Download or read book Research to Develop Biomedical Applications of Free Electron Laser Technology written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific Aim 1: Develop and test plaque characterization criteria based on bireftingence. Coronary artenes were obtained at autopsy and imaged with the existing OCT system in our laboratory. The specimens were opened and imaged at normal body temperature (37-C) in saline. To ensure proper registration of OCT images with histolog the image location was marked with ink viewable on the OCT image and in the histology section. Routine histologic processing was performed using H & E, Elastic and Movat's pentachrome stains. Trichrome was used for fibrous tissue identification. Individual images were oriented and scaled to match histology. In the OCT images, the axial periodicity of the birefringence banding was measured using image processing software. A set of 20 correlated OCT and histology pairs were used to identify characterization criteria basal on birefringence. Our results indicated that fibrous plaque provides a strong birefringence as measured by OCT while lipid rich and calcific plaques can be identified by a complete loss of birefringenee.
Download or read book Medical Materials Research and Applications of Free Electron Laser and Related Technologies written by and published by . This book was released on 1991 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: To investigate biomedical and materials laser-optical systems that have potential clinical and industrial applications. To develop clinical and industrial applications of Free-Electron laser technology and related broadly wavelength tunable, short pulse, ultrafast, high peak power, high average power laser systems that are efficient, compact, reliable and clinically and commercially practical systems. To carry out actual FEL experiments with collaborators at existing FEL facilities at Duke, Vanderbilt and Stanford Universities.
Download or read book Development and Applications of Free Electron Lasers written by Jia Chen and published by CRC Press. This book was released on 1997-05-22 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of the field of free electron lasers. Each chapter is based on a graduate-level lecture given by an internationally-known expert in the field, and is self-contained, beginning with introductory background material and culminating in an in-depth discussion of the author's current research. Written with both the student physicist and the active researcher in mind, this book is sure to be an invaluable reference for graduate students and professionals alike.
Download or read book Biomedical Applications of Free electron Lasers written by Society of Photo-optical Instrumentation Engineers and published by SPIE-International Society for Optical Engineering. This book was released on 2000 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Studies Using Free Electron Laser and Other Laser Systems written by and published by . This book was released on 1995 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Baylor Research Institute, in collaboration with the Dept. of Biomedical Engineering at U.T. Austin and the Dept. of Laser Science at UT-M.D. Anderson hospital in Houston evaluated potential uses for high peak power pulsed and continuous wave lasers and the free-electron lasers at Duke, Stanford, and Vanderbilt for medical use. Resulting developments for potential medical use include eradication of viruses in blood banking, development of photoproducts for use in treatment of AIDS and cancer, photochemicals for non-thermal tissue welding, devices to augment thermal welding, systems for cartilage repair, combined wavelength lasers for tissue hemostasis and ablation, and a new family of photochemicals for use in tracking tumors and with potential as bonding agents in material science. Basic knowledge of laser-tissue interactions was developed.
Download or read book Commercial and Biomedical Applications of Ultrafast and Free electron Lasers written by Glenn S. Edwards and published by SPIE-International Society for Optical Engineering. This book was released on 2002 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Utah Biomedical Physical Sciences Applications of Free Electron Lasers written by John A. Dixon and published by . This book was released on 1987 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Work is presented on the operation, beam characteristics, and biomedical-materials research and sapphire fiber development with the Stanford Mark III free Electron Laser. The MK III FEL has been operated in the wavelength range of 2 micrometers to 4 micrometers at up to 4 mJ per pulse (1-2 microsec). Irradiances as high as 800 GW/cm2 have been obtained with pulse durations as low as 350 femto seconds. Preliminary studies with sapphire fibers are underway in the 2-4 micrometer range. Preliminary studies with biological samples including gallstones, kidney stones and egg shells and in vivo soft tissue samples including albino mouse ear skin and vasculature and with semiconductor materials have been carried over a biologically important water absorption peak (approximately 2.94 micrometers) has been demonstrated.
Download or read book Vanderbilt Free Electron Laser Project in Biomedical and Materials Research written by Richard F. Haglund and published by . This book was released on 1988 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Medical Free Electron Laser Program was awarded to develop, construct and operate a free-electron laser facility dedicated to biomedical and materials studies, with particular emphases on: fundamental studies of absorption and localization of electromagnetic energy on and near material surfaces, especially through electronic and other selective, non-statistical processes; non-thermal photon-materials interactions (e.g., electronic bond-breaking or vibrational energy transfer) in physical and biological materials as well as in long-wavelength biopolymer dynamics; development of FEL-based methods to study drug action and to characterize biomolecular properties and metabolic processes in biomembranes; clinical applications in otolaryngology, neurosurgery, ophthalmology and radiology stressing the use of the laser for selective laser-tissue, laser-cellular and laser-molecule interactions in both therapeutic and diagnostic modalities.
Download or read book Vanderbilt University Free Electron Laser Center for Biomedical and Materials Research Bibliography and Meeting Abstracts written by and published by . This book was released on 1992 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Partial contents:free electron laser construction and operation, mechanisms of photon induced damage in optical materials, desorption of atoms and molecules from surfaces, nonlinear effects of lasers, interaction of lasers with defects in optical materials, picosecond spectroscopy of biopolymers, nonthermal and selective effects of free electron laser irradiation of tissue, Free electron laser based studies of biomemmbrane dynamics and drug interactions, free electron laser applications in neurosurgery.
Download or read book Development and Scientific Utilization of the University of California Santa Barbara Free Electron Laser written by and published by . This book was released on 1991 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: A research program has been carried out to advance the science and technology of free electron lasers and their applications. The overall objectives of the program were the following were; Development of free-electron lasers in the millimeter and far-infrared region; Facilitate the application of far-infrared free-electron lasers to research in frontier science and technology and; Training of researchers in the development, operation and application of free-electron lasers. A free electron laser facility, has been developed which is tunable under computer control and able to deliver kilowatts of millimeter wave and far infrared power.
Download or read book Development and Applications of Free Electron Lasers written by and published by . This book was released on 1997 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Aspects of the Laser written by Leon Goldman and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a review of past and current studies and future plans of the Laser Laboratory in Cincinnati and some of the contributions of laser research groups in other medical centers. Special thanks are due to the Directing Physicist of the Laser Labora tory, R. James Rockwell. Without his advice, constant supervision and corrections, this enthusiastic investigator would continue to upset even many more people than he has done already. The excuse, of course, is to stimulate much needed interest and controlled research and development of the laser for biology and medicine. The Associate Research Physicist, Ralph Schooley, has worked with many phases of laser research but especially in Q spoiling, Raman spectroscopy, and the almost alchemy of holography. Holography, as of now, provides many opportunities for Gumperson's Law, "If anything can go wrong, it will. " Sincere appreciation is expressed to the Surgeons in the Laser Labora tory, who have supplied clinical and investigative surgical supervision often under great difficulties, Dr. V. E. Siler and Dr. Bruce Henderson. We are grateful for help from the Directing Biologist of the Laser Labo ratory, Edmond Ritter, the Director of Laser Neurosurgery, Dr. Thomas Brown and the Professor of Neurosurgery, Dr. Robert McLaurin, for important and basic work in laser neurosurgery. Special thanks are given to Robert Meyer, who has given most of the treatments in careful and skillful fashion, and his associate, Robert Otten.
Download or read book Army Research and Development written by and published by . This book was released on 1976 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of a Free Electron Laser Center and Research in Medicine Biology and Materials Science written by and published by . This book was released on 1992 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free-Electron Laser Construction and Operation under the direction of C.A. Brau, Department of Physics, College of Arts and Science. The objective of this effort has been to commission the free-electron laser and the optical beamline required to distribute the laser beam to the laboratories. Nonthermal and Selective Effects of Free-Electron Laser Irradiation of Tissue. Under the direction of R.H. Ossoff, Department of Otolaryngology, School of Medicine, the objective of this research has been to examine the effects of lasers on tissue, including the effect on wound healing. Free-Electron Laser Based Studies of Biomembrane Dynamics and Drug Interactions. Under the direction of S. Fleischer, Department of Molecular Biology, College of Arts and Science, the objective of this research has been to understand the dynamics of membrane proteins, and how they are related to membrane function. Free-Electron Laser Applications in Neurosurgery. Under the direction of R.J. Maciunas, Department of Neurosurgery, School of Medicine, the objective of this effort has been to study the interaction of pulsed lasers with brain tissue, and to develop the techniques of sterotactic laser neurosurgery.
Download or read book Materials Development and Processing for Biomedical Applications written by Savaş Kaya and published by CRC Press. This book was released on 2022-04-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials Development and Processing for Biomedical Applications focuses on various methods of manufacturing, surface modifications, and advancements in biomedical applications. This book examines in detail about five different aspects including, materials properties, development, processing, surface coatings, future perspectives and fabrication of advanced biomedical devices. Fundamental aspects are discussed to better understand the processing of various biomedical materials such as metals, ceramics, polymers, composites, etc. A wide range of surface treatments are covered in this book that will be helpful for the readers to understand the importance of surface treatments and their future perspectives. Additional Features Include: Examines various properties of biomedical materials at the beginning in several chapters which will enrich the fundamental knowledge of the readers. Discusses advancements in various fields of biomedical applications. Provides a glimpse of characterization techniques for the evaluation of material properties. Addresses biocompatibility, biocorrosion, and tribocorrosion. This book explores new and novel strategies for the development of materials and their biomedical applications. It will serve as a comprehensive resource for both students and scientists working in materials and biomedical sciences.
Download or read book The Biomedical Laser written by Leon Goldman and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laser's range of application is extraordinary. Arthur Schawlow says, "What instrument can shuck a bucket of oysters, correct typing errors, fuse atoms, lay a straight line for a garden bed, repair detached retinas, and drill holes in dia monds?"O The laser's specifically biomedical uses cover a similarly broad and interesting spectrum. In this book, I have endeavored to convey some of the fas cination that the laser has long held for me. It is my hope that both clinicians and researchers in the various medical and surgical specialties will find the book a use ful introduction. Biologists, particularly molecular biologists, should also find a great deal of relevant information herein. This volume's distinguished contributors provide admirably lucid discussions of laser principles, instrumentation, and current practice in their respective special ties. Safety, design, capabilities, and costs of various lasers are also reviewed. We have aimed to create a practical text that is comprehensive but not exhaustive. Our emphasis on the practical, rather than the esoteric, is dictated not only by the short history of biomedical laser use, but by the extent of the community to which this information will appeal.
Download or read book Biomedical Studies with the Free Electron Laser written by and published by . This book was released on 1989 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: An electrostatic VandeGraff FEL was used to study the effects of infrared radiation on the synthesis of DNA and RNA in living vertebrate cells in culture. The laser was operated at wavelengths of 165 and 200 microns at power densities of 0.1 - 30 KW/sq.cm. Cells were incubated in radioactive precursors to either DNA or RNA following exposure to the FEL and analyzed by light microscope autoradiography. The results indicated that the 200 micron wavelength inhibited DNA but not RNA synthesis in a subpopulation of cells and the 165 micron wavelength inhibited RNA synthesis and not DNA synthesis. The statistical significance for the 200 micron wavelength studies was p = 0.05 and for the 165 micron wavelength studies p = 0.001 - 0.005. Partial Contents: Delayed Retinal Effects of Frequency Doubled YAG Laser (532 nm); Tumor Destruction in Photodynamic Therapy; Comparison of Continuous Wave Lasers for Endarterectomy of Experimental Atheromas; Mechanism of Tumor Destruction Following Photodynamic Therapy with Hematoporphyrin Derivative, Chlorin, and Phthalocyanine; Phycocyanin; Laser Activation, Cytotoxic Effects, and Uptake in Human Atherosclerotic Plague; Basic Laser Physics and Tissue Interaction; Biological Studies on the Free Electron Laser; Ablation of Bone and Methacrylate by a Prototype Mid-Infrared Erbium; YAG Laser; and Corneal Healing after Excimer Laser Surface Ablation.
