Download or read book Restoring Functional Behaviors After Traumatic Peripheral Nerve Injuries written by George Davis Bittner and published by Frontiers Media SA. This book was released on 2024-02-20 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral nerve injuries (PNIs) by trauma are the most common neuronal injury in civilian and military populations and significantly burden health care systems. Mammals (including humans) with PNIs experience: (1) immediate loss of sensory and motor functions mediated by the denervated target tissues; (2) rapid (3-7d) Wallerian Degeneration (WD) of severed distal axonal segments; and, (3) slow (~1mm/day) regeneration by naturally occurring axonal outgrowths from surviving, severed proximal stumps that produce poor (if any) functional recovery because of slow axonal regeneration for long distances and lack of axonal guidance. Denervated muscle fibers and sensory organs often atrophy before any re-innervation can occur.

Download or read book The Potential Therapeutic Approaches to Improve Peripheral Nerve Functional Recovery from Injury written by Kuang-Ching Chris Tseng and published by . This book was released on 2015 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Traumatic peripheral nerve crush injuries contribute a great deal of morbidity in patients and little improvement has been made in the treatment of these injuries in many years. Diagnosis and treatment of traumatic peripheral nerve damage suffer from a lack of means of accurately diagnosing the reasons for loss of nerve function and a lack of means of enhancing the time course of repair in injuries in which nerve function is lost for reasons other than axonal transection. In the current work, we demonstrate that administration of erythropoietin (EPO) shortens the time course of recovery after experimental crush injury to the mouse sciatic nerve. We found that systemic EPO administration maintained more myelinated axons at the site of injury in vivo following sciatic nerve crush. In vitro, EPO treatment promotes myelin formation and protects myelin from the effects of nitric oxide exposure in co-cultures of Schwann cells and dorsal root ganglion (DRG) neurons. These results suggested local EPO application might also be effective in promoting functional recovery, which would avoid potential systemic side effects of systemic EPO administration. We therefore developed a novel local treatment for peripheral nerve injury of EPO delivered in a fibrin glue matrix at the site of injury. Local delivery was as effective as systemic EPO administration, and thus may provide a potentially useful approach to enhancing recovery in peripheral nerve injuries. We also demonstrate that a single administration of 4-aminopyridine (4-AP), which enables impulse conduction in demyelinated axons, transiently restores function and allows identification of injuries in which axons are intact but not functional. We further demonstrate that repeated 4-AP administration markedly improves the time course of recovery from crush injuries in the peripheral nerve as determined by behavioral and electophysiological analyses. Equal or greater efficacy is provided by localized delivery of slow-release formulations of 4-AP at the lesion site. In addition, we provide biochemical and ultrastructural evidence to show that repeated systemic 4-AP delivery and localized slow-release delivery enhance remyelination after injury. Thus, we provide a single therapeutic approach that addresses critical issues in diagnosing peripheral nerve injury and enhancing repair, and provides the first pharmacological approach to enhancing myelin repair. As 4-AP is already used in the clinic for treatment of multiple sclerosis, our approaches are highly suitable for rapid translation from the laboratory to clinical analysis"--Pages v-vi.

Download or read book Indwelling Neural Implants written by William M. Reichert and published by CRC Press. This book was released on 2007-12-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel

Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuropathic Pain written by Jianguo Cheng and published by Oxford University Press. This book was released on 2019-01-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathic pain is one of the most common, most debilitating, most costly, and most difficult to treat categories of chronic pain conditions that are characterized by a lesion or disease of the somatosensory nervous system. Managing neuropathic pain is challenging and requires skillful assessment and comprehensive and integrated treatment strategies that are mechanism-guided, evidence-based, and individualized. However, these critical and integral elements are very fragmented in the current literature. The mechanistic understanding of neuropathic pain is typically found in basic research articles. Clinical research evidence is presented in forms of clinical trials with emphasis on minimizing biases such as those from patient selection and assessment. Individualized considerations for each patient are usually presented in case reports and problem-based learning discussions. This book overcomes these barriers and integrates all the critical elements around individual patient care into a coherent management strategy that is practical and applicable to daily clinical practice. Rather than compiling what have been published in the literature, this work emphasizes on identifying and highlighting the key points or findings that guide decision-making in clinical practice. It integrates the key points around a typical case scenario that not only represents the core of the diagnostic and therapeutic processes but also allows introduction and differentiation of painful conditions that bare similarities with the case in hand. The overarching goal is to improve clinical outcomes through better understanding of the mechanisms, more accurate diagnosis, and wiser and more comprehensive treatment strategies.

Download or read book Brachial Plexus Injury written by Jörg Bahm and published by BoD – Books on Demand. This book was released on 2022-01-26 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, specialists from different countries and continents share their knowledge and experience in brachial plexus surgery. It discusses the different types of brachial plexus injury and advances in surgical treatments.

Download or read book The function of Schwann cells in peripheral nervous system written by Bo He and published by Frontiers Media SA. This book was released on 2023-02-08 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biologics in Orthopaedic Surgery written by Augustus D Mazzocca and published by Elsevier Health Sciences. This book was released on 2018-11-27 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed with the practicing clinician in mind, Biologics in Orthopaedic Surgery provides a succinct, easy-to-digest overview of the integration of biologics (platelet-rich-plasma [PRP], bone marrow aspirate [BMA], and stem cells) into today’s orthopaedic practice. Covering relevant basic science as well as clinical applications, this concise reference takes a head-to-toe approach to the emerging role of orthobiologics for specific conditions and procedures, in addition to future directions for implementation.

Download or read book Sports Injuries written by Mahmut Nedim Doral and published by Springer Nature. This book was released on 2015-06-29 with total page 3295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation covers the whole field of sports injuries and is an up-to-date guide for the diagnosis and treatment of the full range of sports injuries. The work pays detailed attention to biomechanics and injury prevention, examines the emerging treatment role of current strategies and evaluates sports injuries of each part of musculoskeletal system. In addition, pediatric sports injuries, extreme sports injuries, the role of physiotherapy, and future developments are extensively discussed. All those who are involved in the care of patients with sports injuries will find this textbook to be an invaluable, comprehensive, and up-to-date reference.

Download or read book Nerve Injury and Repair written by Göran Lundborg and published by . This book was released on 1988-01-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Injury in America written by National Research Council and published by National Academies Press. This book was released on 1985-01-01 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Injury is a public health problem whose toll is unacceptable," claims this book from the Committee on Trauma Research. Although injuries kill more Americans from 1 to 34 years old than all diseases combined, little is spent on prevention and treatment research. In addition, between $75 billion and $100 billion each year is spent on injury-related health costs. Not only does the book provide a comprehensive survey of what is known about injuries, it suggests there is a vast need to know more. Injury in America traces findings on the epidemiology of injuries, prevention of injuries, injury biomechanics and the prevention of impact injury, treatment, rehabilitation, and administration of injury research.

Download or read book Neural Regeneration written by Kwok Fai So and published by Academic Press. This book was released on 2015-02-03 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: - Neural regeneration in lower vertebrates - Neural regeneration in the peripheral nervous system - Neural regeneration in the central nervous system - Transplantation-mediated neural regeneration - Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. - Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration - Highly translational and clinically-relevance - International authors who are leaders in their respective fields - Vivid art work making the chapters easily understood

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Download or read book Apoptosis and Beyond written by James A. Radosevich and published by John Wiley & Sons. This book was released on 2018-09-18 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Download or read book Traumatic Brain and Spinal Cord Injury written by Cristina Morganti-Kossmann and published by Cambridge University Press. This book was released on 2012-07-19 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

Download or read book Peripheral Nerve Injury An Anatomical and Physiological Approach for Physical Therapy Intervention written by Stephen Carp and published by F.A. Davis. This book was released on 2015-04-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here’s everything you need to know about peripheral nerve injuries and how to recognize and treat acute and chronic injuries and conditions across the lifespan. In-depth discussions, organized in a streamlined format, ensure you understand the identification, pathophysiology, assessment, and procedural interventions associated with peripheral nerve injuries. Build the knowledge base you need to evaluate the most common to complex injuries, make a diagnosis, and implement a plan of care with this one-of-a-kind resource.

Download or read book Cellular Molecular Physiological and Behavioral Aspects of Spinal Cord Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-10 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers' understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. - Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after spinal cord injury