Download or read book Protein Folding Evolution and Design written by Eugene I. Shakhnovich and published by IOS Press. This book was released on 2001 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the results of broad, interdisciplinary effort to study proteins in physical and evolutionary perpective. Among authors are physicists, computational, chemists, crystallographers and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented, providing a broad picture of modern biophysical chemistry.
Download or read book Protein Folding Evolution and Design written by R. A. Broglia and published by IOS Press. This book was released on 2001 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the results of broad interdisciplinary effort to study proteins in physical and evolutionary prospectives. Among the authors are physicists, chemists, crystallographers, and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented providing a broad picture of modern biophysical chemistry.
Download or read book Undeniable written by Douglas Axe and published by HarperCollins. This book was released on 2016-07-12 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Named A Best Book of the Year by World Magazine Throughout his distinguished and unconventional career, engineer-turned-molecular-biologist Douglas Axe has been asking the questions that much of the scientific community would rather silence. Now, he presents his conclusions in this brave and pioneering book. Axe argues that the key to understanding our origin is the “design intuition”—the innate belief held by all humans that tasks we would need knowledge to accomplish can only be accomplished by someone who has that knowledge. For the ingenious task of inventing life, this knower can only be God. Starting with the hallowed halls of academic science, Axe dismantles the widespread belief that Darwin’s theory of evolution is indisputably true, showing instead that a gaping hole has been at its center from the beginning. He then explains in plain English the science that proves our design intuition scientifically valid. Lastly, he uses everyday experience to empower ordinary people to defend their design intuition, giving them the confidence and courage to explain why it has to be true and the vision to imagine what biology will become when people stand up for this truth. Armed with that confidence, readers will affirm what once seemed obvious to all of us—that living creatures, from single-celled cyanobacteria to orca whales and human beings, are brilliantly conceived, utterly beyond the reach of accident. Our intuition was right all along.
Download or read book Intelligent Design written by William A. Dembski and published by InterVarsity Press. This book was released on 2002-07-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book William A. Dembski brilliantly argues that intelligent design provides a crucial link between science and theology. This is a pivotal work from a thinker whom Phillip Johnson calls "one of the most important of the `design' theorists."
Download or read book Protein Engineering and Design written by Sheldon J. Park and published by CRC Press. This book was released on 2009-09-25 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science
Download or read book Adam and the Genome written by Scot McKnight and published by Brazos Press. This book was released on 2017-01-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic science indicates that humans descend not from an individual pair but from a large population. What does this mean for the basic claim of many Christians: that humans descend from Adam and Eve? Leading evangelical geneticist Dennis Venema and popular New Testament scholar Scot McKnight combine their expertise to offer informed guidance and answers to questions pertaining to evolution, genomic science, and the historical Adam. Some of the questions they explore include: - Is there credible evidence for evolution? - Do we descend from a population or are we the offspring of Adam and Eve? - Does taking the Bible seriously mean rejecting recent genomic science? - How do Genesis's creation stories reflect their ancient Near Eastern context, and how did Judaism understand the Adam and Eve of Genesis? - Doesn't Paul's use of Adam in the New Testament prove that Adam was a historical individual? The authors address up-to-date genomics data with expert commentary from both genetic and theological perspectives, showing that genome research and Scripture are not irreconcilable. Foreword by Tremper Longman III and afterword by Daniel Harrell.
Download or read book Protein Engineering written by Mallorie N. Sheehan and published by Nova Science Publishers. This book was released on 2013-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research currently taking place into the understanding of protein folding and protein recognition for protein design principles. There are two general strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The second strategy is known as directed evolution and this is where random mutagenesis is applied to a protein, and a selection regime is used to pick out variants that have the desired qualities. This book presents and reviews important data on protein engineering, such as application of engineered proteins and cell adhesive surfaces as scaffolds or other biomedical devices which has the potential to promote tissue repair and regeneration for a wide variety of tissues including bone and skin.
Download or read book Computational Protein Design written by Ilan Samish and published by Humana. This book was released on 2016-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Download or read book Methods in Protein Design written by and published by Academic Press. This book was released on 2013-02-14 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins
Download or read book Protein Folding and Drug Design written by Luis Serrano Romero and published by IOS Press. This book was released on 2007 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the great unsolved problems of science and also of physics is the prediction of the three dimensional structure of a protein from its amino acid sequence. It may be stated that the deep connection existing between physics and protein folding is not so much, or in any case not only, through physical methods, but through physical concepts.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Folding written by Charis Ghelis and published by Academic Press. This book was released on 2012-12-02 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Folding aims to collect the most important information in the field of protein folding and probes the main principles that govern formation of the three-dimensional structure of a protein from a nascent polypeptide chain, as well as how the functional properties appear. This text is organized into three sections and consists of 15 chapters. After an introductory chapter where the main problems of protein folding are considered at the cellular level in the context of protein biosynthesis, the discussion turns to the conformation of native globular proteins. Definitions and rules of nomenclature are given, including the structural organization of globular proteins deduced from X-ray crystallographic data. Folding mechanisms are tentatively deduced from the observation of invariants in the architecture of folded proteins. The next chapters focus on the energetics of protein conformation and structure, indicating the principles of thermodynamic stability of the native structure, along with theoretical computation studies of protein folding, structure prediction, and folding simulation. The reader is also introduced to various experimental approaches; the reversibility of the unfolding-folding process; equilibrium and kinetic studies; and detection and characterization of intermediates in protein folding. This text concludes with a chapter dealing with problems specific to oligomeric proteins. This book is intended for research scientists, specialists, biochemists, and students of biochemistry and biology.
Download or read book Protein Structure and Folding written by Sridhar Govindarajan and published by . This book was released on 1997 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Engineering written by Huimin Zhao and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.
Download or read book Evolutionary Algorithms in Molecular Design written by David E. Clark and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the 'survival of the fittest', in computer programs designed to search for optimal solutions to many kinds of problems. These 'evolutionary algorithms' start from a population of possible solutions to a given problem and, by applying evolutionary principles, evolve successive generations with improved characteristics until an optimal, or near-optimal, solution is obtained. This book highlights the versatility of evolutionary algorithms in areas of relevance to molecular design with a particular focus on drug design. The authors, all of whom are experts in their field, discuss the application of these computational methods to a wide range of research problems including conformational analysis, chemometrics and quantitative structure-activity relationships, de novo molecular design, chemical structure handling, combinatorial library design, and the study of protein folding. In addition, the use of evolutionary algorithms in the determination of structures by X-ray crystallography and NMR spectroscopy is also covered. These state-of-the-art reviews, together with a discussion of new techniques and future developments in the field, make this book a truly valuable and highly up-to-date resource for anyone engaged in the application or development of computer-assisted methods in scientific research.
Download or read book Protein Design written by Raphael Guerois and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
Download or read book Biological Information new Perspectives written by Robert Jackson Marks (II) and published by World Scientific Publishing Company Incorporated. This book was released on 2013 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the spring of 2011, a diverse group of scientists gathered at Cornell University to discuss their research into the nature and origin of biological information. This symposium brought together experts in information theory, computer science, numerical simulation, thermodynamics, evolutionary theory, whole organism biology, developmental biology, molecular biology, genetics, physics, biophysics, mathematics, and linguistics. This volume presents new research by those invited to speak at the conference. The contributors to this volume use their wide-ranging expertise in the area of biological information to bring fresh insights into the explanatory difficulties that biological information raises. Going beyond the conventional scientific wisdom, which attempts to explain biological information reductionistically via chemical, genetic, and natural selective determinants, the work represented here develops novel non-reductionist approaches to biological information, looking notably to telic and self-organizational processes. Several clear themes emerged from these research papers: 1) Information is indispensable to our understanding of what life is. 2) Biological information is more than the material structures that embody it. 3) Conventional chemical and evolutionary mechanisms seem insufficient to fully explain the labyrinth of information that is life. By exploring new perspectives on biological information, this volume seeks to expand, encourage, and enrich research on the nature and origin of biological information.
