Download or read book Ribonucleotide Reductase written by Kristoffer Andersson and published by Nova Publishers. This book was released on 2008 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of this book is the amazing enzyme ribonucleotide reductase (RNR), the enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides. The prerequisite for DNA-synthesis and DNA-repair in all living cells is the supply of the four deoxyribonucleotides. Such molecules result from the enzymatically difficult radical-induced reduction of ribonucleotides, a multistep chemical process catalyzed by RNR. RNR was the first enzyme in which the presence of an amino acid radical (a tyrosyl) in E. coli Class Ia RNR has been proven; since then several other biological amino acid radical species have been found on e.g. tryptophan, glycine, cysteine, lysine residues and on amino acid derived small cofactors like 2 tryptophanes in thryptophan-trypthanyl-radical or cysteine-tyrosyl-radical in other enzymes. As all known cellular life forms store their genetic information as DNA, RNR is likely to be found in all growing cells of every living organism, a fact that is confirmed by a rapidly increasing number of genomic screenings.

Download or read book Some Bioinorganic Chemistry of Ribonucleotide Reductase from Escherichia Coli written by Charlene Joy Haskin and published by . This book was released on 1996 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Electron Transfer Properties of the R2 Protein of Ribonucleotide Reductase from Escherichia Coli written by Kathleen Elizabeth Silva and published by . This book was released on 1995 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Enzymology and Related Areas of Molecular Biology written by F. F. Nord and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological process, and their application in both the laboratory and industry. Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability. With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.

Download or read book Bioinorganic Chemistry written by D.P. Kessissoglou and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic chemistry is primarily concerned with the role of metal atoms in biology and is a very active research field. However, even though such important structures of metalloenzymes are known, as the MoFeCo of nitrogenase, Cu or Mn superoxide dismutase and plastocyanin, the synthetic routes to the modelling of such centers remains a matter of acute scientific interest. Other metalloenzymes, such as the Mn center of the oxygen evolving complex of PSII, are still the focus of in-depth examination, both spectroscopic and structural. Another area of concern is the interaction between drugs and metals and metal ion antagonism. Understanding the chemistry of metal ions in biological systems will bring benefits in terms of understanding such problems as biomineralization and the production of advanced materials by micro-organisms. The 29 contributions to Bioinorganic Chemistry: An Inorganic Perspective of Life give an excellent summary of the state of the art in this field, covering areas from the NMR of paramagnetic molecules to the use of lanthanide porphyrins in artificial batteries.

Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by CRC Press. This book was released on 1994-02-08 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted solely to the research area of metalloenzymes involving amino acid-residue and related radicals. Topics covered include: general considerations; structure, function and engineering of peroxidases; and ribonucleotide reductase in mammalian systems.

Download or read book Chemistry and Biochemistry of B12 written by Ruma Banerjee and published by John Wiley & Sons. This book was released on 1999-11-03 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Definitive New Reference for the Latest Advances in B_12 Chemistry and Biochemistry Over the past decade, the field of B_12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field-from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B_12 community, this work provides B_12 researchers with a dependable and up-to-date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B_12-dependent enzymes, free-radical-mediated reaction mechanisms, biosynthesis, and much more. The role of B_12 in nutrition and disease, and B_12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B_12 is a one-of-a-kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature's most beautiful cofactor."

Download or read book Protein Sensors and Reactive Oxygen Species Part B Thiol Enzymes and Proteins written by and published by Elsevier. This book was released on 2002-03-06 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is a companion to Volume 347 and addresses direct sensing of reactive oxygen species and related free radicals by thiol enzymes and proteins.

Download or read book Regulation of Ribonucleotide Reductase Expression in Escherichia Coli written by Blake Alan Jacobson and published by . This book was released on 1997 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Sensors and Reactive Oxygen Species written by Helmut Sies and published by Academic Press. This book was released on 2002 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is a companion to Volume 347 and addresses direct sensing of reactive oxygen species and related free radicals by thiol enzymes and proteins.

Download or read book Iron Carriers and Iron Proteins written by Thomas M. Loehr and published by Wiley-VCH. This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nitroxide Spin Labels written by Nickolai Kocherginsky and published by CRC Press. This book was released on 1995-05-11 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extending the use of nitroxides as probes into more complex systems such as viable cells and whole animals requires greater knowledge of their interactions in functioning biological systems and appropriate model systems. Nitroxide Spin Labels: Reactions in Biology and Chemistry presents information essential for research in this area. Nitroxide research offers the promise of important new ways of measuring metabolism and will be useful in the diagnosis of important disease categories such as cancer, inflammation, and ischemia.

Download or read book Non Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods

Download or read book Fundamentals of Biochemistry written by JL Jain et al. and published by S. Chand Publishing. This book was released on 2004-09 with total page 1230 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this latest Seventh Edition , five New Chapters (No. 28, 29, 33, 36 and 37) have been added to enhance the scope and utility of the book: three chapters pertain to Bioenergetics and Metabolism (Biosynthesis of Nucleotides, Degradation of Nucleotides, Mineral Metabolism) and two to Nutrition Biochemistry (Principles of Nutrition, Elements of Nutrition). In fact, all the previously-existing 35 chapters have been thoroughly revised, enlarged and updated in the light of recent advancements and the ongoing researches being conducted the world over.

Download or read book Prokaryotic Metabolism and Physiology written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2019-05-16 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.

Download or read book Protein Sensors of Reactive Oxygen Species Part A Selenoproteins and Thioredoxin written by and published by Elsevier. This book was released on 2002-03-12 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.

Download or read book Enzyme Kinetics and Mechanism written by Paul F. Cook and published by Garland Science. This book was released on 2007-03-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme Kinetics and Mechanism is a comprehensive textbook on steady-state enzyme kinetics. Organized according to the experimental process, the text covers kinetic mechanism, relative rates of steps along the reaction pathway, and chemical mechanism—including acid-base chemistry and transition state structure. Practical examples taken from the literature demonstrate theory throughout. The book also features numerous general experimental protocols and how-to explanations for interpreting kinetic data. Written in clear, accessible language, the book will enable graduate students well-versed in biochemistry to understand and describe data at the fundamental level. Enzymologists and molecular biologists will find the text a useful reference.