Download or read book Protein Actions Principles and Modeling written by Ivet Bahar and published by Garland Science. This book was released on 2017-02-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Download or read book Structure And Action Of Molecular Chaperones Machines That Assist Protein Folding In The Cell written by Lila M Gierasch and published by World Scientific. This book was released on 2016-08-08 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a 'clamp' or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.
Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Download or read book Current Perspectives on Insulin like Growth Factor Binding Protein IGFBP Research written by Andreas Hoeflich and published by Frontiers Media SA. This book was released on 2019-02-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.
Download or read book Protein Peptide Letters written by and published by . This book was released on 1999-10 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Protein Structure written by G.E. Schulz and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses.
Download or read book Regulators of G Protein Signaling Part A written by and published by Elsevier. This book was released on 2004-11-25 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulators of G Protein Signaling, Part A is an in-depth treatment of G-Protein Signaling, and will cover general methods of analysis of RGS protein analysis, including Expression and post-translational modification, Assays of GAP activity and allosteric control, Electrophysiological methods and RGS-insensitive Ga subunits, Mouse models of RGS protein action, Methods of RGS protein inhibition, and G-protein regulators of model organisms. - Table of Contents - Expression and post-translational modification - Assays of GAP activity and allosteric control - Electrophysiological methods and RGS-insenstitive Ga subunits - Mouse Models of RGS protein action - Methods of RGS protein inhibition - G-protein regulators of model organisms
Download or read book Heat Shock Protein Based Therapies written by Alexzander A.A. Asea and published by Springer. This book was released on 2015-07-22 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.
Download or read book Protein Moonlighting in Biology and Medicine written by Brian Henderson and published by John Wiley & Sons. This book was released on 2016-12-12 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.
Download or read book New and Nonofficial Drugs written by Council on Drugs (American Medical Association) and published by . This book was released on 1919 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New and Nonofficial Remedies written by Council on Drugs (American Medical Association) and published by . This book was released on 1915 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Descriptions of therapeutic, prophylactic and diagnostic agents evaluated by the Council on Drugs.
Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
Download or read book The Chemistry of Enzyme Actions written by Kaufman George Falk and published by . This book was released on 1921 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms and Pathways of Heterotrimeric G Protein Signaling written by Stephen Sprang and published by Academic Press. This book was released on 2007-10-01 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric Gƒуnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.
Download or read book Mammalian Protein Metabolism written by H. N. Munro and published by Academic Press. This book was released on 2014-05-12 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Protein Metabolism, Volume I focuses on the processes, methodologies, biosynthesis, protein formation, and reactions involved in mammalian protein metabolism. The selection first elaborates on the origin and growth of concepts of protein metabolism, including the development of nitrogen balance as a technique for the study of protein metabolism; identification of proteins as a chemical class; discovery of nitrogen and its biological consequences; and recognition of the importance of nitrogenous compounds. The text then examines protein digestion and absorption in nonruminants and digestion and absorption of nitrogenous compounds in ruminants. Topics include passage of nitrogenous compounds from the rumen; utilization of nitrogenous compounds in the rumen; and endogenous nitrogen entering the reticulum and rumen. The book examines free amino acids and peptides in tissues, metabolic fate of amino acids, protein biosynthesis in mammalian tissues, and metabolism of plasma proteins. Discussions focus on the distribution of proteins between plasma and lymph, interpretation of plasma radioactivities, amino acid activating enzymes, ribosomes and protein synthesis, pathways of amino acid degradation, and synthesis of urea. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.
Download or read book Protein Electron Transfer written by Dr Derek Bendall and published by Garland Science. This book was released on 2020-07-24 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique; the factual content and ideas it expounds are only just beginning to be touched upon in standard texts. Protein Electron Transfer is a major collaborative effort by leading experts and explores the molecular basis of the rapidly expan
Download or read book The Structure and Action of Proteins written by Richard Earl Dickerson and published by . This book was released on 1969 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rules of the game; Bircks and mortar-the structural proteins; Molecular carriers; Molecular catalysts; The next step up.
