Download or read book RNP Particles Splicing and Autoimmune Diseases written by Johannes Schenkel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles. Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.
Download or read book Anatomy of Gene Regulation written by Panagiotis A. Tsonis and published by Cambridge University Press. This book was released on 2003-01-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: No longer simple line drawings on a page, molecular structures can now be viewed in full-figured glory, often in color and even with interactive possibilities. Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three-dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. Throughout, the text employs a discussion of genetics and structural mechanics. The concise and unique synthesis of information will offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states. This textbook and its accompanying web site are appropriate for both undergraduate and graduate students in genetics, molecular biology, structural biology, and biochemistry courses.
Download or read book Israel Journal of Medical Sciences written by and published by . This book was released on 1992 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress in Nucleic Acid Research and Molecular Biology written by and published by Academic Press. This book was released on 1983-11-01 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Nucleic Acid Research and Molecular Biology
Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird and published by Elsevier. This book was released on 1996-11-28 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Download or read book Dubois Lupus Erythematosus and Related Syndromes E Book written by Daniel J. Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
Download or read book RNA Metabolism in Neurodegenerative Diseases written by Rita Sattler and published by Springer. This book was released on 2018-06-18 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1982 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small RNAs written by Wolfgang Nellen and published by Springer Science & Business Media. This book was released on 2007-09-12 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.
Download or read book Transfer and Expression of Eukaryotic Genes written by H.S. Ginsberg and published by Academic Press. This book was released on 2012-12-02 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transfer and Expression of Eukaryotic Genes documents the progress in our understanding of the transfer and expression of eukaryotic genes. This book covers topics organized around three themes: gene expression and its regulation; in vivo gene transfer and development; and viral gene and oncogene systems. This text is divided into three sections encompassing 25 chapters and begins with an overview of the molecular basis of gene expression, with emphasis on transcription complexes that account for transcription control in eukaryotic genes. It then turns to experiments that assess the in vitro stimulatory effect of the SV40 72-bp repeat on specific transcription from heterologous promoter elements using a HeLa whole cell extract. The reader is methodically introduced to the regulation signals and factors of histone gene transcription; transcriptional control of beta-globin and liver-specific genes in mouse cells; and gene transfer in Drosophila and the sea urchin Strongylocentrotus purpuratus. This book also considers the splicing of messenger RNA precursors and the regulation of thymidine kinase enzyme expression, and then concludes with a chapter that describes the activation of the myc oncogene by chromosomal translocation. This book will be of interest to students and researchers in fields ranging from molecular genetics to microbiology, biochemistry, pathology, and immunology.
Download or read book Nuclear Particles written by Harris Busch and published by Academic Press. This book was released on 2013-10-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cell Nucleus, Volume IX: Nuclear Particles, Part B discusses "splicing", "processing", and the controls of transcriptional and transport events which must be essential to cells that are either growing or are phenotypically differentiated. The book describes the characteristics and structure of nuclear 30 S RNP particles; as well as the composition and general topology of RNA and protein in monomer 40 S ribonucleoprotein particles. The text also demonstrates the two-dimensional gel electrophoresis of nuclear particles and immunocytochemistry of nuclear hnRNP complexes; the enzymatic activities associated with hnRNP; and the digestion products of nuclear ribonucleoprotein. The nucleocytoplasmic transport of mRNA; the nucleocytoplasmic transport of ribosomal subparticles; and the rnp particles involved in release of in vitro synthesized poly(a)-containing RNA in isolated nuclei are also considered. The book further tackles nuclear bodies as functional indicators in the target cells of sex steroid hormone; and the functional implications of nuclear glycoproteins and glycosaminoglycans. Cell biologists, geneticists, pharmacologists, molecular biologists, biochemists, and students taking related courses will find the book invaluable.
Download or read book The Journal of Cell Biology written by and published by . This book was released on 2000 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Download or read book Manual of Biological Markers of Disease written by W.J. van Venrooij and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).
Download or read book The Eukaryotic Nucleus written by Samuel H. Wilson and published by CRC Press. This book was released on 1990-08-09 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series provides, in two volumes, a complete and exhaustive review of the subject of the eukaryotic nucleus, the site of the DNA. The focus of the book is how the information in the DNA is transcribed, accessed and maintained.
Download or read book Eukaryotic Nucleus written by Samuel H. Wilson and published by CRC Press. This book was released on 1990-08-31 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spliceosomal Pre mRNA Splicing written by Klemens J. Hertel and published by Humana. This book was released on 2014-02-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo manipulation of splicing events and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.
Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
