Download or read book Regulation and Inhibition of Protein Kinase CK2 written by Gregory Adair Imbrie and published by . This book was released on 2006 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Kinase CK2 From Structure to Regulation written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.

Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2013-01-14 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2012-10-16 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

Download or read book An Updated View on an Emerging Target Selected Papers from the 8th International Conference on Protein Kinase CK2 written by Joachim Jose and published by MDPI. This book was released on 2017-05-22 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals

Download or read book Protein Kinase CK2 Cellular Function in Normal and Disease States written by Khalil Ahmed and published by Springer. This book was released on 2015-03-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

Download or read book A Molecular and Cellular View of Protein Kinase CK2 written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace. Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

Download or read book Protein Kinase CK2 from Structure to Regulation written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Kinase Ck2 From Structure to Regulation Biochemistry Essentials written by Michelle Mcguire and published by Syrawood Publishing House. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase 2 (CK2) is a serine/threonine-selective protein kinase that controls several signaling pathways. The structure of CK2 is tetrameric, which consists of two catalytic and two regulatory subunits. CK2 is a critical regulator of cell cycle progression and it has been observed to regulate cell cycle progression by protein-protein interactions. It is also involved in various biological processes such as DNA damage response, apoptosis, cell proliferation, cell cycle control, circadian rhythm regulation, transcription and translation. Furthermore, other functions of CK2 are related with human infections. There are certain viruses, which exploit the CK2 host cell for sustaining their life. CK2 activity has also been associated with various diseases including cancer, neurological diseases, inflammation, diabetes, obesity, diverse ophthalmic pathologies, and cardiovascular diseases such as cardiac hypertrophy and atherosclerosis. This book aims to shed light on the structure and regulation of protein kinase CK2. It aims to equip students and experts with the advanced topics and upcoming concepts in this area of study.

Download or read book Protein Kinases in Drug Discovery written by Rossen Donev and published by Academic Press. This book was released on 2021-02-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. Contains timely chapters written by well-renown authorities in their field Includes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students Integrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients

Download or read book Regulation of Protein Kinase CK2 by Interaction Partners written by David Anthony Canton and published by . This book was released on 2005 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploring the Mechanisms of Regulation of Protein Kinase CK2 in Mammalian Cells written by Gerda Maria Hübner and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulation of Diverse Cellular Processes by the CK1 and CK2 Protein Kinase Families written by and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphorylation of serine, threonine, and tyrosine residues by protein kinases plays a vital role in the regulation of many diverse cellular processes. Among the first protein kinases ever described, the CK1 and CK2 protein kinase families are serine/threonine kinases ubiquitously expressed in all eukaryotes. These kinases phosphorylate a multitude of substrates within the cell and misregulation of these processes underlies a number of human disease states. Here, we add to the growing list of CK1 and CK2 substrates and describe new, previously unknown roles for these kinases in the regulation of global protein synthesis, circadian rhythms, and transcription. Ribosomal protein S6 (rpS6), one of thirty three proteins that comprise the small 40S ribosomal subunit, has garnered considerable attention due to its ability to undergo inducible phosphorylation. We now show that CK1 is a critical mediator of rpS6 phosphorylation. We go on to demonstrate that CK1dependent phosphorylation of rpS6 promotes its association with the 7methylguanosine cap complex, a key step in translation initiation. In other studies, we implicate CK1 isoforms in regulating the stability of the circadian rhythm protein PERIOD2 (PER2). PER2 is a critical component of the circadian clock and is mutated in the rare sleep disorder, Familial Advance Sleep Phase Syndrome (FASPS). We utilize phosphospecific antibodies to show that the site mutated in FASPS is phosphorylated by CK1 in vivo, and that CK1dependent phosphorylation significantly increases the halflife of PER2. We also show that CK1 and CK2 are critical regulators of cAMP Response Element Binding Protein (CREB), a bZip family transcription factor implicated in metabolism and cell survival. We go on to describe an intricate phosphorylation cascade carried out by Ataxia telangiectasia mutated (ATM), CK1, and CK2 kinases that results in CREB inhibition. Overall, our combined findings provide new insights into the phosphoregulation of diverse targets by CK1 and CK2.

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Download or read book Protein Kinases as Drug Targets written by Bert Klebl and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.

Download or read book Mitotic Regulation of Protein Kinase CK2 written by Nicole A. St. Denis and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 is a serine/threonine kinase with a multitude of substrates and roles in many cellular processes, including mitosis. CK2 is constitutively active, yet we hypothesize that CK2 is indeed regulated in mitosis through subtle means, enabling CK2 to perform its functions unique to cell division. Our aims were to examine the roles of mitotic phosphorylation, subcellular localization, and interplay with mitotic kinases in the regulation of CK2 activity. We first examined the role of four highly conserved mitotic phosphorylation sites located in the unique C-terminus of CK2?. Phosphospecific antibodies generated against the sites show that CK2? phosphorylation is temporally regulated and occurs during prophase and metaphase during normal mitotic progression. Proper phosphorylation of CK2? is required for proper mitotic progression, as stable cell lines expressing phosphorylation site mutants of CK2? display severe mitotic defects. We next examined the impact of these phosphorylation events on the subcellular localization of CK2. We show that CK2?, but not CK2?', localizes to the mitotic spindle. Localization of CK2? to the mitotic spindle is phosphodependent, and requires the peptidyl-prolyl isomerase Pin1. These results are a rare example of functional divergence between the two catalytic isoforms of CK2, and suggest that the role of CK2? phosphorylation during mitosis is to promote localization of CK2 to the mitotic spindle. Finally, we examined the possibility that CK2 activity during mitosis is regulated through hierarchal phosphorylation events, wherein CK2 would phosphorylate proteins only after priming phosphorylation events catalyzed by other mitotic kinases, particularly Cdk1. As this phenomenon has never been systematically investigated, we have investigated the consensus requirements for CK2 primed phosphorylation, and in particular Cdk/CK2 hierarchical phosphorylation. A genome-wide search for potential mitotic substrates matching the consensus sequence suggests that Cdk1/CK2 hierarchical phosphorylation may indeed contribute to mitotic signaling, particularly on the mitotic spindle. Taken together, our results confirm the importance of CK2 in mitotic cell division, and highlight several examples of subtle regulation of CK2, through phosphorylation, subcellular localization, and interplay with other protein kinases. This helps explain how CK2, a constitutively active kinase, can participate in tightly regulated cellular processes like mitosis.

Download or read book Structure function Analysis of CKIP 1 and Investigation of Its Role in the Regulation of Protein Kinase CK2 written by Mary Ellen Kathleen Olsten and published by . This book was released on 2006 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: