Download or read book Airway Remodeling written by Peter Howarth and published by CRC Press. This book was released on 2001 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias! Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodelingdescribes the contribution of inflammatory cells in the development of airway structural changes examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling reviews the action of cytokines and growth factors on ASM signaling outlines novel approaches to regulating smooth muscle growth clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation and more!Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.

Download or read book Morphometry of the Human Lung written by Ewald R. Weibel and published by Academic Press. This book was released on 2013-10-22 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphometry of the Human Lung considers the developments in understanding the quantitative anatomy of the lung, and in the correlation of anatomy with physiology. This book is composed of 11 chapters, and begins with an overview of a systematic approach to a quantitative morphologic analysis of the architecture of the human lung, followed by a presentation of general problems of methodology and the derivation of reliable dimensional models of this organ. The subsequent chapters describe the methods of preparation of tissues, methods of random sampling, and adaptation of methodologies from other fields of science. These topics are followed by discussions the mathematical formulations for the translation of the data into the desired geometric forms and a technique of counting. The final chapters look into the mode of distribution and geometric forms that should eventually facilitate mathematical and physical considerations regarding the function of the lungs. These chapters also consider the application of these quantitative methods to the study of pathologic specimens, providing a most timely renovation of morphologic pathology. This book will be of value to pulmonologists, physiologists, and researchers who are interested in lung morphometry.

Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book SARS MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Download or read book Asthma Treatment written by Dario Olivieri and published by Springer Science & Business Media. This book was released on 1992 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses the recent findings on the biology and pharmacology of asthma, in 27 papers that constitute the proceedings of a ten-day workshop in Erice, Sicily, May 1991. Among the topics are airway neuropeptides, platelets and asthma, bronchial asthma and pulmonary gas exchange, and the management of

Download or read book Lung Stem Cells in Development Health and Disease written by Nikolic, Marko Z. and published by European Respiratory Society. This book was released on 2021-04-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Download or read book Inflammatory Cells and Mediators in Bronchial Asthma written by Devendra K. Agrawal and published by CRC Press. This book was released on 1990-10-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.

Download or read book Airway Mucus Basic Mechanisms and Clinical Perspectives written by D.F. Rogers and published by Springer Science & Business Media. This book was released on 1997-09-23 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.

Download or read book Rhinovirus Infections written by Nathan Bartlett and published by Academic Press. This book was released on 2019-06-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhinovirus Infections: Rethinking the Impact on Human Health and Disease provides a timely review of the impact of rhinovirus infections on human health. It identifies disease mechanisms relating to the virus, human host and environmental factors. This viewpoint allows us to look forward to the development of treatments for a virus for which treatment options are currently non-existent. By providing detailed insights into this virus, its host and the environmental factors that play into rhinovirus induced diseases, this book explains disease mechanisms and summarizes existing and developing therapeutic approaches for better research, diagnosis and potential treatments. - Provides insight into viral diversity and identification of virulence factors, showing how the subtype of rhinovirus affects susceptibility to diseases - Explores host and environmental factors, explaining how age, health status, genotype, lifestyle and environment influence the outcome of a rhinovirus infection - Covers vaccines and treatments, discussing the health burden associated with rhinovirus infections and the driving development of an increasing array of treatment approaches

Download or read book Middleton s Allergy E Book written by A Wesley Burks and published by Elsevier Health Sciences. This book was released on 2019-09-25 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through eight outstanding editions, Middleton's Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. - Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. - Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. - Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. - Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms. - Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. - Features a new team of expert editors and more international contributors for a global perspective of this complex field. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Download or read book Lung Development written by Claude Gaultier and published by Springer. This book was released on 2013-05-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.

Download or read book Ehlers Danlos Syndrome A Multidisciplinary Approach written by J.W.G. Jacobs and published by IOS Press. This book was released on 2018-08-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generalized hypermobility has been known since ancient times, and a clinical description of Ehlers-Danlos syndrome (EDS) is said to have first been recorded by Hippocrates in 400 BC. Hypermobility syndromes occur frequently, but the wide spectrum of possible symptoms, coupled with a relative lack of awareness and recognition, are the reason that they are frequently not recognized, or remain undiagnosed. This book is an international, multidisciplinary guide to hypermobility syndromes, and EDS in particular. It aims to create better awareness of hypermobility syndromes among health professionals, including medical specialists, and to be a guide to the management of such syndromes for patients and practitioners. It is intended for use in daily clinical practice rather than as a reference book for research or the latest developments, and has been written to be understandable for any healthcare worker or educated patient without compromise to the scientific content. The book is organized as follows: chapters on classifications and genetics are followed by chapters on individual types, organ (system) manifestations and complications, and finally ethics and therapeutic strategies, with an appendix on surgery and the precautions which should attend it. A special effort has been made to take account of the perspective of the patient; two of the editors have EDS. The book will be of interest to patients with hypermobility syndromes and their families, as well as to all those healthcare practitioners who may encounter such syndromes in the course of their work.

Download or read book The Non Thrombotic Role of Platelets in Health and Disease written by Steve W. Kerrigan and published by BoD – Books on Demand. This book was released on 2015-11-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

Download or read book Murray and Nadel s Textbook of Respiratory Medicine E Book written by Robert J. Mason and published by Elsevier Health Sciences. This book was released on 2010-06-09 with total page 2457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.