Download or read book RAS Past Present and Future written by and published by Academic Press. This book was released on 2022-01-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. Overview of the history and development of efforts to pharmacologically inhibit RAS. Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Download or read book RAS Drug Discovery written by Adrian Gill and published by Elsevier. This book was released on 2024-10-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS.
Download or read book Renin Angiotensin System written by Anna Tolekova and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.
Download or read book Past Present Future written by Rachel Lynn Solomon and published by Simon and Schuster. This book was released on 2024-06-04 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rowan and Neil, in a committed long-distance relationship while attending different colleges in Boston and New York City, face the challenges of navigating the first months of college life and personal struggles as they strive to make their relationship last.
Download or read book India s Kathak Dance Past Present Future written by Reginald Massey and published by Abhinav Publications. This book was released on 1999 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: All The Major Dance Styles Of The Indian Subcontinent Share A Common Root System Of Ethical And Aesthetic Values. Hence No Single Style Can Claim To Be Purer Or Older Than Any Other. Kathak- The Style That Grew, Took Shape And Flourished In The Northern Regions Of The Subcontinent-Has Been Misunderstood And Misinterpreted On Account Of Ignorance And Prejudice From Various Quarters. This Book Sets Out, Therefore, To Rectify Incorrect Perceptions By Presenting Historical Facts And Placing Kathak Dance In Its Proper Cultural Context. The Background Of The Dance Is Explained In Detail; The Religious, Social And Political Influences Over The Centuries Are Recounted; Myth, Theory And Reality Are Expounded Upon; Current Trends Are Described And Future Possibilities Examine; And, Not Least, The Sheer Beauty Of Kathak Is Exposed To Both The Eye And The Intellect. This Book Provides Not Only Information On Technique And Training But Also Tells The Dance Lover What To Look For In A Typical Kathak Performance. It Will, Indeed, Assist The Reader Better To Appreciate And Understand A Great Dance Style. The Names And Addresses Of Recognised Dance Schools And Teachers, Both In India And Abroad, Will Prove Useful, As Will The Glossary And Bibliography. India S Kathak Dance: Past, Present, Future Is Essential Reading For All Those Who Wish To Be Acquainted With India S Immense Cultural And Artistic Achievements.
Download or read book RAS Family GTPases written by Channing Der and published by Springer. This book was released on 2006-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Download or read book Journal of the Ivernian Society written by and published by . This book was released on 1913 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Minimally Invasive Urology Past Present and Future An Issue of Urologic Clinics E Book written by John Denstedt and published by Elsevier Health Sciences. This book was released on 2021-11-17 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Urologic Clinics provides the urologist with important updates to better manage patients requiring minimally invasive procedures. Top experts in the field cover key topics such as Focal Therapy in Urology, Advances in Ureteroscopy, New Stent Technologies, and more. Provides in-depth, clinical reviews on minimally invasive urology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 12 relevant, practice-oriented topics including New Lasers for Kidney Stone Treatment; New Technologies for Treatment of BPH; Technology for 3D Printing and Simulation; Artificial Intelligence: Applications in Urology; Disposable Endoscopes in Urology: Current State and Future Prospects; and more.
Download or read book Past Present and Future Engineering in the Royal Navy written by and published by . This book was released on 1989 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Living Along Gradients Past Present Future written by Ulrich Bathmann and published by Frontiers Media SA. This book was released on 2020-02-24 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A French Grammar written by Antonin Roche and published by BoD – Books on Demand. This book was released on 2022-06-05 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reprint of the original, first published in 1869.
Download or read book Pancreatic Cancer written by Andrew M. Lowy and published by Springer Science & Business Media. This book was released on 2008-07-10 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.
Download or read book Radiation Injury Prevention and Mitigation in Humans written by Kedar Prasad and published by CRC Press. This book was released on 2012-03-13 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an estimated 3.3 billion ionizing radiation imaging examinations performed worldwide each year, the growing use of x-ray-based diagnostic procedures raises concerns about long-term health risks, especially cancer. In addition, rapid growth in the number of nuclear power plants around the world increases the risk of a nuclear accident similar t
Download or read book Seven Pillars of Servant Leadership written by James W. Sipe and published by Paulist Press. This book was released on 2015 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seven Pillars of Servant Leadership (Rev.) offers concrete, functional skills necessary to practice servant leadership—to lead by serving first.
Download or read book Sea Ice and Iceberg Sedimentation in the Ocean written by Alexander P. Lisitzin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book for researchers working on glacial sediments provides a complete overview of the various glacial deposits in the ocean. It presents a collection of worldwide data on glacio-marine phenomena.
Download or read book The Total Skywatcher s Manual written by Astronomical Society of the Pacific and published by WeldonOwn+ORM. This book was released on 2019-02-12 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Star charts, step-by-step projects, photos, and more: “The Total Skywatcher’s Manual is a fun book, but more importantly, it’s a useful book.” —Sky & Telescope With fully illustrated star charts, gorgeous astrophotography, and step-by-step project instruction, this is the only guide you need to navigate the night (and day) sky. Learn about the phases of the moon, how to conduct your own deep-sky observations, how the universe is expanding, our search for life on other planets, meteors vs. meteorites, sunspots and solar flares, best eclipse-viewing techniques—everything you need to know to appreciate the wonder of our universe. The Total Skywatcher’s Manual will help stargazers, comet-spotters, and planet-seekers: Choose the best telescope Identify constellations and objects in the night sky Search for extraterrestrial phenomena Plan star parties Capture beautiful space imagery and much more For well over a century, the Astronomical Society of the Pacific has provided resources, tools, and information to astronomy enthusiasts, including amateur astronomers, families, and science educators. Now they draw on their wide-ranging expertise to guide you through the skies.
Download or read book Rastaman Routledge Revivals written by E. Cashmore and published by Routledge. This book was released on 2013-10-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1979, this book makes a detailed study of Rastafarianism. It traces the expansion of Rastafarian culture from its origins and development in Jamaica through to the growth of Rastafarian life in Britain. It looks at Rastafarian culture in England in the late 1970s based on the author’s intimate experiences and communications with followers of the movement.
