Download or read book Protein Degradation with New Chemical Modalities written by Hilmar Weinmann and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Download or read book Matrix Proteases in Health and Disease written by Niels Behrendt and published by John Wiley & Sons. This book was released on 2012-07-10 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.

Download or read book Ubiquitin dependent Protein Degradation written by and published by Academic Press. This book was released on 2019-04-04 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in this series on enzymology

Download or read book Muscle 2 Volume Set written by Joseph Hill and published by Academic Press. This book was released on 2012-08 with total page 1469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.

Download or read book The Dictionary of Genomics Transcriptomics and Proteomics 4 Volume Set written by Guenter Kahl and published by John Wiley & Sons. This book was released on 2015-06-08 with total page 2744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

Download or read book Handbook of Food Science Technology and Engineering 4 Volume Set written by Y. H. Hui and published by CRC Press. This book was released on 2005-12-19 with total page 3539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in food science, technology, and engineering are occurring at such a rapid rate that obtaining current, detailed information is challenging at best. While almost everyone engaged in these disciplines has accumulated a vast variety of data over time, an organized, comprehensive resource containing this data would be invaluable to have. The

Download or read book Community Series in Manipulating the Immunological Tumor Microenvironment Volume II written by Huanfa Yi and published by Frontiers Media SA. This book was released on 2023-07-17 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Models for Assessing Drug Absorption and Metabolism written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.

Download or read book Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Download or read book The Model Legume Medicago truncatula 2 Volume Set written by Frans J. de Bruijn and published by John Wiley & Sons. This book was released on 2020-01-29 with total page 1264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully covers the biology, biochemistry, genetics, and genomics of Medicago truncatula Model plant species are valuable not only because they lead to discoveries in basic biology, but also because they provide resources that facilitate translational biology to improve crops of economic importance. Plant scientists are drawn to models because of their ease of manipulation, simple genome organization, rapid life cycles, and the availability of multiple genetic and genomic tools. This reference provides comprehensive coverage of the Model Legume Medicago truncatula. It features review chapters as well as research chapters describing experiments carried out by the authors with clear materials and methods. Most of the chapters utilize advanced molecular techniques and biochemical analyses to approach a variety of aspects of the Model. The Model Legume Medicago truncatula starts with an examination of M. truncatula plant development; biosynthesis of natural products; stress and M. truncatula; and the M. truncatula-Sinorhizobium meliloti symbiosis. Symbiosis of Medicago truncatula with arbuscular mycorrhiza comes next, followed by chapters on the common symbiotic signaling pathway (CSSP or SYM) and infection events in the Rhizobium-legume symbiosis. Other sections look at hormones and the rhizobial and mycorrhizal symbioses; autoregulation of nodule numbers (AON) in M. truncatula; Medicago truncatula databases and computer programs; and more. Contains reviews, original research chapters, and methods Covers most aspects of the M. truncatula Model System, including basic biology, biochemistry, genetics, and genomics of this system Offers molecular techniques and advanced biochemical analyses for approaching a variety of aspects of the Model Legume Medicago truncatula Includes introductions by the editor to each section, presenting the summary of selected chapters in the section Features an extensive index, to facilitate the search for key terms The Model Legume Medicago truncatula is an excellent book for researchers and upper level graduate students in microbial ecology, environmental microbiology, plant genetics and biochemistry. It will also benefit legume biologists, plant molecular biologists, agrobiologists, plant breeders, bioinformaticians, and evolutionary biologists.

Download or read book Physiology of the Gastrointestinal Tract Two Volume Set written by Hamid M. Said and published by Academic Press. This book was released on 2012-07-04 with total page 2250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. - 2013 Highly Commended BMA Medical Book Award for Internal Medicine - Discusses the multiple processes governing gastrointestinal function - Each section edited by preeminent scientist in the field - Updated, four-color illustrations

Download or read book Handbook of Plant Science 2 Volume Set written by Keith Roberts and published by John Wiley & Sons. This book was released on 2007-12-10 with total page 1697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Science, like the biological sciences in general, has undergone seismic shifts in the last thirty or so years. Of course science is always changing and metamorphosing, but these shifts have meant that modern plant science has moved away from its previous more agricultural and botanical context, to become a core biological discipline in its own right. However the sheer amount of information that is accumulating about plant science, and the difficulty of grasping it all, understanding it and evaluating it intelligently, has never been harder for the new generation of plant scientists or, for that matter, established scientists. And that is precisely why this Handbook of Plant Science has been put together. Discover modern, molecular plant sciences as they link traditional disciplines! Derived from the acclaimed Encyclopedia of Life Sciences! Thorough reference of up-to-the minute, reliable, self-contained, peer-reviewed articles – cross-referenced throughout! Contains 255 articles and 48 full-colour pages, written by top scientists in each field! The Handbook of Plant Science is an authoritative source of up-to-date, practical information for all teachers, students and researchers working in the field of plant science, botany, plant biotechnology, agriculture and horticulture.

Download or read book International Textbook of Diabetes Mellitus 2 Volume Set written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-05-18 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

Download or read book Handbook of Cell Signaling Three Volume Set written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2003-12-02 with total page 2560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation* Events in Intracellular Compartments* Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field.Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field!* Contains approximately 470 articles* Provides well-organized sections on each essential area in signaling* Includes discussion on everything from ligand/receptor interactions to organ/organism responses* Extremely user-friendly

Download or read book The Biochemical Journal written by and published by . This book was released on 1922 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. 36- include Proceedings of the Biochemical Society.

Download or read book Phenotyping at Plant and Cell Levels The Quest for Tolerant Crop Development volume II written by Ulrich Schurr and published by Frontiers Media SA. This book was released on 2023-11-22 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Phenotyping at Plant and Cell Levels: The Quest for Tolerant Crop Development series: Phenotyping at Plant and Cell Levels: The Quest for Tolerant Crop Development This Research Topic aims at accelerating the discovery of crop varieties that are able to withstand environmental stresses, via the use of phenotyping approaches at the plant and cellular levels. Climate change is expected to have a drastic impact on agriculture, notably by impacting water availability, precipitations, temperatures, soil nutrients, and the incidence of diseases and pests. A better use of plant genetic resources and plant breeding are key to tackling this challenge from climate change and for food security. Many landraces and wild relatives of crops are conserved in seed and gene banks. These collections are potentially valuable for breeders, but are presently underexploited. Moreover, the contribution of the soil microbiome to enhance the performance of specific plant genotypes has been overlooked. The aim is to generate crops that are resistant against biotic stress or can tolerate abiotic stress without significant impact on their performance. Current studies in the field of sensor technologies and phenomics are mainly empirically based and do not link the phenotypic parameters to the molecular scale. Similarly, many molecular studies do not correlate their findings to the whole plant phenotype. The quantitative high throughput analysis of crop potential and behavior during stress is a form of Genotype x Environment interaction and is a major bottleneck. We urgently need to identify resilient genotypes and to understand the underlying mechanisms of this resilience. Phenotyping science is quickly developing to characterize plant behavior, it's dynamic dimensions, and to quantify features such as growth and stress resilience, which increasingly permit to link the phenotype to genetic control.

Download or read book Abiotic Stress Signaling in Plants Functional Genomic Intervention Volume II written by Girdhar Kumar Pandey and published by Frontiers Media SA. This book was released on 2024-01-31 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Abiotic Stress Signaling in Plants: Functional Genomic Intervention series: Abiotic Stress Signaling in Plants: Functional Genomic Intervention Abiotic stresses such as high temperature, low-temperature, drought and salinity limit crop productivity worldwide. Understanding plant responses to these stresses is essential for rational engineering of crop plants. In Arabidopsis, the signal transduction pathways for abiotic stresses, light, several phytohormones and pathogenesis have been elucidated. A significant portion of plant genomes (most studies are Arabidopsis and rice genome) encodes for proteins involves in signaling such as receptor, sensors, kinases, phosphatases, transcription factors and transporters/channels. Despite decades of physiological and molecular effort, knowledge pertaining to how plants sense and transduce low and high temperature, low-water availability (drought), water-submergence and salinity signals is still a major question before plant biologist. One major constraint hampering our understanding of these signal transduction processes in plants has been the lack or slow pace of application of molecular genomic and genetics knowledge in the form of gene function.