Download or read book Proton Pump Inhibitors A Balanced View written by T. Chiba and published by Karger Medical and Scientific Publishers. This book was released on 2013-09-23 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Download or read book Proton Pump Inhibitors written by Lars Olbe and published by Birkhäuser. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.
Download or read book Synthesis of Best Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!
Download or read book Spine Surgery written by Alexander R. Vaccaro and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides guidance on how to perform a wide-variety of techniques in spine surgery. Topics covered include immobilization techniques, anterior and posterior approaches, and thoracic spine surgery.
Download or read book Diagnosis and Treatment of Gastroesophageal Reflux Disease written by Michael F. Vaezi and published by Springer. This book was released on 2015-07-21 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most recent developments in diagnosis and treatment of patients with gastroesophageal reflux disease (GERD) and those who continue to be refractory to conventional GERD therapies. The book delineates the role of newly developed endoscopic therapies in GERD and outlines the best candidates for surgical fundoplication. Topics as the risks associated with GERD, lifestyle modification in GERD and the role of H2RA and proton pump inhibitor therapy in treating reflux disease are also explored. Written by authorities in the field, Diagnosis and Treatment of Gastroesophageal Reflux Disease is a concise yet comprehensive resource that is useful for primary care providers, gastroenterologists, pulmonologists, surgeons and ENT specialists.
Download or read book Critical Care Pharmacotherapy written by Brian L. Erstad and published by . This book was released on 2016 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proton Pump Inhibitors Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Pump Inhibitors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Proton Pump Inhibitors in a compact format. The editors have built Proton Pump Inhibitors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proton Pump Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proton Pump Inhibitors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Nephrology Secrets written by Edgar V. Lerma and published by Elsevier Health Sciences. This book was released on 2011-06-21 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology Secrets, 3rd Edition, by Drs. Edgar V. Lerma and Allen R. Nissenson, gives you the nephrology answers you need to succeed on your rotations and boards.. Its unique, highly practical question-and-answer format, list of the "Top 100 Nephrology Secrets," and user-friendly format make it perfect for quick reference. Get the most return for your study time with the proven Secrets® format -- concise, easy to read, and highly effective. Skim the "Top 100 Secrets" and "Key Points" boxes for a fast overview of the secrets you must know for success on the boards and in practice. Enjoy faster, easier review and master the top issues in nephrology with mnemonics, lists, quick-reference tables, and an informal tone that sets this review book apart from the rest. Carry it with you in your lab coat pocket for quick reference or review anytime, anywhere. Handle each clinical situation with confidence with chapters completely updated to reflect the latest information. Find the answers you need faster thanks to a new, more streamlined and problem-based organization. Get the high-yield answers you need to address top nephrology questions
Download or read book Proton Pump Inhibitors PPIs written by Barbara Parker and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton pump inhibitors (PPIs) have become a mainstay of therapy not only in the practice of gastroenterology, but also for general medicine and even for the general public. Recently, proton pump inhibitors have been associated with a number of potential complications including impaired vitamin and mineral absorption, altered drug metabolism and increased risk for infections. The outline for the basis for these reported risks are examined in this book, the current clinical evidence is discussed, and the authors offer insight into the likely clinical significance of each complication. Furthermore, the pathophysiology of acid secretion and inhibition, with a specific focus on the pharmacological principles surrounding the use of PPIs are reviewed. Relevant information on the management of acid-related disordered is provided for clinicians. Other chapters explore the current literature on potential complications associated with long-term PPI use, the benefits and risks of routine use of proton pump inhibitors in the intensive care unit (ICU), often associated with adverse events such as a significantly increased risk of infectious complications, and the use and misuse of proton pump inhibitors in the general population.
Download or read book Acid related Diseases written by J. Dent and published by S. Karger AG (Switzerland). This book was released on 1992 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Obesity and Disease in an Interconnected World A Systems Approach to Turn Huge Challenges into Amazing Opportunities written by Judith Wylie-Rosett and published by Bentham Science Publishers. This book was released on 2015-04-02 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Globalization and economic progress has been accompanied with an increase in the incidence of obesity, cardiovascular disease and other non-communicable illnesses worldwide among populations in some countries. Obesity and Disease examines how these rising epidemics of obesity and other lifestyle problems are changing health guidelines globally - from directing health care professionals on how to care for individuals to encouraging them to embrace the interconnected systems involved in chronic disease risk management, prevention and treatment. With a focus on systems, this reference serves as an excellent resource on how to develop a more comprehensive approach to population health. Starting with a systematic approach to health risk assessment in section one, followed by a targeted approach to risk reduction and prevention in section two, the eBook moves along seamlessly into section three calling for a shared responsibility toward strengthening health systems globally that can help determine and improve upon the health of individuals, and societies across the world. Obesity and Disease gives applicable concepts to readers in a multidisciplinary and collaborative approach to alter health systems and implement changes that promote health and wellness in the communities they serve and live in. The information and resources in this eBook also serve as a guideline for collaborations across professional associations with a goal of developing strategic plans to combat obesity and diabetes.
Download or read book Laryngopharyngeal and Gastroesophageal Reflux written by Craig H. Zalvan and published by Springer Nature. This book was released on 2020-09-29 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects of diet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided. Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient.
Download or read book The Influence of the Pharmaceutical Industry on Medicine As Exemplified by Proton Pump Inhibitors written by Helge L. Waldum and published by . This book was released on 2023-04-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based upon 45 years of clinical and scientific experience with gastroenterology, especially the stomach. In clinical medicine, Marshall and Warren's assertion that Helicobacter pylori is the main cause of gastritis, peptic ulcer disease, and gastric cancer made an immense impact. However, although peptic ulcers now can be treated with antibiotics, drugs that inhibit gastric acid secretion, including proton pump inhibitors (PPIs), are used in up to 10% of the adult population in Western countries in the treatment of gastro-oesophageal reflux disease and dyspepsia. For a long time, PPIs were the most frequently sold drugs, which made their economic impact huge. The reduction of gastric acidity induces the release of the gastric hormone gastrin, which stimulates its target, the ECL cell, to release histamine; this subsequently augments the acid secretion from the parietal cell. Gastrin also stimulates ECL cell proliferation, and long-term hyperstimulation leads to the development of tumors. The author of this book began his studies into the role of the ECL cell in human gastric carcinomas by demonstrating ECL cell markers in gastric cancer cells. This incriminated the ECL and its main regulator, gastrin, in gastric carcinogenesis. Every condition with reduced gastric acidity including treatment with drugs inhibiting acid secretion, leads to increased gastrin and thus to a predisposition to gastric cancer. This short book provides ample evidence of the pharmaceutical industry's influence on medical science. It also highlights the lack of respect and attention that the medical world gives to a biological function like gastric acidity, which prevents microbes, including viruses and prions, from entering the body through the gut.
Download or read book Acid Related Diseases written by Irvin M. Modlin and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook explores the history, biology, and treatment of acid related diseases, including gastric and duodenal ulcer disease, gastroesophageal reflux disease (GERD), and the role of H. pylori. The text offers thorough coverage of the subject matter, with an in-depth historical and biological focus. Equal focus is given to the biology and pharmacology of acid secretion and to the specific disease states of ulcers and GERD. This edition is full of new full-color medical illustrations of all aspects of this topic.
Download or read book The Acid Watcher Diet written by Jonathan Aviv, MD, FACS and published by Harmony. This book was released on 2017-01-24 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Aviv guides readers through healthy dietary choices with targeted recipes, helping them balance their bodies and minds for optimal health and break acid-generating habits for good. Do you suffer from abdominal bloating; a chronic, nagging cough or sore throat; postnasal drip; a feeling of a lump in the back of your throat; allergies; or shortness of breath? If so, odds are that you are experiencing acid reflux without recognizing its silent symptoms, which can lead to serious long-term health problems, including esophageal cancer. In The Acid Watcher Diet, Dr. Jonathan Aviv, a leading authority on the diagnosis and treatment of acid reflux disease, helps readers identify those often misunderstood symptoms while providing a proven solution for reducing whole-body acid damage quickly and easily. His 28-day program is part of a two-phase eating plan, with a healthy balance of both macronutrients (proteins, carbs, and fats) and micronutrients (vitamins, minerals, antioxidants), that works to immediately neutralize acid and relieve the inflammation at the root of acid reflux.
