Download or read book The Protective Arm of the Renin Angiotensin System RAS written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. - Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor - Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. - Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases - Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Download or read book Conquering RAS written by Asfar Azmi and published by Academic Press. This book was released on 2016-08-11 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
Download or read book Rass written by Berniece Rabe and published by . This book was released on 1978 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronicles a young boy's continuing conflict with his father while growing up on a Missouri farm during the Depression.
Download or read book Ras and Cancer in the 21st Century written by Linda VanAelst and published by Perspectives Cshl. This book was released on 2018 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.
Download or read book Cryptography for Security and Privacy in Cloud Computing written by Stefan Rass and published by Artech House. This book was released on 2013-11-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: As is common practice in research, many new cryptographic techniques have been developed to tackle either a theoretical question or foreseeing a soon to become reality application. Cloud computing is one of these new areas, where cryptography is expected to unveil its power by bringing striking new features to the cloud. Cloud computing is an evolving paradigm, whose basic attempt is to shift computing and storage capabilities to external service providers. This resource offers an overview of the possibilities of cryptography for protecting data and identity information, much beyond well-known cryptographic primitives such as encryption or digital signatures. This book represents a compilation of various recent cryptographic primitives, providing readers with the features and limitations of each.
Download or read book Waking and the Reticular Activating System in Health and Disease written by Edgar Garcia-Rill and published by Academic Press. This book was released on 2015-04-28 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the "activating properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson's disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders. - First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson's, Alzheimer's, and other neurologic and mental diseases - Offers a new way of thinking about brain function and the role of the RAS in our waking lives - Written by a leading translational neuroscience researcher with contributions by specialists in the field
Download or read book Ras Superfamily Small G Proteins Biology and Mechanisms 1 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-22 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Download or read book The Blues of Heaven written by Barbara Ras and published by University of Pittsburgh Press. This book was released on 2021-03-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Blues of Heaven, Barbara Ras delivers her characteristic subjects with new daring that both rattles and beguiles. Here are poems of grief over her brother’s death; doors to an idiosyncratic working-class childhood among Polish immigrants; laments for nature and politics out of kilter. Ras portrays the climate crisis, guns out of control, the reckless injustice and ignorance of the United States government. At the same time, her poems nimbly focus on particulars—these facts, these consequences—bringing the wreckage of unfathomable harm home with immediacy and integrity. Though her subjects may be dire, Ras also weaves her wise humor throughout, moving deftly from sardonic to whimsical to create an expansive, ardent, and memorable book. Survival Strategies To dig for quahogs, to feel their edges like smiles and pull against their suck to toss them in a bucket. To feel the wind as a friend, to feel its current as luck. To ignore Capricorn and Cancer presuming to slice the globe. To know the lie in “names can never hurt you.” To be a gull breezing the blue, eating nothing but clouds. To measure your ties to the past by the strength of cobwebs. To haunt the widow’s walk, its twelve narrow windows each the size of a child’s coffin. To watch the harbor where the Acushnet runs into Buzzards Bay before it was named a Superfund site full of PCBs. To wonder if that water you swam summer after aimless summer could get you the way something got your brother, too fast, too soon. To bury or burn the whole family you were born to and talk to them only through the smoke of letters you torch at their graves. To see a snake with a ladybug on its back and still refuse to pray.
Download or read book Evidence Based Practice of Critical Care E book written by Clifford S. Deutschman and published by Elsevier Health Sciences. This book was released on 2010-06-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Practice of Critical Care, edited by Drs. Clifford S. Deutschman and Patrick J. Neligan, provides objective data and expert guidance to help answer the most important questions challenging ICU physicians today. It discusses the clinical options, examines the relevant research, and presents expert recommendations on everything from acute organ failure to prevention issues. An outstanding source for "best practices" in critical care medicine, this book is a valuable framework for translating evidence into practice. Gain valuable evidence-based recommendations on key topics such as acute organ failure, infection, sepsis and inflammation, and prevention issues pointing the way to the most effective approaches. Get an overview of each question, an outline of management options, a review of the relevant evidence, areas of uncertainty, existing management guidelines, and authors’ recommendations. Navigate a full range of challenges from routine care to complicated and special situations. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches.
Download or read book III Nitride Ultraviolet Emitters written by Michael Kneissl and published by Springer. This book was released on 2015-11-12 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the state-of-the-art in group III-nitride based ultraviolet LED and laser technologies, covering different substrate approaches, a review of optical, electronic and structural properties of InAlGaN materials as well as various optoelectronic components. In addition, the book gives an overview of a number of key application areas for UV emitters and detectors, including water purification, phototherapy, sensing, and UV curing. The book is written for researchers and graduate level students in the area of semiconductor materials, optoelectronics and devices as well as developers and engineers in the various application fields of UV emitters and detectors.
Download or read book Go de Rass to Sleep A Jamaican translation written by Adam Mansbach and published by Akashic Books. This book was released on 2014-05-19 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Named one of the 20 Greatest New Father's Day Gifts by Advocate.com! "No matter what the country or the language, parents all over the world--loving, frustrated, exhausted parents--know what Adam Mansbach means. Since 2011, his comically obscene picture book has sold more than 1.5 million copies in dozens of languages from Afrikaans to Japanese to Nynorsk. And later this year, his little book will venture into new territory with a Jamaican patois translation: 'Go de R–s to Sleep.'" --The Washington Post/Style Blog "This version of Adam Mansbach's profane, affectionate, and radically honest book will remind whole new audiences about the absurdities of parenting. Just don't read it to the kids." --Advocate.com, The 20 Greatest New Father's Day Gifts Praise for Go the Fuck to Sleep: "A new Bible for weary parents." --New York Times "Incredibly appealing." --NPR "A parenting zeitgeist...A phenomenon that has stunned the publishing world and may just redefine the modern ‘parenting’ market." --Washington Post "Delightfully obscene." --Newsweek "Nothing has driven home a certain truth about my generation, which is approaching the apex of its childbearing years, quite like this deranged book." --New Yorker The best-selling Go the F*** to Sleep has been translated into over thirty languages worldwide. Now it is finally translated for Jamaican and other Caribbean parents of the world. Given how many West Indians live in the US and Canada, the market for this book should be broad, but focused mainly on areas with a large Caribbean community. Go de Rass to Sleep is a bedtime book for parents who live in the real world, where a few snoozing kitties and cutesy rhymes don’t always send a toddler sailing blissfully off to dreamland. Profane, affectionate, and radically honest, California Book Award–winning author Adam Mansbach's verses perfectly capture the familiar--and unspoken--tribulations of putting your little angel down for the night. In the process, they open up a conversation about parenting, granting us permission to admit our frustrations, and laugh at their absurdity. With illustrations by Ricardo Cortés, Go de Rass to Sleep is beautiful, subversive, and pants-wettingly funny--a book for parents new, old, and expectant. You probably should not read it to your children.
Download or read book Game Theory for Security and Risk Management written by Stefan Rass and published by Springer. This book was released on 2018-07-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume explore how various methods from game theory can be utilized to optimize security and risk-management strategies. Emphasizing the importance of connecting theory and practice, they detail the steps involved in selecting, adapting, and analyzing game-theoretic models in security engineering and provide case studies of successful implementations in different application domains. Practitioners who are not experts in game theory and are uncertain about incorporating it into their work will benefit from this resource, as well as researchers in applied mathematics and computer science interested in current developments and future directions. The first part of the book presents the theoretical basics, covering various different game-theoretic models related to and suitable for security engineering. The second part then shows how these models are adopted, implemented, and analyzed. Surveillance systems, interconnected networks, and power grids are among the different application areas discussed. Finally, in the third part, case studies from business and industry of successful applications of game-theoretic models are presented, and the range of applications discussed is expanded to include such areas as cloud computing, Internet of Things, and water utility networks.
Download or read book Regulators and Effectors of Small GTPases Ras Family written by and published by Elsevier. This book was released on 2006-06-07 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. - Includes a database for Ras family proteins and their effectors and regulators - Complimentary to volume 406 coverage of the Rho family - Over 150 international contributors
Download or read book Principles of Orthomolecularism written by R. A. S. Hemat and published by Urotext. This book was released on 2004 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ras Superfamily Small G Proteins Biology and Mechanisms 2 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-26 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Download or read book The ras Superfamily of GTPases 1993 written by Juan Carlos Lacal and published by CRC Press. This book was released on 2017-11-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.
Download or read book The Allan Schore Reader written by Eva Rass and published by Routledge. This book was released on 2017-11-10 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eva Rass, a leading expert on the work of Allan Schore, presents a collection that provides an overview of his core ideas and makes accessible the evolution of his thought. Including interviews and original papers, as well as integrating his ideas with research in psychoanalysis, developmental psychology, biology and developmental psychopathology, this book provides an in-depth introduction to Schore’s theories. Allan Schore: Setting the Course of Development represents a major contribution to the understanding of Schore’s often dense and complex work. The choice of papers, interviews and subject matter is structured and instructive, while the content captures both the depth and breadth of Schore’s ideas, including important extensions into other fields, like paediatrics, social works and family law. Schore’s contribution to the advancing knowledge base – pioneering the paradigm shift in researchers’ focus in psychopathogenesis from the cognitive verbal left brain to the affective, preverbal right brain – is here made accessible to a far greater readership. The book will be of interest to all practitioners, researchers, educators and policy makers dealing with the critically important and broad field of mental health service delivery and prevention of mental illness for those "at risk", particularly psychoanalysts, psychoanalytic psychotherapists and counsellors.
