Download or read book Resampling Based Multiple Testing written by Peter H. Westfall and published by John Wiley & Sons. This book was released on 1993-01-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.

Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Download or read book Modelling and Resampling Based Multiple Testing with Applications to Genetics written by Yifan Huang and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Multiple hypotheses testing is a common problem in practice. For instance, in microarray experiments, whether the goal is to select maintenance genes for normalization or to identify differentially expressed genes between samples, multiple genes are under consideration. Multiplicity inflates the type I error rate of the hypothesis testing, so we need to adjust the testing procedure to control the overly error rate. My research focuses on the strong control of Familywise Error Rate (FWER). There are mainly two different types of approaches to multiple testing. One is modelling based approach and the other non-modelling based. Modelling based approaches fit models to the data so that the joint distribution of the test statistics is tractable. Non-modelling based approaches consist of inequality based methods and resampling based methods. They require less or no information about the joint distribution of the test statistics. I have shown in Chapter 1 that frequently used Hochberg's step-up method is a special case of partition testing based on Simes' test. This is a new result. Hochberg's step-up method is an inequity based non-modelling partition testing. Modelling based partition testing is applicable whether the joint distribution of the test statistics is known or not. By applying modelling based partition testing when the joint distribution of test statistics is known, I illustrate that modelling based approaches are often more powerful than inequality based non-modelling approaches. In Chapter 2, I construct counterexamples to the validity of permutation test, demonstrating that the resampling based methods are often invalid. My results suggest recommendation of modelling based approaches. When the joint distribution of the test statistics is untractable, modelling followed by bootstrap can be applied. I use modelling followed by bootstrap in Chapter 3 to select maintenance genes for normalizing the gene expression data.

Download or read book Multiple Comparisons Using R written by Frank Bretz and published by CRC Press. This book was released on 2016-04-19 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.

Download or read book Multiple Testing Problems in Pharmaceutical Statistics written by Alex Dmitrienko and published by CRC Press. This book was released on 2009-12-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c

Download or read book Stepwise Multiple Testing as Formalized Data Snooping written by Michael Wolf and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is common in econometric applications that several hypothesis tests are carried out at the same time. The problem then becomes how to decide which hypotheses to reject, accounting for the multitude of tests. In this paper, we suggest a stepwise multiple testing procedure which asymptotically controls the familywise error rate at a desired level. Compared to related single-step methods, our procedure is more powerful in the sense that it often will reject more false hypotheses. Unlike some stepwise methods, our method implicitly captures the joint dependence structure of the test statistics, which results in increased ability to detect alternative hypotheses. We prove our method asymptotically controls the familywise error rate under minimal assumptions. Some simulation studies show the improvements of our methods over previous proposals. We also provide an application to a set of real data.

Download or read book Introductory Statistics and Analytics written by Peter C. Bruce and published by John Wiley & Sons. This book was released on 2015-01-08 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concise, thoroughly class-tested primer that features basic statistical concepts in the concepts in the context of analytics, resampling, and the bootstrap A uniquely developed presentation of key statistical topics, Introductory Statistics and Analytics: A Resampling Perspective provides an accessible approach to statistical analytics, resampling, and the bootstrap for readers with various levels of exposure to basic probability and statistics. Originally class-tested at one of the first online learning companies in the discipline, www.statistics.com, the book primarily focuses on applications of statistical concepts developed via resampling, with a background discussion of mathematical theory. This feature stresses statistical literacy and understanding, which demonstrates the fundamental basis for statistical inference and demystifies traditional formulas. The book begins with illustrations that have the essential statistical topics interwoven throughout before moving on to demonstrate the proper design of studies. Meeting all of the Guidelines for Assessment and Instruction in Statistics Education (GAISE) requirements for an introductory statistics course, Introductory Statistics and Analytics: A Resampling Perspective also includes: Over 300 “Try It Yourself” exercises and intermittent practice questions, which challenge readers at multiple levels to investigate and explore key statistical concepts Numerous interactive links designed to provide solutions to exercises and further information on crucial concepts Linkages that connect statistics to the rapidly growing field of data science Multiple discussions of various software systems, such as Microsoft Office Excel®, StatCrunch, and R, to develop and analyze data Areas of concern and/or contrasting points-of-view indicated through the use of “Caution” icons Introductory Statistics and Analytics: A Resampling Perspective is an excellent primary textbook for courses in preliminary statistics as well as a supplement for courses in upper-level statistics and related fields, such as biostatistics and econometrics. The book is also a general reference for readers interested in revisiting the value of statistics.

Download or read book Permutation Tests written by Phillip Good and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: A step-by-step guide to the application of permutation tests in biology, medicine, science, and engineering. The intuitive and informal style makes this manual ideally suitable for students and researchers approaching these methods for the first time. In particular, it shows how to handle the problems of missing and censored data, nonresponders, after-the-fact covariates, and outliers.

Download or read book Bioinformatics and Computational Biology Solutions Using R and Bioconductor written by Robert Gentleman and published by Springer Science & Business Media. This book was released on 2005-12-29 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Full four-color book. Some of the editors created the Bioconductor project and Robert Gentleman is one of the two originators of R. All methods are illustrated with publicly available data, and a major section of the book is devoted to fully worked case studies. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

Download or read book Permutation Tests written by Phillip Good and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A step-by-step manual on the application of permutation tests in biology, business, medicine, science, and engineering. Its intuitive and informal style make it ideal for students and researchers, whether experienced or coming to these resampling methods for the first time. The real-world problems of missing and censored data, multiple comparisons, nonresponders, after-the-fact covariates, and outliers are all dealt with at length. This new edition has more than 100 additional pages, and includes streamlined statistics for the k-sample comparison and analysis of variance plus expanded sections on computational techniques, multiple comparisons, multiple regression, comparing variances, and testing interactions in balanced designs. The comprehensive author and subject indexes, plus an expert-system guide to methods, provide for further ease of use, while the exercises at the end of every chapter have been supplemented with drills and a number of graduate-level thesis problems.

Download or read book Multiple Comparisons and Multiple Tests written by Peter H. Westfall and published by SAS Press. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does your work require multiple inferences? Are you a statistics teacher looking for a study guide to supplement the usually incomplete or outdated multiple comparisons/multiple testing material in your textbook? This workbook, the companion guide written specifically for use with Multiple Comparisons and Multiple Tests Using the SAS System, provides the supplement you need. Use this workbook and you will find problems and solutions that will enhance your understanding of the material within the main text. The workbook also provides updated information about multiple comparisons procedures, including enhancements for Release 8.1 of the SAS System. The chapters correlate with the chapters of the main text, and the format is clear and easy to use. This book and the companion text are quite useful as supplements for learning multiple comparisons procedures in standard linear models, multivariate analysis, categorical analysis, and regression and nonparametric statistics. Book jacket.

Download or read book Feature Engineering and Selection written by Max Kuhn and published by CRC Press. This book was released on 2019-07-25 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of developing predictive models includes many stages. Most resources focus on the modeling algorithms but neglect other critical aspects of the modeling process. This book describes techniques for finding the best representations of predictors for modeling and for nding the best subset of predictors for improving model performance. A variety of example data sets are used to illustrate the techniques along with R programs for reproducing the results.

Download or read book Resampling Methods written by Phillip I. Good and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: "...the author has packaged an excellent and modern set of topics around the development and use of quantitative models...the author has the capability to work at a more modest level. He does that very effectively in this 2nd Edition... If you need to learn about resampling, this book would be a good place to start." -- Technometrics This work is a practical, table-free introduction to data analysis using the bootstrap, cross-validation, and permutation tests; new to the second edition are several additional examples and a chapter dedicated to regression, data mining techniques, and their limitations. The book’s many exercises, practical data sets, and use of free shareware make it an essential resource for students and teachers, as well as industrial statisticians, consultants, and research professionals.

Download or read book Statistical Inference via Data Science A ModernDive into R and the Tidyverse written by Chester Ismay and published by CRC Press. This book was released on 2019-12-23 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Inference via Data Science: A ModernDive into R and the Tidyverse provides a pathway for learning about statistical inference using data science tools widely used in industry, academia, and government. It introduces the tidyverse suite of R packages, including the ggplot2 package for data visualization, and the dplyr package for data wrangling. After equipping readers with just enough of these data science tools to perform effective exploratory data analyses, the book covers traditional introductory statistics topics like confidence intervals, hypothesis testing, and multiple regression modeling, while focusing on visualization throughout. Features: ● Assumes minimal prerequisites, notably, no prior calculus nor coding experience ● Motivates theory using real-world data, including all domestic flights leaving New York City in 2013, the Gapminder project, and the data journalism website, FiveThirtyEight.com ● Centers on simulation-based approaches to statistical inference rather than mathematical formulas ● Uses the infer package for "tidy" and transparent statistical inference to construct confidence intervals and conduct hypothesis tests via the bootstrap and permutation methods ● Provides all code and output embedded directly in the text; also available in the online version at moderndive.com This book is intended for individuals who would like to simultaneously start developing their data science toolbox and start learning about the inferential and modeling tools used in much of modern-day research. The book can be used in methods and data science courses and first courses in statistics, at both the undergraduate and graduate levels.

Download or read book Introduction to Statistics Through Resampling Methods and R written by Phillip I. Good and published by John Wiley & Sons. This book was released on 2013-02-11 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly accessible alternative approach to basic statistics Praise for the First Edition: "Certainly one of the most impressive little paperback 200-page introductory statistics books that I will ever see . . . it would make a good nightstand book for every statistician."—Technometrics Written in a highly accessible style, Introduction to Statistics through Resampling Methods and R, Second Edition guides students in the understanding of descriptive statistics, estimation, hypothesis testing, and model building. The book emphasizes the discovery method, enabling readers to ascertain solutions on their own rather than simply copy answers or apply a formula by rote. The Second Edition utilizes the R programming language to simplify tedious computations, illustrate new concepts, and assist readers in completing exercises. The text facilitates quick learning through the use of: More than 250 exercises—with selected "hints"—scattered throughout to stimulate readers' thinking and to actively engage them in applying their newfound skills An increased focus on why a method is introduced Multiple explanations of basic concepts Real-life applications in a variety of disciplines Dozens of thought-provoking, problem-solving questions in the final chapter to assist readers in applying statistics to real-life applications Introduction to Statistics through Resampling Methods and R, Second Edition is an excellent resource for students and practitioners in the fields of agriculture, astrophysics, bacteriology, biology, botany, business, climatology, clinical trials, economics, education, epidemiology, genetics, geology, growth processes, hospital administration, law, manufacturing, marketing, medicine, mycology, physics, political science, psychology, social welfare, sports, and toxicology who want to master and learn to apply statistical methods.

Download or read book Monte Carlo Simulation and Resampling Methods for Social Science written by Thomas M. Carsey and published by SAGE Publications. This book was released on 2013-08-05 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking the topics of a quantitative methodology course and illustrating them through Monte Carlo simulation, Monte Carlo Simulation and Resampling Methods for Social Science, by Thomas M. Carsey and Jeffrey J. Harden, examines abstract principles, such as bias, efficiency, and measures of uncertainty in an intuitive, visual way. Instead of thinking in the abstract about what would happen to a particular estimator "in repeated samples," the book uses simulation to actually create those repeated samples and summarize the results. The book includes basic examples appropriate for readers learning the material for the first time, as well as more advanced examples that a researcher might use to evaluate an estimator he or she was using in an actual research project. The book also covers a wide range of topics related to Monte Carlo simulation, such as resampling methods, simulations of substantive theory, simulation of quantities of interest (QI) from model results, and cross-validation. Complete R code from all examples is provided so readers can replicate every analysis presented using R.

Download or read book Multiple Comparisons and Multiple Tests Using SAS Second Edition written by Peter H. Westfall and published by SAS Institute. This book was released on 2011 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and extensively updated for SAS 9 and later, this work provides cutting-edge methods, specialized macros, and proven best bet procedures. The book also discusses the pitfalls and advantages of various methods, thereby helping readers to decide which is the most appropriate for their purposes. 644 pp. Pub. 7/11.