Download or read book PSP94 what is it good for third edition written by Martin Laurence and published by Shipshaw Labs. This book was released on 2013-04-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews the literature linking prostate secretory protein 94 (PSP94) to prostate cancer and benign prostatic hyperplasia (BPH). It reveals four important insights not previously reported in the scientific literature: PSP94 is fungicidal within epithelial cells that synthesize it, but it is not fungicidal extracellularly due to inhibition by calcium ions. Prostatic epithelial cells of BPH men secrete an incomplete version of PSP94 which is not fungicidal; non-BPH men only secrete the fungicidal version. Epidemiological data indicate that a yet-to-be-identified sexually transmissible infection is causing prostate cancer, BPH and non-bacterial prostatitis. The gene responsible for the synthesis of PSP94 is expressed in all late onset cancers sites, representing 75% of all cancer cases in developed countries; it is not expressed in any early onset cancer sites of unknown etiology. The etiologies of prostate cancer and BPH are not known. Prostatic inflammation can be observed in 80% of elderly men. Epidemiologists have been predicting for more than a decade that a yet-to-be-identified sexually transmissible infection is causing prostate cancer. The search for prostatic pathogens has resulted in dozens of studies, yet a disease causing agent still eludes researchers. Research has focused on known sexually transmissible infections and bacteria. Two 2008 genome wide association studies reported that a single-nucleotide polymorphism near the PSP94 gene was associated with a 1.6x increase in risk of prostate cancer: the risk allele causes reduced synthesis of PSP94 in the prostate. Taken together, these facts suggest that PSP94's primary purpose is to defend epithelial cells from an intracellular pathogen which is causing prostate cancer and BPH, and possibly other diseases. Though this hypothesis is fully consistent with the current scientific literature, additional studies are necessary. Might this hypothesis be correct or not, understanding the mechanisms behind PSP94's protective properties for prostate cancer and its role in other late onset cancers should be given high priority in cancer research.
Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Elsevier. This book was released on 2024-06-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Download or read book Hypercalcemia of Malignancy written by Friedhelm Raue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Download or read book From Molecules to Networks written by Ruth Heidelberger and published by Academic Press. This book was released on 2009-01-27 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook Discusses emerging new understanding of non-classical molecules that affect neuronal signaling Full colour, professional graphics throughout Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease
Download or read book Medical Toxicology written by Pınar Erkekoglu and published by BoD – Books on Demand. This book was released on 2021-02-03 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical toxicology is a sub-branch of toxicology concerned with the diagnosis, management, and prevention of poisoning and other adverse effects of drugs, cosmetics, personal care products, occupational and environmental toxicants, and biological agents. Poisoning with drugs, herbs, venoms, and toxins is a significant global public health problem. Medical toxicologists are involved in the assessment and treatment of acute or chronic poisoning, substance abuse, adverse drug reactions, drug overdoses, envenomation, industrial accidents, and other chemical exposures. As such, there is a pressing need for safe and specific antidotes, as many antidotes currently in use have a relatively low margin of safety or therapeutic index. This book focuses on poisonings with drugs, venoms, toxins, interaction in clinics, antidotes, and forensics. It provides qualified scientific knowledge on different aspects of medical toxicology, drug and substance abuse, clinical interactions between drugs and herbs, antidotes, antidote networks, and forensic toxicology.
Download or read book Anatomy for Urologic Surgeons in the Digital Era written by Emre Huri and published by Springer Nature. This book was released on 2021-11-01 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide in the use of imaging and visualization technologies in urology. It details how output from diagnostic systems, can be represented through synthetic, virtual and augmented reality tools, such as holograms and three dimensional (3D) modelling and how they can improve everyday surgical procedures including laparoscopic, robotic-assisted, open, endoscopic along with the latest and most innovative approaches. Anatomy for Urologic Surgeons in the Digital Era: Scanning, Modelling and 3D Printing systematically reviews diagnostic imaging, visualization tools available in urology and is a valuable resource for all practicing and in-training urological surgeons.
Download or read book Land Snakes of Medical Significance in Malaysia written by Ahmad Khaldun Ismail and published by Malaysia Biodiversity Information System (MyBIS). This book was released on 2017-07-03 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to highlight the potentially dangerous species to humans, with a list of the main potentially medically significant snakes. It is important to note that if a species is not listed below, it does not necessarily mean that it does not exist in Malaysia nor that its bite cannot cause harmful effects in humans. In particular, the list of colubrid (non-front-fanged) snakes has been selective, to include only a number known to be of potential medical significance. It is also important to note that a poor surveillance of the pet trade and irresponsible importation of exotic snakes may introduce a medically significant species, which is not indigenous to Malaysia. This may add to the complexity of managing envenomings in this country.
Download or read book Precision Medicine for Investigators Practitioners and Providers written by Joel Faintuch and published by Academic Press. This book was released on 2019-11-16 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked
Download or read book Mouse Models of Human Cancer written by Eric C. Holland and published by John Wiley & Sons. This book was released on 2004-08-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.
Download or read book Handbook of Satisfiability written by A. Biere and published by IOS Press. This book was released on 2021-05-05 with total page 1486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Propositional logic has been recognized throughout the centuries as one of the cornerstones of reasoning in philosophy and mathematics. Over time, its formalization into Boolean algebra was accompanied by the recognition that a wide range of combinatorial problems can be expressed as propositional satisfiability (SAT) problems. Because of this dual role, SAT developed into a mature, multi-faceted scientific discipline, and from the earliest days of computing a search was underway to discover how to solve SAT problems in an automated fashion. This book, the Handbook of Satisfiability, is the second, updated and revised edition of the book first published in 2009 under the same name. The handbook aims to capture the full breadth and depth of SAT and to bring together significant progress and advances in automated solving. Topics covered span practical and theoretical research on SAT and its applications and include search algorithms, heuristics, analysis of algorithms, hard instances, randomized formulae, problem encodings, industrial applications, solvers, simplifiers, tools, case studies and empirical results. SAT is interpreted in a broad sense, so as well as propositional satisfiability, there are chapters covering the domain of quantified Boolean formulae (QBF), constraints programming techniques (CSP) for word-level problems and their propositional encoding, and satisfiability modulo theories (SMT). An extensive bibliography completes each chapter. This second edition of the handbook will be of interest to researchers, graduate students, final-year undergraduates, and practitioners using or contributing to SAT, and will provide both an inspiration and a rich resource for their work. Edmund Clarke, 2007 ACM Turing Award Recipient: "SAT solving is a key technology for 21st century computer science." Donald Knuth, 1974 ACM Turing Award Recipient: "SAT is evidently a killer app, because it is key to the solution of so many other problems." Stephen Cook, 1982 ACM Turing Award Recipient: "The SAT problem is at the core of arguably the most fundamental question in computer science: What makes a problem hard?"
Download or read book Models for Prostate Cancer written by Gerald Patrick Murphy and published by . This book was released on 1980 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Viruses and Human Disease written by Ellen G. Strauss and published by Elsevier. This book was released on 2007-09-21 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text
Download or read book Lust written by Pamela C. Regan and published by SAGE. This book was released on 1999-08-27 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accessibly written, this interdisciplinary book reviews theory and research on the characteristics of sexual desire, the individual physical and mental factors that influence the experience of sexual desire (hormones, age, gender, beliefs, mood), the various partner characteristics that incite sexual desire (attractiveness) and the association between sexual desire and interpersonal, relational events and experiences (romantic love). The book concludes with an examination of the personal, interpersonal and societal implications of sexual desire. Throughout, the authors draw on findings from their own body of research on sexual and romantic attraction, as well as on an extensive review of the relevant social, behavioural and medical science
Download or read book Metabolomics From Fundamentals to Clinical Applications written by Alessandra Sussulini and published by Springer. This book was released on 2017-01-28 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Download or read book The Microbiology of Skin Soft Tissue Bone and Joint Infections written by Kateryna Kon and published by Academic Press. This book was released on 2017-04-25 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiology of Skin, Soft Tissue, Bone and Joint Infections: Volume 2 discusses modern approaches in diagnosis, treatment, and prophylaxis of skin, soft tissue, bone, and joint infections. The volume has been divided into three sections. The first section includes chapters on diagnosis, treatment, and prophylaxis of skin and soft tissue infections. It discusses antimicrobial and surgical treatment of wounds, diabetic foot, and different soft tissue infections. Ten chapters are devoted to cutaneous and musculoskeletal infections in special groups of patients, which have their own specificity, i.e. in pediatric and HIV-infected patients. Together with chapters on commonly present diseases, there are chapters which discuss interesting but not well studied pathologies (natal cleft pilonidal sinus) and pathogens (Malassezia and Shewanella spp.). The second section reviews etiology, pathogenesis, diagnosis and treatment of bone and joint infections, mainly osteomyelitis and prosthetic joint infections. Also, one chapter in this section discusses a newly emerging bacterial pathogen that causes skeletal infections, Kingella kingae. The third section incorporates alternative and new approaches—such as nanotechnology, ultrasound, novel delivery approaches and phyto-derived medicines—to the treatment and prophylaxis of skin, soft tissue, bone, and joint infections. Encompasses a broad range of skin, soft tissue, bone, and joint infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment, and prophylaxis Written by highly professional and eminent surgeons, microbiologists, and infectious disease specialists Discusses topics using modern insight, providing all necessary scientific information on each aspect Includes scientific understanding and practical guidelines, which make it interesting for both research scientists and practitioners working with skin, soft tissue, bone, and joint infections
Download or read book The Great Prostate Hoax written by Richard J. Ablin and published by Macmillan. This book was released on 2014-03-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals how fear-based and inaccurate testing is resulting in unnecessary high-risk surgeries, arguing that the PSA test was never intended for prostate cancer screening while sharing the stories of patients who have suffered from damaging procedures. 35,000 first printing.
