Download or read book Commission Proposals on Identifying Endocrine Disruptors written by Nicole Scholz and published by . This book was released on 2016 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruptors are substances that interfere with the functioning of hormones, with potentially harmful effects on health. Defining scientific criteria for their identification is highly complex and has important repercussions. There are gaps in scientific understanding as well as diverging regulatory views. The European Commission's delay in adopting scientific criteria has provoked strong reactions. In a judgment delivered on 16 December 2015, the General Court of the Court of Justice of the European Union found that the Commission had breached EU law by failing to act on endocrine disruptors. The Commission has now proposed the long-awaited criteria, and has presented the draft legal acts required for their implementation. However, stakeholders on all sides of the debate are critical of the proposal. Members of the European Parliament are divided on the issue. The proposed delegated act and implementing act will now have to be approved, according to procedures subject to scrutiny in Parliament and Council. This briefing is an update of an earlier edition, of 27 April 2016.
Download or read book Proposal for Criteria for Identication of Endocrine Disruptors written by European Chemical Industry Council and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Road to regulation of endocrine disruptors and combination effects written by Karina Petersen and published by Nordic Council of Ministers. This book was released on 2014-05-06 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussions regarding regulation of endocrine disruptors (EDs) and combination effects are ongoing in Europe. Among the central topics of discussion are establishment of criteria for identification of EDs, whether there is a threshold for endocrine disrupting effects and how EDs should be handled within relevant EU regulations. In addition, a roadmap for further EU work regarding combination effects has been presented, but more detailed discussions are needed regarding scientific issues and regulatory intervention. Possible Member State initiatives to provide input to these EU processes were discussed in a Nordic workshop held in Oslo in November 2013. This report describes the workshop presentations, initiatives and thoughts from each of the Nordic countries, the plenary discussions, and the main workshop outcomes.
Download or read book New EU criteria for endocrine disrupters written by Nordic Council of Ministers and published by Nordic Council of Ministers. This book was released on 2018-08-30 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruptors (EDs) are substances that adversely affect hormone function. The effects by EDs are thought to depend on both dose and timing of exposure, especially during foetal development. The upcoming EU regulation on identification of EDs, application biocides and pesticides, will have an impact on all actors of the food chain. The consequences of a ban of EDs in foods were discussed in a Nordic workshop (Uppsala, 29-30 Nov 2016) where risk assessors and managers from Nordic food authorities, industry, trade associations, consumer organizations and researchers were represented. It was recognized by all participants that a ban was particularly challenging for the production chain since there are few viable alternatives. A harmonized EU legislation based on scientific risk assessment was preferred compared to national specific legislation as it treats all the actors equally.
Download or read book Research Plan for Endocrine Disruptors written by Gerald T. Ankley and published by . This book was released on 1998 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Screening Methodology to Identify Endocrine Disruptors According to Different Options in the Context of an Impact Assessment written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Several pieces of EU legislation regulate the marketing and use of chemical substances. While several regulations, including the regulations on Plant Protection Products (PPPR), Biocidal Products (BPR) and Chemicals (REACH), include provisions for endocrine disrupting substances (EDs), objective scientific criteria are lacking. In order to evaluate the potential health, socio-economic and environmental impacts of applying four different options for criteria defining EDs across these pieces of legislation, the Commission initiated an Impact Assessment (IA). This IA has been supported by two studies, focusing on (a) selection of substances for the IA and the screening of their potential for identification as EDs according to different options for defining criteria for identification of endocrine disruptors and (b) the potential impacts of various policy options on health, environment, trade, agriculture and socio-economy. This report describes a screening methodology that has been developed by the JRC to support the first study which has assessed almost all pesticide and biocide active ingredients and a selection of substances falling under REACH, the Cosmetic Products Regulation and the Water Framework Directive. This screening methodology is not intended to replace an in-depth risk assessment process, and the results obtained are not intended to pre-empt regulatory conclusions that may eventually be made under different pieces of EU legislation.
Download or read book IPCS Risk Assessment Terminology written by International Program on Chemical Safety and published by World Health Organization. This book was released on 2004 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: A joint project of IPCS/OECD. In two parts: Part 1: IPCS/OECD Key Generic Terms used in Chemical Hazard/Risk Assessment. Part 2: IPCS Glossary of Key Exposure Assessment Terminology. IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals
Download or read book Expert Survey on Identification of Gaps in Available Test Methods for Evaluation of Endocrine Disruptors written by and published by . This book was released on 2017 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the 2012 WHO/UNEP publication 'State of the Science of Endocrine Disrupting Chemicals' research into endocrine disrupting chemicals over the last decade has indicated that, despite the progress achieved in development and validation of test methods for evaluation of endocrine disruptors, there are still several gaps that need to be addressed. Considering the expected significant amount of work needed to fill the gaps and the limited resources available, it will be important to set priorities for the upcoming period (next 5-10 years) for the development and validation of test methods. Thus there is a need to focus the European input to the OECD test guideline programme to effectively enhance the identification of chemical substances with endocrine disrupting properties whilst making best use of existing resources. With this objective in mind, DG Environment, supported by JRC, is organising a European expert workshop on setting priorities for further development and validation of test methods for evaluating endocrine disruption. The workshop will take place on 30 May - 01 June 2017 in Brussels. The deliberations will focus on what is necessary and achievable in the context of resources, timescales and animal welfare considerations. In preparation for the workshop, JRC has drawn up a questionnaire to gather input from experts in the field on key issues to be used as a basis for the further discussions at the workshop. An online survey with the title "Identifying gaps in available test methods for evaluation of endocrine disruptors" was performed on the EU Survey platform and open for commenting from 19/05/2015 until 15/06/2015. A selected group of experts (EFSA Scientific Committee and WG on EDs, ECHA ED WG and RAC, WNT (European members from OECD webpage), Experts identified in Annex 3 of the "Roadmap for setting priorities for further development and validation of test methods and testing approaches for evaluating endocrine disruptors") was invited to participate in the survey. Experts were asked to rank endocrine related diseases/disorders regarding the possibility to predict them with existing test methods (TMs). They were further asked to rank diseases/disorders regarding the need to develop new test methods to better cover those. Experts were then requested to provide their views on including further tests based on those discussed in the OECD (2012) "Detailed Review Paper on the state of the science on novel in vitro and in vivo screening and testing methods and endpoints for evaluating endocrine disruptors" and their views on the current OECD Conceptual Framework and proposals for improvements. Forty experts representing 15 countries and different stakeholder groups (authorities; academia; civil society organisation; industry) replied. The purpose of this report is to present the detailed survey results. Multiple choice questions were evaluated and where possible quantitative rankings were performed. In addition, the survey respondents provided a lot of valuable information in numerous free text comments. Those are included in the report in tables as they were received, without editing them, unless personal information had to be removed. Brief summaries of the main points raised are added after each section
Download or read book OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a Basis for Regulation of Substances with Endocrine Disrupting Properties written by Nordic Council of Ministers and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The existing EU chemical legislation only covers some of the effects caused by endocrine disruption. In the proposal for the new REACH system, endocrine disrupters are covered by the authorisation procedure based on a case-by-case assessment, but no indication of criteria for the assessment is given. Several toxicological and ecotoxicological screening tests for predicting endocrine disrupting properties of a chemical are now under development and international validation within the OECD, but it will probably take several years before the full range of validated testing methods and criteria are developed. In the meantime there is a need for guidance on how to interpret test results from existing test methods and how to identify a substance as an endocrine disrupter. Regulatory instruments that can be used towards endocrine disrupters should also be considered in this interim period. The aim of this project has been to investigate if and how the OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters can be used as a basis for regulatory initiatives towards endocrine disrupters. The report includes an assessment of the tests in the OECD Conceptual Framework, including specification of the endpoint for the test and reliability and relevance for effects in humans. This report is expected to serve as a basis for the Nordic contribution to the discussions in EU on interpretation and use of test results indicating endocrine disruption for regulatory purposes and furthermore, how to integrate endocrine disrupters in the new EU chemicals regulation
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Download or read book Temporal Aspects in the Testing of Chemicals for Endocrine Disrupting Effects in Relation to Human Health and the Environment written by and published by . This book was released on 2017 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruptors are exogenous substances or mixtures that alter function(s) of the endocrine system and consequently cause adverse health effects in an intact organism, its progeny or (sub) populations. Exposure to endocrine disruptors is of particular concern in phases of critical developmental processes, where the endogenous hormonal systems are particularly vulnerable or sensitive to disturbances during certain developmental life stages (e.g. organogenesis), which may consequently lead to serious and irreversible health effects. The Organisation for Economic Co-operation and Development (OECD) is the responsible body for the development and validation of test guidelines for testing endocrine-disrupting properties. The OECD's "Conceptual Framework for Testing and Assessment of Endocrine Disrupters" (as revised in 2012) lists the OECD Test Guidelines (TGs) and standardised test methods available, under development or proposed that can be used to evaluate chemicals for endocrine disruption. However, there are currently gaps and limitations in the existing OECD TGs that hinder the identification of health effects from endocrine-disrupting chemicals (EDCs) such as insufficient coverage of examining the temporal aspects of EDC exposure and effects in the current TGs. Therefore, in order to identify these gaps and limitations of the existing OECD TGs regarding temporal aspects of chemical exposure and effects, a critical literature review on the existing scientific knowledge on this topic was conducted. Afterwards, a comparative analysis was performed between studies following OECD TGs and those using modified or non-OECD TG protocols, e.g. to identify what temporal aspects of EDC exposure and effects have been observed in the non-OECD TG studies but are not addressed in the TGs. This technical report presents the outcomes of the critical literature review and the comparative analysis.
Download or read book TSCA written by Lynn L. Bergeson and published by American Bar Association. This book was released on 2000 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Road to Regulation of Endocrine Disruptors and Combination Effects written by Birgitte Lindeman and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussions regarding regulation of endocrine disruptors (EDs) and combination effects are ongoing in Europe. Among the central topics of discussion are establishment of criteria for identification of EDs, whether there is a threshold for endocrine disrupting effects and how EDs should be handled within relevant EU regulations. In addition, a roadmap for further EU work regarding combination effects has been presented, but more detailed discussions are needed regarding scientific issues and regulatory intervention. Possible Member State initiatives to provide input to these EU processes were discussed in a Nordic workshop held in Oslo in November 2013. This report describes the workshop presentations, initiatives and thoughts from each of the Nordic countries, the plenary discussions, and the main workshop outcomes
Download or read book The Identification and Distribution of Environmental Endocrine Disruptors in Boston Harbor and Massachusetts Bay a Dissertation written by Raymond Siegener and published by . This book was released on 2005 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Risk Assessment written by Peter Fisk and published by John Wiley & Sons. This book was released on 2013-10-28 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential guide and support to understanding of the science and policy, procedure and practice that underpins the REACH risk assessments required for the use and placing on the market of chemicals in the European Union. A clear understanding of information provision and how this affects the assessment of chemical safety is fundamentally important to the success of policy on chemicals and ultimately to the sustainability of the chemicals industry. Within the book, the scientific processes that underpin the policy are explained in a practical way. Importantly, it includes coverage of techniques to help solve the problems of using potentially risky and hazardous chemicals through the use of less hazardous alternatives and ‘green chemistry’, and also the analysis of the risks of the use of the most hazardous substances against the social and economic benefits of use. Chemical Risk Assessment: A Manual for REACH covers the following main themes: i) Assessment of chemical risk; ii) Risk management; iii) Hazard reduction, substitution and green chemistry; iv) Risk versus benefit – socio-economic analysis. The book acts as a practical guide and overview to chemicals risk assessment and risk management (in the EU context), as well as a support text for planning for the challenges of the future, which will see ever-increasing pressure to withdraw hazardous substances from the EU (and global) market, balanced against opportunities for innovation in the development of less hazardous chemicals.
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
