Download or read book Routes to Acylated Sydnones Utilizing Microwave Chemistry written by Amber C. Rumple and published by . This book was released on 2010 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Routes to Acylated Sydone Esters written by Amanda Marie Balaguer and published by . This book was released on 2011 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various 4-acyl-3-[2'-(carboalkoxy)phenyl]sydnones were synthesized by reaction of the parent sydnone with the corresponding anhydrides and Montmorillonite K-10. In the Q-tube, the acylation using acetic anhydride, which normally took 1.5 days for complete conversion thermally, was complete in 8.5 hours. Use of bismuth triflate as catalyst reduced the reaction time to 5 hours and, in the microwave, reactions were complete in 30 minutes and provided comparable yields. New sydnones were synthesized with acetic, propionic, butyric, and isobutyric anhydrides. Extension to various homogeneous metal triflates (lanthanum, yttrium, scandium, hafnium, gadolinium, and indium) was explored. Reactions were performed with 3-phenylsydnone as reactant, initially under thermal conditions overnight, individually with the six chosen catalysts. When optimal conditions were achieved, these predetermined parameters were employed for further optimization, performed under microwave irradiation. After multiple reactions, the best catalysts were determined to be the gadolinium and indium triflates.
Download or read book March s Advanced Organic Chemistry written by Michael B. Smith and published by John Wiley & Sons. This book was released on 2007-01-29 with total page 2379 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
Download or read book Handbook of Heterocyclic Chemistry written by Alan R. Katritzky and published by Elsevier. This book was released on 2017-01-31 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.
Download or read book Radiopharmaceutical Chemistry written by Jason S. Lewis and published by Springer. This book was released on 2019-04-02 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
Download or read book Energetic Compounds written by Mohammad Hossein Keshavarz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-05-05 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses methods for the assessment of energetic compounds through heat of detonation, detonation pressure, velocity and temperature, Gurney energy and power. The authors focus on the detonation pressure and detonation velocity of non-ideal aluminized energetic compounds. This 2nd Edition includes an updated and improved presentation of simple, reliable methods for the design, synthesis and development of novel energetic compounds.
Download or read book The Nitrile Imine 1 3 Dipole written by Craig Jamieson and published by Springer Nature. This book was released on 2020-03-25 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the nitrilimine 1,3-dipole, from its initial discovery in 1959 to the most recent publications. Covering topics such as the core properties of the dipole and the various methods of synthesis available, it particularly highlights the diverse reactivity profile of the nitrilimine and its numerous applications in bioorthogonal and materials chemistry. The book is of interest to academic and industrial researchers working in this area and to those new to the field.
Download or read book Advanced Organic Chemistry written by Jerry March and published by Wiley-Interscience. This book was released on 1985-03-11 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This survey of advanced chemistry covers virtually all the useful reactions--600 all told--with the scope, limitations, and mechanism of each described in detail. Extensive general sections on the mechanisms of the important reaction types, and five chapters on the structure and stereochemistry of organic compounds and reactive intermediates are included as well. Of the more than 10,000 references included, 5,000 are new in this edition.
Download or read book The Chemistry of Heterocycles written by Vishnu Ji Ram and published by Elsevier. This book was released on 2019-06-05 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles
Download or read book Organic Syntheses Based on Name Reactions and Unnamed Reactions written by Alfred Hassner and published by Elsevier. This book was released on 2013-10-22 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.
Download or read book Comprehensive Organic Reactions in Aqueous Media written by Chao-Jun Li and published by John Wiley & Sons. This book was released on 2007-06-04 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive update of the classic reference on organic reactions in water Published almost a decade ago, the first edition has served as the guide for research in this burgeoning field. Due to the cost, safety, efficiency, and environmental friendliness of water as a solvent, there are many new applications in industry and academic laboratories. More than forty percent of this extensively updated second edition covers new reactions. For ease of reference, it is organized by functional groups. A core reference, Comprehensive Organic Reactions in Aqueous Media, Second Edition: * Provides the most comprehensive coverage of aqueous organicreactions available * Covers the basic principles and theory and progresses to applications * Includes alkanes, alkenes, aromatics, electrophilic substitutions, carbonyls, alpha, beta-unsaturated carbonyls, carbon-nitrogen bonds, organic halides, pericyclic reactions, photochemical reactions, click chemistry, and multi-step syntheses? * Provides examples of applications in industry This is the premier reference for chemists and chemical engineers in industry or research, as well as for students in advanced-level courses.
Download or read book Name Reactions in Heterocyclic Chemistry II written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2011-09-28 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: The up-to-DATE guide to name reactions in heterocyclic chemistry Name Reactions in Heterocyclic Chemistry II presents a comprehensive treatise on name reactions in heterocyclic chemistry, one of the most exciting and important fields within organic chemistry today. The book not only covers fresh ground, but also provides extensive information on new and/or expanded reactions in: Three- and four-membered heterocycles Five-membered heterocycles (pyrroles and pyrrolidines, indoles, furans, thiophenes, and oxazoles) Six-membered heterocycles, including pyridines, quinolines, and isoquinolines Featuring contributions from the leading authorities in heterocyclic chemistry. Each section includes a description of the given reaction, as well as the relevant historical perspective, mechanism, variations and improvements, synthetic utilities, experimental details, and references to the current primary literature. The reactions covered in Name Reactions in Heterocyclic Chemistry have been widely adopted in all areas of organic synthesis, from the medicinal/pharmaceutical field, to agriculture, to fine chemicals, and the book brings the most cutting-edge knowledge to practicing synthetic chemists and students, along with the tools needed to synthesize new and useful molecules.
Download or read book Modern Heterocyclic Chemistry 4 Volumes written by Julio Alvarez-Builla and published by John Wiley & Sons. This book was released on 2011-08-15 with total page 2531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eine Fülle von Information zum attraktiven Preis bietet Ihnen dieses vierbändige Handbuch der Heterocyclenchemie.
Download or read book Oxidation of Alcohols to Aldehydes and Ketones written by Gabriel Tojo and published by Springer Science & Business Media. This book was released on 2006-06-15 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to help people performing routine operations in Organic Synthesis in a laboratory. This book, the first one in a series, focuses on the oxidation of alcohols to aldehydes and ketones. Probably, this is the most important routine operation in Organic Synthesis.
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Download or read book Thiazole and Its Derivatives written by Jacques V. Metzger and published by . This book was released on 1979 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
