Download or read book pts 1 3 Grade 5 written by School Mathematics Study Group and published by . This book was released on 1965 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book 2 1 2 Ton 6X6 M44A1 and M44A2 Series Trucks multifuel pts 1 4 Maintenance organizational level written by and published by . This book was released on 1981 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inhibiting PARP as a Strategic Target in Cancer written by Christina Annunziata and published by Frontiers Media SA. This book was released on 2016-08-05 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
Download or read book Stereotactic Body Radiation Therapy written by Yasushi Nagata and published by Springer. This book was released on 2015-08-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide for the use of stereotactic body radiation therapy in clinics. On the basis of more than 10 years of clinical experience with lung cancer, liver cancer and other cancers, a remarkable volume of knowledge has been accumulated. At the same time, great progress in techniques has been achieved. Various new fixing apparatuses, new respiratory regulation techniques, new dose fractionation schedules and new image-guided radiation therapy machines have been developed. This book reviews the history of those developments and reports on various types of toxicities. Review of recent clinical studies is also included. The authors were key members of the JCOG 0403 clinical trials on stereotactic body radiation therapy (SBRT) for both inoperable and operableT1N0M0 primary lung cancer. Readers will learn of the superior outcomes obtained with SBRT for lung cancer and other cancers in terms of local control and toxicities. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists and senior nurses as well as medical oncologists and surgical oncologists who are interested in radiotherapy.
Download or read book The Role of Microtubules in Cell Biology Neurobiology and Oncology written by Antonio Tito Fojo and published by Springer Science & Business Media. This book was released on 2009-01-14 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.
Download or read book Robotic Radiosurgery Treating Prostate Cancer and Related Genitourinary Applications written by Lee E. Ponsky and published by Springer Science & Business Media. This book was released on 2011-11-19 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of prostate cancer continues to be problematic owing to serious side-effects, including erectile dysfunction and urinary incontinence. Robotic radiosurgery offers a novel, rapid, non-invasive outpatient treatment option that combines robotics, advanced image-guided spatial positioning, and motion detection with submillimeter precision. This book examines all aspects of the treatment of prostate cancer with robotic radiosurgery. It explains how image-guided robotic radiosurgery overcomes the problem of patient motion during radiation therapy by continuously identifying the precise location of the prostate tumor throughout the course of treatment. Hypofractionated radiation delivery by means of robotic radiosurgery systems is also discussed in detail. The book closes by examining other emerging genitourinary applications of robotic radiosurgery. All of the authors are experts in their field who present a persuasive case for this fascinating technique.
Download or read book New Frontiers in Gene Modified T Cell Technology written by Ignazio Caruana and published by Frontiers Media SA. This book was released on 2024-06-13 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
Download or read book Immunological Challenges Following Pediatric Hematopoietic Transplantation written by Robert James Hayashi and published by Frontiers Media SA. This book was released on 2021-09-28 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Publishers Weekly written by and published by . This book was released on 1917 with total page 2180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalog of Copyright Entries Part 1 B Group 2 Pamphlets Etc New Series written by Library of Congress. Copyright Office and published by . This book was released on 1938 with total page 970 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Download or read book Cancer Neurology in Clinical Practice written by David Schiff and published by Springer Science & Business Media. This book was released on 2002-09-15 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Cancer Neurology in Clinical Practice, leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how they should be interpreted and evaluated. Organized by both symptom and organ, the book carefully describes each diagnostic neurologic entity-from symptomatology to diagnostic studies to management and prognosis-and presents each major type of cancer in terms of it neurologic problems and how they should be handled. The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem. Multidisciplinary and up-to-date, Cancer Neurology in Clinical Practice explains to the busy physicians treating cancer patients the latest findings in neuro-oncology that will help them to focus their differential diagnosis, diagnostic strategy, and treatment plan for the cancer patient with neurologic symptoms and findings.
Download or read book The Publishers Weekly written by and published by . This book was released on 1917 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalog of Copyright Entries written by and published by . This book was released on 1936-07 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Oncology written by Duccio Volterrani and published by Springer Nature. This book was released on 2022-10-04 with total page 2241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.
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Download or read book Pacific Yew Draft Environmental Impact Statement appendices written by and published by . This book was released on 1993 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Item no. 0080-F.
