Download or read book RNA Helicases written by and published by Academic Press. This book was released on 2012-11-13 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-10-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view

Download or read book RNA Helicases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Helicases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about RNA Helicases in a compact format. The editors have built RNA Helicases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about RNA Helicases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of RNA Helicases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Characterisation of the yeast RNA helicase Prp43 written by Annika Heininger and published by Göttingen University Press. This book was released on 2016 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA helicases have many important roles in cell metabolism and are involved in numerous pathways, e.g. translation, pre-mRNA splicing and biogenesis. Interestingly, an increasing number of RNA helicases have been shown to be required for more than one cellular pathway. Therefore, protein cofactors have been suggested to recruit multifunctional RNA helicases to their substrates and regulate their activity. The best characterised family of helicase cofactors are G-patch proteins, which all contain a glycine-riche domain. This work focuses on the characterisation of the yeast RNA helicase Prp43 and its G-patch protein cofactors. Additionally, a new G-patch protein cofactor of Prp43 was identified and characterised. Together, the data suggest that protein cofactors can regulate the distribution and activity of RNA helicases in different pathways.

Download or read book DNA helicases expression functions and clinical implications written by Fumiaki Uchiumi and published by Frontiers Media SA. This book was released on 2015-06-26 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-09-21 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps. Presents updates on the functions and features of helicases across the different kingdoms Begins with a chapter on the evolutionary history of helicases Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view

Download or read book Translation Initiation Reconstituted Systems and Biophysical Methods written by and published by Elsevier. This book was released on 2007-10-09 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

Download or read book Multiplication of RNA Plant Viruses written by Chundi L. Mandahar and published by Springer Science & Business Media. This book was released on 2006-09-05 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. This book generates understanding of multiplication of plus-sense RNA plant viruses, especially at molecular level. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages. Each is a complex phenomenon requiring specific factors and conditions.

Download or read book DNA Helicases and DNA Motor Proteins written by Maria Spies and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Download or read book RNA Nucleotidyltransferases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Nucleotidyltransferases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about RNA Nucleotidyltransferases in a concise format. The editors have built RNA Nucleotidyltransferases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about RNA Nucleotidyltransferases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of RNA Nucleotidyltransferases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Structural and Functional Studies on the Human DEAD box Helicase DDX1 written by Julian Kellner and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2015-07-07 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA helicases are essential in all steps of RNA maturation, beginning with transcription and ending with RNA decay. They catalyze the separation of nucleic acid double strands and thereby facilitate structural remodeling. Their cellular importance is reflected in severe diseases caused by RNA helicase dysregulation. The largest group of RNA helicases is confined by the so called DEAD-box helicases of superfamily 2, characterized by the signature sequence D-E-A-D. DEAD-box helicases share a structurally conserved core of two RecA-like domains that carry signature motifs involved in ATP-binding, ATP-hydrolysis, RNA-binding and RNA-remodeling. An exceptional member of the DEAD-box protein family is the human RNA helicase DDX1(DEAD-box helicase1). In contrast to all other family members, DDX1 harbors a SPRY domain insertion in between the signature motifs of the helicase core. DDX1 is involved in a plethora of different RNA maturation processes and has been associated with tumor progression. Moreover due to its versatile function in RNA processing, it is hijacked by viruses for their replication. This medical relevance makes DDX1 a potential target for the development of pharmaceutics.

Download or read book Regulation of Bacterial Virulence written by Michael L. Vasil and published by American Society for Microbiology Press. This book was released on 2012-12-05 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive compendium of scholarly contributions relating to bacterial virulence gene regulation. • Provides insights into global control and the switch between distinct infectious states (e.g., acute vs. chronic). • Considers key issues about the mechanisms of gene regulation relating to: surface factors, exported toxins and export mechanisms. • Reflects on how the regulation of intracellular lifestyles and the response to stress can ultimately have an impact on the outcome of an infection. • Highlights and examines some emerging regulatory mechanisms of special significance. • Serves as an ideal compendium of valuable topics for students, researchers and faculty with interests in how the mechanisms of gene regulation ultimately affect the outcome of an array of bacterial infectious diseases.

Download or read book Regulating with RNA in Bacteria and Archaea written by Gisela Storz and published by John Wiley & Sons. This book was released on 2020-07-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.

Download or read book The Biology of mRNA Structure and Function written by Marlene Oeffinger and published by Springer Nature. This book was released on 2019-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

Download or read book RNA Nucleotidyltransferases Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Nucleotidyltransferases: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about RNA Nucleotidyltransferases in a compact format. The editors have built RNA Nucleotidyltransferases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about RNA Nucleotidyltransferases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of RNA Nucleotidyltransferases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2022-06-24 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.