Download or read book Power and Powerlessness written by John Gaventa and published by University of Illinois Press. This book was released on 1982 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains to outsiders the conflicts between the financial interests of the coal and land companies and the moral rights of the vulnerable mountaineers.

Download or read book Tumor Dormancy Quiescence and Senescence Volume 1 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.

Download or read book Tumor Dormancy Quiescence and Senescence Volume 2 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Download or read book Tumor Dormancy Quiescence and Senescence Vol 3 written by M.A. Hayat and published by Springer. This book was released on 2014-09-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Download or read book Cellular Quiescence written by H. Daniel Lacorazza and published by Humana Press. This book was released on 2017-10-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.

Download or read book Towards Quiescence and Immortality written by Barenya K. Banerji and published by . This book was released on 1981 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book American Journal of Physiology written by and published by . This book was released on 1926 with total page 1468 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Politics as Symbolic Action written by Murray Edelman and published by Elsevier. This book was released on 2013-09-03 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Politics as Symbolic Action: Mass Arousal and Quiescence deals with the dynamics of development of political threats related to political behavior. The book discusses the conditions under which the dynamics related to political behavior are the prior causes of political arousal, violence, and quiescence. The text examines the influence of governmental activity on people's beliefs and perceptions—how non-empirical cognitions become the resistant basis of change. The text also examines how the individual phenomenon and the group phenomenon become linked through symbol formation and myths. The book discusses emotion as a catalyst of political ritual and political violence as inferred from Theodore Sarbin's role theory. The use of metaphors, language forms, and mass tensions can all be social-psychological and political processes that can lead to political arousal or quiescence. The book also explains major violent disturbances as having patterns reflective of organization, disorganization, or by leadership example; the book notes the popular notion that the organization or the leader's direction starts or worsens the violence as very simplistic. The book then proposes that political perceptions and beliefs are changeable and that phenomenological perceptions of specific groups of people can identify which political behavior are systematic. The text is suitable for political analysts, political scientists, sociologists, and educators involved in group psychology and analyses.

Download or read book Reneging Quiescence written by Samiha Zubair and published by Createspace Independent Publishing Platform. This book was released on 2017-01-08 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: My book Reneging Quiescence, is a poke to the heart, a brushing up of memories piled under dust in a morgue of shed chronicles. The book is a reminder that sometimes conspiracy to silence makes us allies and victim to the sequelae of wrong deeds.

Download or read book Sleep Evolution and Functions written by Vibha M. Jha and published by Springer Nature. This book was released on 2020-10-31 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the evolution of sleep and its possible function in the higher invertebrates and vertebrates, including humans. It describes the current concept of sleep and its functions, based on research on the mammalian system. To date, electrophysiological recordings of the brain waves, muscle activity, and eye movements are the only tools available for characterizing the sleep architecture in the majority of animals. In mammals and birds, only two distinct types of sleep are found – non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Since the discovery of REM sleep, studies have been performed to understand the purpose of the two distinct sleep states in higher vertebrates (birds and mammals), and how REM sleep was evolved. The book summarizes the role of both REM and NREM sleep in the proper functioning of the brain and body. It covers various aspects of the role of sleep in important physiological processes, including memory consolidation, induction of synaptic plasticity, energy restoration, enhancing immune response, and maturation of neuronal circuitries during early life. Lastly, the book reviews the effects of chronic/acute sleep deprivation on memory consolidation, obesity, and the immune system in animal models and humans.

Download or read book A New English Dictionary on Historical Principles written by James Augustus Henry Murray and published by . This book was released on 1910 with total page 1030 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The spatiotemporal dynamics of longevity defining cellular processes and its modulation by genetic dietary and pharmacological anti aging interventions written by Vladimir I. Titorenko and published by Frontiers E-books. This book was released on with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging of multicellular and unicellular eukaryotic organisms is a highly complex biological phenomenon that affects a plethora of processes within cells. This wide array of longevity-defining cellular processes - which are governed by an evolutionarily conserved signaling network - includes oxidative metabolism and protein synthesis in mitochondria, lipid and carbohydrate metabolism, NAD+ homeostasis, amino acid biosynthesis and degradation, ammonium and amino acid uptake, ribosome biogenesis and translation, proteasomal protein degradation, nuclear DNA replication, chromatin assembly and maintenance, actin organization, apoptosis, necrosis, autophagy, protein folding, stress response, signal transduction, cell cycle, and cell growth. The focus of this Frontiers Special Topic Issue is on an important conceptual advance in our understanding of how cells integrate and control these numerous processes and how genetic, dietary and pharmacological anti-aging interventions extend longevity by altering their functional states and spatiotemporal dynamics. The Issue will highlight the various strategies used by evolutionarily diverse organisms for coordinating these longevity-defining cellular processes in space and time, critically evaluate the molecular and cellular mechanisms underlying such coordination, and outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field.

Download or read book The Relics of Illayan written by Kathryn Knowles and published by Mad Endeavour. This book was released on 2021-11-16 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The engrossing, action-packed first book in an epic fantasy adventure trilogy full of complex, morally-grey characters, mysterious magic, and romance. In the stillness, a power wakes Caerlon is a kingdom where the power of Resonance has long been bound to a single bloodline, a single all-powerful ruler. Now, for the first time in centuries, the magic has been divided. On the night of the new king’s coronation, something causes his magic to fracture, and Catanya, a young woman living on the outskirts of Caerlon discovers the long-kept secret of her connection to the throne. Driven mad by his lust for power, King Cadyan sends his soldiers to hunt her down. He is determined to reclaim his birthright and uncover the truth about the legendary Relics of Illayan, which could hold the key to eternal power and immortality. On the run, terrified and alone, Catanya must decide how—or even if—she can wield the magic of Caerlon to protect herself and save everyone she loves. The Relics of Illayan is the first book in The Quiescence Trilogy: an action-packed high fantasy series that draws you into its lush world of warring kingdoms, secrets, and ancient legends, as two passionate but flawed young women navigate dangerous magic, fiery romance, and political treachery to determine the fate of humanity and save the ones they love most. What readers are saying: ★ ★ ★ ★ ★ “Witty, bloody, and page turning drama make up book one! And I can't wait to snag hardcovers of books 2 & 3 when I can!” ★ ★ ★ ★ ★ “I loved this! The world building of Caerlon draws you in from the very beginning and once I picked this up I found myself lost to this world. It’s well written with incredible characters.” ★ ★ ★ ★ ★ “Reading this book made me realize how much I miss reading!” ★ ★ ★ ★ ★ “This book was a ride from start to finish...The plot really draws you in, and you can't help but keep reading, even through the dark parts.” ★ ★ ★ ★ ★ I had a lot of fun reading this book and I’m looking forward to the next one!” ★ ★ ★ ★ ★ "Loved it! The first book in what could be a new favorite fantasy trilogy for me." Note: This book contains mature content and scenes of violence which could be triggering to some readers. Reader discretion is advised.

Download or read book Report of the and Meetings of the British Association for the Advancement of Science written by British Association for the Advancement of Science. Meeting and published by . This book was released on 1912 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Report of the Meeting of the British Association for the Advancement of Science written by British Association for the Advancement of Science. Meeting and published by . This book was released on 1912 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The American Shropshire Sheep Record written by Mortimer Levering and published by . This book was released on 1919 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes constitution, rules and breeders of the Association.

Download or read book Formal Approaches to Software Testing written by Jens Grabowski and published by Springer Science & Business Media. This book was released on 2005-03-07 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing often accounts for more than 50% of the required e?ort during system development.Thechallengeforresearchistoreducethesecostsbyprovidingnew methods for the speci?cation and generation of high-quality tests. Experience has shown that the use of formal methods in testing represents a very important means for improving the testing process. Formal methods allow for the analysis andinterpretationofmodelsinarigorousandprecisemathematicalmanner.The use of formal methods is not restricted to system models only. Test models may alsobeexamined.Analyzingsystemmodelsprovidesthepossibilityofgenerating complete test suites in a systematic and possibly automated manner whereas examining test models allows for the detection of design errors in test suites and their optimization with respect to readability or compilation and execution time. Due to the numerous possibilities for their application, formal methods have become more and more popular in recent years. The Formal Approaches in Software Testing (FATES) workshop series also bene?ts from the growing popularity of formal methods. After the workshops in Aalborg (Denmark, 2001), Brno (Czech Republic, 2002) and Montr ́ eal (Canada, 2003), FATES 2004 in Linz (Austria) was the fourth workshop of this series. Similar to the workshop in 2003, FATES 2004 was organized in a?liation with the IEEE/ACM Conference on Automated Software Engineering (ASE 2004). FATES 2004 received 41 submissions. Each submission was reviewed by at least three independent reviewers from the Program Committee with the help of some additional reviewers. Based on their evaluations, 14 full papers and one wo- in-progress paper from 11 di?erent countries were selected for presentation.