Download or read book Redesigning the Molecules of Life written by Steven A. Benner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.
Download or read book Redesigning the Molecules of Life written by Steven A. Benner and published by Springer. This book was released on 2011-12-14 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.
Download or read book Redesigning the Molecules of Life written by Steven Albert Benner and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Way of the Cell written by Franklin M. Harold and published by Oxford University Press, USA. This book was released on 2003 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading microbiologist provides thought-provoking insights into the question of "What is Life?" as he examines the relationship of living things to the inorganic realms of physics and chemistry, explains how lifeless chemicals come together to form living beings, and details the true complexity of seemingly simple microorganisms such as E. coli.
Download or read book Regenesis written by George M Church and published by Basic Books. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Size Limits of Very Small Microorganisms written by National Research Council and published by National Academies Press. This book was released on 1999-09-13 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: How small can a free-living organism be? On the surface, this question is straightforward-in principle, the smallest cells can be identified and measured. But understanding what factors determine this lower limit, and addressing the host of other questions that follow on from this knowledge, require a fundamental understanding of the chemistry and ecology of cellular life. The recent report of evidence for life in a martian meteorite and the prospect of searching for biological signatures in intelligently chosen samples from Mars and elsewhere bring a new immediacy to such questions. How do we recognize the morphological or chemical remnants of life in rocks deposited 4 billion years ago on another planet? Are the empirical limits on cell size identified by observation on Earth applicable to life wherever it may occur, or is minimum size a function of the particular chemistry of an individual planetary surface? These questions formed the focus of a workshop on the size limits of very small organisms, organized by the Steering .Group for the Workshop on Size Limits of Very Small Microorganisms and held on October 22 and 23, 1998. Eighteen invited panelists, representing fields ranging from cell biology and molecular genetics to paleontology and mineralogy, joined with an almost equal number of other participants in a wide-ranging exploration of minimum cell size and the challenge of interpreting micro- and nano-scale features of sedimentary rocks found on Earth or elsewhere in the solar system. This document contains the proceedings of that workshop. It includes position papers presented by the individual panelists, arranged by panel, along with a summary, for each of the four sessions, of extensive roundtable discussions that involved the panelists as well as other workshop participants.
Download or read book Physics in Molecular Biology written by Kim Sneppen and published by Cambridge University Press. This book was released on 2005-08-25 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.
Download or read book About Life written by Paul S. Agutter and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uses modern biological knowledge to tackle the question of what distinguishes living organisms from the non-living world. The authors first draw on recent advances in cell and molecular biology to develop an account of the living state that applies to all organisms (and only to organisms). This account is then used to explore questions about evolution, the origin of life, and the possibility of extraterrestrial life. The novel approach taken by this book to issues in biology will interest and be accessible to both the general reader as well as students and specialists in the field.
Download or read book Biologically Active Molecules written by Urs P. Schlunegger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few years there has been a remarkable and rapid development of modern analytical methods, and the fields of nuclear magnetic resonance and mass spectrometry have been no exception. In addition to being able to do "more and faster", new innovative techniques have also arisen to contribute to a growing understanding of the relationship between chemical structure and biological activity. In order to explore a few of the more interesting points of those developments and applications, a seminar "From Biological Activity to Structure" was organized from September 5-7, 1988, at Interlaken. The four invited speakers, Richard M. Caprioli, Howard R. Morris, Wolfgang Steglich and Dudley H. Williams were kind enough to attend and discuss many facets of their research, especially methodological and technical developments and their applications to specific problems. Participants were introduced to continuous flow FAB (fast atom bombardment) and its use, for example, in the real time monitoring of biochemical reactions in vitro and in vivo; the structural elucidation of secondary metabolites from fungi; the analysis of molecule-receptor interactions; the determination of posttranslational modifications of peptides; and the location of S-S bridges in determining the tertiary structure of proteins.
Download or read book Bioorganic Chemistry Frontiers written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. K. Kano: Selectivities of Applied Chemistry 2. A. Pl}ckthun: Antibody Engineering to Study Protein-Ligand Interactions and Catalysis: The Phosphorylcholine Binding Antibodies 3. M.W. Hosseini: Supramolecular Catalysis of Phosphoryl Transfer Processes 4. G. von Kiedrowski: Minimal Replicator Theory II: Parabolic versus ExponentialGrowth 5. A. Bacher, W. Eisenreich, K. Kis, R. Ladenstein, G. Richter, J. Scheuring, S. Weinkauf: Biosynthesis of Flavins 6. C.L. Hannon, E.V.Anslyn: The Guanidinium Group: Its Biological Role and Synthetic Analogs.
Download or read book Water and Life written by Ruth M. Lynden-Bell and published by CRC Press. This book was released on 2010-05-21 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting a rich technical and interdisciplinary exchange of ideas, Water and Life: The Unique Properties of H20 focuses on the properties of water and its interaction with life. The book develops a variety of approaches that help to illuminate ways in which to address deeper questions with respect to the nature of the universe and our place withi
Download or read book The Aptamer Handbook written by Sven Klussmann and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.
Download or read book Science in Society 56 written by Dr. Mae-Wan Ho and published by Institute of Science in Soc. This book was released on 2012-11-14 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue: From the Editors - GM Cancer Warning Can no Longer Be Ignored Freeing the World from GMOsExcess Cancers & Deaths from GM Feed: Stats Stand UpStudy Confirms GM Crops Increased Pesticide Use Synthetic Biology Good & BadSynthetic Biology Should We Be Afraid?Aptamers for Biosensing, Diagnosis, Drug Delivery and TherapyMass Genome Engineering Contaminated VaccinesDNA Contamination in HPV Vaccines Letters to the Editor Institute of Science in Society Special ReportWhy Glyphosate Should Be Banned News in Brief Technology WatchNanoparticles Bioaccumulate & Harm Soybean CropsPhotosynthetic Bacterium Converts CO2 into Petrochemical & O2 Save Our WaterWorld Water Supply in JeopardyPharmaceutical Cocktails Anyone? No NuclearFukushima Mutant Butterflies Confirm Harm from Low-Dose Radiation
Download or read book Systems Biology and Synthetic Biology written by Pengcheng Fu and published by John Wiley & Sons. This book was released on 2009-08-13 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.
Download or read book Atomic Design written by Brad Frost and published by . This book was released on 2016-12-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Redesign Your Life in Modern Age written by Balvinder Kumar and published by Balvinder Kumar. This book was released on 2020-02-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: All around us, we are witnessing major changes that are transforming our lives because of science and technology. In fact, multiple revolutions including relating to digital technologies are simultaneously taking place across the world. The way we think, work, interact and connect with others, is changing at increasingly fast pace. On the one hand, the world is becoming a better place to live. We are becoming healthier, wealthier, leading a more comfortable life. But sadly, at the same time, we are becoming more and more unhappy and discontented with our life. We are seeing increased incidents of mental illnesses like depression and anxiety, life style diseases like diabetes, obesity, heart and lung diseases. The life style diseases are the biggest killers in India. Increasingly, people are getting addicted to social media. Everyone is now busier on mobile or other digital screens, too many distractions; our attention span is further declining. In a broader sense, we are getting disconnected from each other and their inner self. The whole world is facing a serious challenge as how to cope up with the changing scenario of digital age. With this background in mind, the author has written his 3rd book titled, ‘Redesign Your Life in Modern Age’. His earlier 2 books were first, Man’s Spiritual Journey and second, Awakening the Thinking Mind The book attempts to touch the whole gamut of subjects, which are very relevant and significant to contemporary world. The topics of discussion range from ‘human destiny’ to our own inner journey. From pain, suffering, mental stress, loneliness, fear, anxiety, digital obsession and attention deficit to success, pleasure, happiness and likewise many other subject matters have been included in the book. How each one of us can redesign our life’s journey in view of challenges faced in the modern age, is the simple mantra behind writing this book.
