Download or read book Safety and Efficacy of Bone Marrow Derived Progenitor Cells in Patients with Chronic Ischaemic Heart Failure written by Abduk M. Mozid and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Safety and Efficacy of Bone Marrow Derived Progenitor Cells in Patients with Chronic Ischaemic Heart Failure written by Abdul M. Mozid and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bone Marrow Derived Progenitors written by Katalin Kauser and published by Springer Science & Business Media. This book was released on 2007-06-07 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ambitious goal of this volume is to provide – in chapters written by accomplished scientists and experts in their field – a comprehensive overview of the currently available information related to the therapeutic utility of adult bone marrow-derived cells. With excitement generated almost daily about the possible uses of stem cells to treat human disease, but the controversy surrounding their use still raging, adult bone-marrow derived cells are more readily available, and have a staggering range of uses.

Download or read book Chronic Coronary Artery Disease A Companion to Braunwald s Heart Disease E Book written by James de Lemos and published by Elsevier Health Sciences. This book was released on 2017-01-03 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring expert guidance from Drs. James de Lemos and Torbjørn Omland, as well as other globally known leaders in cardiology, Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes. This brand-new companion to Braunwald's Heart Disease was designed as a stand-alone reference for physicians treating patients who present with complex, unique challenges, offering the latest information on the use of imaging modalities in diagnosis and treatment, advances in interventional and surgical approaches to revascularization, new medications to improve symptoms and outcomes in chronic CAD, and much more. Covers every aspect of evaluation and treatment of patients who suffer from chronic coronary syndromes. Provides both evidenced based recommendations from the most recent guidelines from the major cardiology societies: AHA, ACC, and ESC, as well as practical management tips from leading experts with extensive clinical experience. Highlights new developments concerning epidemiology and prevention, pathophysiology, and clinical findings, as well as laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, and prognosis and management of chronic coronary syndromes. Features information on today's hot topics, including the use of novel imaging modalities in diagnosis and treatment and emerging therapies to improve outcomes in chronic CAD.

Download or read book Aging and Heart Failure Alter the Bone Marrow Derived Inflammatory Response and Impair Cardiac Remodeling Following Myocardial Infarction written by Tina Binesh Marvasti and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Title: Aging and Heart Failure Alter the Bone Marrow Derived Inflammatory Response and Impair Cardiac Remodeling Following Myocardial Infarction Name: Tina Binesh Marvasti Degree: Doctor of Philosophy Year of convocation: November 2020 Institute of Medical Sciences, University of Toronto In adult humans, sudden loss of cardiomyocytes as a result of any strain or injury to the myocardium can potentially overwhelm the innate regenerative capability of this tissue. This results in formation of a collagen based scar, which could either stabilize or expand and result in ventricular dilation and heart failure. Considering the limited therapeutic options available to treat heart failure, autologous bone marrow stem cell based regenerative therapies have gained attention due to their promising results in myocardial function recovery post infarction in pre-clinical investigations. However the results from clinical investigations have been variable and relatively inconsistent. Inconsistencies in patient outcome and inconclusive data from some clinical trials has led us to hypothesis that patient intrinsic factors could play a crucial role in the quality and function of bone marrow derived stem cells which can influence the efficacy of their function in myocardial recovery. Factors investigated in this thesis were patients' age and early cardiac dysfunction. I profiled the post ischemia immune modulating response originating from the bone marrow derived stem and hematopoietic progenitor cells. I developed and optimised a specific humanized mouse model for investigating human immune cells' response to ischemia by transplanting patient CD34 stem cells in the bone marrow of NOD-SCID NSG mice and assessed patient specific characteristics that modify and dampen the proper immune response. Using these techniques, I demonstrate how lack of regulatory T cell (Treg) expansion in old patients' bone marrow derived immune modulatory cells could lead to infarct expansion and left ventricular remodelling. I also show how the quality of bone marrow stem cells isolated from patients showing early stage heart failure symptoms indicate signs of bone marrow exhaustion. Here, we demonstrate the importance of how patient specific characteristics such as aging and early stage heart failure can modify the quality of bone marrow stem cells' response to myocardial recovery. Future clinical investigations should consider adjunct complementary immune therapy and providing appropriate personalized therapy where characterization of patients' immune profile would take the centre stage.

Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Download or read book Handbook of Cardiac Stem Cell Therapy written by Ioannis Dimarakis and published by Imperial College Press. This book was released on 2009-01-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.

Download or read book Human Mesenchymal Stem Cells written by Mitchell Khan and published by Nova Science Publishers. This book was released on 2021 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--

Download or read book Regenerative Medicine from Protocol to Patient written by Gustav Steinhoff and published by Springer. This book was released on 2016-06-14 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 5 contains clinical science and translation surveys on the circulatory system, visceral, musculoskeletal and skin. The state-of-the-art descriptions involve concepts for clinical diagnosis, stem cell and gene therapy, biomaterials for tissue replacement and pharmacological/biomolecule treatment strategies.

Download or read book Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium written by Hung-Fat Tse and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium: From Bench to Bedside" by Hung-fat, Tse, 謝鴻發, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract Abstract of thesis entitled Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium- From Bench to Bedside Submitted by Hung-Fat TSE for the Degree of Doctor of Philosophy (Ph.D.) at The University of Hong Kong in May 2007 Abstract Coronary artery disease (CAD) remains the leading cause of morbidity and mortality in the Western world and in Asia, including Hong Kong and China. Despite the advances in medical and surgical therapies, up to 20%-37% of patients with severely CAD are either unsuitable or can only receive incomplete revascularization with conventional revascularization procedures. Recent experimental studies showed that bone marrow (BM) cells can be used to regenerate cardiomyocytes and to induce neovascularization in injured myocardium after myocardial infarction. Nevertheless, several major issues concerning autologous BM cell therapy remained to be addressed. This thesis comprises both experimental and clinical studies on the use of BM cells for therapeutic angiogenesis in chronic ischemic left ventricular (LV) myocardium. In a swine model, I demonstrated the acute safety and feasibility of catheter-based direct endomyocardial injection for delivering BM cells into the targeted sites within the LV. Furthermore, the functional role of BM mononuclear cells (MNC) versus BM endothelial progenitor cells (EPC) in enhancing therapeutic angiogenesis was studied in a porcine chronic ischemic myocardium model. It was found that catheter-based direct endomyocardial injection of BM-MNC was more effective than BM-EPC or saline in enhancing neovascularization and improving LV function in chronic ischemic myocardium. I performed the world's first human study on percutaneous direct endomyocardial injection of autologous BM-MNC in patients with "end-stage" CAD. The initial clinical results suggested that autologous transplantation of BM-MNCs enhanced myocardial perfusion and improved symptoms in these patients. Mid-term of follow-up of patients in this pilot study suggested that direct endomyocardial injection Abstract of autologous BM cells was not associated with any major adverse effects. Furthermore, the beneficial effect of direct endomyocardial injection was over and beyond those noted in those treated with percutaneous laser myocardial revascularization, suggesting a potential direct therapeutic effect of BM cells, rather than the effects resulting from myocardial channeling alone. Nevertheless, the possible potent placebo effect on symptoms observed in these pilot studies highlights the need for a randomized, placebo-controlled group to prove the clinical efficacy of cell based angiogenic therapy for treatment of severe CAD. In the first human randomized controlled study (PROTECT-CAD) including 28 patients enrolled from 2 centers, I studied the safety and clinical efficacy of electromechanical guided catheter-based direct endomyocardial delivery of BM cells into targeted ischemic myocardium. This randomized, placebo controlled trial showed beneficial effects of BM cell therapy over saline injection on symptoms and functional capacity in patients with chronic myocardial ischemia who failed conventional medical and revascularization procedures. In conclusion, the findings of this thesis provide important information

Download or read book T1 Mapping in Myocardial Disease written by Phillip C. Yang and published by Springer. This book was released on 2018-08-28 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the advances in cardiac MRI that have enabled quantitative tissue characterization of the myocardium using myocardial and blood T1 measurements, which have enabled reliable detection of diffuse pathological processes in both the cardiomyocytes and the interstitial cells of the myocardium. Evaluation of the native myocardial and interstitial fibrosis, and measurement of the extracellular volume fraction has allowed an unprecedented opportunity to elucidate the pathology, diagnosis and prognosis of cardiovascular disease. T1-Mapping in Myocardial Disease: Principles and Applications reviews a wide spectrum of significant cardiovascular disease and provides relevant guidance for the clinical implementation of this innovative technique. The specific topics covered include principles of T1-mapping in cardiovascular disease and the role of T1-mapping in hypertensive heart disease and hypertrophic cardiomyopathy, cardiotoxicity from cancer treatment, cardiacfibrosis, left ventricular hypertrophy in aortic stenosis, peri-infarct injury in ischemic cardiomyopathy, and stem cell therapy. This comprehensive coverage of the utility of T1-mapping in cardiovascular diseases will greatly appeal to the entire cardiovascular medicine and imaging communities.

Download or read book Stem Cell and Gene Therapy for Cardiovascular Disease written by Emerson c. Perin and published by Academic Press. This book was released on 2015-08-21 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Download or read book Braunwald s Heart Disease E Book written by Robert O. Bonow and published by Elsevier Health Sciences. This book was released on 2011-02-25 with total page 2049 pages. Available in PDF, EPUB and Kindle. Book excerpt: Braunwald’s Heart Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, and Peter Libby, this dynamic, multimedia reference helps you apply the most recent knowledge in molecular biology and genetics, imaging, pharmacology, interventional cardiology, electrophysiology, and much more. Weekly updates online, personally selected by Dr. Braunwald, continuously keep you current on the most important new developments affecting your practice. Enhanced premium online content includes new dynamic cardiac imaging videos, heart sound recordings, and podcasts. With sweeping updates throughout, and contributions from a "who’s who" of global cardiology, Braunwald’s is the cornerstone of effective practice. Continuously access the most important new developments affecting your practice with weekly updates personally selected by Dr. Braunwald, including focused reviews, "hot off the press" commentaries, and late-breaking clinical trials. Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Search the complete contents online at www.expertconsult.com. Stay on top of the latest advances in molecular imaging, intravascular ultrasound, cardiovascular regeneration and tissue engineering, device therapy for advanced heart failure, atrial fibrillation management, structural heart disease, Chagasic heart disease, ethics in cardiovascular medicine, the design and conduct of clinical trials, and many other timely topics. Hone your clinical skills with new dynamic cardiac imaging videos, heart sound recordings, and podcasts at www.expertconsult.com.

Download or read book Coronary Care Manual written by Peter L. Thompson and published by Elsevier Health Sciences. This book was released on 2011-01-28 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive coronary care textbook for medical, nursing and paramedic staff The Coronary Care Manual, 2nd Edition is a practical medical manual designed to assist with management of the acute coronary patient. This respected medical resource is written by a group of coronary experts, both Australian and international. Its aim is to strike a balance between a large and rapidly-changing evidence base and practical application in the Coronary Care Unit, Intensive Care Unit, Emergency Department and the ambulance. The second edition of this important health textbook covers an extensive range of coronary care medicine, providing a handy companion for a night ‘on call’. Chapter topics in the Coronary Care Manual, 2nd Edition include pathophysiology, drug and non-drug therapies and postcoronary management, with chapters organised into subsections. Completely redesigned with fresh, new artwork, this new edition of the Coronary Care Manual is organised to suit academics and medical practitioners alike. • covers a broad range of coronary care medicine • provides specific advice on the management of common clinical problems • eliminates the need to refer to a larger reference book • features a consistent style and focus, with standardised artwork for figures • is now also available as an eBook! A code inside the Coronary Care Manual enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material

Download or read book Novel Perspectives For The Therapy And Prevention Of Heart Failure written by Eliot Ohlstein and published by Frontiers Media SA. This book was released on 2022-08-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Textbook of Cardiovascular Intervention written by Craig A. Thompson and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The field of interventional cardiology and interventional vascular medicine now comprises the dominant diagnostic and therapeutic field within cardiovascular medicine, and continues to grow in terms of patients managed and physicians trained. The Textbook of Cardiovascular Intervention is intended to provide a modern, comprehensive and practical text on interventional cardiology for the current, rapidly evolving practice environment. It is written by a group of worldwide experts in the field and will appeal to fellows, residents and physicians in cardiology, interventional cardiology, cardiothoracic and vascular surgery, vascular and endovascular medicine, neurointerventional radiology and surgery, emergency medicine and intensive care.