Download or read book Molecular Signatures of Infectious Agents in Cancer written by M. Verma and published by IOS Press. This book was released on 2002 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Biomarkers Research Group (CBRG) of the Division of Cancer Prevention (DCP), National Cancer Institute, sponsored a workshop entitled Molecular Signatures of Infectious Agents in Bethesda, Maryland, September 7 - 8, 2000, to identify molecular signatures of infectious agents and to utilize this information for risk assessment and development of prevention strategies against these infectious agents. The specific objectives of the workshop were to review state-of-the-science in detection technology that can identify extraneous genomic insertion in human cancers and to establish future research directions for using the molecular signatures of infectious agents for early detection, risk assessment and prevention of cancer.

Download or read book Molecular Detection of Human Viral Pathogens written by Dongyou Liu and published by CRC Press. This book was released on 2016-04-19 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being recognized and fought against over countless centuries, human viral pathogens continue to cause major public health problems worldwide-killing millions of people and costing billions of dollars in medical care and lost productivity each year. With contributions from specialists in their respective areas of viral pathogen research, Mol

Download or read book Comparative studies between HTLV 1 and HTLV 2 function and pathobiology written by Umberto Bertazzoni and published by Frontiers Media SA. This book was released on 2015-06-11 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.

Download or read book Cancer Principles and Practice of Oncology written by Vincent T. DeVita (Jr.) and published by . This book was released on 2001 with total page 1768 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book AIDS Research and Human Retroviruses written by and published by . This book was released on 1995 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Emerging Human Viral Diseases Volume II written by Prudhvi Lal Bhukya and published by Springer Nature. This book was released on with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Pathology of HTLV 1 written by Umberto Bertazzoni and published by Frontiers Media SA. This book was released on 2019-03-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.

Download or read book Identification of Novel STAT5 Target Genes in Human T cells written by Michelle M. Fung and published by . This book was released on 2005 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a major growth factor of T-cells, interleukin-2 (IL-2) promotes, among other biological effects, cell proliferation and anti-apoptosis. These biological consequences are thought to occur via IL-2 activation of signal transduction pathways, such as the Ras/ERK, PI3K, and JAK/STAT pathways, which transmit signals from the IL-2R to the nucleus, resulting in gene expression. Under normal circumstances, these pathways work to promote T-cell clonal expansion, which is critical to the successful mounting of an immune response. However, infection of T-cells by human T-cell leukemia, type I (HTLV-1) can lead to constitutive activation of these signaling cascades, and, ultimately, IL-2-independent T-cell growth. Much of the effects of HTLV-1 have been attributed to a viral oncoprotein called Tax, which affects cellular and viral transcriptional regulation, cell cycle control, DNA repair, and apoptosis. The work presented in this dissertation was aimed at investigating the signaling pathways activated by IL-2 in primary human T-cells and Tax-immortalized human T-cells. IL-2-induced gene expression, and its regulation by the transcription factor STAT5, was also studied in both cell types. The data demonstrate that IL-2 activates the Ras/ERK, PI3K, and JAK/STAT pathways in primary human T-cells to promote cell proliferation, and that significant crosstalk exists between them in the form of PI3K 2!MEK/ERK 2!STAT3. Interestingly, IL-2 activation of all these pathways was not observed in Tax-immortalized cells as only STAT5 activation was detected. A systematic computational approach that coupled microarray analysis to transcription factor binding site prediction was subsequently performed to evaluate STAT5-regulated gene expression in response to IL-2 stimulation in both cell types. Primary human T-cells exhibited numerous genes modulated by the growth factor, of which several were predicted to be regulated by STAT5 due to possession of a putative STAT5 binding site. Many genes were also found to be regulated by IL-2 in Tax-immortalized cells. Interestingly, several of them, including the cytokines il-5, il-9, and il-13, were unique to these cells and discovered to be STAT5 targets. Taken together, the results presented here provide an increased understanding of the molecular mechanisms induced by IL-2 stimulation in primary human T-cells and Tax-immortalized cells, as well as demonstrate how bioinformatics provides valuable tools for scientific discovery.

Download or read book DNA and Cell Biology written by and published by . This book was released on 2006 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Cancer Handbook written by Malcolm Alison and published by Wiley. This book was released on 2007 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Handbook provides a comprehensive overview of scientific and clinical information in cancer research and medicine (oncology). This area is one of the most intensively studied in biology and medicine, resulting in a huge amount of new information being published every year. This book summarizes and explains key facts and recent developments. It is aimed at a wide variety of readers who need easy access to knowledge concerning all major aspects of cancer biology, without too much clinical detail or specialist research material. The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. It is also important for laboratory scientists to appreciate the potential applications of their research and the practical issues involved in translating it to clinical practice. For this second edition, all the sections have been fully revised and updated, with new chapters addressing important topics that have gained prominence in recent years. New editors and authors have brought additional expertise to the project. For example, in the section on the Molecular and Cellular Basis of Cancer, there are new chapters on stem cells, epigenetics, and microRNAs, as well as chapters on the links between cancer and development and inflammation. In the Treatment section, the emphasis is now on multidisciplinary team management of different cancers, plus there are new chapters on clinical trial design, RNA interference and rational drug design. The page design and the quality of the diagrams has been improved, with all illustrations now in full colour. The glossary has been made more informative and easy to use.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1824 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Abstracts 24th Annual Meetings January 5 26 1995 written by and published by . This book was released on 1995 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Download or read book Viruses and Human Cancer written by Mei Hwei Chang and published by Springer Science & Business Media. This book was released on 2013-09-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.

Download or read book Clinical Epidemiology of Acute Lymphoblastic Leukemia written by Juan Manuel Mejia-Arangure and published by BoD – Books on Demand. This book was released on 2013-04-17 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes different perspectives of childhood acute lymphoblastic leukemia. The approach includes aspects of molecular epidemiology, particularly molecular features that influence the genesis and prognosis of the disease. Some aspects of the prognosis of lymphoblastic leukemias are very detailed, highlighting the use of molecular biology in the early identification of complications that may occur in diseased patients. The authors of the present book conform a Mexican group who identifies the causes of leukemia, and they summarize their experience in research, results and proposals for future studies. A causal model is included in which the authors hypothesized the origin of acute lymphoblastic leukemias, particularly in children. This hypothesis can be useful to better understand other cancers during childhood. This book will help the reader to identify different molecular aspects involved in leukemia, and its relation to the development and evolution of the disease.

Download or read book Cell Cycle Control written by Eishi Noguchi and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field. Beginning with the overviews of various cell cycle regulations, this title presents the most current protocols and state-of-the-art techniques used to generate latest findings in cell cycle regulation, such as protocols to analyze cell cycle events and molecules. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Control: Mechanisms and Protocols, Second Edition will be a valuable resource for a wide audience, ranging from the experienced cell cycle researchers looking for new approaches to the junior graduate students giving their first steps in cell cycle research.