Download or read book Quantitative Approaches to Drug Design written by Avon) European Symposium on Chemical Structure-Biological Activity: Quantitative Approaches (4th : 1982 : Bath and published by . This book was released on 1983 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative approaches to drug design proceedings of the Fourth European Symposium on Chemical Structure Biological Activity Quantitative Approaches Bath U K September 6 9 1982 written by John C. Dearden, 1935- and published by . This book was released on 1983 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Approaches to Drug Design written by John C. Dearden and published by Elsevier Publishing Company. This book was released on 1983 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Theoretical Drug Design Methods written by Rainer Franke and published by Elsevier Publishing Company. This book was released on 1984 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book QSAR in Drug Design and Toxicology written by Dušan Hadži and published by Elsevier Publishing Company. This book was released on 1987 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Design Strategies written by David J. Livingstone and published by Royal Society of Chemistry. This book was released on 2012 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of.
Download or read book QSAR Rational Approaches to the Design of Bioactive Compounds written by C. Silipo and published by Elsevier Publishing Company. This book was released on 1991 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative structure-activity relationships constitute a subject which has seen enormous growth in the past decade. Techniques which have been developed and used widely outside of medicinal chemistry are now used by those working with QSAR. These techniques employ powerful computers, molecular graphics systems and sophisticated software. Although QSAR techniques have been developed to optimize activities of known sets of analogs, recent methodologies suggest that these techniques can be useful in the modeling of new chemical entities. The contributions in this state-of-the-art volume cover a wide range of disciplines, tools and ideas which will be of interest to medicinal chemists, pharmacologists and biologists. The book gives an update of progress in the science of the quantitative approaches of the interface between chemistry, physical chemistry and biology-pharmacology. The use of molecular graphics, computational and conformational methods in drug research is extensively covered.
Download or read book QSAR in Environmental Toxicology written by K.L. Kaiser and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since Rachel Carson's Silent Spring, we have generally become aware of environmental contaminants and their effects on the ecosystem. The findin~ of PCB's in fish by Soren Jensen in Sweden, the recognition of mirex as contaminant in fish from Lake Ontario, and the discoveries of contaminant laden leachates from dumpsites such as the Love Canal have become milestones in the search for and charac terization of contaminants in our environment. At this time, the problem no longer is so much the identifi cation of contaminants and their sources. Rather, we are now faced with solving questions on the fates and effects of such compounds. This includes the search for mechanisms to deal effectively with the large number of chemicals already found in water, air and biota. One of such time and cost saving scientific avenues is the field of quantitative structure-activity correlations for the prediction of the environmental behavior and effects of compounds.
Download or read book Innovative Approaches in Drug Research written by A. F. Harms and published by Elsevier Publishing Company. This book was released on 1986 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Water the Environment written by Rose and published by CRC Press. This book was released on 2017-12-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compilation of papers provides useful insights on the differing approaches to water quality and the diversity of strategies in water quality management worldwide. Considering the current situation and looking to the future, the aim of this publication is to provide a sensible addition to the literature by concentrating on several important aspects of water and the environment.
Download or read book Design of Anti AIDS Drugs written by Erik De Clercq and published by Elsevier Publishing Company. This book was released on 1990 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are several steps in the replicative cycle of human immunodeficiency virus (HIV) that could be considered as adequate targets for chemotherapeutic intervention, e.g., virus attachment to the cells, virus penetration and uncoating, transcription of the viral (RNA) genome to proviral DNA, integration of the proviral DNA into host cell DNA, transcription of the proviral precursor proteins to mature viral proteins, assembly and release ('budding') of the viral particles. These processes depend on, and are regulated by, specific viral proteins. This makes many of these processes and proteins plausible targets for the design of selective inhibitors. The contributions assembled in this book are aimed at presenting what is known anno 1990 about (1) the different steps in the HIV replicative cycle that could be considered as targets for anti-HIV agents, (2) the compounds that interact with these targets and offer promise as candidate drugs for the treatment of HIV infection, and (3) to the extent that it has been resolved, the mechanism of interaction of the anti-HIV agents with their putative targets.
Download or read book Antilipidemic Drugs written by Donald T. Witiak and published by Elsevier Publishing Company. This book was released on 1991 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly, a major disorder of these times is Coronary Heart Disease (CHD) with atherosclerosis being the underlying cause. The biochemistry of this multifaceted disease of lipid and lipoprotein metabolism, our understanding of atherogenesis, and the medicinal chemical basis of antilipidemic and antiatherogenic organic chemicals have recently undergone major advances. These advances, the major epidemiological studies and drug trials involved, are well reflected in this book, along with information demonstrating treatment efficacy of diet and pharmaceuticals in both animal and clinical trials and a mechanism-based understanding of these treatment modalities. The physiology and pathophysiology of lipid and lipoprotein metabolism and the relationship of the underlying metabolic processes to the development of the atherosclerotic plaque are also covered, as are many more topics in this extensive treatize. The 17th volume in this well-known series, it provides up-to-date coverage of the medicinal, chemical and biochemical aspects of antilipidemic drugs.
Download or read book Medicinal Chemistry of Steroids written by F. J. Zeelen and published by Elsevier Publishing Company. This book was released on 1990 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The many new and fascinating data which have been gathered in the period 1985-1990 have made molecular endocrinology into a mature discipline stimulating creative chemists to design innovative drugs. Within a few years, the primary structures of all the steroid receptor proteins and most of the steroid-converting enzymes have been determined and detailed studies of their mechanism of action at a molecular level have become possible. Medicinal chemists have developed steroidal affinity probes to examine the binding sites of enzymes and receptors, and these investigations were supplemented with studies of modified enzymes and receptors prepared with the aid of site-directed mutagenesis. In view of these rapid scientific developments, the author deemed it appropriate to review the present knowledge of the medicinal chemistry of the steroids. In this book, the discussion is supported by the addition of some chapters which summarize the available data on the biological counterparts of the steroids, the steroid-converting enzymes and the steroid receptors.
Download or read book Trends in Medicinal Chemistry 88 written by H. van der Goot and published by Elsevier Publishing Company. This book was released on 1989 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Trends in Drug Research written by V. Claassen and published by Elsevier Publishing Company. This book was released on 1990 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the invited lectures of the Seventh Noordwijkerhout-Camerino Symposium. The authors of the 28 papers give a detailed account of recent advances in the fields of receptor-drug interactions, structure-activity relationships, molecular toxicology, drug targeting, peptidergic drugs, inhibitors of cholesterol biosynthesis, antimalarial and antileprosy drugs. Containing up-to-date surveys of recent trends in synthetical and biological investigations in drug design, this volume should prove invaluable to medicinal chemists and to pharmacologists and toxicologists working in the field of drug design and development.
