Download or read book Renal clearable Gold Nanoparticle based Drug Delivery Systems written by Chuanqi Peng and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineered nanoparticles (NPs) have demonstrated unprecedented physiological understandings and versatile biomedical applications. However, clinical translation of cancer nanomedicines remains slow due to limited tumor targeting but elevated body retention of off-target therapeutics. With decreased size and surface passivation, the engineered, ultrasmall NPs have shown not only efficient body elimination through renal pathway, but also high targeting efficiency to the disease tissues as tumors. Therefore, such renal-clearable NPs could possibly address the many challenges faced by non-renal-clearable nanocarriers, once the efficient and stable drug loading as well as systematic physiological understandings of such ultrasmall delivery systems were achieved. In Chapter 1, we prepared the delivery vector by using the renal-clearable gold nanoparticles (AuNPs) with high tumor targeting efficiency. By rational design and modification, we firstly loaded the widely used anticancer drug, doxorubicin (DOX), on the renal-clearable AuNPs at high loading capacity, and then investigated the physiological stability, drug release and in vitro cytotoxicity studies. In addition, this ultrasmall AuNPs can also load many other small-molecule therapeutic or imaging agents as well as small-interfering RNAs for gene therapy. In Chapter 2 and 3, we systematically investigated blood circulation, tumor targeting, intratumoral transport, as well as body elimination of the renal-clearable 5-nm AuNP-based drug delivery system (DDS). The renal-clearable DDS not only significantly enhanced delivery efficiency and intratumoral transport of drug but also accelerated the renal clearance and body elimination of offtarget drug compared to both free drug (DOX) and the non-renal-clearable 30-nm DDS. As a result, the therapeutic index was improved by both enhanced efficacy and safety. In Chapter 4, we investigated the targeting and imaging of poorly permeable brain tumors (gliomas) by using the renal-clearable zwitterionic 3-nm AuNPs. The renal-clearable AuNPs increased tumor targeting efficiency and specificity compared to non-renal-clearable 18-nm counterpart. The effective NP penetration in brain tumorssuggeststhat renal-clearable AuNPs may achieve early brain tumor detection once integrated with nuclear imaging techniques used in the clinics. In Chapter 5, we investigated the ligand-directed in situ growth of AuNPs in biological tissues and the possible biological interaction of biomolecules. The results indicate that the ligand-directed AuNP growth can serve as a novel tool for tissue imaging via nanoparticle labeling with multimodality and multi-scale characterization. Herein, we not only report the design and practice of renal-clearable AuNP-based DDS as well as tissue targeting and imaging with AuNPs, we also conclude the outlook and future work for the renal-clearable AuNPs. We believe the renal-clearable AuNPs can shift the paradigm in drug delivery and expedite the clinical translation of cancer nanomedicines once some critical challenges are further addressed in the near future.
Download or read book Advances in Nanotechnology Based Drug Delivery Systems written by Anupam Das Talukdar and published by Elsevier. This book was released on 2022-06-06 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. - Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems - Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market - Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more
Download or read book Renal Clearable Luminescent Gold Nanoparticles for In vitro Bioimaging written by Jessica Lynn Jacobe and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Renal clearable fluorescent gold nanoparticles (AuNPs) have potential to become tumor imaging and drug delivery agents because of their minimized accumulation in the body. However, they cannot actively target tumor receptors at both in vitro and in vivo levels. Since transferrin, a proliferative protein, has been widely used for targeted delivery of nanoparticles, in this thesis, we investigated targeting of transferrin after being conjugated with renal clearable fluorescent gold nanoparticles at the in vitro cellular level. Our results show that transferrin lost its targeting functionality due to the conjugation renal clearable AuNPs while it still can retain targeting capabilities after being conjugated onto organic dyes. Our further studies use a well-known ligand, biotin, also lost its binding affinity to avidin. Renal clearable AuNPs effect on the functionality of active targeting ligands are highly complicated, which demands extensive efforts in the future studies.
Download or read book Nanoparticulate Drug Delivery Systems written by Raj K. Keservani and published by CRC Press. This book was released on 2019-01-23 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.
Download or read book Gold Nanoparticles for Drug Delivery written by Prashant Kesharwani and published by Elsevier. This book was released on 2023-11-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Drug Delivery discusses the synthesis and characterization of gold nanoparticles (AuNPs), presenting an historical introduction to the developments in the area, discussing methods and characterization parameters, covering targeted delivery strategies, treatment of cancer, CNS conditions, infectious diseases, HIV/AIDS infection, wound healing and tissue regeneration, dentistry, gene delivery, and its photo properties used in diagnostic and therapies, and finally presenting regulatory aspects such as theranostic applications, vaccine development, toxicity, and the translation of research to marketable products. This book is a complete reference for researchers in nanotechnology drug delivery and pharmaceutical disciplines. Researchers in pharmaceutical industries, especially those involved in the use of gold nanoparticles in the field of drug delivery, diagnosis, targeted and early therapies will also benefit from this book. - Covers gold nanoparticles' characterization and synthesis techniques related to drug delivery - Focuses on targeting strategies using gold nanoparticles for efficient drug delivery - Provides a consolidated overview of applications of gold nanoparticles for drug delivery to several systems and conditions
Download or read book Gold Nanoparticles as Drug Delivery Vectors for Photodynamic Therapy of Cancers written by Yu Cheng and published by . This book was released on 2011 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticle-drug conjugates have attracted increasing attention in drug delivery for photodynamic cancer therapy. The nanoparticle acts as a water-soluble and bio-compatible platform that allows the delivery of hydrophobic drugs to the site of therapy. Due to the favorable surface area, hundreds of molecules can be attached to a 5 nm gold nanoparticle. More importantly, the versatile nanoparticle surface plays a vital role in targeted drug delivery. In this dissertation, we focus on efficient drug vectors for cancer therapy by synthesizing PEGylated gold nanoparticle-phthalocyanine conjugates. Both covalent and non-covalent drug binding can be achieved by designing the functionality of the nanoparticle surface. Due to the design of the gold nanoparticle carrier, using amphiphilic polymers, the drug delivery can be facilitated based on its size and the enhanced permeability and retention in the tumor tissue. Compared to the covalent approach, the non-covalent delivery approach of the hydrophobic photodynamic therapy drug Pc 4 through gold nanoparticles has provided rapid release and enhanced photocytotoxicity in cancer cells. In vivo studies in cancer bearing mice have shown an efficient deep penetration of the drug into the target tumors by the nanoparticle carriers within hours. In addition, controlled drug delivery system using visible-NIR light is achieved by a masked Pc 4-gold nanoparticle conjugate system. Targeted drug delivery can be achieved by modification of the carrier surface with active targeting ligands. After modification of the gold nanoparticle-Pc 4 conjugates with an EGF peptide, drug uptake into the tumor cells is dramatically improved due to the combination of active and passive targeting compared to untargeted conjugates. A 10-fold increase of the drug accumulation in a brain tumor was observed for the targeted drug delivery system. This shows that the designed gold nanoparticle-based drug delivery vector is able to cross the blood brain tumor barrier to address the brain tumor owning to the EGF targeted effect. The biodistribution of the drug and gold nanoparticles in vivo was investigated over a time frame of seven days. The biodistribution of the drug was studied by monitoring its intrinsic fluorescence in the organs and the gold nanoparticle concentrations in the corresponding organs have been quantified as well. Both gold nanoparticles and the drug can be removed from the body through renal clearance and the hepatobiliary system within days after drug administration.
Download or read book Nanoscale Materials written by Luis M. Liz-Marzán and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized nanoassemblies of inorganic nanoparticles and organic molecules are building blocks of nanodevices, whether they are designed to perform molecular level computing, sense the environment or improve the catalytic properties of a material. The key to creation of these hybrid nanostructures lies in understanding the chemistry at a fundamental level. This book serves as a reference book for researchers by providing fundamental understanding of many nanoscopic materials.
Download or read book Interactions of Renal Clearable Gold Nanoparticles with the Kidneys in Vitro and in Vivo written by Jing Xu and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of renal clearable inorganic nanoparticles (NPs) offers a great opportunity to address the health concern raised by nonspecific accumulation of conventional inorganic NPs in the macrophage system, mostly in the liver and spleen. In recent decades, we have dedicated a remarkable amount of research in developing renal clearable gold nanoparticles (AuNPs) and investigating their biointeractions. Our group discovered that glutathione-coated renal clearable AuNPs (GS-AuNPs) can be efficiently excreted through the urinary system resulting in significantly reduced accumulation in the liver and spleen. By integrating the near-infrared fluorescence, GS-AuNPs can sensitively probe kidney clearance kinetics and indicate renal dysfunction. Future clinical translation requires a fundamental understanding of nano-bio interactions in the kidneys and the biocompatibility of GS-AuNPs. In this dissertation, Chapter 1 covers the status of renal clearable inorganic NPs and the current understanding of their biointeractions in the kidneys. Chapter 2 describes using X-ray imaging to visualize the transport of GS-AuNPs in the kidney components under both normal and pathological conditions. The unique deposition of GS-AuNPs in the diseased kidney offers a great chance to diagnose renal injury noninvasively. Chapter 3 focuses on the blood transport and biocompatibility of GS-AuNPs. The dose effect on the blood transport and renal clearance efficiency of GS-AuNPs is unraveled which results in high biocompatibility. Chapter 4 describes an in vitro study on the surface-ligand-density effect on interactions between GS-AuNPs and human kidney proximal tubular cells. The results demonstrate precise responses of proximal tubular cells to GS-AuNPs with different ligand densities in membrane affinity, cytotoxicity and the mechanism of cell death. Finally, a summary of the obtained understanding and future perspective are presented in Chapter 5.
Download or read book Nanoconjugate Nanocarriers for Drug Delivery written by Raj K. Keservani and published by CRC Press. This book was released on 2018-09-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents a plethora of new research on the use of nanoconjugate nanocarriers in drug delivery. Nanotechnology as drug carriers has been observed to increase the level of sophistication through a variety of ways. It helps to alleviate some of the pitfalls of conventional dosage forms, such as few pitfalls such as non-specific drug delivery, dose dumping, poor patient compliance, toxicities linked with higher doses, etc. With chapters from highly skilled, experienced, and renowned scientists and researchers, Nanoconjugate Nanocarriers for Drug Delivery is divided into four sections, providing an introduction to nanocarriers for drug delivery, physicochemical features of nanocarriers, and specific applications dealing with drug delivery in particular. The materials used as well as formulation and characterization have been discussed in detail. The nanocarriers covered in the book include nanoparticles, vesicular carriers, carriers having carbon as the core constituent, dispersed systems, etc. The book also delves into the interaction and associations between drug delivery research and its therapeutic applications in practice. The book integrates a wide variety of case studies, research, and theories in an attempt to reveal the diversity and capture the novel approaches of nanoconjugate nanocarriers for drug delivery employed by developers and content experts in the field. This timely publication will be an essential reference and current awareness source, building on the available literature in the field of pharmacy and biomedical science, while also providing ideas for further research opportunities in this dynamic field.
Download or read book Colloidal Gold Nanoparticles for Cancer Therapy written by Kate Y. J. Lee and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticle has emerged as an attractive platform for drug delivery applications by complementing the existing drug delivery carriers. Currently, only a few gold nanoparticle-based anticancer drug delivery systems have been reported, compared to the polymer-based delivery systems. Additionally, there is still a lack of understanding for the behavior and fate of the gold-drug conjugate in the body that further attention is required. The overall goal of this thesis is to investigate the in vivo behavior of colloidal gold nanoparticle and its therapeutic efficacy in an animal model, especially in a drug delivery application. To achieve this goal, we investigated the feasibility of using colloidal gold nanoparticle as an anticancer agent delivery vehicle for treatment of cancer. Then, long-term clearance, toxicity, and biodistribution of colloidal gold nanoparticle were studied to further aid in understanding of using colloidal gold nanoparticle as a drug delivery platform. In particular, two representative sizes of gold nanoparticles, 5nm and 60nm, were investigated for the size effect on the therapeutic efficacy, toxicity, biodistribution, and clearance in cancer nanotherapy. We believe that nanoparticle size plays a critical role in not only delivering the drug to the target site but also determining the in vivo behavior such as biodistribution and clearance. By choosing an appropriate size scale for the system, we successfully used the small-sized gold nanoparticles for drug delivery applications, which also displayed no apparent toxicity with desirable clearance from the biological system. This work is significant by providing an insight on a potential ideal candidate for drug delivery carrier for cancer nanotherapy.
Download or read book Nanomaterial Based Drug Delivery Systems written by Chandrakantsing V. Pardeshi and published by Springer Nature. This book was released on 2023-06-21 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effective drug delivery systems are essential in maximizing the therapeutic effects of the drugs in question. This book thoroughly analyses recent technological advances in new, nanomaterial-based drug delivery systems for the diagnosis and treatment of various diseases. These systems also have diverse applications in pharmaceutical, biomedical, biomaterial, and biotechnological fields. This book explains the different types of nanocarriers currently in development and covers both therapeutic and theranostic applications of drug-loaded nanocarriers and nanomedicine. Clinical research professionals, industrial pharmaceutical scientists, and veteran drug delivery developers benefit from the unique structure of this book, making it essential for the drug delivery researcher. Students, research scholars, and industrial professionals alike benefit from the current technological advancements, regulatory aspects, and the history of discovery and development in the field of nanomedicine presented in this book.
Download or read book Smart Pharmaceutical Nanocarriers written by Vladimir P Torchilin and published by World Scientific. This book was released on 2015-12-31 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery systems and pharmaceutical nanocarriers that respond to different types of stimuli, such as internal ones, intrinsic for the pathological area (changes in pH, temperature, redox condition, activity of certain enzymes), or external, artificially applied (magnetic field, ultrasound, various irradiations), represent an important and continuously growing area of research. Smart Phramaceutical Nanocarriers overviews the various stimuli used for drug release and delivery by smart pharmaceutical carriers and presents cutting-edge research and the newest data from the leading laboratories in each area.
Download or read book Renal Clearable Luminescent Gold Nanoparticles Conjugated with Organic Dyes written by Shasha Sun and published by . This book was released on 2016 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: In chapter 1, we reviewed luminescent gold nanoparticles and organic fluorophores. Progresses of dye conjugated gold nanoparticles as well as their biomedical sensing and imaging applications were reviewed, demonstrating the significance of the work present in this dissertation. In chapter 2, we described 5(6)-Carboxytetramethylrhodamine (TAMRA) conjugated luminescent gold nanoparticles that can serve as an ultrasmall nanoindicator to fluorescently report local pH in a ratiometric way. This pH-dependent dimerization is not limited to pH-insensitive dye; it can also enhance the pH sensitivity of a well-known pH-sensitive dye, fluorescein, within a larger pH range, opening up a new pathway to design ultrasmall fluorescent ratiometric nanoindicators with tunable wavelengths and pH response ranges. In chapter 3, we synthesized an organic fluorophore, TAMRA conjugated gold nanoparticles, and did a series of comparison studies of their in vitro and in vivo behaviors with that of GS-AuNPs. Our study showed that the conjugation of TAMRA to GS-AuNPs could affect the cell membrane binding of GS-AuNPs; however, it has no impact on their serum protein binding affinity. The TG-AuNPs has longer normal tissue and tumor retention times than GS-AuNPs. Additionally, the fluorescence signals from TAMRA could not truly reflect the in vivo behaviors of TG-AuNPs. In chapter 4, we used renal clearable glutathione coated gold nanoparticles as a delivery vector to deliver the only FDA approved NIR dye – ICG to the targeting site. When we combined them together, the ICG-AuNPs showed interesting clearance kinetics in which the NPs dissociated in the body. Moreover, compared with clinically used ICG-HSA, ICG-AuNPs showed a tumor imaging time window more than three orders longer as well as a tumor area 40 times brighter, all the while maintaining their renal clearance property and low accumulation in RES organs. In chapter 5, by taking advantage of robust single-particle fluorescence and giant Raman enhancements of unique polycrystalline silver NPs (AgNPs), we quantitatively investigated the effects of two well-known surface chemistries, passive PEGylation and active c-RGD peptide conjugation, on in vitro behaviors of AgNPs at high temporal and spatial resolution as well as chemical level using fluorescence and Raman microscopy.
Download or read book Nanocarriers Drug Delivery System written by Nirmal Shah and published by Springer Nature. This book was released on 2021-01-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.
Download or read book Engineered Nanoparticles as Drug Delivery Systems written by Nahid Rehman and published by CRC Press. This book was released on 2022-12-30 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights application of nanomaterials for drug delivery, therapy, and engineering. It covers stimuli-sensitive drug delivery systems including an overview of the physical, chemical, biological, and multi-stimuli-responsive nanosystems. It also presents analysis of clinical status for different types of nanoplatforms and assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting. It further discusses the advantages and disadvantages of each application of pertinent nanomaterials. Features: Provides academic introduction to the uses of nanotechnology in drug delivery. Discusses use of nanomaterials in targeting a drug to specific tissues and cells. Presents an analysis of clinical status for different types of nanoplatforms. Covers applications in drug delivery, therapy, and engineering. Focuses on how novel nanotechnology-orientated methods can help improve treatment. This book is aimed at researchers and graduate students in biomedical and biochemical engineering, pharmaceutical, chemical and bioprocess engineering, materials science, and drug delivery mechanisms.
Download or read book Gold Nanoparticles and Drug Delivery written by David J. Solfiell and published by . This book was released on 2014 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles are important tools in biotechnology and biomedical research. Gold nanoparticles (AuNPs) have emerged as a particularly important class of nanobiotechnological tools as a result of a number of unique and useful attributes. These attributes include the high degree of biocompatibility of AuNP cores, the similarity in size of AuNPs and biomacromolecules, and the great chemical flexibility of AuNP surface design. One of the most promising applications of AuNPs in biotechnology and biomedicine is their use as drug delivery vehicles. Drug delivery vehicles provide therapeutics with desired delivery properties by targeting them specifically to the environments in which their therapeutic activity is sought and by overcoming solubility barriers. The drug delivery properties of AuNPs are a function of their sizes and surface chemistries. The nanometer scale of AuNPs allows these three-dimensional and diffusible self-assembled monolayers to act as substructures for supramolecular assemblies, to extravasate from tumor-supplying endothelia, and to undergo cellular uptake by endocytosis. AuNPs have become a versatile platform for the creation of multifunctional delivery vehicles. This work represents a collection of studies in which AuNPs have been used as probes in fundamental biological research and delivery systems for small molecules and biologics. In these studies, precision control of surface chemistry on the nanometer scale, made possible by AuNPs, has been used to find solutions to the problems of unraveling the role of hydrophobicity in immune system activation, delivering proteins past mammalian cell membranes, development of a sustained release drug delivery platform, and condensation and cellular delivery of siRNA.
Download or read book Nanotechnology and Drug Delivery Volume One written by José L. Arias and published by CRC Press. This book was released on 2014-08-04 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatfo
