Download or read book Recent Advances in Mitocondrial Medicine and Coenzyme Q10 written by Anna Gvozdjáková and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Mitochondrial Medicine and Coenzyme Q10 (eds. Anna Gvozdjáková, Germaine Cornélissen, Ram B Singh) is an updated version of a book Mitochondrial Medicine (ed. A. Gvozdjáková) published by Springer, The Netherlands, in 2008. International contributors and world specialists in Mitochondrial Medicine and Coenzyme Q10 provide up-to-date knowledge in mitochondrial physiology, and review the role played by mitochondria in relation to diseases, diagnosies and therapies pertinent to various fields of medicine. This monograph covers topics related to mitochondrial physiology, mitochondrial sirtuins, supercomplexes, chronobiology, epigenetics, genetics, neurology, cardiology, nephrology, immunology, diabetology, oncology, and reproductive medicine. A chapter on the history of coenzyme Q10 focuses on the work of Prof. Frederick L Crane, discoverer of coenzyme Q10, who died in 2015. Current diagnostic methods of mitochondrial disturbances are reviewed, including a new non-invasive approach using high-resolution respirometry in human blood cells. The effectiveness of supplementary therapies of mitochondrial disturbances is examined for the case of natural antioxidants, melatonin, high protein diet, omega-3-PUFA, omega-6-PUFA, natural mineral water sources and polarized light. Targeting mitochondrial therapy involves coenzyme Q10 (ubiquinone, ubiquinol), prospective mitochondrial replacement therapy and mitochondrial transplantation. This book is intended for general medical practitioners and specialists in various fields of medicine, including neurologists, cardiologists, geneticists, nephrologists, diabetologists, lipidologists, immunologists, oncologists, pharmacists, biochemists and nutritionists. Pre- and post-graduate education physicians, pharmacists and biochemists will also benefit from material covered in this monograph.

Download or read book Recent Advances in Mitocondrial Medicine and Coenzyme Q10 written by Anna Gvozdjáková and published by . This book was released on 2018 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mitochondrial Medicine written by Anna Gvozdjáková and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Download or read book Functional Foods and Nutraceuticals in Metabolic and Non communicable Diseases written by Ram B. Singh and published by Academic Press. This book was released on 2021-11-30 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases presents strategies for the prevention of non-communicable diseases and undernutrition through the use of functional foods and nutraceuticals. Research has shown that the use of certain functional foods and nutraceuticals, including spices, herbs, and millets, animal foods and plant foods can play a role in the treatment and prevention of various diseases and in health promotion. Finally, the book explores epigenetic modulation as a new method for the development of functional foods and functional farming. Intended for nutritionists, food scientists and those working in related health science professions, this book contributes to the discussions focused on nutritional transition, globalization, how to administer foods in the treatment of metabolic syndrome, hypertension, diabetes, heart attacks, neuropsychiatric disorders, bone and joint diseases, and carcinogenesis. Places emphasis on food diversity to provide perfect combinations of nutritional ingredients Presents the utility and necessity of functional food production for health promotion Offers suggestions to increase functional food production while simultaneously decreasing production costs

Download or read book Mitochondrial Medicine written by Salvatore DiMauro and published by CRC Press. This book was released on 2006-04-19 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Download or read book Mitochondrial Dysfunction in Ageing and Diseases written by Jaime M. Ross and published by MDPI. This book was released on 2018-09-28 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Download or read book Antioxidants written by and published by BoD – Books on Demand. This book was released on 2019-11-06 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antioxidants are substances that can prevent or slow damage to living cells caused by free radicals, which are unstable molecules the body produces as a reaction to environmental and other pressures. Sometimes called “free-radical scavengers,” free radicals can cause mutation in different biological compounds such as protein, nucleic acids, and lipids, which lead to various diseases (cancer, cardiovascular disease, aging, etc.). Healthy foods are considered a main source of antioxidant compounds and from the beginning of a person’s life, a strong relationship is seen between antioxidant compounds and the prevention of certain diseases, such as types of inflammations, cardiovascular diseases, and different kinds of cancers. It is thus of great importance that new data relating to antioxidants and their biological activity be collected and that antioxidant modes of action be illustrated.Experts from around the world contributed to the current book, discussing antioxidant sources, modes of action, and their relation to human diseases. Twenty-five chapters are presented in two sections: Antioxidants: Sources and Modes of Action and Antioxidants Compounds and Diseases.

Download or read book The Miracle Nutrient written by Emile G. Bliznakov and published by Bantam. This book was released on 1987 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: CoQ10 is a natural nutrient essential to the life and health of every living cell. Without it, our bodies are unable to fight back against infections and disease. Unfortunately, many of us, especially as we age, lack sufficient CoQ10, putting us at risk of serious illness. now Dr. Emile G. Bliznakov and medical writer Gerald L. Hunt tell the whole remarkable story of this life-preserving nutrient already hailed as the immune system miracle. They show that by supplementing your body's natural ability to supply CoQ10, you may dramatically reverse the effects of again, poor diet, and decreasing health to: Revitalize the immune system and aid in its defense against cancer infections. Reverse the effects of again naturally. Protect and strengthen the heart and cardiovascular system. Normalize high blood pressure without side effects. Control or even reverse periodontal (gum) disease. Energize your body and increase your tolerance for exertion. Reduce weight naturally without dieting or drugs. Updated to include the latest medical studies and complete with dietary lists and natural CoQ10 food sources, this important new book is the definitive new guide to CoQ10--the miracle nutrient produced from natural sources now available at pharmacies and health food stores nationwide.

Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Download or read book Pathophysiology Risk Factors and Management of Chronic Heart Failure written by Ram B. Singh and published by Academic Press. This book was released on 2024-04-25 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Heart Failure: Pathophysiology, Risk factors, and Mechanisms is the first of two separate but closely related volumes which aim to provide an inclusive overview on Chronic Heart Failure (CHF). This first volume is focused on the epidemiology, classification, molecular mechanisms, pathophysiology, causes, identification and interactions of heart failure. It will explain the uncertainties and issues in Heart Failure by helping readers understand the physiopathology of CHF in the light of behavioural risk factors. 2D and 3D speckle tracking echocardiography have been used to quantify regional alterations of longitudinal strain and area strain, through their polar projection, which allows a further evaluation of both the site and extent of myocardial damage. The analysis of strain can identify subclinical cardiac failure (myocyte remodelling) which is a major issue in CHF. Myocardial Strain, measure by speckle tracking echocardiography, is frequently attenuated in these conditions and can be utilized for the evaluation of disease progression and the effect of therapeutic interventions as well as prevention because it could be a manifestation of behavioural risk factors. These 2 separate volumes serves as essential references to both researchers and practicing clinicians, proposing novel methods of research by using behavioural and environmental risk factors as intervention agent, as well as discussing deficiency in the present approaches in management of HF and proposing new methods of early diagnosis and therapies for the clinical management of CHF. Includes a number new and controversial topics: Roles of both behavioural and nutritional risk factors in CHF; considering behavioural intervention which may change the remodelling, as well as nutrient supplementation or change of diet in preventing CHF or converting resistant HF in to HF responding to therapy; Evidence-based knowledge on CHF, with an emphasis on viewing CHF as a disease of the brain and contribution from other systems; Pre–Heart failure which can be prevented to restore normal cardiomyocyte function; Pathogenesis of HF in chronic kidney disease; 2D and 3D speckle tracking echocardiography Includes never-published tables and figures to aid understanding of the topics Contributions from international leading experts in the field, written with the aim of serving both researchers and practicing clinicians

Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-02-09 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Download or read book Mitochondrial Dysfunction in Aging and Diseases of Aging written by Richard H. Haas and published by MDPI. This book was released on 2019-10-01 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Download or read book Mitochondria and Brain Disorders written by Stavros Baloyannis and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.

Download or read book Taurine 5 written by John B. Lombardini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Taurine Symposium- "Taurine: Beginning the 21'' Century"- was held September 20-23, 2002, on the beautiful island of Kauai in Hawaii. The headquarters of the meeting was the Radisson Kauai Beach Resort. This international meeting was attending by approximately 80 individuals from 23 nations and 4 continents. Seventy-five papers were presented either as platform presentations or poster presentations. Taurine, first isolated from ox bile in 1827 by Tiedemann and Gmelin and named in 1838 by Demarcay, became of significant scientific interest in 1968 when the first extensive review article was published by Jacobsen and Smith. Interest in taurine grew exponentially after 1975 when the first taurine symposium was organized by Ryan Huxtable in Tucson, Arizona. Since that date, taurine symposia have been held approximately every two years held in various cities and resort areas around the world. Taurine investigators have had the privilege of attending these scientific meetings on three continents - Asia, Europe, and North America. Since the initial meeting in 1975, a central question addressed during many of the symposia has been: "What is physiological, pharmacological, nutritional, and pathological role of taurine?". Although taurine has been established as an important osmolyte, it appears to affect many other biological processes. However, the exact mechanism(s) by "which taurine acts" has not yet been definitively answered. In Kauai, the patticipants discussed many topics and asked many questions regarding the role and actions of taurine.