Download or read book Drug Repositioning written by Michael J. Barratt and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Download or read book Repositioning the Missionary written by Vicente M. Diaz and published by University of Hawaii Press. This book was released on 2010-07-13 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the vein of an emergent Native Pacific brand of cultural studies, Repositioning the Missionary critically examines the cultural and political stakes of the historic and present-day movement to canonize Blessed Diego Luis de San Vitores (1627–1672), the Spanish Jesuit missionary who was martyred by Mata'pang of Guam while establishing the Catholic mission among the Chamorros in the Mariana Islands. The work juxtaposes official, popular, and critical perspectives of the movement to complicate prevailing ideas about colonialism, historiography, and indigenous culture and identity in the Pacific. The book is divided into three sections. The first, "From Above, Working the Native," focuses exclusively on the narratological reconsolidation of official Roman Catholic Church viewpoints as staked in the historic (seventeenth century) and contemporary (twentieth century) movements to canonize San Vitores, including the symbolic costs of these viewpoints for Native Chamorro cultural and political possibilities not in line with Church views. Section two, "From Below: Working the Saint," shifts attention and perspective to local, competing forms of Chamorro piety. In their effort to canonize San Vitores, Natives also rework the saint to negotiate new cultural and social canons for themselves and in ways that produce new meanings for their island. "From Behind: Transgressive Histories" shifts from official and lay Roman and Chamorro Catholic viewpoints to the author’s own critical project of rendering alternative portrayals of San Vitores and Mata'pang. Theoretically innovative and provocative, humorous, and inspired, Repositioning the Missionary melds poststructuralist, feminist, Native studies, and cultural studies analytic and political frameworks with an intensely personal voice to model a new critical interdisciplinary approach to the study of indigenous culture and history.

Download or read book Repositioning Business written by Yamini Meduri and published by Routledge. This book was released on 2021-09-30 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is an attempt to bring together selected manuscripts presented in the third International Conference on Impact of Current Events on the Future of Business in April 2021. The book contains 13 chapters from across domains of business management with the core theme of 'response to Covid-19 pandemic'.

Download or read book Optimizing Liner Shipping Fleet Repositioning Plans written by Kevin Tierney and published by Springer. This book was released on 2015-06-16 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph addresses several critical problems to the operations of shipping lines and ports, and provides algorithms and mathematical models for use by shipping lines and port authorities for decision support. One of these problems is the repositioning of container ships in a liner shipping network in order to adjust the network to seasonal shifts in demand or changes in the world economy. We provide the first problem description and mathematical model of repositioning and define the liner shipping fleet repositioning problem (LSFRP). The LSFRP is characterized by chains of interacting activities with a multi-commodity flow over paths defined by the activities chosen. We first model the problem without cargo flows with a variety of well-known optimization techniques, as well as using a novel method called linear temporal optimization planning that combines linear programming with partial-order planning in a branch-and-bound framework. We then model the LSFRP with cargo flows, using several different mathematical models as well as two heuristic approaches. We evaluate our techniques on a real-world dataset that includes a scenario from our industrial collaborator. We show that our approaches scale to the size of problems faced by industry, and are also able to improve the profit on the reference scenario by over US$14 million.

Download or read book Repositioning Restorative Justice written by Lode Walgrave and published by Routledge. This book was released on 2012-12-06 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, based on papers presented at the 5th international conference held at Leuven, Belgium in 2002, aims to provide an overview of recent experience of restorative justice.

Download or read book Drug Repurposing and Repositioning written by Institute of Medicine and published by National Academies Press. This book was released on 2014-08-08 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.

Download or read book Modelling Empty Container Repositioning Logistics written by Dong-Ping Song and published by Springer Nature. This book was released on 2022-01-20 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book takes the inventory control perspective to tackle empty container repositioning logistics problems in regional transportation systems by explicitly considering the features such as demand imbalance over space, dynamic operations over time, uncertainty in demand and transport, and container leasing phenomenon. The book has the following unique features. First, it provides a discussion of broad empty equipment logistics including empty freight vehicle redistribution, empty passenger vehicle redistribution, empty bike repositioning, empty container chassis repositioning, and empty container repositioning (ECR) problems. The similarity and unique characteristics of ECR compared to other empty equipment repositioning problems are explained. Second, we adopt the stochastic dynamic programming approach to tackle the ECR problems, which offers an algorithmic strategy to characterize the optimal policy and captures the sequential decision-making phenomenon in anticipation of uncertainties over time and space. Third, we are able to establish closed-form solutions and structural properties of the optimal ECR policies in relatively simple transportation systems. Such properties can then be utilized to construct threshold-type ECR policies for more complicated transportation systems. In fact, the threshold-type ECR policies resemble the well-known (s, S) and (s, Q) policies in inventory control theory. These policies have the advantages of being decentralized, easy to understand, easy to operate, quick response to random events, and minimal on-line computation and communication. Fourth, several sophisticated optimization techniques such as approximate dynamic programming, simulation-based meta-heuristics, stochastic approximation, perturbation analysis, and ordinal optimization methods are introduced to solve the complex stochastic optimization problems. The book will be of interest to researchers and professionals in logistics, transport, supply chain, and operations research.

Download or read book REPOSITIONING Marketing in an Era of Competition Change and Crisis written by Jack Trout and published by McGraw Hill Professional. This book was released on 2009-10-30 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book that completes Positioning . . . Thirty years ago, Jack Trout and Al Ries publishedtheir classic bestseller, Positioning: The Battle for YourMind—a book that revolutionized the world of marketing.But times have changed. Competition is fiercer.Consumers are savvier. Communications are faster. Andonce-successful companies are in crisis mode. Repositioning shows you how to adapt, compete—andsucceed—in today’s overcrowded marketplace. Globalmarketing expert Jack Trout has retooled his mosteffective positioning strategies—providing a must-havearsenal of proven marketing techniques specificallyredesigned for our current climate. With Repositioning,you can conquer the “3 Cs” of business: Competition,Change, and Crisis . . . BEAT THE COMPETITION: Challenge your rivals,differentiate your product, increase your value,and stand out in the crowd. CHANGE WITH THE TIMES: Use the latesttechnologies, communications, and multimediaresources to connect with your consumers. MANAGE A CRISIS: Cope with everything fromprofi t losses and rising costs to bad pressand PR nightmares. Even if your company is doing well, these cutting-edgemarketing observations can keep you on top of your gameand ahead of the pack. You’ll discover how expandingproduct lines may decrease your overall sales, why newbrand names often outsell established brands, and whyslashing prices is usually a bad idea. You’ll learn thedangers of attacking your competitors head-on—andthe value of emphasizing value. You’ll see how consumerscan have too many choices to pick from—and whatyou can do to make them pick your brand. Drawing from the latest research studies, consumer statistics,and business-news headlines, Trout reveals thehidden psychological motives that drive today’s market.Understanding the mindset of your consumers is halfthe battle. Winning in today’s world is often a matter ofrepositioning. It’s how you rethink the strategies you’vealways relied on. It’s how you regain the success you’veworked so hard for. It’s how you win the new battle ofthe mind.

Download or read book Repositioning UPDNet written by and published by . This book was released on 2004 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nursing Home Federal Requirements written by James E. Allen MSPH, PhD, CNHA and published by Springer Publishing Company. This book was released on 2010-11-24 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: "[The book] lists all the federal requirements that are evaluated by state surveyors during the annual survey visit to nursing homes and for complaint visits. The exhibit section contains forms used by surveyors to gather data during the survey visit. Visually, the format makes the regulations easy to read. If nursing home staff used the book to prepare for a survey, they would be well prepared." Marcia Flesner, PhD, RN, MHCA University of Missouri-Columbia From Doody's Review The Federal government, together with more than 50 advocacy groups, has spent the past 40 years writing and refining the rules and guidelines in this manual. This book presents the latest federal guidelines and protocols used by federal surveyors in certifying facilities for participation in Medicare and Medicaid funding. It is an essential resource for long-term care facilities to have on hand to be ready for a survey at any time. It provides information straight from CMS's Internet-Only Manual-in print and at your fingertips for easy access. Divided into four accessible and user-friendly parts, this manual includes: Federal requirements and interpretive guidelines Rules for conducting the survey Summary of the requirements for long-term care facilities and surveyors CMS forms commonly used by surveyors This newly updated and revised edition spans every aspect and service of a nursing home and represents the latest requirements to ensure that outstanding quality assurance and risk management programs are in place. New to This Edition: Section on how to use manual Summarization of federal requirements Updated definitions of Medicare and Medicaid Compliance requirements with Title VI of the Civil Rights Act of 1964 SNF/Hospice requirements when SNF serves hospice patients SNF-based home health agencies Life safety code requirements Changes in SNF provider status Surveyor qualifications standards Management of complaints and incidents New medical director guidelines

Download or read book Consumer Behaviour And Branding Concepts Readings And Cases The Indian Context written by S. Ramesh Kumar and published by Pearson Education India. This book was released on 2009-09 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: India is one of the emerging markets that pose a unique set of challenges to marketers. The importance of the context and the usefulness of concepts in the Indian context is the core proposition of the book. The diversity of a mix of factors such as cultural aspects, lifestyles, demographics and unbranded offerings make consumer behaviour a fascinating study. This book focuses on the behavioural principles of marketing and its application to branding in the Indian context. * Consumer behaviour concepts associated with branding * A combination of recent and traditional examples reflecting the application of behavioural concepts * Touch of reality boxes to indicate context-based examples * Caselets and cases drawn from real-life situations * Research findings associated with the Indian context * Topical issues in consumer behaviour like cultural aspects, digital marketing and experiential branding

Download or read book Kellogg on Branding in a Hyper Connected World written by and published by John Wiley & Sons. This book was released on 2019-03-19 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: World-class branding for the interconnected modern marketplace Kellogg on Branding in a Hyper-Connected World offers authoritative guidance on building new brands, revitalizing existing brands, and managing brand portfolios in the rapidly-evolving modern marketplace. Integrating academic theories with practical experience, this book covers fundamental branding concepts, strategies, and effective implementation techniques as applied to today’s consumer, today’s competition, and the wealth of media at your disposal. In-depth discussion highlights the field’s ever-increasing connectivity, with practical guidance on brand design and storytelling, social media marketing, branding in the service sector, monitoring brand health, and more. Authored by faculty at the world’s most respected school of management and marketing, this invaluable resourceincludes expert contributions on the financial value of brands, internal branding, building global brands, and other critical topics that play a central role in real-world branding and marketing scenarios. Creating a brand—and steering it in the right direction—is a multi-layered process involving extensive research and inter-departmental cooperation. From finding the right brand name and developing a cohesive storyline to designing effective advertising, expanding reach, maintaining momentum, and beyond, Kellogg on Branding in a Hyper-Connected World arms you with the knowledge and skills to: Apply cutting-edge techniques for brand design, brand positioning, market-specific branding, and more Adopt successful strategies from development to launch to leveraging Build brand-driven organizations and reinforce brand culture both internally and throughout the global marketplace Increase brand value and use brand positioning to build a mega-brand In today’s challenging and complex marketplace, effective branding has become a central component of success. Kellogg on Branding in a Hyper-Connected World is a dynamic, authoritative resource for practitioners looking to solve branding dilemmas and seize great opportunities.

Download or read book Indonesia Rising written by Anthony Reid and published by Institute of Southeast Asian Studies. This book was released on 2012 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are reasons for thinking that this is at last Indonesia's moment on the world stage. Having successfully negotiated its difficult transition to democracy after 1998, Indonesia has held three popular elections with a low level of violence by the standards of southern Asia. Recetly its economic growth rate has been high (above 6 per cent a year) and rising, where China's has been dropping and the developed world has been in crisis. Indonesia's admission in 2009 to the G20 club of the world's most influential states seemed to confirm a status implied by its size, as the world's fourth-largest country by population, and the largest with a Muslim majority. Some international pundits have been declaring that Indonesia is the new star to watch, and that its long-awaited moment in the sun may at last have arrived.

Download or read book Marketing and Branding written by S. Ramesh Kumar and published by Pearson Education India. This book was released on 2007 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Consumer Behavior in Action written by Geoffrey P. Lantos and published by M.E. Sharpe. This book was released on 2010-08-23 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Down-to-earth, highly engaging, and thorough, Consumer Behavior in Action does more than any other consumer behavior textbook to generate student interest and involvement through extensive in-class and written application exercises. The text's four parts can be covered in any sequence after Part I, which provides an overview of consumer behavior and covers foundational material on market segmentation. Part II covers the consumer decision-making process in general as well as each of the specific stages of that process. Part III investigates societal influences on consumer behavior, from society and culture to interpersonal, and Part IV deals with the micro-psychological influences on consumer decision-making. Each chapter includes several exercises in self-contained units, each with its own applications, as well as learning objectives and an easy-to-understand background textual discussion. Each chapter also includes a key concepts list, review questions, and a solid summary to help initiate further student research. The text includes ten different types of engaging exercises: analysis of advertisements, analysis of scenarios, introspection into students' own consumer behavior, interactive Internet exercises, experimental and survey fieldwork, quantitative exercises, creative exercises, debatable issues, ethical analyses, and marketplace analyses. An Online Instructor's Manual is available to adopters.

Download or read book Reposition Yourself written by T.D. Jakes and published by Simon and Schuster. This book was released on 2007-05-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A bestselling author and leader of a congregation of 30,000, Jakes teaches spiritual principles of prosperity and success. He explains from a Christian point of view how to reconstruct attitudes about giving, sharing, and reaping life's rewards.

Download or read book Repositioning the Hong Kong Government written by Stephen Wing Kai Chiu and published by Hong Kong University Press. This book was released on 2012-04-01 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship between government and society in Hong Kong has become an intensely debated topic as the complexities of governance grow and the old strategies of consensus building without genuine public participation fail to satisfy. Increasingly interventionist, yet lacking democratic credentials, the Hong Kong SAR government finds itself more and more limited in its capacity to implement policies and less able to rely on traditional allies. A society dissatisfied with old forms of governance has become ever more ready to mobilize itself outside of the formal political structures. This collection of studies by leading scholars examines the Hong Kong government's efforts to reposition itself in the economy and society under the pressures of globalization, economic and political restructuring and the rise of the civil society. Drawing on changing theoretical conceptions of state, market and citizenship and on comparisons with other Asian economies,Repositioning the Hong Kong Governmentoffers new interpretations of the problems of governance in Hong Kong and puts forward positive suggestions for resolving them.