Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2013-01-14 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7
Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2012-10-16 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7
Download or read book Protein Kinase CK2 From Structure to Regulation written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
Download or read book Protein Kinase CK2 Cellular Function in Normal and Disease States written by Khalil Ahmed and published by Springer. This book was released on 2015-03-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Download or read book A Molecular and Cellular View of Protein Kinase CK2 written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace. Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.
Download or read book An Updated View on an Emerging Target Selected Papers from the 8th International Conference on Protein Kinase CK2 written by Joachim Jose and published by MDPI. This book was released on 2017-05-22 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals
Download or read book A Molecular and Cellular View of Protein Kinase CK2 written by O. G Issinger and published by . This book was released on 1999 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinases and Stress Signaling in Plants written by Girdhar K. Pandey and published by John Wiley & Sons. This book was released on 2020-12-03 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of stress signaling in plants using genomics and functional genomic approaches Improving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation. Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals. This timely resource: Summarizes the role of various kinases involved in stress management Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions Examines mitogen-activated protein kinases (MAPKs) in different stresses Describes the different aspects of calcium signaling under different stress conditions Examines photo-activated kinases (PAPKs) in varying light conditions Briefs the presence of tyrosine kinases in plants Highlights the cellular functions of receptor ]like protein kinases (RLKs) Possible implication of these kinases in developing stress tolerant crops Protein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.
Download or read book Regulation and Inhibition of Protein Kinase CK2 written by Gregory Adair Imbrie and published by . This book was released on 2006 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase Ck2 From Structure to Regulation Biochemistry Essentials written by Michelle Mcguire and published by Syrawood Publishing House. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase 2 (CK2) is a serine/threonine-selective protein kinase that controls several signaling pathways. The structure of CK2 is tetrameric, which consists of two catalytic and two regulatory subunits. CK2 is a critical regulator of cell cycle progression and it has been observed to regulate cell cycle progression by protein-protein interactions. It is also involved in various biological processes such as DNA damage response, apoptosis, cell proliferation, cell cycle control, circadian rhythm regulation, transcription and translation. Furthermore, other functions of CK2 are related with human infections. There are certain viruses, which exploit the CK2 host cell for sustaining their life. CK2 activity has also been associated with various diseases including cancer, neurological diseases, inflammation, diabetes, obesity, diverse ophthalmic pathologies, and cardiovascular diseases such as cardiac hypertrophy and atherosclerosis. This book aims to shed light on the structure and regulation of protein kinase CK2. It aims to equip students and experts with the advanced topics and upcoming concepts in this area of study.
Download or read book Protein Kinase CK2 in Health and Disease written by Khalil Ahmed and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kinomics written by Heinz-Bernhard Kraatz and published by John Wiley & Sons. This book was released on 2015-11-16 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das umfassende Referenzwerk zur Kinase-Forschung: Ausführlich werden die Themen Kinase-Engineering, Peptidsubstrat-Engineering, das Design von Co-Substraten und Kinasehemmer erläutert sowie deren Anwendung in der Bio- und Pharmaforschung beschrieben.
Download or read book Protein Kinase CK2 from Structure to Regulation written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Expression of Epitope tagged Protein Kinase CK2 in Mammalian Cells written by and published by . This book was released on 1905 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 (also known as Casein Kinase II) is a protein serine/threonine kinase. It is an ubiquitously distributed tetrameric enzyme composed of two catalytic subunits ($\alpha$ and/or $\alpha\sp\prime$) and two regulatory subunits ($\beta$). The $\alpha$ and $\alpha\sp\prime$ are quite similar except their carboxyl termini. The precise role of CK2 in biological responses remains to be characterized, but a great deal of recent evidence indicates that CK2 is involved in the regulation of proliferative events. As a first step towards determining whether the phosphorylation of CK2 is important for cell division, Cos-7 cells have been transfected with cDNAs encoding wild type or non-phosphorylatable mutants of CK2$\alpha, $ CK2$\alpha\sp\prime$ or CK2$\beta .$ To discriminate between the transfected CK2$\alpha, $ CK2$\alpha\sp\prime$ or CK2$\beta$ and their endogenous counterparts, the cDNAs have been modified by the addition of different epitope tags at the amino or carboxyl terminus. The studies described in this thesis are an important prelude to a systematic examination of the functional role of CK2 and its phosphorylation during cell cycle progression. (Abstract shortened by UMI.).
Download or read book Regulation of Protein Kinase CK2 by Interaction Partners written by David Anthony Canton and published by . This book was released on 2005 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oncogenic Role of Protein Kinase CK2 written by Esther Landesman-Bollag and published by . This book was released on 2002 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Strange Case of Protein Kinase CK2 written by Kendra Tosoni and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
