Download or read book Robotic Cell Manipulation written by Dong Sun and published by Academic Press. This book was released on 2022-05-31 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robotic Cell Manipulation introduces up-to-date research to realize this new theme of medical robotics. The book is organized in three levels: operation tools (e.g., optical tweezers, microneedles, dielectrophoresis, electromagnetic devices, and microfluidic chips), manipulation types (e.g., microinjection, transportation, rotation fusion, adhesion, separation, etc.), and potential medical applications (e.g., micro-surgery, biopsy, gene editing, cancer treatment, cell-cell interactions, etc.). The technology involves different fields such as robotics, automation, imaging, microfluidics, mechanics, materials, biology and medical sciences. The book provides systematic knowledge on the subject, covering a wide range of basic concepts, theories, methodology, experiments, case studies and potential medical applications. It will enable readers to promptly conduct a systematic review of research and become an essential reference for many new and experienced researchers entering this unique field. - Introduces the applications of robot-assisted manipulation tools in various cell manipulation tasks - Defines many essential concepts in association with the robotic cell manipulation field, including manipulation strategy and manipulation types - Introduces basic concepts and knowledge on various manipulation devices and tasks - Describes some cutting-edge cell manipulation technologies and case studies

Download or read book Robotics for Cell Manipulation and Characterization written by Changsheng Dai and published by Elsevier. This book was released on 2023-04-20 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robotics for Cell Manipulation and Characterization provides fundamental principles underpinning robotic cell manipulation and characterization, state-of-the-art technical advances in micro/nano robotics, new discoveries of cell biology enabled by robotic systems, and their applications in clinical diagnosis and treatment. This book covers several areas, including robotics, control, computer vision, biomedical engineering and life sciences using understandable figures and tables to enhance readers' comprehension and pinpoint challenges and opportunities for biological and biomedical research. - Focuses on, and comprehensively covers, robotics for cell manipulation and characterization - Highlights recent advances in cell biology and disease treatment enabled by robotic cell manipulation and characterization - Provides insightful outlooks on future challenges and opportunities

Download or read book Robotic Manipulation of Reproductive Cells written by Changsheng Dai and published by Springer. This book was released on 2024-03-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to focus on robotic reproductive cell manipulation. It provides readers with the fundamental principles underpinning robotic manipulation of reproductive cells, including sperm, oocytes, and embryos, state-of-the-art technical advances in actuation, sensing and control for cell manipulation, and emerging automated systems for reproductive cell manipulation. The methods presented in the book are generic and can be translated to manipulating other types of cells, such as cancer cells and cardiomyocytes. Robotic Manipulation of Reproductive Cells will be an essential reference for graduate students and researchers working on small-scale robotic systems for cell manipulation and characterization, healthcare professionals interested in nanoscale, microscale, milli-scale robotic techniques for clinical cell surgeries and assisted reproduction, and engineers developing small-scale robotic systems for biomedical engineering, biology, and medicine.

Download or read book Autonomous Robot Aided Optical Manipulation for Biological Cells written by Mingyang Xie and published by Academic Press. This book was released on 2021-05-12 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulation systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts. - Provides a series of latest results in, including but not limited to, design, sensing, actuation, modeling, and control of micro/nano manipulation system using optical tweezers - Gives recent advances of theory, technological aspects, and applications of advanced sensing, actuation, modeling and control methodologies in biomedical engineering applications - Offers simulation and experimental results in each chapter in order to reflect the biomedical engineering practice, yet demonstrate the main focus of the developed design, analysis and synthesis approaches

Download or read book Robotic Single Cell Manipulation for Biological and Clinical Applications written by Clement Leung and published by . This book was released on 2011 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Single cell manipulation techniques have important applications in laboratory and clinical procedures such as intracytoplasmic sperm injection (ICSI) and polar body biopsy for preimplantation genetic diagnosis (PGD). Conventionally, manipulation of cells conducted in these procedures have been performed manually, which entails long training hours and stringent skills. Conventional single cell manipulation also has the limitation of low success rates and poor reproducibility due to human fatigue and skill variations across operators. This research focuses on the integration of computer vision microscopy and control algorithms into a system for the automation of the following single cell manipulation techniques: (1) sperm immobilization, (2) cell aspiration into a micropipette, and cell positioning inside a micropipette, and (3) rotational control of cells in three-dimensions. These automated techniques eliminate the need for significant human involvement and long training. Through experimental trials on live cells, the automated techniques demonstrated high success rates.

Download or read book Millimeter Scale Magnetically Actuated Robotic Tools for Surgery and Cell Manipulation written by Onaizah Onaizah and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small scale robots are precise end-effectors that can manipulate objects with a high degree of accuracy. Many surgical and on-chip tasks can be performed by manipulating these robots in their dedicated environments. Mobile untethered surgical robots are an attractive research area because of their ability to maneuver inside small and constrained environments and perform tasks that were previously considered infeasible. These robots enable us to make surgery minimally invasive. Surgeons can drill a hole in your skull and insert the tools inside the ventricles from where they can navigate their way to either cut or grasp tissue. Because these robots are too small for electronics and on-board power, they are often actuated remotely using magnetic fields as these field can penetrate most environments and are relatively safe for biological organisms. This makes them an ideal tool to use inside the human body and for on-chip applications. Magnetic tools can be developed and placed inside microfluidic platforms for cell manipulation such as sorting and stimulation. Both on-chip and mobile devices are explored in this thesis focusing on applications related to cell manipulation as well as surgical tools. Specifically, this thesis involves a discussion on the development of a pair of micro-surgical scissors for cutting of soft tissues as well as a magnetically oscillating beam that can be used to apply shear stress to cells and used for cell sorting purposes.

Download or read book Microdevices and Microsystems for Cell Manipulation written by Aaron T. Ohta and published by MDPI. This book was released on 2018-07-03 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Microdevices and Microsystems for Cell Manipulation" that was published in Micromachines

Download or read book Fundamentals of Mechanics of Robotic Manipulation written by Marco Ceccarelli and published by Springer Nature. This book was released on 2022-03-30 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book explores the fundamental issues of robot mechanics for both the analysis and design of manipulations, manipulators and grippers, taking into account a central role of mechanics and mechanical structures in the development and use of robotic systems with mechatronic design. It examines manipulations that can be performed by robotic manipulators. The contents of the book are kept at a fairly practical level with the aim to teach how to model, simulate, and operate robotic mechanical systems. The chapters have been written and organized in a way that they can be red even separately, so that they can be used separately for different courses and purposes. The introduction illustrates motivations and historical developments of robotic mechanical systems. Chapter 2 describes the analysis and design of manipulations by automatic machinery and robots; chapter 3 deals with the mechanics of serial-chain manipulators with the aim to propose algorithms for analysis, simulation, and design purposes; chapter 4 introduces the mechanics of parallel manipulators; chapter 5 addresses the attention to mechanical grippers and related mechanics of grasping.

Download or read book Development of a Five Degree of freedom Robot for the Manipulation of Biological Cells written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of individual cells via microscopy and microinjection are a key component in research on gene functions, cancer, stem cells, and reproductive technology. As biomedical experiments become more complex, there is an urgent need for robotic systems to: improve cell manipulation, increase throughput, reduce lost cells, and improve reaction detection. Automation of these tasks using visual servoing creates significant benefits for biomedical laboratories including repeatability of experiments, higher throughput, and a controlled environment capable of operating 24 hours a day. In this work the design and development of a new five degree-of-freedom biomanipulator designed for single-cell microinjection, is described. The biomanipulator employs three degrees of linear motion and two degrees of rotation. This provides the ability to manipulate/micro-inject cells at varying orientations, thereby increasing flexibility in dealing with complex operations such as injecting clustered cells. The capability of the biomanipulator is shown with preliminary experimental results using mouse myeloma cells.

Download or read book Robotics written by Oliver Brock and published by MIT Press. This book was released on 2009 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: State-of-the-art robotics research on such topics as manipulation, motion planning, micro-robotics, distributed systems, autonomous navigation, and mapping. Robotics: Science and Systems IV spans a wide spectrum of robotics, bringing together researchers working on the foundations of robotics, robotics applications, and analysis of robotics systems. This volume presents the proceedings of the fourth annual Robotics: Science and Systems conference, held in 2008 at the Swiss Federal Institute of Technology in Zurich. The papers presented cover a range of topics, including computer vision, mapping, terrain identification, distributed systems, localization, manipulation, collision avoidance, multibody dynamics, obstacle detection, microrobotic systems, pursuit-evasion, grasping and manipulation, tracking, spatial kinematics, machine learning, and sensor networks as well as such applications as autonomous driving and design of manipulators for use in functional-MRI. The conference and its proceedings reflect not only the tremendous growth of robotics as a discipline but also the desire in the robotics community for a flagship event at which the best of the research in the field can be presented.

Download or read book Dynamic Region Control for Robot assisted Cell Manipulation Using Optical Tweezers written by and published by . This book was released on with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current manipulation techniques of optical tweezers treat the position of the laser beam as the control input and an open-loop kinematic controller is designed to move the laser source. In this paper, a closed-loop robotic control method for optical tweezers is formulated and solved. While robotic manipulation has been a key technology driver in factory automation, robotic manipulation of cells or nanoparticles is less well understood. The proposed formulation shall bridge the gap between traditional robot manipulation techniques and optical manipulation techniques of cells. A dynamic region controller is proposed for cell manipulation using optical tweezers. The desired objective can be specified as a dynamic region rather than a position or trajectory, and the desired region can thus be scaled up and down to allow flexibility in the task specifications. Experimental results are presented to illustrate the performance of the proposed controller.

Download or read book Development of a Five Degree of freedom Robot for the Manipulation of Biological Cells written by Kelly D. R. Sakaki and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of individual cells via microscopy and microinjection are a key componentin research on gene functions, cancer, stem cells, and reproductive technology. Asbiomedical experiments become more complex, there is an urgent need for roboticsystems to: improve cell manipulation, increase throughput, reduce lost cells, andimprove reaction detection. Automation of these tasks using visual servoing createssignificant benefits for biomedical laboratories including repeatability of experiments, higher throughput, and a controlled environment capable of operating 24 hours a day. In this work the design and development of a new five degree-of-freedom biomanipulatordesigned for single-cell microinjection, is described. The biomanipulator employsthree degrees of linear motion and two degrees of rotation. This provides the abilityto manipulate/micro-inject cells at varying orientations, thereby increasing flexibilityin dealing with complex operations such as injecting clustered cells. The capabilityof the biomanipulator is shown with preliminary experimental results using mousemyeloma cells.

Download or read book Robotic Cell Manipulation for Intracytoplasmic Sperm Injection ICSI written by Changsheng Dai and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility is a global health issue and affects millions of people. ICSI is the most commonly used technique for infertility treatment, and it achieved higher live birth rate than artificial insemination. ICSI involves the injection of a single sperm into an oocyte with a sharp glass micropipette. However, manual operation of ICSI suffers from inconsistency and potential damage to the cells. This research has addressed these two limitations by developing techniques of automation and less invasiveness for ICSI. Automated system was developed for measuring both motility and morphology of individual live sperm, to provide quantitative data for embryologists to select a single sperm for ICSI. The system has been validated to be highly reproducible and reliable. With customized design to add rotational degree of freedom, robotic micropipette alignment was developed based on kinematics modeling and controller design. The accurate alignment helped increase the success rate of sperm immobilization. Automated sperm aspiration was also proposed by establishing a nonlinear dynamics model and an adaptive controller to achieve high positioning accuracy within micropipette. To reduce cell damage during ICSI operation, robotic orientation control of deformable cells was developed. Polar body needs to be rotated towards 12 o'clock orientation before injection to prevent damaging the spindle. Deep neural networks were trained for robust detection of polar bodies to provide visual feedback. By force modeling and optimal control, an oocyte can be effectively rotated while consistently maintaining minimal cell deformation to avoid cell damage. Oocytes also suffer large deformation during injection, and cytoplasm needs to be aspirated into the micropipette to break oolemma. A new piezo drill was designed to penetrate the oocyte with less deformation and without cytoplasm aspiration. Robotic techniques were also developed to minimize the disturbance of piezo drill to cytoplasm. These techniques of robotic cell manipulation for clinical ICSI can achieve consistent outcomes independent of operator training and experience, increase operation safety by removal of human errors, and improve outcomes by reducing cell damage.

Download or read book Dynamic Modeling and Control of Cell Migration Using a Robot tweezers Cell Manipulation System written by 楊浩 and published by . This book was released on 2015 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design and Testing of a High Accuracy Robotic Single cell Manipulator written by Jun Young Yoon (S.M.) and published by . This book was released on 2011 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have designed, built and tested a high accuracy robotic single-cell manipulator to be able to pick individual cells from array of microwells, each 30 Pm or 50 pm cubed. Design efforts have been made for higher accuracy, higher throughput, and compactness. The proposed system is designed to have a T-drive mechanism with two linear stages for XY-plane positioning to have higher stiffness and less structurally inherent error. Precision is especially required in Z-axis movement for successful cell-retrieval procedure and so a rotational mechanism with a voice coil actuator, among many options, is selected for the Z-axis motion because this results in relatively smaller reaction on the system and has advantages of direct drive. The prototype of the robotic single-cell picker integrates the Z-axis and XY stage motion, realtime microscopy imaging, and cell manipulation with a NI PXI-controller centered as a main real-time controller. This prototype is built to test performances of the proposed system in terms of single-cell retrieval and this thesis also discusses the experiments for the cell-retrieval process with microbeads of the equivalent size and the results as well. This proposed system will be used to help select and isolate an individual hybridoma from polyclonal mixture of cells producing various types of antibodies. It is important to be able to do this cell-retrieval task since a single isolated hybridoma cell produces monoclonal antibody that only recognizes specific antigens, and this monoclonal antibody can be used to develop cures and treatments for many diseases. Our research's development of accurate and dedicated mechatronics solution will contribute to more rapid and reliable investigation of cell properties. Such analysis techniques will act as catalyst for quicker discovery of treatments and vaccines on a wide range of diseases including HIV infection, tuberculosis, hepatitis C, and malaria with potential impact on the society.

Download or read book Integrating Remote learning and Teleoperation for the Control and Manipulation of Robotic Cells written by Ofir Goldstain and published by . This book was released on 2009 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Robotics Research written by Paolo Dario and published by Springer. This book was released on 2005-08-24 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: ISRR, the "International Symposium on Robotics Research", is one of robotics’ pioneering symposia, which has established some of the field's most fundamental and lasting contributions over the past two decades. This book presents the results of the eleventh edition of "Robotics Research" ISRR03, offering a broad range of topics in robotics. The contributions provide a wide coverage of the current state of robotics research: the advances and challenges in its theoretical foundation and technology basis, and the developments in its traditional and new emerging areas of applications. The diversity, novelty, and span of the work unfolding in these areas reveal the field's increased maturity and expanded scope, and define the state of the art of robotics and its future direction.