Download or read book Proton and Neutron Microdosimetry written by Lawrence Albert Smith and published by . This book was released on 1975 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetry Relevant to Neutron and Proton Cancer Therapy Up to 62 MeV written by Antonio Carlos Alves de Aro and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetry written by Lennart Lindborg and published by CRC Press. This book was released on 2017-07-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master’s and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.
Download or read book Microdosimetric Investigations at the Fast Neutron Therapy Facility at Fermilab written by Katja Maria Langen and published by . This book was released on 1997 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetry written by Lennart Lindborg and published by CRC Press. This book was released on 2020-10-02 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master's and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.
Download or read book La province d Auvergne written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neutron Dosimetry written by John W. Baum and published by . This book was released on 1955 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physics and Engineering of Radiation Detection written by Syed Naeem Ahmed and published by Elsevier. This book was released on 2014-11-20 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physics and Engineering of Radiation Detection presents an overview of the physics of radiation detection and its applications. It covers the origins and properties of different kinds of ionizing radiation, their detection and measurement, and the procedures used to protect people and the environment from their potentially harmful effects. The second edition is fully revised and provides the latest developments in detector technology and analyses software. Also, more material related to measurements in particle physics and a complete solutions manual have been added. Discusses the experimental techniques and instrumentation used in different detection systems in a very practical way without sacrificing the physics content Provides useful formulae and explains methodologies to solve problems related to radiation measurements Contains many worked-out examples and end-of-chapter problems Detailed discussions on different detection media, such as gases, liquids, liquefied gases, semiconductors, and scintillators Chapters on statistics, data analysis techniques, software for data analysis, and data acquisition systems
Download or read book The Physics Dosimetry and Microdosimetry of Boron Neutron Capture Therapy written by Zamir Ghani and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A validated experimental and numerical procedure is described detailing macroscopic and microscopic dose calculations forming the basis of a protocol for the pre-clinical biological characterisation of the University of Birmingham's BNCT facility. Fundamental reference dosimetric measurements have been carried out at the University of Birmingham's accelerator based NCT facility and the Massachusetts Institute of Technology (MIT) research reactor to characterise macroscopic and microscopic doses and derive correction factors for the irradiation of V79 cells incubated in boric acid and irradiated as monolayers. On and off-axis thermal neutron, fast neutron and photon doses have been measured and calculated with standard macroscopic dosimetry techniques (foils and ion chambers) from which normalised MCNPX calculations are used to derive perturbation factors and off-axis corrections for cell flask irradiations. Microdosimetric correction factors are calculated for the boron dose component using Monte Carlo methods to simulate lithium ion and alpha particle tracks in semi-stochastic geometries representative of cell monolayer irradiations, incubated in a medium with 50ppm boric acid. Further simulations of recoil protons from nitrogen capture reactions allow for the calculation of correction factors for the non-uniform distribution of the nitrogen dose at the cellular level.
Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
Download or read book A Microdosimetric Analysis of the Interactions of Mono energetic Neutrons with Human Tissue written by Christopher Lund and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nuclear reactions induced during high-energy radiation therapy produce secondary neutrons that, due to their carcinogenic potential, constitute an important risk for the development of iatrogenic cancer. Experimental and epidemiological findings indicate a marked energy dependence of neutron relative biological effectiveness (RBE) for carcinogenesis, but little is known about its physical basis. While the exact mechanism of radiation carcinogenesis is yet to be fully elucidated, numerical microdosimetry can be used to predict the biological consequences of a given irradiation based on its microscopic pattern of energy depositions. Building on recent work, this thesis studies the physics underlying neutron RBE by using the microdosimetric quantity dose-mean lineal energy (yD) as a proxy.A simulation pipeline was constructed to explicitly calculate the yD of radiation fields that consists of (i) the open source Monte Carlo (MC) toolkit Geant4, (ii) its radiobiological extension Geant4-DNA, and (iii) a weighted track-sampling algorithm. This approach was used to evaluate the yD of mono-energetic neutrons with initial kinetic energies between 1 eV and 10 MeV at multiple depths in a tissue-equivalent phantom approximately the size of a human adult torso. Spherical sampling volumes with diameters between 2 nm and 1000 nm were considered. To obtain a measure of RBE, the neutron yD values were divided by those of 250 keV x-rays that were calculated in the same way. Qualitative agreement was found with published radiation protection factors and simulation data, allowing for the dependencies of neutron RBE on depth and energy to be discussed in the context of the neutron interaction cross sections and secondary particle distributions in human tissue"--
Download or read book Aspects of Fast Neutron Microdosimetry written by Judith Helen Meek and published by . This book was released on 1983 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neutron Interactions with Biological Tissue Progress Report 1992 1993 written by and published by . This book was released on 1993 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first area of research focuses on track structure effects in neutron microdosimetry and nanodosimetry. This is an investigation of the effect of proton energy-loss straggling and the associated transport of energy by secondary electrons on neutron event-size distributions in small sites. Secondly, energy deposition spectra and their moments for fast neutrons are investigated. Using calculated charged particle initial spectra and slowing-down spectra the authors can calculate the energy deposition in spherical cavities. Lastly, an attempt was made to study the relation of neutron energy deposition calculations to biology and biophysical models.
Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Download or read book Microdosimetric Investigations at the Fast Neutron Therapy Facility at Fermilab written by and published by . This book was released on 1997 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e. oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 " 0.04 determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated. In the unmodified beam, a negligible enhancement for a 50 ppm boron loading was measured. To boost the boron dose enhancement to 3% it was necessary to change the primary proton energy from 66 MeV and to filter the beam by 90 mm of tungsten.
Download or read book Microdosimetry of Therapeutic Proton Beams written by Anna Bianchi (Doctor of Engineering Technology) and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in Microdosimetry of Intermediate Energy Neutrons written by Ihsan Ali Mahmoud Al-Affan and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
