Download or read book Quinazolinone and Quinazoline Derivatives written by Ali Gamal Al-kaf and published by BoD – Books on Demand. This book was released on 2020-05-06 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the problems with modern public health is target searching for new highly effective medicinal preparations. Among those medicinal preparations are the natural and synthetic origins of quinazolinone-4 derivatives. Quinazolinone derivatives are reported to be physiologically and pharmacologically active. They also exhibit a wide range of activities such as anticonvulsant, antiinflammatory, antifungal, antimalarial, and sedative properties. Some of these compounds are identified as drugs used as diuretics, vasodilators, and antihypertensive agents. Moreover, sulfonamide derivatives have been widely used as bacteriostatic agents. Prompted by the above-mentioned facts and in conjunction with our ongoing program on the utility of readily obtainable starting material for the synthesis of heterocyclic systems of biological interest, we have decided to synthesize a series of quinazolinone derivatives having sulfonamide moiety with a potentially wide spectrum of biological responses.

Download or read book Recent Advances on Quinazoline written by Ali Gamal Al-Kaf and published by BoD – Books on Demand. This book was released on 2024-03-20 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates and identifies novel therapeutic compounds for the treatment of a range of illnesses. Heterocyclic compounds are a significant class of substances with biological activity. Among them, quinazoline has attracted a lot of interest because of its important biological properties. Numerous compounds with quinazoline moiety have been shown to exhibit a wide range of therapeutic properties, including antioxidant, antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, and antibacterial activities. This book presents a comprehensive overview of quinazoline and its derivatives. The chapters address recent advances in the synthesis of several different heterocyclic compounds, the use of computational studies for finding new active quinazoline derivatives, the biological activities of quinazoline, and much more.

Download or read book Metal and Nonmetal Assisted Synthesis of Six Membered Heterocycles written by Navjeet Kaur and published by Elsevier. This book was released on 2020-04-25 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. - Highlights new methodologies for the synthesis of different six-membered heterocycles - Provides an up-to-date overview of this fast-moving field with an easy-to-use structure - Includes novel approaches used in the study and application of catalysts in synthetic organic reactions

Download or read book Alkaloids written by S. William Pelletier and published by . This book was released on 1983 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quinazolines Volume 55 Supplement 1 written by Desmond J. Brown and published by John Wiley & Sons. This book was released on 2009-09-17 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: This supplement reflects and emphasizes current research trends. Due to the vast increase in the number and types of individual quinazolines described in recent literature, the author has replaced the myriad classified tables of known quinazolines with a single alphabetical table of simple known quinazolines. To facilitate recovery of any earlier data from the tables in the original volume, a cross-reference has been added (when appropriate) to each individual entry in the new table. Contains an extensive chapter on primary syntheses.

Download or read book Green Synthetic Approaches for Biologically Relevant Heterocycles written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-02-26 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Download or read book Metalation of Azines and Diazines written by Michael Schnürch and published by Springer. This book was released on 2013-08-19 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactions of Pyridines, Benzopyridines and Azapyridines with Organomagnesiums and Organolithiums, by Manfred Schlosser Lithiations and Magnesiations on Quinoline and Isoquinoline, by Floris Chevallier, Florence Mongin Metalation Reactions of Pyridines, Quinolines, and Isoquinolines with Ate Bases and Their Alkali Metal Salt-Modified Congeners, by Costa Metallinos, Kathryn Stromski Lithiations and Grignard Reactions on Pyrimidine and Quinazoline, by Andrej Kolarovic Other Stoichiometric Metalation Reactions on Pyrimidine and Quinazoline, by Philippe C. Gros Metalation of Pyrazine and Quinoxaline, by Nelly Plé1, Corinne Fruit Metalation of Pyridazine, Cinnoline, and Phtalazine, by Ernst Horkel

Download or read book Further Investigations in the Quinazoline Group written by Harvey Ambrose Seil and published by . This book was released on 1906 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Copper in N Heterocyclic Chemistry written by Ananya Srivastava and published by Elsevier. This book was released on 2020-11-13 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. - Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds - Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals - Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail

Download or read book Recent Highlights in the Discovery and Optimization of Crop Protection Products written by Peter Maienfisch and published by Academic Press. This book was released on 2021-03-24 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field. - Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection - Provides real-world perspectives on pesticide and disease control progress - Presents scientific developments from an international array of contributing authors

Download or read book Key Heterocyclic Cores for Smart Anticancer Drug Design Part II written by Rajesh Kumar Singh and published by Bentham Science Publishers. This book was released on 2022-09-02 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents

Download or read book Organofluorine Compounds in Biology and Medicine written by V Prakash Reddy and published by Newnes. This book was released on 2015-01-25 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. - Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds - Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways - Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

Download or read book Advances in Heterocyclic Chemistry written by and published by Academic Press. This book was released on 2019-03-19 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive, updated release includes chapters on Metal-Catalyzed Direct Arylation of 1,2-Azoles, The Literature of Heterocyclic Chemistry, Part XVII, 2017, Pyrrolo-, Imidazoquinolines and Pyrroloquinazolines with a Bridgehead Nitrogen, Synthesis and Reactions of Arsole, Stibole, and Bismole, Advances in Synthesis and Chemistry of Aziridines, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Download or read book Frontiers in Chemistry Editor s Pick 2022 written by Frontiers in Chemistry Editorial Office and published by Frontiers Media SA. This book was released on 2022-09-06 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to introduce the 2022 Frontiers in Chemistry: Editor’s Pick collection, showcasing articles stimulating interest in the field, carefully selected in collaboration with our Field Chief Editor, Prof. Steven Suib, of University of Connecticut. With this ebook we aim to highlight and disseminate important findings across the domains of chemistry research, capturing the multidisciplinary and inclusive approach our journal takes towards advancing the field of chemistry and supporting new technological breakthroughs that help humanity live healthier lives on a healthy planet. 2021 was a year which saw our highest journal impact factor yet, international community growth, and a record-breaking number of articles to choose from. We wish to elevate the contributions made by authors, encourage readership and innovation through our open-access philosophies, and thank our Editorial Board for their continued hard work and collaboration.

Download or read book Natural Poisons and Venoms written by Eberhard Teuscher and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-11-18 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs. Numerous images of plants and chemical structural formulas complete the book, as well as extensive references for further reading. The multivolume reference is an essential resource for physicians, veterinarians, pharmacists, chemists, biochemists, food chemists and biologists, for students in the relevant fields, and maybe for interested laymen. All aspects of natural toxins based on the latest scientific knowledge are included: All aspects of the toxicology of all living organisms and natural foods, chemistry, action mechanisms, symptoms of intoxications. The only book arranged on a strictly scientific base according to the biogenetic origin and chemical structure. Natural Poisons and Venoms in 5 Volumes: Volume 1: Plant Toxins: Terpenes and Steroids 2023, ISBN 978-3-11-072472-1 Volume 2: Plant Toxins: Polyketides, Phenylpropanoids and Further Compounds 2024, ISBN 978-3-11-072851-4 Volume 4: Animal Toxins 2023, ISBN 978-3-11-072854-5 Volume 5: Fungal and Microbial Toxins 2025, ISBN 978-3-11-072856-9

Download or read book Green Chemistry Synthesis of Bioactive Heterocycles written by K. L. Ameta and published by Springer. This book was released on 2014-06-17 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.

Download or read book Comparative Qsar written by James Devillers and published by CRC Press. This book was released on 1998-03-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the 21st century approaches, there is little doubt that the tools and resources are available to unlock all the secrets of Quantitative Structure-Activity Relationships (QSAR) in order to design more efficient drugs and safer chemicals. The comparison QSAR models provide are a key to reach a deep understanding of the foundation and a better optimisation of the use of these statistical tools. Seeking out the similarities and differences among QSAR Models allows the user to estimate their simulation performances, find chemo-taxonomical links, and uncover In vivo/In Vitro relationships. The purpose of this book is to highlight the multifaceted aspect of the term "comparative QSAR" by bringing together QSAR experts of various origins and allowing them to offer their views on this diverse subject.