Download or read book Free Radicals in Diagnostic Medicine written by Donald Armstrong and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry. The theme was "A Systems Approach To Laboratory Technology, Clinical Correlations And Antioxidant Therapy." The symposium was held on October 7-8, 1993 at the Hyatt Hotel and on October 9 at Roswell Park Cancer Institute, Buffalo, New York. This proceedings volume contains chapters from platform presentations, poster sessions and from invited special lectures in the areas of basic science, clinical applications and efficacy of treatment. A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan. The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than 5.0 and a diabetic person with vascular complications often exceeds 7.5 nmol/ml. Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions relative to the amount of lipid peroxidation. The BASIC SCIENCES portion of the program examined: "Mechanisms of Action, Pathophysiology and Laboratory Tests" in six presentations.
Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.
Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by Oxford University Press, USA. This book was released on 1989 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.
Download or read book Lipid Peroxides in Biology and Medicine written by Kunio Yagi and published by Elsevier. This book was released on 2012-12-02 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Peroxides in Biology and Medicine emphasizes the importance of the control of lipid peroxides in the body for the prevention and treatment of degenerative diseases. This book discusses the production of free radicals in vivo from the action of xenobiotics, and comparative aspects of several model lipid peroxidation systems. The lipid peroxidation and membrane alterations in erythrocyte survival, and lipid peroxidations of cholesterol are also deliberated. This text likewise covers the mechanism of protection against membrane peroxidation, lipid peroxides as a cause of vascular diseases, and peroxide-mediated metabolic activation of carcinogens. Other topics include lipid peroxide in aging process and production of ethane and pentane during lipid peroxidation. This publication is valuable to biologists, medical practitioners, and clinicians researching on lipid peroxides.
Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by Oxford University Press. This book was released on 2015 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Download or read book Radical Medicine written by Louisa L. Williams and published by Simon and Schuster. This book was released on 2011-07-12 with total page 1240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A “radical” approach to holistic healing that examines the root causes and cures for ailments such as Alzheimer’s disease, breast cancer, and heart attacks • Offers cutting-edge detoxification and draining therapies to address the tremendous chemical onslaught of modern life • Explains the profound health problems caused by dental amalgams, vaccinations, antibiotics, cosmetics With the historic use of toxic mercury amalgam fillings, excessive courses of antibiotics, damaging childhood vaccines, and the many industrial pollutants and chemicals that have been spread into our air, water, and food over the past century, general holistic health guidelines are simply no longer adequate for most people. Only through radical measures--that is, getting to the true root or underlying cause of disease--can effective healing occur. In Radical Medicine, naturopathic physician Louisa Williams describes how to treat these and other modern-day “obstacles to cure,” in order to ensure against future degenerative disease and achieve the optimal health that is our birthright. Examining the many health problems triggered by dental amalgams and poor dentistry, Dr. Williams explains that our teeth are focal points for health issues that arise elsewhere in the body. She explores the impact of vaccinations, the excessive use of antibiotics, and the chemical-laden products used as health and beauty aids--which are linked to Alzheimer’s disease, heart attacks, and breast and other cancers--and provides information on cutting-edge detoxification treatments as well as drainage and nutritional therapies. A practical guide for practitioners and patients alike, Radical Medicine offers a wealth of holistic, natural therapies for overcoming what is poisoning us and our world so we can achieve optimal health and well-being.
Download or read book Free Radicals in Human Health and Disease written by Vibha Rani and published by Springer. This book was released on 2014-11-14 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.
Download or read book Free Radical Medicine and Biology written by and published by BoD – Books on Demand. This book was released on 2020-07-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.
Download or read book Analysis of Free Radicals in Biological Systems written by A. Favier and published by Birkhäuser. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Oxidative stress" is used as the generic term describing the involve ment of reactive oxygen species in various human diseases. The scope of such a topic is becoming increasingly wide. The recent interest in radicals such as nitric oxide and the discovery of new mechanisms such as the effect of free radicals on redox sensitive proteins and genes are enlarging our understanding of the physiological role of free radicals. Oxidative stress is involved in numerous pathological. processes such as ageing, respiratory or cardiovascular diseases, cancer, neurological pathologies such as dementia or Parkinson's disease. It still remains difficult, however, to demonstrate by chemical measurement the in vivo production of free radicals and even more to realise their speciation. Therefore, the development of new tools and indicators is engrossing many researchers working in this field. Reliable indicators are abso lutely necessary not only to monitor the evolution of oxidative stress in patients but also to evaluate the efficiency of new antioxidant treat ments. The French Free radical club of Grenoble, the CERLIB has been involved for many years in the organisation of international training programs on methodology, in order to provide both theoretical and practical help to researchers from various countries. Such training sessions have been highly successful and participants value the oppor tunity to learn reliable techniques. This positive echo explains why the researchers of CERLIB decided, with the help of Prof. Dr. B. Kalyanaraman, to publish selected techniques on free radical re search.
Download or read book Free Radicals and Diseases written by Rizwan Ahmad and published by BoD – Books on Demand. This book was released on 2016-10-26 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.
Download or read book Essentials of Free Radical Biology and Medicine written by Robert Z. Hopkins and published by . This book was released on 2017-03-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in an accessible style and consistent format, "Essentials of Free Radical Biology and Medicine" takes a unique approach to integrating the fundamental principles with high quality cutting-edge research discoveries, and the basic bioscience with clinical medicine so as to provide the reader a comprehensive picture of the field in a concise manner. The book (i) blends basic and clinical sciences needed to effectively demonstrate the importance of the field; (ii) includes full-color illustrations to facilitate the understanding of the essential concepts; (iii) cites references mostly from highly influential journals to ensure the top quality of the information; (iv) uses self-assessment questions and glossary to enhance the assimilation of the cutting-edge knowledge; and (v) serves as a valuable reference or textbook for students, faculty, and other professionals in the fields of biology, pharmaceutical science, biomedical science, and clinical medicine.
Download or read book Free Radicals in Medicine written by Radu Olinescu and published by Nova Publishers. This book was released on 2002 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of reactive oxygen species and other free radicals in normal and disease processes has become a major area of interest in the medical scientific community. In the past 30 years, this area of study has advanced from outright rejection, to general acceptance, to intense study. While there is still some dispute as to the exact role of these highly reactive molecules in pathology, it is clear that they are present in and influence many biological processes. This book provides an overview of the possible biological effects of reactive oxygen species and other free radicals with an emphasis on pathology. The various types of free radicals that may affect the body are discussed along with the potential sources of free radicals, both internal and external to the body. The extensive defenses the body raises against the effects of these molecules in the form of enzymatic and non-enzymatic antioxidants is reviewed. A variety of conditions in which free radicals have been proposed to play a role are discussed. These include the physiological effects of oxygen stress in aging, exercise, and pregnancy. Pathologic conditions discussed include cancer, liver cirrhosis, respiratory problems, and others.
Download or read book Free Radicals in Biology and Medicine written by Okezie I. Aruoma and published by IOS Press. This book was released on 2006-10 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the pivotal roles of reactive oxygen and nitrogen species (ROS and RNS) in the pathogenesis of many clinical conditions (together with their involvement in the ageing process of lower (yeast) cells, and higher organisms including plants). This book also discusses the potential applications of dietary-derived antioxidants.
Download or read book Free Radical Reactions in Medicine written by Janos Feher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a concise review of the medical aspects of free radical reactions. Until now, there have been extensive reviews of the subject in a physiological, pathophysiological and biochemical context. Here, however, the authors concentrate on the biology of free radical reactions as relevant to medical practice, emphasizing that the topic is not just a branch of basic science. Consequently, a short introduction on chemical and biological aspects is followed by a detailed discussion of the role played by free radical reactions in the pathogenesis and development of several human diseases and in therapeutic possibilities. The summary of data from the literature is supplemented by the authors' own experimental results. The presentation will help medical researchers to notice so far unknown connections among several diseases and to make them aware of the existance of the so-called "free radical diseases".
Download or read book Oxidative Stress and Antioxidant Protection written by Donald Armstrong and published by John Wiley & Sons. This book was released on 2016-01-14 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
Download or read book Oxidative Stress and Free Radical Damage in Neurology written by Natan Gadoth and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
Download or read book Free Radicals from Basic Science to Medicine written by POLI and published by Birkhäuser. This book was released on 2013-03-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.
