Download or read book Role of Dietary Carbohydrate Source in the Development of Obesity in Rodent Models of Diet induced Obesity written by Kristin Lynnet Morris and published by . This book was released on 2003 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se

Download or read book Nutrient Requirements of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases written by Patrick C. Even and published by Frontiers Media SA. This book was released on 2018-02-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.

Download or read book Dietary Induction Models of Nutritional Disorders in Rodents written by Jailane de Souza Aquino and published by Cambridge Scholars Publishing. This book was released on 2023-06-16 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses one of the most controversial topics in Ethics and Bioethics since the beginning of physiology and comparative anatomy, as viewed from the perspective of experienced researchers in the fields of nutrition, bioethics and translational research. The book provides up-to-date information on dietary induction models of diabetes, obesity, hypertension, dyslipidaemia and malnutrition in experimental animal models, with a focus and direction for future clinical studies in the area of health sciences. It directly describes the importance of pre-clinical studies in the construction of translational research, being useful for academic-scientific institutions, students and health professionals such as nutritionists, doctors, pharmacists, psychologists, and nurses, among others.

Download or read book Textbook of Obesity written by Sharon R. Akabas and published by John Wiley & Sons. This book was released on 2012-03-20 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Obesity is designed to cover all of the essential elements concerning the etiology, prevention and treatment of obesity suitable for students in nutrition, dietetics and health science courses. Providing core knowledge for students is an essential and urgent requirement to ensure that those graduating will be properly equipped to deal with the high prevalence of overweight and obesity, currently affecting almost two-thirds of the population of the USA and with prevalence in much of the rest of the world rapidly catching up. This landmark text is organized into 5 parts comprising 27 chapters, each carefully written in a user-friendly style by experts in the area. Part I helps the reader to understand the scope and complexity of the problem of obesity. Part II focuses on obesity etiology. Part III examines the health consequences of obesity for both children and adults. Part IV discusses the challenge of assessing obesity in humans and offers insights into community factors that influence the risk of obesity. Finally, Part V dedicates 13 chapters to a discussion of a wide variety of obesity prevention and treatment interventions that are currently in use. Textbook of Obesity is an essential purchase for students and the many health professionals dealing with obesity on a day-to-day basis. A dedicated companion website features an extensive bank of questions and answers for readers to test their understanding, and all of the book’s illustrations for instructors to download: www.wiley.com/go/akabas/obesity

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Download or read book Weight Management written by Institute of Medicine and published by National Academies Press. This book was released on 2003-12-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Franz J. Hock and published by Springer. This book was released on 2015-11-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc.

Download or read book OBESITY and the Effect of High Fat Diets a Study written by Omega Life Omega Life and Health Series and published by . This book was released on 2018-09-12 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prevalence of obesity and overweightOver the last decades the prevalence of overweight and obesity has become a major health problem and is now the fifth leading risk of global deaths. Based on the most recent estimates by the WHO more than 1.4 billion adults (>20 yrs) worldwide are now considered overweight, and 500 millions of them are obese. Childhood obesity is also an increasing problem, with numbers showing that more than 40 million children under the age of five are overweight. One of the highest percentages of overweight is seen in the United States where about two-thirds of the population is classified as overweight or obese.Although there has been a decline in the dietary fat intake over the last decade, the prevalence of obesity and type 2 diabetes is still rising. The contemporary Western diet provides an average of 49 % energy from carbohydrate, 35 % from fat and 16 % from protein. Earlier studies have demonstrated that increasing the dietary amount of protein at the expense of sucrose attenuates obesity development in mice fed high fat diets.We undertook writing this book and doing this study to investigate the impact of protein:sucrose ratio in combination with other protein sources, such as cod and pork. Furthermore, we aimed to elucidate some of the underlying mechanisms by which different protein sources influence obesity development. Interestingly, of all protein sources tested, casein was the only protein to attenuate body weight gain. Content1.1 Overweight and obesity 1.1.1 Definition and quantification of overweight and obesity. 1.1.2 Prevalence of obesity and overweight. 1.1.3 What causes obesity and overweight? 1.1.4 Health consequences associated with overweight and obesity. 1.2 Adipose tissue 1.2.1 White adipose tissue (WAT)1.2.2 Brown adipose tissue (BAT) 1.2.3 Browning in white adipose tissue. 1.3 Weight loss and obesity prevention1.3.1 Macronutrient composition. 1.3.2 Low-carbohydrate diets. 1.3.3 High-protein diets. - The effect of protein on satiety. - The effect of protein on energy expenditure. - The effect of protein on insulin:glucagon ratio. 3.1 Introduction to the study 3.2 Aim of the book and research 4 MATERIALS AND METHODS 4.1 Animal experiment 4.2 Glucose tolerance test (GTT) 4.3 Insulin tolerance test (GTT) 4.4 Meal tolerance test 4.5 Indirect calorimetry... 4.6 Histology 4.7 Real time qPCR 4.8 Elisa insulin kit 4.9 Statistical analyses 5 RESULTS... 5.1 Body weight gain and development of obesity 5.2 Glucose tolerance and insulin sensitivity 5.3 Feed efficiency and digestibility 5.4 Gene expression 5.5 Indirect calorimetry 5.6 Meal tolerance test 6 DISCUSSION... 6.1 Increasing the dietary protein:sucrose ratio attenuates obesity development 6.2 Substituting casein with cod or pork protein promotes obesity development 6.3 The effect of protein amount and protein source on glucose toleranceand insulin sensitivity 6.4 The animal model and relevance to humans 6.5 Future perspectives 7 CONCLUSION

Download or read book Obesity and Lipotoxicity written by Ayse Basak Engin and published by Springer. This book was released on 2017-06-05 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Download or read book Perinatal Programming written by Andreas Plagemann and published by Walter de Gruyter. This book was released on 2011-11-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perinatal Programming addresses the environment-dependent setting of fundamental life functions and dispositions for diseases in developmental periods during pregnancy and in early infancy. It provides a new view of the origins of health and diseases. To realize these associations may enable us to prevent diseases for the long term. This book reviews actual state-of-the-art knowledge in the perinatal programming field. The authors are internationally known scientists of this research area.

Download or read book Regulation of Body Weight written by Claude Bouchard and published by . This book was released on 1996-06-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fact that about 30-40% of the adults in the Western world are overweight or obese testifies to the frequency of the disturbances in body weight regulation. Scientists have established that caloric intake, macronutrient composition of the diet, basal and resting metabolic rate, thermic response to food, energy expenditure associated with movement and physical activity, and preferential storage of the surplus of calories as fat or lean tissues are critical determinants of energy balance and body weight. While much has been learned, the field is poised for major advances with the advent of a variety of imaging techniques, progress in quantitative and molecular genetics, use of transgenic rodent models and of breeding experiments with informative inbred strains, availability of stable isotopes for metabolic and behavioral studies, and a growing number of useful experimental animal and human models. This volume takes an integrative approach to obesity. It is structured around four major topics: (1) the animal and human models currently available for the study of body weight regulation with their strengths and limitations, (2) the molecular and genetic basis of the regulation of body weight, (3) the metabolic and physiological mechanisms involved, and (4) the behavioral and social determinants. The 13 background papers provide a critical overview of the present knowledge base while the group reports summarize the extensive deliberations of 38 international experts. Particular emphasis has been given to promising research areas and on the advances needed to ensure a better understanding of the biological and behavioral mechanisms of the regulation of body weight, with a particular emphasis on overweight and obesity.

Download or read book The Nature of Nutrition written by Stephen J. Simpson and published by Princeton University Press. This book was released on 2012-07-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition has long been considered more the domain of medicine and agriculture than of the biological sciences, yet it touches and shapes all aspects of the natural world. The need for nutrients determines whether wild animals thrive, how populations evolve and decline, and how ecological communities are structured. 'The Nature of Nutrition' addresses nutrition's enormously complex role in biology, both at the level of individual organisms and in their broader ecological interactions.

Download or read book Chinmedomics written by Xijun Wang and published by Academic Press. This book was released on 2015-07-15 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics

Download or read book Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease written by Andrew J. Krentz and published by Springer. This book was released on 2019-04-02 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Download or read book The Carnivore Diet written by Shawn Baker and published by Victory Belt Publishing. This book was released on 2019-11-19 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shawn Baker’s Carnivore Diet is a revolutionary, paradigm-breaking nutritional strategy that takes contemporary dietary theory and dumps it on its head. It breaks just about all the “rules” and delivers outstanding results. At its heart is a focus on simplicity rather than complexity, subtraction rather than addition, making this an incredibly effective diet that is also easy to follow. The Carnivore Diet reviews some of the supporting evolutionary, historical, and nutritional science that gives us clues as to why so many people are having great success with this meat-focused way of eating. It highlights dramatic real-world transformations experienced by people of all types. Common disease conditions that are often thought to be lifelong and progressive are often reversed on this diet, and in this book, Baker discusses some of the theory behind that phenomenon as well. It outlines a comprehensive strategy for incorporating the Carnivore Diet as a tool or a lifelong eating style, and Baker offers a thorough discussion of the most common misconceptions about this diet and the problems people have when transitioning to it.