Download or read book Protein Tyrosine Phosphatases in Cancer written by Benjamin G. Neel and published by Springer. This book was released on 2016-08-05 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases written by Lalima G. Ahuja and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-10-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes.
Download or read book Investigating Two Cancer related Protein Tyrosine Phosphatases Using Chemical Genetics written by Anna Mari Lone and published by . This book was released on 2007 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Deciphering the Regulation and Role of Protein Tyrosine Phosphatase 1B in Prostate Cancer written by David Labbé and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Despite the early diagnosis and efficient treatment of most early-stage tumors, prostate cancer (PCa) remains the second leading cause of cancer-related deaths in North American men. This reflects the use of androgen deprivation therapy, initially described in 1941, as the standard treatment for patients diagnosed with advanced disease despite the eventual development of incurable castration-resistant metastatic cancer. Therefore there is an urgent need for novel and innovative approaches to effectively treat this disease. Elevated tyrosine phosphorylation is a major contributor to tumor progression. As such, many tyrosine kinase inhibitors are presently being tested for the treatment of advanced PCa in clinical trials. However, one largely unexplored mechanism in prostate tumorigenesis is the regulation of tyrosine phosphorylation by classical protein tyrosine phosphatases. Owing to the putative oncogenic role of the protein tyrosine phosphatase 1B (PTP1B) in various cancers, the objective of my doctoral research was to investigate its regulation and role in PCa. First, we identified the androgen receptor (AR) as a critical regulator of PTPN1 (encoding PTP1B) transcription in human PCa cell lines and human PCa tissues. Importantly, we described PTP1B as a tumor promoter in these cell lines, particularly when the AR signaling axis was activated. Second, we described the frequent amplification of a chromosomal region within the hereditary PCa genetic-susceptibility locus located on chromosome 20 (HPC20) in metastatic tumors. Interestingly, PTPN1 is included in the maximal common amplified region, which is frequently co-amplified with the AR. This coordinated copy number gain might result in a synergistic increase in the transcription of most genes located on the amplicon as many are AR-regulated. Finally, using prostate-specific PTEN-null mice, we demonstrated that genetic depletion of PTPN1 results in a slightly more aggressive phenotype when mice are fed a regular chow diet. Strikingly, when mice are fed a high fat diet, PTPN1 knockout mice exhibited a dramatic increase in the number of microinvasive lesions that then progress to fully invasive carcinoma. In summary, the data presented herein identifies PTPN1 as a context-dependent PCa gene that can act as an oncogene when the AR signaling axis is activated, or as a tumor suppressor in PTEN-null tumors. These results suggest that parameters such as genetic alterations and diet should be taken into consideration when designing new clinical trials for PTP1B inhibitors in cancer." --
Download or read book Protein Tyrosine Phosphatases in Breast Cancer written by Mairin Rafferty and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Tyrosine Phosphatases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Protein Tyrosine Phosphatases in a compact format. The editors have built Protein Tyrosine Phosphatases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Tyrosine Phosphatases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Tyrosine Phosphatases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Hydrogen Peroxide and Cell Signaling Part B written by and published by Academic Press. This book was released on 2013-07-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates, and peroxiredoxins as preferential targets in H2O2-induced signaling.
Download or read book Characterization of Protein Tyrosine Phosphatases in Human Breast Epithelial Cells Neoplastically Transformed by the NEU Oncogene written by Yifan Zhai and published by . This book was released on 1993 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Protein Tyrosine Phosphatases in Breast Cancer written by Christina Holzer and published by . This book was released on 2009 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases in Tumor Progression and Metastasis written by Carmen Ferreira and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reversible phosphorylation of proteins, executed by kinases and phosphatases, is the major posttranslational protein modification in eukaryotic cells, causing them to become activated or deactivated. This intracellular event represents a critical regulatory mechanism of several signaling pathways and can be related to a broad number of diseases, including cancer. Few decades ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors. However, nowadays, accumulating evidence demonstrates that a misregulation of PTP activities plays a crucial and decisive role in cancer progression and metastasis. In this chapter, we will focus on the molecular aspects that support the crucial role of PTPs in cancer and in turn make them promising for prediction, monitoring, and rational appropriate therapy selection of individual patients.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Protein Tyrosine Kinases written by Doriano Fabbro and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.
Download or read book Protein Tyrosine Phosphatases written by Damien Thévenin and published by Springer Nature. This book was released on 2024-01-27 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with discussions on the latest advancements in protein tyrosine phosphatases (PTP) research used to investigate these essential enzymes and new inhibitors. The new techniques covered in the chapters of this book include studying enzymes in vitro, in cells, and in animal models through proteomics, genomics, and structural biology. Furthermore, new advances in pharmacology and drug design have contributed to the developing novel therapeutics that target PTPs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein Tyrosine Phosphatases: Methods and Protocols, Second Edition is a valuable resource for both experienced and novel researchers in this field, and will lead to discoveries and accelerated progress in the field of PTP, signal transduction, and drug development.
Download or read book Adhesion Linked Protein Tyrosine Phosphatases Morphogenesis and Breast Cancer Progression written by and published by . This book was released on 2006 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stromal-epithelial interactions regulate breast cell fate via integrin-growth factor receptor (GFR) interactions that activate tyrosine kinases that are tempered by protein tyrosine phosphatases (PTP). Using a series of molecular screening approaches we profiled PTP expression in normal transformed and phenotypically-reverted breast tissue and identified the Band 4.1 PTPs MEGI and D1 as candidate PTP metastasis suppressors. Our studies have implicated two Band 4.1 PTPs MEGI and D1 as important regulators of adhesion-dependent mammary morphogenesis that are consistently altered in tumors by aberrant tumor-generated mechanical force. Specifically we implicated PTP MEGI as a key regulator of adherens junction assembly/integrity and found that matrix force and tumor-generated contractility chronically increase PTP expression. Importantly ectopic elevated expression of MEGI in nonmalignant MECs enhanced their integrin-dependent cell adhesion disrupted tissue polarity and altered cell growth and survival. Studies are in progress to identify MEGI- specific effector proteins in normal transformed and phenotypically-reverted MECs and to dissect out the mechanism whereby force regulates PTP expression.
Download or read book Involvement of Tyrosine Phosphatases in Insulin Signaling and Apoptosis in Breast Cancer written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our preliminary studies demonstrated that increased intracellular calcium activates calpain to induce partial proteolysis and cytoplasmic translocation of PTP1B, a tyrosine phosphatase proposed to regulate signaling by insulin, IGF-1 and other cytokines. Cytoplasmic translocation of PTP1B results in a distinct pattern of protein tyrosine phosphorylation and these events may regulate cell growth or apoptosis by reducing activated growth factor signaling. In this scheme, calcium-mediated apoptosis and growth inhibition may be directed through mobilization of PTP1B.
Download or read book Protein Tyrosine Phosphatases in Human Breast Cancer Cell written by Universitat de València. Facultat de Ciències Biològiques and published by . This book was released on 2011 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
