Download or read book Pulmonary Deposition and Retention of Inhaled Aerosols written by Theodore F. Hatch and published by Elsevier. This book was released on 2013-09-12 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject. The book opens with an introductory chapter on the relationship between the dose of an inhaled aerosol and the kind and degree of response, and classification of particulate substances. This is followed by separate chapters on pulmonary deposition and retention of inhaled aerosols; the factors that influence disease risks associated with atmospheric exposure to aerosols; and measurement of aerosol composition and concentration. It is hoped that the book will help the specialists from both sides as well as technical and administrative personnel to acquire a common understanding of the important intermediate factors that operate between the outside dusty atmosphere and the internal tissue damage and disease—factors that may operate to make one exposure dangerous to life and another altogether innocuous.
Download or read book Aerosols and the Lung written by Stewart W. Clarke and published by Elsevier. This book was released on 2015-08-11 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aerosols and the Lung covers all aspects of aerosols and the lung, including the use of aerosol in clinical medicine. This volume was developed from the editors' longstanding interest in lung defenses coupled with the radioaerosol technique of assessing their efficiency. This book is organized into 11 chapters. The coverage of these chapters include the physical properties of aerosol required to evaluate their inhalation into the lung, production of aerosol that is suitable for inhalation, determination of aerosol deposition in the lungs and the assessment of lung clearance. This book also highlights the importance of radioaerosols in estimating airway calibre, in detecting airway disease and in ventilation imaging. This book will be of interest to medical students and professionals, particularly those dealing with studies of the human lungs and aerosols.
Download or read book Drug Delivery to the Lung written by Hans Bisgaard and published by CRC Press. This book was released on 2001-10-02 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract!Featuring over 1300 references, drawings, tables, and photographs.
Download or read book Optimization of Aerosol Drug Delivery written by Leon Gradon and published by Springer Science & Business Media. This book was released on 2003-11-30 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
Download or read book Extrapolation of Dosimetric Relationships for Inhaled Particles and Gases written by James D. Crapo and published by . This book was released on 1989 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extrapolation Modeling, Advancements and Research Issues in Lung Dosimetry; Lung Structure, Function Relationships; Species Differences in Airway Cell Distribution and Morphology; Alternative Methods to Evaluate Species Differences in Upper Airway Structure, Function; Preparation of Rat Nasal Airway Casts and Their Application to Studies of Nasal Airflow; Age Related Morphometric Analysis of Human Lung Casts; Anatomical Modeling of Microdosimetry of Inhaled Particles and Gases in the Lung; Experimental Dosimetry; Particle Deposition at the Alveolar Duct Bifurcations; Effects of Airway Branch Angle, Branch Point Number, and Gravity on Particle Deposition and Retention; Regional Deposition of Inhaled Particulates in Conducting Airways and Lung Segments; The Physical Properties of Mainstream Cigarette Smoke and Their Relationship to Deposition in the Respiratory Tract; Localization of 14C Dotriacontane Labeled Cigarette Smoke Particulate in the Dog Lung; Human Lung Clearance Following Bolus Inhalation of Radioaerosols; Effects of Ventilatory Patterns and Pre-existing Disease on Deposition of Inhaled Particles in Animals; Nasopharyngeal Uptake of Ozone in Humans and Animals; New Methods; Regional Dosimetry of Inhaled Particles Using SPECT; Dual Laser Doppler System for Real Time, Simultaneous Characterization of Aerosols by Size and Concentration; Dosimetry of Inhaled Particles by Means of Light Scattering; Modeling Approaches; Issues That Must Be Addressed When Constructing Anatomical Models of the Developing Lung; Significances of the Variability of Tracheobronchial Airway Paths and Their Air Flow Rates to Dosimetry Model Predictions of the Absorption of Gases; Predicting Respiratory Tract Clearance in Man; The Role of Particle Hygroscopicity in Aerosol Therapy and Inhalation Toxicology; Age-Dependent Lung Dosimetry of Radon Progeny; Deposition and Retention Modeling of Inhaled Cadmium in Rat and Human Lung, An Example for Extrapolation of Effects and Risk Estimation.
Download or read book Inhalation Aerosols written by Anthony J. Hickey and published by CRC Press. This book was released on 1996-06-07 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference integrates the theory and practical use of aerosols in inhalation therapy into a single resource-presenting the physical chemistry of formulation, the physics of aerosol generation, aerodynamic behavior, and therapeutic implications. Offers up-to-date techniques for droplet and particle generation, including air-blast and ultrasonic nebulizers, propellant-driven metered-dose inhalers, dry-powder inhalers, and elecctrospray systems!
Download or read book Pharmaceutical Inhalation Aerosol Technology Second Edition written by Anthony J. Hickey and published by CRC Press. This book was released on 2003-09-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.
Download or read book Aerosols And The Human Lung An Introduction written by Chantal J Darquenne and published by World Scientific. This book was released on 2020-03-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the field of aerosol science related to particle inhalation and its effect on the lung, predominately in humans. It covers the basics of aerosol behavior, transport, deposition, clearance, and effects of aerosols, both environmental and therapeutic. Aimed at the researcher entering the field of aerosol inhalation it provides a valuable introductory resource in an accessible format.
Download or read book The Mechanics of Inhaled Pharmaceutical Aerosols written by Warren H. Finlay and published by Academic Press. This book was released on 2019-06-01 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. - Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols - Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles - Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area
Download or read book Inhaled Particles written by Chiu-sen Wang and published by Elsevier. This book was released on 2005-01-20 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled Particles integrates all that is known about inhaled particles in a unified treatment. It aims to provide a scientific framework essential to a reasonable understanding of inhaled particles. The emphasis is placed on demonstrating the key roles of lung morphology on airflow and particle transport as well as identifying physical and biological factors that influence deposition. Special attention is paid to maintaining consistency of treatment and a balance between theoretical modeling and experimental measurements. The book covers all important aspects of inhaled particles including inhalability, aerosol dispersion, particle deposition, and clearance. It reviews concisely the basic background of lung morphology, respiratory physiology, aerodynamics, and aerosol science pertinent to the subject. Essential aspects of health effects and applications are also included. An easy-to-read, self contained introduction to the field An excellent source of updated research information Useful for students and professionals in aerosol science, environmental health science, occupational hygiene, health physics and biomedical engineering
Download or read book Inhaled Medicines written by Stavros Kassinos and published by Academic Press. This book was released on 2021-02-05 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues
Download or read book Aerosols in Medicine written by Folke Morén and published by Elsevier Publishing Company. This book was released on 1993 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition includes chapters on the diagnostic and therapeutic use of aerosols, systemic therapy, and particle size analysis of therapeutic aerosols. It reviews the current state-of-the-art, details important applications and assesses environmental and occupational aerosols.
Download or read book Pulmonary Depostion and Retention of Inhaled Aerosols written by Theodore Frederick Hatch and published by . This book was released on 1964 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Air Pollution the Automobile and Public Health written by Sponsored by The Health Effects Institute and published by National Academies Press. This book was released on 1988-01-01 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
Download or read book Pharmaceutical Inhalation Aerosol Technology Third Edition written by Anthony J. Hickey and published by CRC Press. This book was released on 2019-03-26 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors
Download or read book Airborne Particles written by National Research Council (U.S.). Subcommittee on Airborne Particles and published by . This book was released on 1979 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inhaled Particles VI written by J. Dodgson and published by Elsevier. This book was released on 2013-09-17 with total page 1244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled Particles VI contains the proceedings of an international symposium and workshop on lung dosimetry, organized by the British Occupational Hygiene Society in cooperation with the Commission of the European Communities and held at Cambridge on September 2-6, 1985. The symposium presents results of research on the entry, destiny, and effects of respired particles, with emphasis on mechanisms and dose-response relationships. This book contains, in three separate parts, 84 papers from the symposium, 34 workshop papers, and 20 poster presentations. Parts 1 and 2 are further divided into sections. Section 1 presents several papers concerning the influence of breathing pattern and activity on regional deposition of inhaled particles. Section 2 shows comparative studies of aerosol deposition in experimental animals and humans. Subsequent sections explore the mineral content of lungs to differing exposures; biological effects of dusts; hazard parameters; dust measurement; exposure of workers to vermiculite and attapulgite; effects of dust exposure in the coal mining industry; and effects of silica dust exposure. Other topics of significance include toxicity of artificial mineral fibers and utility of magnetopneumography as a non-invasive investigational test.
