Download or read book Regulation of Cubitus Interruptus and the Ci Signaling Complex by Hedgehog Signaling written by Mark Alan Lefers and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hedgehog (Hh) signaling pathway plays a vital role in many developmental pathways. Much of our understanding of this pathway comes from studies using Drosophila. The pathway gets its name from the Hh morphogen that regulates differential gene expression through the zinc finger transcription factor Cubitus interruptus (Ci).
Download or read book Regulation of the Hedgehog Signaling Effector Cubitus Interruptus by Slimb Dependent Partial Proteolysis and Control of Specific Activity written by Margery G. Smelkinson and published by . This book was released on 2007 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hh also regulates the specific activity of Ci-155. Prior evidence supported a role for phosphorylation as a suppressor of Ci-155 activation independent of proteolysis. However, we show flaws in these previous data and determine that neither phosphorylation nor the cytoplasmic tethering function of Cos2 significantly restricts the activity of a Ci-155 variant that cannot be proteolyzed. We further provide evidence that Su(fu) is the key silencer of specific activity and Fused kinase activity is required to counter this inhibition to activate Ci.
Download or read book Hedgehog Signaling Protocols written by Jamila I. Horabin and published by Springer Science & Business Media. This book was released on 2007-09-13 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: In both vertebrates and invertebrates, Hedgehog signaling regulates the development of the tissues and structures of the body. In addition, many cancers and diseases arise as a result of misregulation of the pathway, which makes it an incredibly important system to understand. This volume examines various methods used in the analysis of the Hedgehog signaling pathway, bringing together different lines of analyses into one accessible and comprehensive text. This volume provides a single source for investigators, presenting several different experimental approaches, which are all varied and broad in nature, as well as procedures for a variety of different model systems. Researchers will find this volume to be an invaluble tool as they work towards deeper understanding of the underlying molecular events that the Hedgehog signaling pathway regulates.
Download or read book Regulation of Cubitis Interruptus by Hedgehog written by Qun Tian Wang and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hedgehog (Hh) family of secreted proteins play important roles in multiple aspects of development in both invertebrates and vertebrates. In Drosophila, the embryonic segments and the larval imaginal discs are both patterned by Hh and offer excellent model systems to study the mechanisms of Hh signal transduction.
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2002-03-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book Hedgehog Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Download or read book Hedgehog signaling activation in human cancer and its clinical implications written by Jingwu Xie and published by Springer Science & Business Media. This book was released on 2011-04-30 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Avian Embryology written by and published by Academic Press. This book was released on 2011-09-21 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised edition will continue to serve as the most complete and up-to-date guide to the use of the avian embryo in studies of vertebrate development. It will include new approaches to analysis of the chick genome, gene knock-out studies using RNA interference, morpholinos, and other cutting edge techniques. As with the original edition, emphasis has been placed on providing practical guidance, highlighting potentials and pitfalls of all key cell biological and embryological techniques. *fully revised second edition *organized into basic and advanced Methods *new section on Functional Genomics
Download or read book Molecular Basis of Epithelial Appendage Morphogenesis written by Cheng-Ming Chuong and published by Landes Bioscience. This book was released on 1998 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent experimental findings and current thinking on epithelial appendage morphogenesis. Contains sections on overview, morphogenesis of epithelial appendages on the body surface and within the body, molecular mechanisms, models, and approaches. Specific subjects include early molecular events in feather morphogenesis, evolutionarily conserved gene interactions, and molecular biology of anhidrotic ectodermal dysplasia. Many chapters contain summary diagrams of the formative process of organs, with cellular and molecular explanations. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
Download or read book Developmental Biology of Neoplastic Growth written by Alvaro Macieira-Coelho and published by Springer Science & Business Media. This book was released on 2005-11-04 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.
Download or read book Shh and Gli Signalling in Development written by Sarah Howie and published by Springer Science & Business Media. This book was released on 2008-05-24 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (shh) pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.
Download or read book The Smoothened Receptor in Cancer and Regenerative Medicine written by Martial Ruat and published by Springer. This book was released on 2015-06-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Download or read book Reduction and Mechanism written by Alex Rosenberg and published by Cambridge University Press. This book was released on 2020-06-04 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reductionism is a widely endorsed methodology among biologists, a metaphysical theory advanced to vindicate the biologist's methodology, and an epistemic thesis those opposed to reductionism have been eager to refute. While the methodology has gone from strength to strength in its history of achievements, the metaphysical thesis grounding it remained controversial despite its significant changes over the last 75 years of the philosophy of science. Meanwhile, antireductionism about biology, and especially Darwinian natural selection, became orthodoxy in philosophy of mind, philosophy of science, and philosophy of biology. This Element expounds the debate about reductionism in biology, from the work of the post-positivists to the end of the century debates about supervenience, multiple realizability, and explanatory exclusion. It shows how the more widely accepted 21st century doctrine of 'mechanism' - reductionism with a human face - inherits both the strengths and the challenges of the view it has largely supplanted.
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in Drosophila Eye written by Amit Singh and published by Springer Nature. This book was released on 2020-05-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.
