Download or read book Purine Metabolism in Man IV Clinical and therapeutic aspects regulatory mechanisms written by Chris H. M. M. de Bruyn and published by . This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man IV written by Chris H. De Bruyn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes, entitled "Purine Metabolism in Man IV" con tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo lism under normal and pathological conditions has been growing rapid ly. Apart from the more or less classical topics such as hyperuricae mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re ported which indicate clear differences in the pathways of ATP metabo lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel oped.
Download or read book Purine Metabolism in Man IV written by Chris H. De Bruyn and published by Springer. This book was released on 2012-12-22 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes, entitled "Purine Metabolism in Man IV" con tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo lism under normal and pathological conditions has been growing rapid ly. Apart from the more or less classical topics such as hyperuricae mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re ported which indicate clear differences in the pathways of ATP metabo lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel oped.
Download or read book Purine Metabolism in Man 4 written by and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man IV written by Chris H De Bruyn and published by Springer. This book was released on 2014-01-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man IV written by Chris H. De Bruyn and published by Springer. This book was released on 1984-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes, entitled "Purine Metabolism in Man IV" con tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo lism under normal and pathological conditions has been growing rapid ly. Apart from the more or less classical topics such as hyperuricae mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re ported which indicate clear differences in the pathways of ATP metabo lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel oped.
Download or read book Purine Metabolism in Man III written by A. Rapado and published by Springer. This book was released on 2012-11-25 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes contain the papers which were presented at the Third International Symposium on Purine Metabolism in Man held in Madrid (Spain) in June, 1979. The previous meetings in the series were held in Tel Aviv (Israel) and in Baden (Austria) in 1973 and 1976, respective1y. The proceedings were also published by Plenum. Knowledge of the pathophysio1ogy of the purines has developed greatly since the 1950's when it was main1y re1ated to c1inica1 gout, and it is now relevant to many fie1ds of Medicine and Biology. These volumes include papers reporting new work on clinical gout and uro1ithiasis as we11 as on some of the subjects which have featured prominently in the previous volumes, including: regulatory aspects of the intermediary metabolism of purines and re1ated com pounds, enzymology, methodology, and the resu1ts of mutations which affect purine metabolism. However, there have been many new develop ments during the last three years and the scope of the communications reflects not only increasing depth of know1edge, but also a widening of the field. This publication has clinical and fundamental imp1i cations for internal medicine, pediatrics, uro1ogy, biochemistry, immunology, genetics, and oncology.
Download or read book Purine Metabolism in Man IV Clinical and therapeutic aspects regulatory mechanisms written by Chris H. M. M. de Bruyn and published by Plenum Publishing Corporation. This book was released on 1984 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man III written by A Rapado and published by Springer. This book was released on 2014-01-15 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man III written by Aurelio Rapado and published by . This book was released on 1980 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine Metabolism in Man IV written by Chris H. De Bruyn and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes, entitled "Purine Metabolism in Man IV" con tain the papers presented at the Fourth International Symposium on Human Purine and Pyrimidine Metabolism", held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo lism under normal and pathological conditions has been growing rapid ly. Apart from the more or less classical topics such as hyperuricae mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting mych new data on both issues have been re ported which indicate clear differences in the pathways of ATP metabo lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel oped.
Download or read book Purine and Pyrimidine Metabolism in Man V written by W. L. Nyhan and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr. , was scheduled to be the speaker at our banquet. Unfortunate ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1984 with total page 1084 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purine and Pyrimidine Metabolism in Man VI written by K. Mikanagi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.
Download or read book Purine and Pyrimidine Metabolism in Man V Basic science aspects written by William L. Nyhan and published by . This book was released on 1986 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U.S.A.) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it permitted us to honor Dr. J.E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W.E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr., was scheduled to be the speaker at our banquet. Unfortunately, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been published following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive. New or previously unrecognized disorders of purine metabolism continue to be uncovered. An entire section on disorders of purine and pyrimidine metabolism other than deficiency of HPRT is led off by two papers on adenylosuccinase deficiency. Among the disorders of pyrimidine metabolism there are papers on orotic aciduria and dihydrothymine dehydrogenase deficiency. Clinical and biochemical studies of gout and urolithiasis continue to be actively pursued. At the same time the study of purine metabolism has become an integral feature of immunology. The importance of purines in clinical oncology was first demonstrated with the synthesis by George Hitchings of 6-mercaptopurine. Its continuing impact on hematology and oncology is seen throughout these volumes, particularly in the effects of inhibition of adenosine deaminase on T cells and on T cell leukemia. This publication has implications for internal medicine, pediatrics, urology, biochemistry, immunology, genetics, hematology, and oncology. Modern molecular biology and techniques involving recombinant DNA were evident in papers on HPRT and on adenosine deaminase, as well as in studies on APRT and UMP synthase. The genes for HPRT, adenosine deaminase and puine nucleoside phosphorylase have been cloned. The background for ultimate approaches to gene therapy in man was provided in papers from Dr. Seegmiller's laboratory on the insertion of HPRT cDNA into human bone marrow cells and on metabolic cooperation. Purine receptors have been discovered in the central nervous system, in lymphocytes and in a variety of other tissues. There are also adenosine receptors in Leishmania and a number of purine riboside analogs are under study as potential therapeutic agents in leishmaniasis.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
