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Book Replacement  Reduction and Refinement of Animal Experiments in the Development and Control of Biological Products

Download or read book Replacement Reduction and Refinement of Animal Experiments in the Development and Control of Biological Products written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past, animal experimentation has played an important part in the development and quality control of immunobiological products. These days, however, concern about animal welfare is growing and, consequently, increasing emphasis is placed on the use of in vitro methods. This book reports the proceedings of a symposium held at the Paul Ehrlich Institute in Langen, Germany, in November 1994, at which the application of the three Rs principle - replacement, reduction and refinement of the use of animal experiments - was evaluated and recommendations were given. A review of the history of animal experimentation is followed by reports of various international organizations (including the European Pharmacopoeia and the World Health Organization) about their activities with respect to upholding the three Rs principle. It is shown that significant progress has been made in the last few years in the fields of pyrogen testing, hormones, blood products and vaccines. Several new in vitro methods for potency, efficacy and safety testing of vaccines are presented and discussed. General problems such as harmonization, statistics and validation, serological methods and cell cultures are also addressed. Demonstrating that sound science and animal welfare are not irreconcilable, this volume is a valuable resource for all those concerned with the development and manufacture of biological products.

Book Guide for the Care and Use of Laboratory Animals

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Book Current Catalog

    Book Details:
  • Author : National Library of Medicine (U.S.)
  • Publisher :
  • Release :
  • ISBN :
  • Pages : 1060 pages

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Book Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use

Download or read book Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of alternative in vitro reduction and refinement methods in the development and control of biological products has increased considerably in the last few years. The issues raised are of concern to the scientific community as well as to manufacturers, regulatory authorities and those involved in animal ethics and welfare. A large number of physicochemical, immunochemical, biochemical and cell biological methods have been proposed for the replacement, reduction and refining of animal tests in the development and control of human and veterinary vaccines and other biological products. However, the implementation, validation and ultimate regulatory acceptance of these procedures are still at a very early stage. This volume contains the proceedings of a meeting, which brought together research scientists, manufacturers and regulators with the aim of promoting an exchange of scientific knowledge and increasing awareness of the importance of validation studies.

Book National Library of Medicine Current Catalog

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1988 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Animal Genomics for Animal Health

Download or read book Animal Genomics for Animal Health written by Marie-Hélène Pinard and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: "It includes a review of the state of the art in animal genomics and its applications to animal health. The contributions describe the new tools available, such as HapMaps for chicken and cattle, and show how the understanding of gene structure and function can be successfully applied to delineate the molecular mechanisms of disease and determine complex phenotypes associated with health traits. A critical evaluation of future needs and future applications of animal genomics is also presented. The integration of animal genomics in animal health research is likely to revolutionize the way scientists approach the challenges of discovering highly effective drugs and vaccines for animal diseases."--BOOK JACKET.

Book Vaccines and Diagnostics for Transboundary Animal Diseases

Download or read book Vaccines and Diagnostics for Transboundary Animal Diseases written by J.A. Roth and published by Karger Medical and Scientific Publishers. This book was released on 2013-04-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transboundary animal diseases (TADs) are a major threat to livestock. They are highly contagious or transmissible, and they have the potential to cause high morbidity and mortality in both susceptible animal populations and humans. In addition, not only are TADs detrimental to national economies, they are also a serious threat to world food security. This volume presents the proceedings of an international workshop on Vaccines and Diagnostics for Transboundary Animal Diseases that was held in Ames (Iowa, USA) in 2012. Experts and scientists from academia, industry and government reviewed the current status of vaccines and diagnostics for high priority TADs, decision-making and regulatory processes for veterinary biologics, and the roles and responsibilities of government agencies. The discussions also addressed achievements and gaps in vaccine and diagnostics development for 11 important TADs as well as the translation of research findings into licensed novel vaccines and diagnostics for high-priority TADs.

Book Guide to the Care and Use of Experimental Animals

Download or read book Guide to the Care and Use of Experimental Animals written by and published by . This book was released on 1980 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Management of Animal Care and Use Programs in Research  Education  and Testing

Download or read book Management of Animal Care and Use Programs in Research Education and Testing written by Robert H. Weichbrod and published by CRC Press. This book was released on 2017-09-07 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

Book Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones

Download or read book Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2002 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation plays a major role in the development and control of biological products and large numbers of animals are used for routine batch control. During the past few years considerable attention has been paid to the concept of replacing, reducing and refining (the three Rs) the use of animals for this purpose. This volume contains the proceedings of an international meeting held in Utrecht in November 2001 in which the problems associated with applying the three Rs were discussed. Particular emphasis was given to the validation and regulatory acceptance of in vitro methods and new concepts of quality control. Those issues are important for the scientific community at large as well as manufacturers, regulatory authorities and everyone concerned with animal welfare.

Book OIE FAO International Scientific Conference on Avian Influenza

Download or read book OIE FAO International Scientific Conference on Avian Influenza written by Alejandro Schudel and published by S. Karger AG (Switzerland). This book was released on 2006 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph comprises the proceedings of the International Conference on Avian Influenza held in Paris, France, in April 2005. Discussed were new scientific discoveries in the domain of avian influenza (AI), with special emphasis on the highly pathogenic avian influenza (HPAI). It provides important up-to-date information on the virology, epidemiology and molecular biology as well as the history of episodes of avian influenza in different parts of the world and their consequences. The publication aims at making recommendations to compare and improve the international procedures and standards related to the identification, prevention, control and elimination of AI epizootics as they are a threat to the livelihood of farmers, especially in developing countries, to public health as well as to national economies. Chief veterinary officers, animal health regulatory officials, veterinarians, poultry-raising associations, consumer associations, specialised journalists and all those who need to understand and control AI episodes will benefit from reading this book.

Book Handbook of Facilities Planning  Laboratory animal facilities

Download or read book Handbook of Facilities Planning Laboratory animal facilities written by Theodorus Ruys and published by Van Nostrand Reinhold Company. This book was released on 1990 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Proceedings of the 7th General Meeting on Advances in Animal Cell Technology

Download or read book Proceedings of the 7th General Meeting on Advances in Animal Cell Technology written by European Society of Animal Cell Technology. General Meeting and published by . This book was released on 1987 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Virological Safety Aspects of Plasma Derivative

Download or read book Virological Safety Aspects of Plasma Derivative written by and published by . This book was released on 1993 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: