Download or read book Planarian Regeneration written by Jochen C. Rink and published by Humana. This book was released on 2018-06-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
Download or read book The First Brain written by Oné R. Pagán and published by Oxford University Press. This book was released on 2014-03-18 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Planarians, a class of flatworm, are extraordinary: they possess the remarkable ability to regenerate lost body parts, including complete regeneration of the nervous system. If cut into pieces, each piece of the planarian can regenerate into a complete organism. They are also unique among invertebrates in that they display addiction-like behaviors to many drugs abused by humans. Because of these distinct neurological traits, the planarian is often used as an animal model in neurological research, being used most recently for developments in neuropharmacology. The First Brain is a discussion of how planarians have been used in neuropharmacology, and what role they have played in scientific developments that have a high impact on our culture. Planarians have been the animal models for research in drug addiction, antidepressant development, and various other topics in biology, neurobiology, and even zoology. Pagán uses these flatworms as a framework to explore the history of biological research. The book provides accessible background information on how biomedical research is impacted by evolution, and defines neurobiology and neuropharmacology in ways that are easy to understand. At the same time, Pagán provides enough detail for the book to useful for scientists working in various subsections of biology. The planarian has played a key role in the history biological, neuropharmacological, and zoological research, and has even made appearances in a few unexpected places in popular culture. Oné Pagán explores all these roles, and shows us why the planarian truly is one of the most extraordinary and influential organisms in scientific research today.
Download or read book Regeneration in Planarians written by Thomas Hunt Morgan and published by . This book was released on 1901 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regeneration in Planarians written by Thomas Hunt Morgan and published by . This book was released on 1900 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regeneration written by Thomas Hunt Morgan and published by . This book was released on 1901 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Studies of the Regeneration of Planaria Maculata written by Thomas Hunt Morgan and published by . This book was released on 1898 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planarian Regeneration written by Jochen C. Rink and published by Humana. This book was released on 2019-07-03 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
Download or read book Observations and Experiments on Regeneration in Planarians written by Harriet Randolph and published by . This book was released on 1897 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planaria A Model for Drug Action and Abuse written by Robert B. Raffa and published by CRC Press. This book was released on 2008-12-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of drug action has benefitted greatly from the development and use of in vivo model systems. In model systems, manipulations and observations can be more rigorously controlled and screens of novel therapeutic agents can be more safely conducted.No single model system provides all of the possible advantages. At one end, mammalian models al
Download or read book The Germ plasm written by August Weismann and published by . This book was released on 1898 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planarian Regeneration written by Holger Valdemar Brøndsted and published by . This book was released on 1955 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planarian Regeneration written by Holger Valdemar Brøndsted and published by Pergamon. This book was released on 1969 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developmental Biology A Very Short Introduction written by Lewis Wolpert and published by Oxford University Press. This book was released on 2011-08-25 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.
Download or read book Pattern Formation and Essential Responses for Regeneration in Planarians written by Aneesha Ghanhi Tewari and published by . This book was released on 2019 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, patterning cues and a set of cellular and molecular responses collectively called the "missing tissue" or "regenerative" response. The missing tissue response has long been considered a fundamental requirement of planarian regeneration. follistatin, which encodes an extracellular Activin inhibitor, is required for the missing tissue response after head amputation, and for subsequent regeneration. We found that follistatin is required for the missing tissue response regardless of the wound context, but only causes regeneration failure after head amputation. This head regeneration failure involves follistatin-mediated regulation of Wnt signaling at wounds, and is not a consequence of a diminished missing tissue response. We found that all tested contexts of regeneration, including head regeneration, could occur with a defective missing tissue response, however, at a slower pace. Our findings suggest that in the absence of major cellular and molecular programs induced by large injuries, regulation of wound-induced Wnt signaling to enable regenerative re-patterning along with continuous tissue turnover can mediate successful regeneration in essentially any wound context. Wnt signaling regulates primary body axis formation across the Metazoa, with high Wnt signaling specifying posterior identity. Whether a common Wnt-driven transcriptional program accomplishes this broad role is poorly understood. We identified genes acutely affected after Wnt signaling inhibition in the posterior of two regenerative species, the planarian Schmidtea mediterranea and the acoel Hofstenia miamia, which are separated by >550 million years of evolution. Wnt signaling was found to maintain positional information in muscle and regional gene expression in multiple differentiated cell types. sp5, Hox genes, and Wnt pathway components are down-regulated rapidly after [beta]-catenin RNAi in both species. brachyury, a vertebrate Wnt target, also displays Wnt-dependent expression in Hofstenia. Planarian sp5 inhibits Wnt-dependent expression of trunk genes in the tail, promoting separate tail-trunk body domains. We propose that common regulation of a small gene set – Hox, sp5, and brachyury – might underlie the widespread utilization of Wnt signaling in primary axis patterning across the Bilateria.
Download or read book Observations And Experiments On Regeneration In Planarians written by Harriet Randolph and published by . This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planarian Regeneration written by H. V. Brøndsted and published by Elsevier. This book was released on 2013-10-22 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Planarian Regeneration deals with regeneration problems including embryogenesis and morphogenesis. The book compares the principles involved in the regeneration processes with those in ontogenesis from the egg. The author also reviews the works of Thomas H. Morgan and Charles M. Child which became the basis for systematic scientific investigation of regeneration. The head regenerates vigorously, with a faster rate behind the eyes, then at various levels along the longitudinal axis of the planarian body. A time-graded regeneration includes inhibitory forces and some genetic codes that determine such rate. The time-graded field has been proven by transplantation experiments; the author addresses the morphological structure to which biochemical factors or processes determine the different rate of regeneration. He notes that the nervous system conforms to these processes as shown by studies of Lender and Klein (1961). The author suggests that the study of regeneration in planarians should involve time considerations quantitatively to explain some substance, if any, from the nervous system that activates the cytoplasm of neoblasts, and then the genome. This book will prove valuable for zoologists and researchers in genetics, biochemistry or molecular biology.
Download or read book In the Hurricane s Eye written by Nathaniel Philbrick and published by Penguin. This book was released on 2018-10-16 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER "Nathaniel Philbrick is a masterly storyteller. Here he seeks to elevate the naval battles between the French and British to a central place in the history of the American Revolution. He succeeds, marvelously."--The New York Times Book Review The thrilling story of the year that won the Revolutionary War from the New York Times bestselling author of In the Heart of the Sea and Mayflower. In the concluding volume of his acclaimed American Revolution series, Nathaniel Philbrick tells the thrilling story of the year that won the Revolutionary War. In the fall of 1780, after five frustrating years of war, George Washington had come to realize that the only way to defeat the British Empire was with the help of the French navy. But coordinating his army's movements with those of a fleet of warships based thousands of miles away was next to impossible. And then, on September 5, 1781, the impossible happened. Recognized today as one of the most important naval engagements in the history of the world, the Battle of the Chesapeake—fought without a single American ship—made the subsequent victory of the Americans at Yorktown a virtual inevitability. A riveting and wide-ranging story, full of dramatic, unexpected turns, In the Hurricane's Eye reveals that the fate of the American Revolution depended, in the end, on Washington and the sea.
