Download or read book Quantification and Optimization Techniques for Dynamic Brian Imaging in High Resolution Positron Emission Tomography written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern positron emission tomography (PET) scanners have a large number of detector crystals which corresponds to an even larger number of lines of response (LOR) addressing the coincidence events. This increasing complexity makes the image reconstruction much more challenging especially in dynamic imaging where the acquired number of counts per frame or per LOR is much less as compared to that in the static case. The low statistical quality of the data thus degrades the quantitative accuracy of the images. Moreover, the increasing number of LORs and dynamic frames requires a longer computational time and larger data storage for the image reconstruction task. A dual reconstruction scheme, a novel scatter calibration, and a practical scatter and randoms approximation methods were developed in this work. These methods have been validated using phantom, non-human primate, and human studies and have been demonstrated to improve the quantification accuracy of the images, to accelerate the image formation task, and to reduce the data storage requirement for dynamic brain imaging in high resolution PET. In conclusion, these studies contribute to increasing the accuracy and to decreasing the computational burden for dynamic high resolution quantitative PET imaging. The proposed methods are modular and can be applied to any PET scanners with the exception of the dual reconstruction scheme which requires list-mode acquisition capability. These methods are particularly beneficial for high resolution scanners which have a large number of LORs, such as the high resolution research tomograph (HRRT).
Download or read book Correction Techniques in Emission Tomography written by Mohammad Dawood and published by CRC Press. This book was released on 2012-04-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an interdisciplinary team of medical doctors, computer scientists, physicists, engineers, and mathematicians, Correction Techniques in Emission Tomography presents various correction methods used in emission tomography to generate and enhance images. It discusses the techniques from a computer science, mathematics, and physics viewpoint. The book gives a comprehensive overview of correction techniques at different levels of the data processing workflow. It covers nuclear medicine imaging, hybrid emission tomography (PET-CT, SPECT-CT, PET-MRI, PET-ultrasound), and optical imaging (fluorescence molecular tomography). It illustrates basic principles as well as recent advances, such as model-based iterative algorithms and 4D methods. An important aspect of the book is on new and sophisticated motion correction techniques in PET imaging. These techniques enable high-resolution, high-quality images, leading to better imaging analysis and image-based diagnostics. Reflecting state-of-the-art research, this volume explores the range of problems that occur in emission tomography. It looks at how the resulting images are affected and presents practical compensation methods to overcome the problems and improve the images.
Download or read book Quantification in Positron Emission Tomography written by Pablo Aguiar and published by LAP Lambert Academic Publishing. This book was released on 2010-10 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is focused on the development of processing, quantification and standarization methods, aimed at enhancing the quality and accuracy of Positron Emission Tomography (PET) images, both for human brain studies and for high-resolution small animal studies. Firstly, the effects of scatter, reconstruction method, anatomical variability, positron range, partial volume effect and non-colinearity on the quantification of PET studies are investigated. Several correction methods for the essential degradations are presented. Finally, the suitability of Monte Carlo techniques for simulating PET studies is also assessed.
Download or read book The Studies of Improved Quantification Techniques for Positron Emission Tomography written by Xiujuan Zheng and published by . This book was released on 2011 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Furthermore, the frequent invasive arterial blood sampling to obtain input function poses many challenges and inconvenience for tracer kinetic modeling with dynamic PET imaging. Non-invasive approaches were proposed to address this issue. A simple non-invasive quantification method based on Patlak graphic analysis (PGA) that uses a reference region to obtain the relative influx rate without an input function has recently been proposed. This non-invasive Patlak (nPGA) method was extended to whole-body FDG-PET studies and systematically investigated using a set of mouse studies and computer simulations. In the mouse studies, a high linearity of relative influx rates was observed between the nPGA and PGA for most pairs of reference and target regions, when an appropriate underlying kinetic model was used. The simulation results demonstrated that the accuracy of the nPGA method was similar to that of the PGA method, with a higher reliability for most pairs of reference and target regions. The results proved that the nPGA method could provide a non-invasive and indirect way of quantifying the FDG kinetics in the tissues where the k4 and vascular effect were negligible. The automatic non-invasive approach can further facilitate the analysis of dynamic PET imaging. A novel hybrid clustering method (HCM) was proposed to objectively delineate the regions of interest (ROIs) in dynamic PET images for the automatic estimation of image-derived input function (IDIF) and was demonstrated the application to the mouse FDG-PET studies. The results showed that the HCM achieved accurate ROIs delineation in both computer simulations and experimental mouse studies. In the mouse studies the predicted IDIF had a high correlation with the gold standard, the PTAC derived from invasive blood sampling. The results indicate that the proposed HCM has a great potential in ROI delineation for automatic estimation of IDIF in dynamic FDG-PET studies. In summary, this thesis has significantly contributed to the improvement of several critical quantification approaches for preclinical small-animal studies and clinical patient examinations.
Download or read book Algorithms for High resolution Positron Emission Tomography written by Kyle Morgan Champley and published by . This book was released on 2010 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac SPECT Imaging written by E. Gordon DePuey and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac SPECT Imaging, Second Edition offers the best of all possible worlds--a critical topic, internationally recognized authors and cutting-edge coverage. It guides you through all aspects of the modality--from basic principles (acquiring and processing images, quality control)...and clinical applications (evaluating myocardial infarction and coronary artery disease)...to the very latest equipment. It even compares SPECT with other modalities (PET, CT, MRI, and echocardiography) to ensure smart, cost-effective decisions by both the cardiologist and nuclear medicine physician.Look for new chapters on attenuation correction, gated perfusion SPECT, radiopharmaceuticals, and myocardial perfusion SPECT, as well as the very latest on myocardial perfusion SPECT in conjunction with exercise and pharmacologic stress, assessment of perfusion/viability with Tc-99m agents, how SPECT compares with other advanced cardiac imaging modalities, and more!
Download or read book Clinical PET and PET CT written by H. Jadvar and published by Springer Science & Business Media. This book was released on 2006-01-20 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical manual covering the full spectrum of PET and PET/CT imaging, now in common clinical practice, this book includes images of normal variants, artifacts, and pathologic conditions. Indications for and the relative clinical value of PET in the armamentarium of diagnostic medical imaging are reviewed. The information in the book is organized to be brief, concise, easy-to-understand and readily accessed. This book is intended for all health practitioners who need a concise reference and review of PET imaging indications, protocols and clinical applications. It will be useful to radiologists, nuclear medicine physicians, and clinicians who refer their patients to PET Centers for diagnostic imaging, including neurologists, neurosurgeons, psychiatrists, cardiologists, internists, and oncologists. Radiologic and nuclear medicine technologists, and physicians in training will also benefit from this work.
Download or read book PET MRI in Oncology written by Andrei Iagaru and published by Springer. This book was released on 2018-01-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, experts from premier institutions across the world with extensive experience in the field clearly and succinctly describe the current and anticipated uses of PET/MRI in oncology. The book also includes detailed presentations of the MRI and PET technologies as they apply to the combined PET/MRI scanners. The applications of PET/MRI in a wide range of oncological settings are well documented, highlighting characteristic findings, advantages of this dual-modality technique, and pitfalls. Whole-body PET/MRI applications and pediatric oncology are discussed separately. In addition, information is provided on PET technology designs and MR hardware for PET/MRI, MR pulse sequences and contrast agents, attenuation and motion correction, the reliability of standardized uptake value measurements, and safety considerations. The balanced presentation of clinical topics and technical aspects will ensure that the book is of wide appeal. It will serve as a reference for specialists in nuclear medicine and radiology and oncologists and will also be of interest for residents in these fields and technologists.
Download or read book Diffusion Weighted MR Imaging written by Dow-Mu Koh and published by Springer Science & Business Media. This book was released on 2010-01-13 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a great privilege to introduce this book devoted to the current and future roles in research and clinical practice of another exciting new development in MRI: Diffusi- weighted MR imaging. This new, quick and non-invasive technique, which requires no contrast media or i- izing radiation, offers great potential for the detection and characterization of disease in the body as well as for the assessment of tumour response to therapy. Indeed, whereas DW-MRI is already ? rmly established for the study of the brain, progress in MR techn- ogy has only recently enabled its successful application in the body. Although the main focus of this book is on the role of DW-MRI in patients with malignant tumours, n- oncological emerging applications in other conditions are also discussed. The editors of this volume, Dr. D. M. Koh and Prof. H. Thoeny, are internationally well known for their pioneering work in the ? eld and their original contributions to the l- erature on DW-MRI of the body. I am very much indebted to them for the enthusiasm and engagement with which they prepared and edited this splendid volume in a record short time for our series Medical Radiology – Diagnostic section.
Download or read book Acute Ischemic Stroke written by R. Gilberto González and published by Springer Science & Business Media. This book was released on 2010-10-05 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Download or read book SPECT and SPECT CT written by Chun K. Kim and published by Thieme. This book was released on 2017-06-14 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: FOUR STARS from Doody's Star Ratings™ Internationally renowned authorities in the field of hybrid imaging contribute firsthand expertise on the practical application of single-photon emission computed tomography (SPECT) and SPECT/CT. By combining clear anatomic markers from CT with functional knowledge from SPECT, SPECT/CT provides added value for patient evaluation and is becoming increasingly prevalent in routine clinical practice. Indeed, hybrid imaging is touted by many as a game changer in nuclear medicine. The first two chapters of this book provide a foundation for understanding SPECT and SPECT/CT technological principles, including the associated radiopharmaceuticals. The remaining chapters detail the utility of SPECT and SPECT/CT in clinical practice including neuroscience and pediatrics, as well as specific pathologies. The book concludes with in-depth discussion of select case studies. Key Features Efficacious use of SPECT and SPECT/CT for primary body systems, including the central nervous, cardiovascular, respiratory, and skeletal systems Value for the assessment of neoplastic disease, infection/inflammation, thyroid and parathyroid gland disorders Fourteen high-quality videos delineate specific techniques and clinical applications Meticulous, four-color graphics clearly elucidate key concepts Illustrative case studies offer educational teaching pearls Together, the concise, evidence-based text and wealth of SPECT/CT images deliver a solid knowledge base, enabling practitioners to learn the effective use of this technology. This must-have book is certain to be an invaluable resource for a diverse spectrum of practicing and trainee clinicians in fields such as radiology, nuclear medicine, and radiation oncology.
Download or read book Positron Emission Tomography and Autoradiography written by Michael E. Phelps and published by Lippincott Williams & Wilkins. This book was released on 1986 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book PET in Oncology written by Stefan Dresel and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a comprehensive compilation of the accumulated knowledge on PET and PET/CT in oncology. It covers the entire spectrum from solidly documented indications, such as staging and monitoring of lung and colorectal cancer, to the application of PET/CT in head and neck surgery, gynecology, radiation therapy, urology, pediatrics and others. The chapters are supplemented by an introduction into the underlying techniques of both imaging devices and radiopharmacy.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Pericardial Disease written by J. Soler-Soler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November 1986, I was invited to attend a symposium held in Barcelona on Diseases of the Pericardium. The course was directed by Dr. J. Soler-Soler, director of Cardiology at Hospital General Vall d'Hebron in Barcelona. During my brief but delightful visit to this institution, my appreciation of the depth and breadth of study into pericardial diseases, carried out by Dr. Soler and his group, grew into the conviction that these clinical investigators have accumulated a wealth of information concerning pericardial diseases, and that investigators and clinicians practicing in English speaking countries would greatly profit from ready access to the results of the clinical investiga tions into pericardial disease carried out in Barcelona. The proceedings of the Barcelona conference were published in a beauti fully executed volume in the Spanish language edited by Dr. Soler and pro duced by Ediciones Doyma. Because I believe that this work should be brought to the attention of the English speaking scientific and clinical com munities, I encouraged Dr. Soler to have the book translated into English. I knew that this task could be accomplished and that the book would be trans lated into good English without change of its content. My confidence was based upon a translation of my own book, The Pericardium, into Spanish undertaken by Dr. Permanyer, who is a contributor and co-editor of the pre sent volume.
Download or read book Brain Tumor Imaging written by Elke Hattingen and published by Springer. This book was released on 2015-09-02 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Download or read book Pediatric PET Imaging written by Martin Charron and published by Springer Science & Business Media. This book was released on 2006-04-19 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The technique for successfully completing a PET procedure is complex and involves a knowledge of physics, pharmacy, anatomy, physiology, and the disease process; applying PET scanning to children is even more challenging and technically demanding. One cannot simply adopt the approach used for adults but instead must receive specialized training in order to master pediatric PET procedures. This one-of-a-kind, interdisciplinary book is one of the first practical guides to imaging children with PET. The text opens with a section that focuses on practical and technical issues of pediatric PET imaging, including radiation dose and sedation. Principles of operation, instrumentation, and nuclear medicine regulations are also discussed. Subsequent sections cover the clinical applications of PET in pediatrics. With contributions from leading international authorities in the field, each chapter is heavily illustrated and provides the reader with extensive coverage of the essentials of clinical PET studies in oncology and neurology, which standout as key areas for PET imaging in pediatrics.
