Download or read book Role of Cytosolic Heat Shock Proteins in the Processing and Presentation of Endogenous Antigens by Tumor Cells written by Andrew D. Wells and published by . This book was released on 1996 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Heat Shock Proteins in Signaling Pathways written by Alexzander A. A. Asea and published by Springer. This book was released on 2019-07-09 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Download or read book Heat Shock Proteins in Human Diseases written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2021-03-23 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Download or read book Immunology for Pharmacy E Book written by Dennis Flaherty and published by Elsevier Health Sciences. This book was released on 2011-09-02 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. - Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. - 165 full-color illustrations help to illuminate difficult concepts. - Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. - Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. - A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. - Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. - A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. - Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. - Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. - Over 60 tables summarize and provide quick reference to important material. - A companion Evolve website includes animations and pharmacy terminology flashcards.
Download or read book General Principles of Tumor Immunotherapy written by Howard L. Kaufman and published by Springer Science & Business Media. This book was released on 2007-10-12 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Download or read book An Interplay of Cellular and Molecular Components of Immunology written by Indrakant Kumar Singh and published by CRC Press. This book was released on 2022-12-19 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our immune system defends us against infection by employing multiple lines of defense. The relevance of the immune response in human health, disease prevention, and vaccinations becomes evident when the immune system is compromised as in the case of pathogenic infections or autoimmune diseases. The reader will gain a fundamental understanding of the essential principles of immunology, such as how our immune system recognizes/fights infectious agents, how our body differentiates between foreign and self-cells/molecules, and how the memory from previous infections aids in a faster and more effective immune response. The book is divided into 17 chapters, providing an overview of the immune system and its components, including its organs and cells. Chapters on the major histocompatibility complex, the complement system, hypersensitivity and tolerance, antibody diversity through DNA rearrangements, and autoimmune diseases are included in the book which further broadens the understanding of this very complex system of our body. Chapters on transplantation immunology and vaccines provide a perspective on the application of these immunological concepts and will be of great interest to readers. Key features of the book: Simple, direct, and lucid language Comprehensive coverage of concepts for better understanding Well-labeled illustrations, flowcharts, and tables for enhanced learning Every chapter is followed up with a detailed summary and questionnaire A detailed glossary for users to know the right words Chapters contributed/reviewed by experienced experts in this field The book provides broad, accessible, and up-to-date information about immunological perspectives to biotechnologists, biomedical scientists, biochemists, molecular biologists, and students from various streams of life sciences, including zoology, biotechnology, and microbiology, as well as instant access to a wealth of information.
Download or read book Knowles Neoplastic Hematopathology written by Attilio Orazi and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 3806 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of Knowles Neoplastic Hematopathology has been thoroughly updated by the world's experts to cover all aspects of neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. Now in full-color, this completely revised and expanded edition integrates the basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. It is the most comprehensive, encyclopedic textbook concerning neoplastic hematopathology available on the market today.
Download or read book Immune Surveillance written by Richard T. Smith and published by Elsevier. This book was released on 2012-12-02 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.
Download or read book Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy written by Daniel M. Trifiletti and published by Springer. This book was released on 2019-06-27 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients. Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.
Download or read book Heat Shock Proteins and Inflammation written by Willem van Eden and published by Birkhäuser. This book was released on 2012-12-06 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.
Download or read book Vaccines and Autoimmunity written by Nicola Luigi Bragazzi and published by John Wiley & Sons. This book was released on 2015-05-11 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
Download or read book Systemic immune dysregulation in malignant disease Insights monitoring and therapeutic exploitation written by Petros Christopoulos and published by Frontiers Media SA. This book was released on with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1982 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Wintrobe s Clinical Hematology written by John P. Greer and published by Lippincott Williams & Wilkins. This book was released on 2009 with total page 1360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology continues to be an industry leader with its ability to correlate basic science with the clinical practice of hematology. With the first edition of Wintrobe's Clinical Hematology published in 1942 clearly establishing hematology as a distinct subspecialty of Internal Medicine, the latest edition continues the influence of the Wintrobe name and helps to set this book apart from the competition.With its strong focus on the clinical aspects of hematology, the book has generated a strong following among internists and general practitioners who want a single resource to consult for their patients who present any blood related disorder. The Twelfth Edition is in full color for the first time, boasts a new editorial team, and includes expanded coverage of new medications and four new chapters on Newborn Anemias, Pathology of LHC, Spleen Tumors, and Myeloproliferative Disorders and Mast Cell Disease. A companion Website will offer the fully searchable text and an image bank.
