Download or read book Research and development landscape for childhood cancer written by World Health Organization and published by World Health Organization. This book was released on 2023-10-27 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Making Better Drugs for Children with Cancer written by National Research Council and published by National Academies Press. This book was released on 2005-03-31 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successes that have been achieved in treating childhood cancers stand as beacons against the less dramatic improvements for adults with cancer. Progress began to accelerate in the 1960s and 1970s, as treatment regimens were built up, primarily by building combinations of chemotherapeutic drugs. However the near absence of research in pediatric cancer drug discovery threatens to halt the progress in childhood cancer treatment achieved during the past four decades. Making Better Drugs for Children with Cancer identifies the major issues to be addressed in developing new agents for childhood cancers, the gaps in research and development, and the steps that have been suggested to move the process forward. This report also makes a new proposal to capitalize on today's science to bring new treatments to children's cancers.
Download or read book Pediatric Cancer Therapy written by Carl Pochedly and published by . This book was released on 1979 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Shaping the global innovation and access landscape for better paediatric medicines written by World Health Organization and published by World Health Organization. This book was released on 2022-08-26 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Childhood Cancer and Functional Impacts Across the Care Continuum written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2021-09-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Download or read book Drug Discovery and Development written by Vishwanath Gaitonde and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
Download or read book Comprehensive Cancer Care for Children and Their Families written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-08-31 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Childhood cancer is an area of oncology that has seen both remarkable progress as well as substantial continuing challenges. While survival rates for some pediatric cancers present a story of success, for many types of pediatric cancers, little progress has been made. Many cancer treatments are known to cause not only significant acute side effects, but also lead to numerous long-term health risks and reduced quality of life. Even in cases where the cancer is considered curable, the consequences of treatment present substantial long-term health and psychosocial concerns for children, their families, their communities, and our health system. To examine specific opportunities and suggestions for driving optimal care delivery supporting survival with high quality of life, the National Cancer Policy Forum of the Institute of Medicine and the American Cancer Society co-hosted a workshop which convened experts and members of the public on March 9 and 10, 2015. At this workshop, clinicians and researchers in pediatric oncology, palliative, and psychosocial care, along with representatives from the U.S. Food and Drug Administration, National Cancer Institute, Children's Oncology Group, pharmaceutical companies, and patient advocacy organizations, discussed and developed a menu of options for action to improve research, quality of care, and outcomes for pediatric cancer patients and their families. In addition, parents of children with cancer and pediatric cancer survivors shared their experiences with care and provided poignant personal perspectives on specific quality of life concerns and support needs for children and families across the life spectrum. This report summarizes the presentations and discussion of the workshop.
Download or read book Pediatric Cancer Therapeutics Development written by Jorge DiMartino and published by Springer Nature. This book was released on 2022-11-18 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the scientific, medical, regulatory, and economic considerations associated with the discovery, development, and delivery of novel therapeutics for children with cancer. Co-authored by a diverse team from academic, government, and industry backgrounds, the book describes the steps in the process from the identification of a promising therapeutic target to the evaluation of drug candidates in the various phases of clinical testing and regulatory review. Throughout, special emphasis is placed on the unique biology of pediatric malignancies and the medical and social needs of children and their families. In providing a firm grounding in the drug development process, the book will be of value to all with an interest in how medicines currently used to treat pediatric cancer were made available. This includes trainees as well as established practitioners and others participating in translational and clinical research in the academic setting.
Download or read book McCance Huether s Pathophysiology E Book written by Julia Rogers and published by Elsevier Health Sciences. This book was released on 2022-08-03 with total page 1738 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW! More than 50 new or revised illustrations visually reinforce pathophysiology concepts. NEW! Emerging Science boxes highlight the most current research and clinical developments.
Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Download or read book Landscape and Sustainable Development written by Council of Europe and published by Council of Europe. This book was released on 2006-01-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Council of Europe landscape convention was adopted in Florence (Italy) on 20 October 2000 with the aim of promoting the protection, management and planning of European landscape and organising European co-operation in this area. It is the first international treaty covering all aspects of European landscape. It applies to the entire territory of the contracting parties and covers natural, rural, urban and peri-urban areas. It concerns landscapes that might be considered outstanding, commonplace or deteriorated. By taking into account landscape, culture and nature, the Council of Europe seeks to protect the quality of life and well-being of Europeans in a sustainable development perspective.
Download or read book Research in Landscape Architecture written by Adri van den Brink and published by Routledge. This book was released on 2016-11-10 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defining a research question, describing why it needs to be answered and explaining how methods are selected and applied are challenging tasks for anyone embarking on academic research within the field of landscape architecture. Whether you are an early career researcher or a senior academic, it is essential to draw meaningful conclusions and robust answers to research questions. Research in Landscape Architecture provides guidance on the rationales needed for selecting methods and offers direction to help to frame and design academic research within the discipline. Over the last couple of decades the traditional orientation in landscape architecture as a field of professional practice has gradually been complemented by a growing focus on research. This book will help you to develop the connections between research, teaching and practice, to help you to build a common framework of theory and research methods. Bringing together contributions from landscape architects across the world, this book covers a broad range of research methodologies and examples to help you conduct research successfully. Also included is a study in which the editors discuss the most important priorities for the research within the discipline over the coming years. This book will provide a definitive path to developing research within landscape architecture.
Download or read book A New Deal for Cancer written by Abbe R. Gluck and published by PublicAffairs. This book was released on 2021-11-16 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: An unprecedented constellation of experts—leading cancer doctors, policymakers, cutting-edge researchers, national advocates, and more—explore the legacy and the shortcomings from the fifty-year war on cancer and look ahead to the future. The longest war in the modern era, longer than the Cold War, has been the war on cancer. Cancer is a complex, evasive enemy, and there was no quick victory in the fight against it. But the battle has been a monumental test of medical and scientific research and fundraising acumen, as well as a moral and ethical challenge to the entire system of medicine. In A New Deal for Cancer, some of today’s leading thinkers, activists, and medical visionaries describe the many successes in the long war and the ways in which our deeper failings as a society have held us back from a more complete success. Together they present an unrivaled and nearly complete map of the battlefield across dimensions of science, government, equity, business, the patient provider experience, and more, documenting our emerging understanding of cancer’s many unique dimensions and offering bold new plans to enable the American health care system to deliver progress and hope to all patients.
Download or read book Pediatric Neuro oncology written by Katrin Scheinemann and published by Springer. This book was released on 2024-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.
Download or read book Advancing the Science of Implementation Across the Cancer Continuum written by David A. Chambers and published by Oxford University Press, USA. This book was released on 2018 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many effective interventions have been developed with the potential to significantly reduce morbidity and mortality from cancer, they are of no benefit to the health of populations if they cannot be delivered. In response to this challenge, Advancing the Science of Implementation across the Cancer Continuum provides an overview of research that can improve the delivery of evidence-based interventions in cancer prevention, early detection, treatment, and survivorship. Chapters explore the field of implementation science and its application to practice, a broad synthesis of relevant research and case studies illustrating each cancer-focused topic area, and emerging issues at the intersection of research and practice in cancer. Both comprehensive and accessible, this book is an ideal resource for researchers, clinical and public health practitioners, medical and public health students, and health policymakers.
Download or read book Delivering High Quality Cancer Care written by Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population and published by National Academies Press. This book was released on 2014-01-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the barriers to achieving excellent care for all cancer patients remain daunting. Care often is not patient-centered, many patients do not receive palliative care to manage their symptoms and side effects from treatment, and decisions about care often are not based on the latest scientific evidence. The cost of cancer care also is rising faster than many sectors of medicine--having increased to $125 billion in 2010 from $72 billion in 2004--and is projected to reach $173 billion by 2020. Rising costs are making cancer care less affordable for patients and their families and are creating disparities in patients' access to high-quality cancer care. There also are growing shortages of health professionals skilled in providing cancer care, and the number of adults age 65 and older--the group most susceptible to cancer--is expected to double by 2030, contributing to a 45 percent increase in the number of people developing cancer. The current care delivery system is poorly prepared to address the care needs of this population, which are complex due to altered physiology, functional and cognitive impairment, multiple coexisting diseases, increased side effects from treatment, and greater need for social support. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis presents a conceptual framework for improving the quality of cancer care. This study proposes improvements to six interconnected components of care: (1) engaged patients; (2) an adequately staffed, trained, and coordinated workforce; (3) evidence-based care; (4) learning health care information technology (IT); (5) translation of evidence into clinical practice, quality measurement and performance improvement; and (6) accessible and affordable care. This report recommends changes across the board in these areas to improve the quality of care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides information for cancer care teams, patients and their families, researchers, quality metrics developers, and payers, as well as HHS, other federal agencies, and industry to reevaluate their current roles and responsibilities in cancer care and work together to develop a higher quality care delivery system. By working toward this shared goal, the cancer care community can improve the quality of life and outcomes for people facing a cancer diagnosis.
Download or read book Cancer Principles Practice of Oncology written by Vincent T. DeVita and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of Oncology, this unique publication brings together the basic scientific information on the molecular biology of cancer. The format is designed to be useful both to research scientists interested in the study of cancer and to oncologists who need to understand these new developments that are having a profound impact on the care of patients with cancer. Leading scientists and clinicians in the field of molecular biology and clinical oncology have lent their expertise to this project. The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells. Part II includes an up-to-date description of how this new information has affected the understanding of the biology of 19 of the most common cancers, with an emphasis on how these new findings have been translated to impact the management of cancer patients. This distinctive text provides a single concise source of information for scientists and clinicians in this rapidly developing field
