bodily fluids.
Download or read book Essentials of Bioinformatics Volume II written by Noor Ahmad Shaik and published by Springer Nature. This book was released on 2019-10-18 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.
Download or read book Regenerative Approaches in Dentistry written by Sepanta Hosseinpour and published by Springer Nature. This book was released on 2021-01-25 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides evidence-based information in the field of regenerative dentistry discussing the most recent advances, current clinical applications, limitations and future directions. The coverage encompasses the regeneration of alveolar bone, the dentine-pulp complex, enamel, the periodontium and other tissues associated with the oral cavity. A full description is provided of regenerative approaches in dentistry including regenerative endodontics and tooth repair, regenerative periodontics, regenerative assisted orthodontics, regenerative approaches in oral medicine, and dental tissue derived stem cells and their potential applications. The book is written by an international team of leading experts. It will be beneficial for students, practitioners and researchers in the fields of endodontics, periodontics and implantology.
Download or read book ISCOMS Book of Abstracts written by and published by ISCOMS. This book was released on 2005 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Download or read book Organ Tissue Engineering written by Daniel Eberli and published by Springer. This book was released on 2021-04-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function. In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.
Download or read book Stem Cells and Human Diseases written by Rakesh K. Srivastava and published by Springer Science & Business Media. This book was released on 2012-01-31 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.
Download or read book Organ Regeneration Based on Developmental Biology written by Takashi Tsuji and published by Springer. This book was released on 2018-09-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews three-dimensional (3D) stem cell culture and proof of concept for organ regeneration. The chapters present studies based on developmental biology but not tissue engineering using bio-degradative scaffolds. The ultimate goal of regenerative therapy, the next generation of regenerative therapy, is to develop fully functioning bioengineered 3D organs that can replace lost or damaged organs following disease, injury, or aging. Next-generation regenerative therapy will consist of organ-replacement regenerative therapy, which aims to reproduce reciprocal epithelial and epithelial interactions and epithelial and mesenchymal interactions that occur during embryogenesis. The book then discusses the generation of several 3D functional organs and organoids such as brain, inner ear, tooth, hair, salivary glands, lacrimal glands, gastrointestinal organs, kidney, liver, and lung. This work will appeal to a wide readership such as medical scientists, developmental biologists, clinicians, and patients. The volume provides valuable information and ideas to form a next-generation field of science.
