Download or read book The Saga of the Nerve Growth Factor written by Rita Levi-Montalcini and published by World Scientific. This book was released on 1997 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of articles written by Nobel Laureate Rita Levi-Montalcini and published from 1942 to 1995. Studies described in the first part set the stage for the discovery of a protein molecule which became known as the Nerve Growth Factor (NGF), described in detail in the second part. The NGF synthesized in minute amounts in all vertebrate tissues, plays an essential role in the differentiation and survival of several nerve cell populations in the peripheral and central nervous system. The discovery of the NGF was defined by the Nobel Foundation as a milestone in developmental neurobiology, and the author was awarded in 1986 with this prestigious award. Studies pursued in subsequent years and still in progress, have unveiled other fundamental properties of the NGF, described in the third part of this volume.
Download or read book Saga Of The Nerve Growth Factor The Preliminary Studies Discovery Further Development written by Rita Levi-montalcini and published by World Scientific. This book was released on 1997-04-01 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of articles written by Nobel Laureate Rita Levi-Montalcini and published from 1942 to 1995. Studies described in the first part set the stage for the discovery of a protein molecule which became known as the Nerve Growth Factor (NGF), described in detail in the second part. The NGF synthesized in minute amounts in all vertebrate tissues, plays an essential role in the differentiation and survival of several nerve cell populations in the peripheral and central nervous system. The discovery of the NGF was defined by the Nobel Foundation as a milestone in developmental neurobiology, and the author was awarded in 1986 with this prestigious award. Studies pursued in subsequent years and still in progress, have unveiled other fundamental properties of the NGF, described in the third part of this volume.
Download or read book Recent Advances in NGF and Related Molecules written by Laura Calzà and published by Springer Nature. This book was released on 2021-08-27 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Download or read book Neurotoxin Modeling of Brain Disorders Life long Outcomes in Behavioral Teratology written by Richard M. Kostrzewa and published by Springer. This book was released on 2016-07-13 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.
Download or read book Rita Levi Montalcini written by Lisa Yount and published by Infobase Publishing. This book was released on 2009 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a woman growing up in early 20th-century Italy, Rita Levi-Montalcini was expected to marry, not pursue an education. Against the objections of her father, she attended Turin School of Medicine, graduating with honors as an M.D. But her hopes of an academic position vanished with the fascist Italian government's persecution of the Jews in the late 1930s and early 1940s. At the risk of her own life, Levi-Montalcini continued studying how the body s nervous system develops and discovered the nerve growth factor, a protein that controls the growth of neurons and is required for their survival. Building upon her findings, she and a host of other researchers unearthed a whole class of compounds that are intimately involved in every stage of a cell s or an organism s life, from conception to death. Today, scientists are still exploring the implications of her work, from cancer treatments to Alzheimer s disease management to research on birth defects, and more. As Rita Levi-Montalcini shows, this woman's incredible persistence and faith in herself allowed her to persevere through tough opposition and earn a Nobel Prize in Physiology or Medicine in 1986.
Download or read book Signal Transduction written by Bastien D. Gomperts and published by Gulf Professional Publishing. This book was released on 2002-03-18 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prologue: Signal transduction, origins and personalities. -- First messengers. -- Receptors. -- GTP-binding proteins and signal transduction. -- Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase. -- The regulation of visual transduction. -- Calcium and signal transduction. -- Calcium signalling. -- Phosphorylation and dephosphorylation:protein kinases A and C. -- Growth Factors :setting the framework. -- Signalling pathways operated by receptor protein tyrosine kinases. -- Signalling pathways operated by non-receptor protein tyrosine kinases. -- Phosphoinositide 3-kinases. -- Signal transduction to and from adhesion molecules. -- Adhesion molecules and trafficking of leukocytes. -- Signalling through receptor bound protein serine-threonine kinases. -- Protein dephosphorylation and protein phosphorylation. -- Protein domains and signal transduction.
Download or read book Neurodegeneration From Genetics to Molecules Volume II written by Victoria Campos-Peña and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rita Levi Montalcini Pioneer and Ambassador of Science written by Francesca Valente and published by Barbera Foundation. This book was released on with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: “My experience in childhood and adolescence of the subordinate role played by the female in a society run entirely by men had convinced me that I was not cut out to be a wife.”—Rita Levi-Montalcini Self-assured from an early age, Rita knew that she was cut out for a number of other roles and the difference she could make in the lives of others. Prevailing over her father’s traditional values, Rita attended medical school and continued to study the development of the nervous system after graduating. But as a Jew in fascist Italy, her work came to a halt with discriminatory race laws and again later, when she was forced into hiding from the Nazis. In a makeshift lab built from black-market items, Rita continued her research in a small space she shared with her family. Rita’s courage to accept a fellowship in the United States when she didn’t speak the language was repaid when her six-month stay stretched into thirty-three years. When, at seventy-seven years old, she and Stanley Cohen won the Nobel Prize for their discovery of nerve growth factor—now used in search of cures for Alzheimer’s and Parkinson’s diseases—Rita felt like her life was just beginning. Over the next two decades, she spoke around the globe as an ambassador for science and humanitarianism and accomplished more than most do during an entire lifetime.
Download or read book Rita Levi Montalcini written by Susan Tyler Hitchcock and published by Infobase Publishing. This book was released on 2009 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the life of Rita Levi-Montalcini, a woman scientist who won the Nobel Prize or her research in neurology.
Download or read book Recent Advances in NGF and Related Molecules written by Laura Calzà and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Download or read book American Book Publishing Record written by and published by . This book was released on 1997-09 with total page 1466 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cumulative Book Index written by and published by . This book was released on 1998 with total page 2362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A world list of books in the English language.
Download or read book Intellettuali italiani del secondo Novecento written by Angela Barwig and published by . This book was released on 2007 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Scientist written by and published by . This book was released on 1973 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book The Hostage Brain written by Bruce S. McEwen and published by Rockefeller Univ. Press. This book was released on 1994 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Praise Of Imperfe written by Rita Levi-Montalcini and published by . This book was released on 1988-05-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The autobiography of Levi-Montalcini, who won the Nobel Prize for Medicine in 1986. Born in Torino into a middle-class Jewish family, she experienced the rise of fascism and antisemitism in the 1930s-40s (discussed on pp. 73-105). After the promulgation of the racial laws in 1938, it was impossible for her to pursue research at the Neurological Clinic and she continued her work in private. She survived the war hiding in a small town in Italy and later emigrated to the United States.
