Download or read book Iron Metabolism written by Robert Crichton and published by John Wiley & Sons. This book was released on 2016-05-31 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Download or read book Williams Hematology 9E written by Kenneth Kaushansky and published by McGraw Hill Professional. This book was released on 2015-12-23 with total page 2528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2019! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Download or read book Dietary Reference Intakes for Vitamin A Vitamin K Arsenic Boron Chromium Copper Iodine Iron Manganese Molybdenum Nickel Silicon Vanadium and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Download or read book Proteins of Iron Metabolism written by Ugo Testa and published by CRC Press. This book was released on 2019-08-30 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins. Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature. The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.

Download or read book Inorganic Biochemistry of Iron Metabolism written by Robert R. Crichton and published by John Wiley & Sons. This book was released on 2001-10-17 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature which has led to the need for this second edition. This second edition also: Introduces many illustrations and colour photos to make the basic concepts far clearer Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc Provides additional anecdotes Incorporates an extensive and up-to-date bibliography

Download or read book Iron Physiology and Pathophysiology in Humans written by Gregory J. Anderson and published by Springer Science & Business Media. This book was released on 2012-01-14 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Download or read book A Systems Biology Approach to Blood written by Seth Joel Corey and published by Springer. This book was released on 2014-12-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.

Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Download or read book Iron Fortification of Foods written by Fergus Clydesdale and published by Elsevier. This book was released on 2012-12-02 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Fortification of Foods discusses in detail the problems encountered with different iron sources in staple foods, beverages, condiments, and salt, as well as provides a “how to approach toward solving these problems in both developed and developing countries. Organized into three parts, the book begins with the discussion on the prevalence, causes, and treatment of anemia, as well as the effect of food on the availability of iron fortificants. It then describes the different iron sources, their interaction with food, and their bioavailability. Lastly, it explores the critical area of product application. The book significantly provides needed information for almost anyone, in any country, interested in fortifying food with iron and in treating iron deficiency anemia.

Download or read book Progress in Iron Research written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th International Conference on Hemochromatosis and the 11th International Conference on Iron and Iron Proteins took place in Jerusalem on April 27 -30 and on May 2 -7 1993, respectively. The first, a clinical meeting, and the second, a forum designed primarily for basic scientists. Both meetings are held regularly on alter nate years and represent probably the most important forum for the exchange of information in iron research. The present volume "Progress in Iron Research" is based on a selection of presentations delivered at these meetings. However, this volume represents much more than a publication of conference proceedings. It offers a comprehensive state-of-the-art review on most aspects of iron metabolism. We have tried to offer a balanced review of the most important recent developments in iron research including both basic research and clinical investigation. However, the scope of chapters was based, by definition, on the actual participants at the meetings and some important fields in iron research such as plant physiology, microbial aspects of iron metabolism, and free radical research have not been dealt with. Many of the authors of the 40 chapters have beel). pt1rsonally responsible for some of the most important developments in iron research ~~vidffig: n~~~ights into iron physiology and pathophysiology. The Editors wish to express their gratitude for the outstanding and timely cooperation of all contributors to this volume.

Download or read book The Physiology of Microalgae written by Michael A. Borowitzka and published by Springer. This book was released on 2016-03-21 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the state-of-the-art of microalgae physiology and biochemistry (and the several –omics). It serves as a key reference work for those working with microalgae, whether in the lab, the field, or for commercial applications. It is aimed at new entrants into the field (i.e. PhD students) as well as experienced practitioners. It has been over 40 years since the publication of a book on algal physiology. Apart from reviews and chapters no other comprehensive book on this topic has been published. Research on microalgae has expanded enormously since then, as has the commercial exploitation of microalgae. This volume thoroughly deals with the most critical physiological and biochemical processes governing algal growth and production.

Download or read book Proteins of Iron Metabolism written by Elmer Burrell Brown and published by Saunders. This book was released on 1977 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Binding Transport and Storage of Metal Ions in Biological Cells written by Wolfgang Maret and published by Royal Society of Chemistry. This book was released on 2014-07-09 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Download or read book Haematology at a Glance written by Atul B. Mehta and published by John Wiley & Sons. This book was released on 2014-04-07 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the familiar, easy-to-use at a Glance format, Haematology at a Glance, Fourth Edition is a broad and accessible introduction to the study of blood. Fully revised and updated to reflect advances in the field and in clinical practice, this new edition covers essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment. This new edition of Haematology at a Glance: • Features expanded sections on the underlying mechanisms, diagnostic techniques and management of the malignant haematological diseases. Also incorporates recent advances in knowledge of thrombosis and the newer oral anticoagulants • Contains the very latest clinical treatments • Includes updated illustrations and clinical photographs to illustrate concepts and aid understanding • Features extensive online self-assessment at www.ataglanceseries.com/haematology This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.

Download or read book Trace Elements and Minerals in Health and Longevity written by Marco Malavolta and published by Springer. This book was released on 2018-11-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Download or read book Proteins of Iron Storage and Transport written by Geneviève Spik and published by Elsevier Science & Technology. This book was released on 1985 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Antimicrobial Peptides and Human Disease written by William Shafer and published by Springer Science & Business Media. This book was released on 2006-10-05 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.