Download or read book Role of the Immune System in Renal Transplantation Importance Mechanism and Therapy written by Long Zheng and published by Frontiers Media SA. This book was released on 2024-03-11 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immune Regulation in Kidney Diseases Importance Mechanism and Translation written by Cheng Yang and published by Frontiers Media SA. This book was released on 2021-03-16 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Transplant Rejection and Tolerance Advancing the Field through Integration of Computational and Experimental Investigations written by Giorgio Raimondi and published by Frontiers Media SA. This book was released on 2017-12-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
Download or read book Perioperative Care for Organ Transplant Recipient written by Alexander Vitin and published by BoD – Books on Demand. This book was released on 2019-10-02 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is addressed to physicians and researchers working in the ever-expanding research and practice fields of transplantation medicine. Its purpose is to present the transplantation community with a collection of works written by prominent experts in a variety of transplant-related fields, encompassing the most recent scientific and practical developments and accomplishments in the highly specialized segment of transplantation medicine, such as perioperative care for organ transplant candidates and recipients.
Download or read book Current Issues and Future Direction in Kidney Transplantation written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2013-02-13 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.
Download or read book Kidney Transplantation written by Peter J. Morris and published by W.B. Saunders Company. This book was released on 1984 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth edition of KIDNEY TRANSPLANTATION remains the most comprehensive and definitive text on all aspects of renal transplantation as well as the psychological and ethical issues involved. Almost every chapter has been revised or rewritten by new authors, to incorporate the most essential and up-to-date information.
Download or read book Pathophysiology written by David C. Gaze and published by BoD – Books on Demand. This book was released on 2018-05-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathophysiology is the convergence of pathology (the discipline of observed changes in a diseased state) with physiology (the mechanisms of systems operation). It represents the functional changes that occur because of injury or disease. This volume provides state-of-the-art up-to-date literature reviews on pathophysiological processes in a number of disease states. The book is organised methodically in a head-to-toe systems approach examining aspects of neuropathophysiology, endocrine pathophysiology, structural biology, renal pathophysiology and genitourinary pathophysiology. This short volume on pathophysiology is intended for general medical and biomedical students at both undergraduate and postgraduate levels. In addition, it is a useful short update of recent advances in research and translational biology to those working in academia or healthcare science.
Download or read book Primary Glomerular Diseases ECAB written by Ramadas Pisharody and published by Elsevier Health Sciences. This book was released on 2013-07-12 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic functional unit of kidney is the glomerulus. Any renal derangement at that level can lead to a multitude of diseases. The renal as well as glomerular disorders secondary to other causes such as hypertension, diabetes, other vasculites, drugs, malignancies, etc. have been adequately addressed. However, the primary glomerular disorders, due to an ambiguity regarding their genesis, have yet to be explored properly. Though these diseases are clubbed under the common head of "primary", they consist of various distinct subtypes with markedly different mechanisms of pathogenesis, course of the disease, response to treatment and prognoses. This clinical update explores the various types of pimary glomerular diseases with an aim to enhance the reader’s knowledge and aid in timely recognition and precise diagnosis of glomerular diseases to help chart the appropriate treatment of each individual condition. The first chapter elucidates the clinicopathological correlation of primary glomerular diseases to help differentiate them from each other and from other similar differential diagnoses without resorting to renal biopsy in all the cases. The second, third and fourth, chapters explore the various aspects of Proliferative Glomerulonephritis, Idiopathic Nephrotic Syndrome and Heredofamilial Glomerular Diseases. The last chapter summarizes the clinically relevant current perspectives regarding the pathogenesis and treatment modalities of all the primary glomerular diseases. This book will help the readers understand the intricacies of the aspects mentioned above and guide the practitioner to diagnose and manage Primary Glomerular Diseases with special reference to practical experience in India. The authors have put together the most relevant facts about the disease for an easy comprehension and understanding of primary glomerular diseases by practitioners and students across the specialty.
Download or read book Extending Medicare Coverage for Preventive and Other Services written by Institute of Medicine and published by National Academies Press. This book was released on 2000-05-07 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report, which was developed by an expert committee of the Institute of Medicine, reviews the first three services listed above. It is intended to assist policymakers by providing syntheses of the best evidence available about the effectiveness of these services and by estimating the cost to Medicare of covering them. For each service or condition examined, the committee commissioned a review of the scientific literature that was presented and discussed at a public workshop. As requested by Congress, this report includes explicit estimates only of costs to Medicare, not costs to beneficiaries, their families, or others. It also does not include cost-effectiveness analyses. That is, the extent of the benefits relative to the costs to Medicareâ€"or to society generallyâ€"is not evaluated for the services examined. The method for estimating Medicare costs follows the generic estimation practices of the Congressional Budget Office (CBO). The objective was to provide Congress with estimates that were based on familiar procedures and could be compared readily with earlier and later CBO estimates. For each condition or service, the estimates are intended to suggest the order of magnitude of the costs to Medicare of extending coverage, but the estimates could be considerably higher or lower than what Medicare might actually spend were coverage policies changed. The estimates cover the five-year period 2000-2004. In addition to the conclusions about specific coverage issues, the report examines some broader concerns about the processes for making coverage decisions and about the research and organizational infrastructure for these decisions. It also briefly examines the limits of coverage as a means of improving health services and outcomes and the limits of evidence as a means of resolving policy and ethical questions.
Download or read book Pediatric Renal Transplantation written by Amir H. Tejani and published by Wiley-Liss. This book was released on 1994-08-16 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed, contributed reference offering broad coverage of renal transplantation in children. Diagnosis, the patient's medical management, operative methods, surgical and medical complications, donor selection, immunosuppression, late effects on growth and development and psychosocial factors are among the topics discussed. Features a chapter on how to set up and manage a pediatric renal transplant program.
Download or read book Contemporary Kidney Transplantation written by Carlo Gerardo B. Ramirez and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive guide to successful kidney transplantation in the highly regulated environment of today. It covers the history of kidney transplant to highlight innovations that have made kidney transplantation so successful as well as the new deceased donor kidney allocation strategy and postulates what types of changes might occur with this new policy. The book highlights special areas of nephrology concern in kidney transplantation, especially diseases likely to recur following transplant. It deals with many of the medications used in kidney transplantation including different commonly used antirejection protocols. It also provides a complete reference on the various operations involved in kidney transplantation. The text includes detailed pictures and surgical technique sections on cadaveric kidney transplantation and living kidney transplantation. It includes information on living kidney donation surgery with a chapter dedicated to the minimally invasive techniques that have been popularized in the last fifteen years. Some coverage on open living kidney donation is presented. Included in this section is discussions of how to handle certain operative challenges like severe atherosclerosis, venous sclerosis and various urinary system aberrancies. Comprehensive coverage of common surgical complications is presented including management of urinary strictures, urinary leaks, lymphoceles, vascular probl ems following transplant, and what steps should be taken when an early kidney transplant biopsy is necessary. It also covers in detail what is required for maintenance of health after kidney transplantation including the major risks for graft loss as well as what disease processes kidney transplant patients are particularly vulnerable to.
Download or read book Endocrine Immunology written by W. Savino and published by Karger Medical and Scientific Publishers. This book was released on 2017-02-28 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decades, several in vitro and in vivo studies have revealed the existence of a very complex network between the neuroendocrine and immune system. Important molecular mechanisms underlying these interactions, in both physiological and pathological conditions, have also been described. Indeed, hormones play a pivotal role in the development and functional regulation of the immune system – both innate and acquired responses. Immune system cells present specific hormone receptors and themselves produce some hormones, thus influencing hormone secretion. More recently, the modulation of hormone secretion has been attempted for treating associated autoimmune disorders, further supporting the strong interplay between the endocrine and immune system. Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. The focus is on the various aspects of endocrine-neuro-immune connections, providing an updated panorama - from basics to clinical applications - of current knowledge and still debated issues.
Download or read book Oxford Textbook of Fundamentals of Surgery written by William E. G. Thomas and published by Oxford University Press. This book was released on 2016-07-28 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.
Download or read book Underwood s Pathology written by Simon Cross and published by Elsevier Health Sciences. This book was released on 2018-03-09 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Underwood’s Pathology (formerly General and Systematic Pathology) is an internationally popular and highly acclaimed textbook, written and designed principally for students of medicine and the related health sciences. Pathology is presented in the context of modern cellular and molecular biology and contemporary clinical practice. After a clear introduction to basic principles, it provides comprehensive coverage of disease mechanisms and the pathology of specific disorders ordered by body system. An unrivalled collection of clinical photographs, histopathology images and graphics complement the clear, concise text. For this seventh edition, the entire book has been revised and updated. Well liked features to assist problem-based learning – including body diagrams annotated with signs, symptoms and diseases and a separate index of common clinical problems – have been retained and refreshed. The advent of whole genome sequencing and increased knowledge of the genetics of disease has been recognised by updated sections in many chapters. Download the enhanced eBook version (from studentconsult.com) for anytime access to the complete contents plus bonus learning materials, including: clinical case studies – to help apply essential principles to modern practice the fully revised, interactive self-assessment section with over 200 questions and answers – to check your understanding and aid exam preparation especially produced video and podcast tutorials – to further explain and bring to life key topics bonus pathology crosswords – to recall key words and topics in a fun and interactive way This all combines to make Underwood’s an unsurpassed learning package in this fascinating and most central medical specialty. From reviews of previous editions: "...it truly is an outstanding textbook...highly recommended" Histopathology "...no doubt it will remain a bestseller – excellent value for undergraduates" Journal of Clinical Pathology "A book of this kind deserves a wide readership" Modern Pathology ".. the definitive textbook of pathology...expands on previous success and cements its position as the market leader for undergraduate pathology" The Bulletin A prize winner: Previous editions have won First Prize in the Medical Writers Group of the Society of Authors Awards, the British Book Design and Production Awards and the British Medical Association Student Textbook Award.
Download or read book The Treatment of Glomerulonephritis written by C.D. Pusey and published by Springer Science & Business Media. This book was released on 2007-05-28 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glomerulonephritis is one of the commonest causes of end-stage renal failure worldwide. Although there have been considerable advances in the management of renal failure by dialysis and transplantation, there has been relatively little progress in its prevention. This volume sets out to review current practice in the treatment of glomerulonephritis, which is aimed both at controlling the clinical manifestations, e.g. nephrotic syndrome, and at preventing the progression to renal failure. The term glomerulonephritis covers a wide range of conditions with different immunological, histological and clinical features. This volume therefore starts with reviews of the immunology and pathology of different types of glomerulonephritis. This is followed by detailed consideration of the treatment of the commoner primary and secondary forms of the disease. There are separate chapters on special circumstances, such as glomerulonephritis in pregnancy or following renal transplantation. In each chapter, attempts are made to review the evidence for the effectiveness of treatment, based on controlled trials, immunopathological principles and the authors' considerable experience. Although some aspects of the treatment of glomerulonephritis can be found in the standard texts on renal disease, this volume provides an up-to-date, thoroughly referenced, and practical guide to management. As such, it should be of value to nephrologists and general physicians, including those in training, and to postgraduate students of nephrology.
Download or read book Frontiers in Transplantology written by Hesham Abdeldayem and published by BoD – Books on Demand. This book was released on 2016-09-07 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.
