Download or read book Prostate Cancer Unmasked written by Ray M. Schilling, M.d. and published by Createspace Independent Publishing Platform. This book was released on 2017-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FDA approved the PSA test in 1986 as a "monitor for treatment response and disease recurrence". Later in 1994 the FDA approved the PSA test as a screening tool for prostate cancer. But the question remained: what was the best treatment tool? I am reviewing 9 different treatment approaches in this book. They are all currently in use by different physicians. But they do not necessarily serve the patient best. Brachytherapy does not quite do it. It improves the cancer for a period of time, and after a few years it returns with a vengeance. The radical prostatectomy and the robotic prostatectomy have helped a significant amount of patients. But long-term studies show that there can be a recurrence rate of as much as 25 to 30%. In addition there are significant side effects like a killed sex life and involuntary dribbling of urine, if the bladder outlet was injured during the surgery. Quite often urologists recommend "active surveillance". This approach to prostate cancer means that a 71 to 75 year old prostate cancer sufferer is kept in suspense by the urologist. An initial rectal biopsy is done with a histology assessment where a Gleason score is analyzed. If this score is 6 or less, the cancer is presumed to be less aggressive and active surveillance is done. Another biopsy is done 1 year later and this could go on until the patient dies of a heart attack or a stroke. I think that prostate cancer should be treated early before metastases develop and the cancer gets out of control. There are other methods that actually can get rid of the prostate cancer, for instance cryoablation therapy following a mapping biopsy. In this latter method 60 biopsies are placed like a grid through the entire prostate gland to identify the exact location where prostate cancer has developed. This is done through the perineum (between the scrotum and the anal opening). Prostate cancer can often be multifocal: there may be two or three areas where prostate cancer is located. One month after the mapping procedure probes are introduced in the same way, through the perineum and the identified cancer lesions are treated with cryotherapy twice. I am explaining this in chapter 15 in more detail. According to Dr. Onik, an interventional radiologist in Ft. Lauderdale, active surveillance is something that should be abandoned. Instead the following treatment approach should be adopted. 1. A rising PSA or single PSA above 30 should trigger a referral for a mapping biopsy through the perineal approach under a general anesthetic. The treating physician can sterilize the area and perform biopsies in a sterile fashion, which prevents infection. This is a huge advantage above the standard transrectal approach, which can lead to infections like prostatitis and blood poisoning. 2. Based on the result of the mapping biopsy targeted ablation cryotherapy is performed one month later eradicating all the cancer foci determined through the mapping biopsy. 3. Follow-up PSA levels are obtained every three months for 2 years. If the PSA is less than 3.0, the patient is considered cured. If there is a rising PSA level point 1 and 2 above are repeated until a cure is achieved. Dr. Gary Onik published a 10-year follow-up study that had a 100% survival rate and a 94% cure rate in 70 men with prostate cancer. The reason for such good results is that attention is paid to detail, to the exact location of the cancer and that all cancer is completely eradicated. In my opinion this is the new blueprint of a common sense approach to prostate cancer. Read more details about this in chapter 15. Apart from the above mentioned treatment methods I reviewed external beam radiotherapy, laser ablation therapy and high-intensity focused ultrasound treatment. I noticed that the long-term cure rates over 10 years differ considerably from one treatment modality to the next. All of this is reviewed in detail in this book.
Download or read book FDR Unmasked 73 Years of Medical Cover ups That Rewrote History written by Steven Lomazow and published by Kugler Publications. This book was released on 2023-05-05 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: FDR Unmasked chronicles Franklin Delano Roosevelt’s life from a physician’s perspective. It tells a harrowing story of heroic achievement by a great leader determined to impart his vision of freedom and democracy to the world while under constant siege by serious medical problems.
Download or read book Prostate Cancer written by Jack H. Mydlo and published by Elsevier. This book was released on 2003-07-11 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future. Key Features * Provides a translational resource for scientists and clinicians working on prostate cancer * Reviews current surgical interventions and highlights their related pitfalls * Presents the latest laparoscopic techniques with figures and illustrations of step-by-step procedures * Offers insight into the potential for novel approaches to treatment in the future * Includes personal perspectives from patients
Download or read book After Prostate Cancer written by Arnold Melman and published by OUP USA. This book was released on 2011-08-03 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many books explain the different types of prostate cancer treatments, but most end once a treatment choice has been made, offering readers little in the way of guidance through the challenges of the post-treatment period. After Prostate Cancer picks up where those books leave off. Dr. Arnold Melman, Chair of the Department of Urology at the Albert Einstein College of Medicine, offers a thorough description of what the prostate cancer recovery process is like and what readers can do to optimize recovery and attain the best possible health and long-term prognosis.
Download or read book Androgen Action in Prostate Cancer written by Donald Tindall and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Download or read book Standard Practice in Sexual Medicine written by Hartmut Porst and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new international standard reference work for sexual medicine Written under the auspices of the International Society for Sexual Medicine, (www.issm.info), the leading professional society in sexual medicine and founder of the most influential journal in the field, The Journal of Sexual Medicine, published by Blackwell Publishing Comprehensive coverage of the full range of diagnostic and treatment options in all aspects of male and female sexual dysfunctions Provides information on recent progress in pharmacologic approaches, including the highly successful drug treatments for ED Useful for any part of the patient-clinician consultation, from gathering symptoms to diagnosis to treatment to reports on potential and developing treatments
Download or read book Evidence Based Procedural Dermatology written by Murad Alam and published by Springer. This book was released on 2019-05-16 with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the best evidence in procedural dermatology, including skin cancer surgery, laser techniques, minimally invasive cosmetic surgery, and emerging techniques. Building on the highly successful first edition, this volume provides much expanded coverage of a range of topics. The best information is provided to reveal the most appropriate interventions for particular indications, optimal treatment techniques, and strategies for avoiding adverse events. Evidence-Based Procedural Dermatology, 2nd edition, includes two types of chapters: procedures and indications. Each chapter is designed to be clear and concise, with tables and flowcharts to showcase main findings. Each cited study is tagged with a level of evidence, and every recommendation includes a strength of evidence score. More than double the length of the first edition, this newest edition includes added procedures and interventions like: new lasers and energy devices for skin resurfacing and pigmentation; non-invasive fat reduction and skin tightening using cryolipolysis, radiofrequency, ultrasound, and chemical adipocytolysis; specific post-skin cancer excision reconstruction techniques; and novel approaches for melanoma.
Download or read book 100 Questions Answers About Men s Health Keeping You Happy Healthy Below the Belt written by Pamela Ellsworth and published by Jones & Bartlett Publishers. This book was released on 2010-04-20 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: 100 Questions & Answers About Men's Health: Keeping You Happy & Healthy Below the Belt is a comprehensive guide to men's genitourinary health. This essential text provides authoritative, practical answers to the key questions about erectile dysfunction, prostate cancer and benign prostate disease, urinary retention, and treatments for all of these problems. Written by Dr. Pamela Ellsworth, a prominent urologist and best-selling author, this easy to read and invaluable resource is for all men interested in maintaining everything in good working order “down there.”
Download or read book Clinical Oncology written by Martin D. Abeloff and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have reference, this new edition provides practical information on treatment guidelines, details of diagnosis and therapy, and personal recommendations on patient management from experts in the field. Consistently formatted chapters allow for a user-friendly presentation for quick access of key information by the practicing clinician. Completely updated, this new edition includes all of the latest developments in treatment strategies of medical, surgical and radiation oncologists.
Download or read book Management of Castration Resistant Prostate Cancer written by Fred Saad and published by Springer. This book was released on 2014-08-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.
Download or read book Fundamentals of Cancer Prevention written by David Alberts and published by Springer Science & Business Media. This book was released on 2005-04-20 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative work that provides a detailed review of the current status of practice and research in cancer prevention and control – an essential reference guide and tool for primary care physicians, the research community and students. Written as a collaborative work by the faculty of the nationally-renowned Cancer Prevention and Control Program at the Arizona Cancer Center, this book harnesses the expertise of researchers, investigators and clinicians in cancer prevention and control, to provide insights into this field for the benefit of nonspecialists.
Download or read book Male Hypogonadism written by Stephen J. Winters and published by Springer Science & Business Media. This book was released on 2003-12-12 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in cellular and molecular biology have markedly increased our understanding of normal and abnormal hypothalamic–pituitary–testicular function. Like other volumes in the Contemporary Endocrinology series, the goal of Male Hy- gonadism: Basic, Clinical, and Therapeutic Principles is to link current knowledge of basic biology to the practice of medicine. The development of new methods for testost- one replacement has substantially increased the number of men who are seeking to determine whether they are hypogonadal, and who are using testosterone replacement therapy, thus mandating a broader understanding of testosterone deficiency. The chapters of this book were contributed by authors from around the world, and from various scientific and clinical disciplines, who have devoted their careers to the study of the physiology and pathophysiology of the male. Thus, this comprehensive and focused volume is intended for a wide audience encompassing both basic scientists and practicing clinicians. Its scope will provide a wealth of information for students and fellows as well.
Download or read book When Political Transitions Work written by Fanie du Toit and published by Oxford University Press. This book was released on 2018-07-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peaceful end of apartheid in South Africa was a monumental event in late twentieth century history. A racist regime built upon a foundation of colonialist exploitation, South Africa had become by that point a tinderbox: suffused with day-to-day violence and political extremism on all sides. Yet two decades later it was a stable democracy with a growing economy. How did such a deeply divided, conflicted society manage this remarkable transition? In When Political Transitions Work, Fanie du Toit, who has been a participant and close observer in post-conflict developments throughout Africa for decades, offers a new theory for why South Africa's reconciliation worked and why its lessons remain relevant for other nations emerging from civil conflicts. He uses reconciliation as a framework for political transition and seeks to answer three key questions: how do the reconciliation processes begin; how can political transitions result in inclusive and fair institutional change; and to what extent does reconciliation change the way a society functions? Looking at South Africa, one of reconciliation's most celebrated cases, du Toit shows that the key ingredient to successful reconciliations is acknowledging the centrality of relationships. He further develops his own theoretical approach to reconciliation-as-interdependence-the idea that reconciliation is the result of an integrated process of courageous leadership, fair and inclusive institutions, and social change built toward a mutual goal of prosperity. As du Toit conveys, the motivation for reconciliation is the long-term well-being of one's own community, as well as that of enemy groups. Without ensuring the conditions in which one's enemy can flourish, one's own community is unlikely to prosper sustainably.
Download or read book Cancer Chemotherapy Immunotherapy and Biotherapy written by Bruce A. Chabner and published by Lippincott Williams & Wilkins. This book was released on 2024-06-18 with total page 1541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on individual patient needs, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Seventh Edition, provides thorough, comprehensive information from Drs. Bruce A. Chabner, Dan L. Longo, and an authoritative team of clinicians and scientists working at renowned cancer centers across the globe. It covers fundamental information about mechanism of action, pharmacokinetics, clinical toxicity, and drug interactions, all essential to the safe and effective use of the drug.
Download or read book Smith and Tanagho s General Urology Eighteenth Edition written by Donald Ridgeway Smith and published by McGraw Hill Professional. This book was released on 2013 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smith's General Urology is the classic reference for a brief, concise overview of urology. The book simultaneously serves residents in urology with the base of knowledge they will draw upon for their rotatations and boards, and serves junior faculty with the review they rely upon when they are on the wards.
Download or read book Multi targeted Natural Products as Cancer Therapeutics Challenges and Opportunities Volume I 2nd edition written by Jiang-Jiang Qin and published by Frontiers Media SA. This book was released on 2024-01-11 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of a series with: Multi-targeted Natural Products as Cancer Therapeutics: Challenges and Opportunities, Volume II Cancer remains a leading cause of disease-related deaths worldwide, despite recent advances in our understanding of cancer initiation, progression, and metastasis. Chemotherapy and radiotherapy have been used as standard non-surgical treatments of human cancer for decades, however, the survival rates of patients with cancer, especially those with advanced diseases are still very low due to the high toxicities of these treatments as well as the severe side effects. This fact has motivated researchers to discover new cancer therapeutics with minimum side effects, which intensively promotes the rapid development of single specific molecule-targeted therapies (SSMTT). Many efforts have been made in world-wide cancer drug discovery research and several single molecule-targeted therapies have been successfully developed. Unfortunately, most of the investments failed because cancer is a genetic disease and always harbors multiple alternations of molecules or genes at the genomic, genetic and epigenetic levels. The inhibition of a single molecule or signaling pathway by SSMTT frequently results in a hyperactive compensation of other cancer-related molecules and signaling pathways as well as the subsequent development of drug resistance. Therefore, identifying multi-targeted therapies, i.e. drugs that are able to target multiple cancer-related genes, proteins, or signaling pathways is a more promising way to success in developing new cancer therapeutics. Natural products, especially those from traditional Chinese medicine and folk remedies in other countries are an extraordinarily important source for new drug discovery over the past decades. Of note, many natural products have often been demonstrated to target several crucial genes or proteins in cancer-related signaling networks and exert synergistic effects. For example, Japonicone A, a dimeric sesquiterpenoid from the medicinal plant Inula japonica, has been found to inhibit tumor growth and metastasis by dually targeting the TNF-α/NF-κB and p53/MDM2 signaling pathways. Traditionally, researchers have believed that the multi-targeting mechanisms of natural products have limited their use in cancer treatment due to the low specificity and potential side effects. The growing interest in developing multi-targeted cancer therapies may provide another golden opportunity to develop natural products as new cancer therapeutics. Nevertheless, critical investigations for a comprehensive understanding of the molecular mechanisms of natural products also mean more challenges. Our long-term goals are to fully understand the molecular targets and mechanisms of action of anticancer natural products and develop them as novel cancer preventive and therapeutic agents. The specific goal of this Research Topic is to bring together the recent findings of newly identified anticancer natural products, especially those with multiple molecular targets. Papers (Original Research articles or Reviews) which discuss the in vitro and in vivo efficacy and pharmacological and toxicological properties of natural products are also welcome to be submitted. Guidelines for the conception and review of submissions As many anticancer drugs working as cytotoxic compounds have non-selective effects annihilating their potential therapeutic benefits, manuscripts are advised to provide evidence of a significant selectivity towards cancer cells (vs. healthy cells). Specifically, if the studied anticancer drug or modality does not target an oncogenic pathway, the authors should make every effort possible to prove that the cytotoxic or cytostatic effects they have identified exhibit selectivity for cancer cells (ideally 1 log difference in EC50 or IC50) vs. non-malignant cells (eg, fibroblasts or primary culture of cells). The authors should also demonstrate the applicability of their anticancer modalities on a minimum of two well-authenticated cancer cell lines (ideally originating from distinct organs/tissues). For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.
Download or read book Molecular Mechanisms of Cancer written by Georg F. Weber and published by Springer Science & Business Media. This book was released on 2007-09-12 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
