Download or read book Quantitative Functional Brain Imaging with Positron Emission Tomography and Irreversible Tracers written by Mattia Veronese and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Functional Brain Imaging with Positron Emission Tomography written by Richard E. Carson and published by Elsevier. This book was released on 1998-09-08 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. Authored by international authorities in PET Provides the latest up-to-date techniques and applications Covers all fundamental disciplines of PET in one volume A comprehensive resource for students, clinicians, and new PET researchers

Download or read book Quantification of Brain Function Using PET written by and published by Elsevier. This book was released on 1996-07-17 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions. Covers the PET imaging process from tracer selection to analysis and interpretation Contains 79 concise reports with abundant illustrations The definitive state-of-the-art book for functional neuroscience with PET

Download or read book Physiological Imaging of the Brain with PET written by Albert Gjedde and published by Academic Press. This book was released on 2001 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain. Key Features * Provides the latest techniques and applications of positron emission tomography (PET) * Covers all fundamental disciplines of PET in one volume * Serves as a comprehensive resource for students, clinicians and new researchers

Download or read book Brain Imaging Using PET written by Michio Senda and published by Gulf Professional Publishing. This book was released on 2002 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses PET technique and instrumentation, as well as developments in a range of fields such as kinetics, enzyme/neurotransmitter transport, language acquisition, and neuropathology. This title offers an analysis of brain imaging and techniques, from the foundations to the practical applications of the modern techniques used in PET.

Download or read book Development of Novel Computational Algorithms for Quantitative Voxel wise Functional Brain Imaging with Positron Emission Tomography written by Gaia Rizzo and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Cerebral SPECT and PET Imaging written by Ronald L. Van Heertum and published by Lippincott Williams & Wilkins. This book was released on 2013-04-09 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Fourth Edition reflects the significant recent progress that has occurred in functional brain imaging, particularly the increased use of PET/SPECT, the use of SPECT and PET in movement disorders and dementia, and advances in radiopharmaceutical development and instrumentation. Chapter topics include PET physics and instrumentation, PET radiopharmaceuticals, SPECT radiopharmaceuticals, and technical factors. The entire book has been thoroughly revised to reflect an appropriate balance between SPECT and PET applications. Highlights of this edition include a new chapter on neuroreceptor imaging and kinetic modeling, a new chapter on brain imaging in movement disorders, and significant updates on SPECT radiopharmaceuticals.

Download or read book Functional Brain Imaging written by William W. Orrison and published by Elsevier Health Sciences. This book was released on 2017-02-24 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Brain Imaging

Download or read book Brain Imaging in Behavioral Neuroscience written by Cameron S. Carter and published by Springer Science & Business Media. This book was released on 2011-11-04 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.

Download or read book PET CT and PET MRI in Neurology written by Andrea Ciarmiello and published by Springer. This book was released on 2016-05-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using SWOT analysis, this book examines in detail the strengths and weaknesses of the hybrid modalities PET-CT and PET-MRI for imaging of the central nervous system, comparing their merits and evaluating their advantages over the stand-alone modalities. The aim is to employ a truly systematic approach in order to define the potential clinical benefit of these modalities and to identify shortcomings, opportunities, and threats. Clinical application of the modalities is explored in a range of conditions, including dementia and related disorders, movement disorders, psychiatric disorders, cerebrovascular disease, infection/inflammation, brain tumors, and pediatric neurologic disorders. In addition, the basics of hybrid imaging are addressed, covering physics, instrumentation, data analysis and quantitation, radiopharmaceuticals, and contrast media. PET-CT and PET-MRI in Neurology, written by experts from Europe and the United States, will be essential reading for imaging specialists and of value for neurologists, psychiatrists, neurosurgeons, and pediatricians.

Download or read book Fundamentals of Functional Brain Imaging written by Andrew C. Papanicolaou and published by CRC Press. This book was released on 1998-01-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This generously illustrated guide to functional imaging responds to the needs of non-specialists, professionals and students of psychology, cognitive neuroscience, psychiatry, behavioral neurology, and epistemology. It enables them to understand the basic principles of the highly specialized and constantly evolving imaging technologies and to assess for themselves the contribution of these technologies to their respective fields. Fundamentals of Functional Brain Imaging will be useful for practitioners and advanced students in psychology, cognitive neuroscience, and neuropsychology, residents in psychiatry and neurology, as well as the interested general public.

Download or read book Brain Imaging with Positron Emission Tomography written by Mirwais Wardak and published by . This book was released on 2013 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a unique and powerful imaging technique that is used to visualize and quantify various biological processes in living subjects in health and disease. PET imaging can also provide biological information for the assessment of therapies. In this dissertation, we will cover three projects that utilize the quantitative capability of PET for studying two neurological disorders: Alzheimer's disease and brain tumors. One of the goals in PET imaging is to produce an image volume that accurately describes the true distribution of the injected radioactivity. The correction factor that has the most significant impact on the quantitative aspects of a PET image is attenuation correction. Without it, the reconstructed images will give a distorted view of the true activity distribution. Head movement during a PET scan (especially a dynamic scan) can also lead to a loss in the information content contained in a PET image. This is especially true when scanning patients with dementia or movement disorders. The transmission scan, which is typically acquired at the start of a PET study, corrects for photon attenuation in each of the serial emission scans that are acquired afterwards. In the first project of this dissertation, we developed a retrospective image-based movement correction (MC) method and evaluated its implementation on dynamic 18F-FDDNP PET images of cognitively intact control subjects and patients with Alzheimer's disease (AD), each with varying degrees of head movement. 18F-FDDNP is a PET probe that binds to beta-amyloid plaques and neurofibrillary tangles, the neuropathological hallmarks of AD. The MC method corrected for transmission-emission misalignments as well as for emission-emission misalignments that might have been present in the dynamic PET scan. The image quality, tracer kinetics, and diagnostic accuracy of the 18F-FDDNP PET images were significantly improved after applying the MC method. In the second project of this dissertation, we investigated whether changes in 18F-FLT kinetic parameters, taken early after the start of therapy, could predict overall survival and progression-free survival in patients with recurrent malignant glioma undergoing treatment with bevacizumab (an angiogenesis inhibitor) and irinotecan (a chemotherapeutic agent). 18F-FLT is a radiotracer used in PET to measure cellular proliferation. We found that when a group of optimal kinetic parameter changes are incorporated into a linear discriminant function, one could accurately classify patients into their known survival groups. This method is advantageous because by reliably identifying short- and long-term survivors early during therapy, clinicians can discontinue ineffective treatment strategies and switch to more advanced treatment regimens that could improve patient outcome. Our third project expanded on what we did in our second project in that we acquired longitudinal 18F-FDOPA PET scans in addition to 18F-FLT PET scans. We also tried to predict overall survival as a continuous outcome variable using multiple linear regression (as opposed to a dichotomous categorical variable with discriminant analysis from before). In brain tumors, 18F-FDOPA is used to image amino acid transport. We found that in patients with recurrent malignant glioma, kinetic information from 18F-FLT alone was more predictive than using information from 18F-FDOPA alone. Using both probes combined provided comparable results to using 18F-FLT alone, suggesting that a single tracer may provide sufficient information for predicting OS with reasonable accuracy. The studies reported in this dissertation have demonstrated in three examples that the utility of kinetic quantification can significantly improve the value of PET for imaging biological functions in brain tissues in vivo. The developed methodologies in these examples are also expected to be useful in other quantitative brain PET imaging studies & ndash; for other applications or using other tracers.

Download or read book Optical Imaging of Brain Function and Metabolism 2 written by Arno Villringer and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re sults obtained with optical methods and other functional techniques the latest in our under standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.

Download or read book Imaging of the Brain in Psychiatry and Related Fields written by Konrad Maurer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last two decades imaging of the brain, or neuroimaging, has become an integral part of clinical and research psychiatry. This is due to recent advances in computer technology, which has made it relatively easy to generate brain images representing structure and function of the central nervous system. Currently used clinical diagnostic imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) , provide predominantly anatomic information. CT images reflect X-ray attenuation distribution within the brain, whereas MRI signals depend primarily on proton sensitivity and tissue relaxivity. The chapter "Structural Imaging Methods" reviews CT and MRI studies on schizophrenic and affective disorders and degenera tive central nervous system diseases. The impact of fast three dimensional (3-0) imaging and the automatic transfer from 3-D elements in the brain to artificial diagrams based on this information is considered. Since the original report of the findings of Ingvar and Franzen in 1974 and the introduction of regional cerebral blood flow (rCBF) measurements, single photon emission computed tomography (SPECT) has been gaining acceptance as one of the major imaging techniques, and it is available in most nuclear medicine depart ments. The section "Functional Imaging Methods (Cerebral Blood Flow - CBF, Single Photon Emission Computerized Tomography - SPECT)" describes rCBF studies with the 133Xe inhalation method utilizing a 254 detector system and rCBF images measured by SPECT using the tracer 99mTc-HMPAO.

Download or read book SPECT Imaging of the Brain written by R. Duncan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the developed world, images of brain structure are available as an everyday diagnostic aid, and the characteristic appearances of most pathological conditions can be looked up in a textbook. Functional brain imaging is to this day less widely used, partly because most pressing diagnostic questions can be answered by refer ence to the patient's cerebral anatomy, partly for reasons of technical limitations of functional techniques. PET as a technique is sufficiently resource-demanding and complex to inhibit its use as an everyday diagnostic technique. SPECT lacked suitable tracers for many years, and early systems had poor spatial resolution. However, rotating gamma camera technology has advanced to the point where images of the brain of reasonable quality can be obtained at most large hospitals, and practical tracers, particularly of regional cerebral blood flow, are easily avail able. As research advances, clinical applications are emerging. A recent report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology! details a number of currently recognised clinical appli cations, some of which are dealt with in this book. Given this recognition, it is increasingly important that clinicians (particularly neuroclinicians, psychiatrists and specialists in cerebrovascular disease), nuclear medicine specialists and physicists acquire an idea of the major applications of the technique, and the research background on which these applications are based.

Download or read book Functional Imaging in Movement Disorders written by W. R. Wayne Martin and published by CRC Press. This book was released on 2019-08-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.

Download or read book Exploring Brain Functional Anatomy with Positron Tomography written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the application of positron emission tomography (PET) to the mapping of human cerebral cortical function. Coverage includes all aspects of PET technology. Includes chapters on somatosensory, motor and visual systems, and higher-order processes such as attention, memory, learning, intention and language. The clinical usefulness of PET is discussed in relation to psychiatric illness and to functional recovery after brain injury.